abstracts of the 3rd int sym on inborn errors of metabolism in humans paper only



J. Salway G. Metabolism at a Glance J. Salway G. Metabolism at a Glance Новинка

J. Salway G. Metabolism at a Glance

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Metabolism at a Glance presents a concise, illustrated summary of metabolism in health and disease. This essential text is progressively appropriate for introductory through to advanced medical and biochemistry courses. It also provides a succinct review of inborn errors of metabolism, and reference for postgraduate medical practitioners and biomedical scientists who need a resource to quickly refresh their knowledge. Fully updated and extensively illustrated, this new edition of Metabolism at a Glance is now in full colour throughout, and includes new coverage of sports biochemistry; the metabolism of lipids, carbohydrates and cholesterol; glyceroneogenesis, α-oxidation and ω-oxidation of fatty acids. It also features the overlooked “Krebs Uric Acid Cycle”. Metabolism at a Glance offers an accessible introduction to metabolism, and is ideal as a revision aid for students preparing for undergraduate and USMLE Step 1 exams.
Hugo Kubinyi Drug Metabolism Prediction Hugo Kubinyi Drug Metabolism Prediction Новинка

Hugo Kubinyi Drug Metabolism Prediction

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The first professional reference on this highly relevant topic, for drug developers, pharmacologists and toxicologists. The authors provide more than a systematic overview of computational tools and knowledge bases for drug metabolism research and their underlying principles. They aim to convey their expert knowledge distilled from many years of experience in the field. In addition to the fundamentals, computational approaches and their applications, this volume provides expert accounts of the latest experimental methods for investigating drug metabolism in four dedicated chapters. The authors discuss the most important caveats and common errors to consider when working with experimental data. Collating the knowledge gained over the past decade, this practice-oriented guide presents methods not only used in drug development, but also in the development and toxicological assessment of cosmetics, functional foods, agrochemicals, and additives for consumer goods, making it an invaluable reference in a variety of disciplines.
Vicki Rosen Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Vicki Rosen Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Новинка

Vicki Rosen Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

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Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th Edition is the comprehensive revision of the field-leading reference on bone and mineral health. The eighth edition has been fully revised by the leading researchers and clinicians in the field to provide concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. Chapters look to explain basic biological factors of healthy development and disease states and make it easily translatable to clinical interventions. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease. Visit the companion site to access supplementary materials including videos, editorial team details, downloadable figures, and more.
David A. Bender Amino Acid Metabolism David A. Bender Amino Acid Metabolism Новинка

David A. Bender Amino Acid Metabolism

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Amino Acid Metabolism, 3rd Edition covers all aspects of the biochemistry and nutritional biochemistry of the amino acids. Starting with an overview of nitrogen fixation and the incorporation of inorganic nitrogen into amino acids, the book then details other major nitrogenous compounds in micro-organisms, plants and animals. Contents include a discussion of the catabolism of amino acids and other nitrogenous compounds in animals, and the microbiological reactions involved in release of nitrogen gas back into the atmosphere. Mammalian (mainly human) protein and amino acid requirements are considered in detail, and the methods that are used to determine them. Chapters consider individual amino acids, grouped according to their metabolic origin, and discussing their biosynthesis (in plants and micro-organisms for those that are dietary essentials for human beings), major metabolic roles (mainly in human metabolism) and catabolism (again mainly in human metabolism). There is also discussion of regulatory mechanisms for all these metabolic pathways, and of metabolic and genetic diseases affecting the (human) metabolism of amino acids. Throughout the book the emphasis is on the nutritional importance of amino acids, integration and control of metabolism and metabolic and other disturbances of relevance to human biochemistry and health. Completely revised edition of this comprehensive text covering all the latest findings in amino acid metabolism research Written by an authority in the field Covers new advances in structural biology Clear illustrations of all structures and metabolic pathways Full list of recommended further reading for each chapter and bibliography of papers cited in the text
Gottfried Unden Host - Pathogen Interaction. Microbial Metabolism, Pathogenicity and Antiinfectives Gottfried Unden Host - Pathogen Interaction. Microbial Metabolism, Pathogenicity and Antiinfectives Новинка

Gottfried Unden Host - Pathogen Interaction. Microbial Metabolism, Pathogenicity and Antiinfectives

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In light of the rapidity increasing incidence rate of bacterial and fungal infections with multi-resistant pathogens, the metabolic changes associated with host-pathogen interactions offer one of the most promising starting points for developing novel antibiotics. . Part one of this comprehensive guide describes the metabolic adaptation of pathogenic microbes in humans, while part two points to routes for the development of novel antibiotics. This is volume six of the book series on drug discovery in infectious diseases by Paul Selzer.
Tucker Maurice E. Carbonate Diagenesis Tucker Maurice E. Carbonate Diagenesis Новинка

Tucker Maurice E. Carbonate Diagenesis

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Over the years, many papers on carbonate diagenesis have been published in Sedimentology, the journal of the International Association of Sedimentologists. This volume presents a collection of these papers with a commentary. The emphasis of the book is on the diagenesis of shallow-marine carbonate sediments and the editors have chosen 12 papers which are reproduced in full. To widen the scope of this volume the abstracts for another 16 papers are presented. These provide further examples of diagenetic studies and help to extend the coverage of the book. The reprints and abstracts are divided into three groups, dealing with marine, meteoric and burial diagenesis respectively. Each collection is preceded by a commentary which briefly summarizes the topic and introduces the reprints and abstracts to come
Kang Y. Conversational Chinese 301 Vol.2 (3rd edition) / Разговорная китайская речь 301 Часть 2 (Третье издание) - Рабочая тетрадь Kang Y. Conversational Chinese 301 Vol.2 (3rd edition) / Разговорная китайская речь 301 Часть 2 (Третье издание) - Рабочая тетрадь Новинка

Kang Y. Conversational Chinese 301 Vol.2 (3rd edition) / Разговорная китайская речь 301 Часть 2 (Третье издание) - Рабочая тетрадь

This Workbook is to be used along with the textbook Conversational Chinese 301 (3rd Ed.), Vol. 2. The Workbook adopts the most efficient method to develop Chinese speaking proficiency proved by teaching and learning practice. Based on the test form of HSK and focusing on the most frequently occurring mistakes of beginners, it corrects the easily committed errors and provides comprehensive drilling from multi-perspectives, from the collocation of words to structural transformation in different language situations and reading comprehension.
Fred Smith H. The Origins of Modern Humans. Biology Reconsidered Fred Smith H. The Origins of Modern Humans. Biology Reconsidered Новинка

Fred Smith H. The Origins of Modern Humans. Biology Reconsidered

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This update to the award-winning The Origins of Modern Humans: A World Survey of the Fossil Evidence covers the most accepted common theories concerning the emergence of modern Homo sapiens—adding fresh insight from top young scholars on the key new discoveries of the past 25 years. The Origins of Modern Humans: Biology Reconsidered allows field leaders to discuss and assess the assemblage of hominid fossil material in each region of the world during the Pleistocene epoch. It features new fossil and molecular evidence, such as the evolutionary inferences drawn from assessments of modern humans and large segments of the Neandertal genome. It also addresses the impact of digital imagery and the more sophisticated morphometrics that have entered the analytical fray since 1984. Beginning with a thoughtful introduction by the authors on modern human origins, the book offers such insightful chapter contributions as: Africa: The Cradle of Modern People Crossroads of the Old World: Late Hominin Evolution in Western Asia A River Runs through It: Modern Human Origins in East Asia Perspectives on the Origins of Modern Australians Modern Human Origins in Central Europe The Makers of the Early Upper Paleolithic in Western Eurasia Neandertal Craniofacial Growth and Development and Its Relevance for Modern Human Origins Energetics and the Origin of Modern Humans Understanding Human Cranial Variation in Light of Modern Human Origins The Relevance of Archaic Genomes to Modern Human Origins The Process of Modern Human Origins: The Evolutionary and Demographic Changes Giving Rise to Modern Humans The Paleobiology of Modern Human Emergence Elegant and thought provoking, The Origins of Modern Humans: Biology Reconsidered is an ideal read for students, grad students, and professionals in human evolution and paleoanthropology.
Robert Crichton Iron Metabolism. From Molecular Mechanisms to Clinical Consequences Robert Crichton Iron Metabolism. From Molecular Mechanisms to Clinical Consequences Новинка

Robert Crichton Iron Metabolism. From Molecular Mechanisms to Clinical Consequences

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Iron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems a natural target for pathogenic microorganisms and parasites. Uniquely, humans suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health. The 4th edition of Iron Metabolism is written in a lively style by one of the leaders in the field, presented in colour and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism/homeostasis.
Gupta Ramesh C. Anticholinesterase Pesticides. Metabolism, Neurotoxicity, and Epidemiology Gupta Ramesh C. Anticholinesterase Pesticides. Metabolism, Neurotoxicity, and Epidemiology Новинка

Gupta Ramesh C. Anticholinesterase Pesticides. Metabolism, Neurotoxicity, and Epidemiology

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This book offers an important reference source about the most common classes of pesticides for researchers engaged in the area of neurotoxicology, metabolism, and epidemiology. The book presents details about thorough characterization of target and non-target enzymes and proteins involved in toxicity and metabolism; and epidemiology of poisonings and fatalities in people from short- and long- term exposures to these pesticides in different occupational settings on an individual country basis as well as on a global basis. The early portion of the book deals with metabolism, mechanisms and biomonitoring of anticholinesterase pesticides, while the later part deals with epidemiological studies, regulatory issues, and therapeutic intervention.
Phillip R. Sloan, Brandon Fogel Creating a Physical Biology. The three-man paper and early molecular biology Phillip R. Sloan, Brandon Fogel Creating a Physical Biology. The three-man paper and early molecular biology Новинка

Phillip R. Sloan, Brandon Fogel Creating a Physical Biology. The three-man paper and early molecular biology

In 1935 geneticist Nikolai Timoféeff-Ressovsky, radiation physicist Karl G. Zimmer, and quantum physicist Max Delbrück published “On the Nature of Gene Mutation and Gene Structure,” known subsequently as the “Three-Man Paper.” This seminal paper advanced work on the physical exploration of the structure of the gene through radiation physics and suggested ways in which physics could reveal definite information about gene structure, mutation, and action. Representing a new level of collaboration between physics and biology, it played an important role in the birth of the new field of molecular biology. The paper’s results were popularized for a wide audience in the What is Life? lectures of physicist Erwin Schrödinger in 1944. Despite its historical impact on the biological sciences, the paper has remained largely inaccessible because it was only published in a short-lived German periodical. Creating a Physical Biology makes the Three Man Paper available in English for the first time. Brandon Fogel’s translation is accompanied by an introductory essay by Fogel and Phillip Sloan and a set of essays by leading historians and philosophers of biology that explore the context, contents, and subsequent influence of the paper, as well as its importance for the wider philosophical analysis of biological reductionism.Издательство - The University of Chicago Press
L. А. Karoly Fast methods for jackknifing inequality indices L. А. Karoly Fast methods for jackknifing inequality indices Новинка

L. А. Karoly Fast methods for jackknifing inequality indices

The jackknife is a resampling method that uses subsets of the original database by leaving out one observation at a time from the sample. The paper develops fast algorithms for jackknifing inequality indices with only a few passes through the data. The number of passes is independent of the number of observations. Hence, the method provides an efficient way to obtain standard errors of the estimators even if sample size is large. We apply our method using micro data on individual incomes for Germany and the US.
John Vincent The Bioinorganic Chemistry of Chromium John Vincent The Bioinorganic Chemistry of Chromium Новинка

John Vincent The Bioinorganic Chemistry of Chromium

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Chromium exists in nature as complexes of two stable oxidation states – trivalent chromium(III) and hexavalent chromium(VI). Although trivalent chromium is required in trace amounts for sugar and lipid metabolism in humans and its deficiency may cause a disease called chromium deficiency; hexavalent chromium is toxic and carcinogenic. As chromium compounds were used in dyes and paints and the tanning of leather, these compounds are often found in soil and groundwater at abandoned industrial sites, now needing environmental cleanup and remediation. The Bioinorganic Chemistry of Chromium: From Biochemistry to Environmental Toxicology takes a critical look at what the biochemical data indicate about chromium's role in the body and the biological mechanisms of its toxicology. Topics covered include: What do we know about the biochemical roles and mechanisms of chromium? Is chromium an essential element in the mammalian diet? Is chromium(III) effective as a nutraceutical, a therapeutic agent, and as a supplement in animal feed? What is the biochemistry behind the toxicology of chromium(III) and chromium(VI):the mechanisms of metabolism, genetic and epigenetic effects, and disruption of cell signalling? What are the current chromium(VI) policies and positions from regulatory agencies? The Bioinorganic Chemistry of Chromium: From Biochemistry to Environmental Toxicology is an important contribution to the bioinorganic and trace element biochemical fields which will find a place on the bookshelves of bioinorganic chemists, biochemists, inorganic chemists, toxicologists, nutritionists and regulatory affairs professionals.
Alan Crozier Plant Metabolism and Biotechnology Alan Crozier Plant Metabolism and Biotechnology Новинка

Alan Crozier Plant Metabolism and Biotechnology

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Various plant metabolites are useful for human life, and the induction and reduction of these metabolites using modern biotechnical technique is of enormous potential important especially in the fields of agriculture and health. Plant Metabolism and Biotechnology describes the biosynthetic pathways of plant metabolites, their function in plants, and some applications for biotechnology. Topics covered include: biosynthesis and metabolism of starch and sugars lipid biosynthesis symbiotic nitrogen fixation sulfur metabolism nucleotide metabolism purine alkaloid metabolism nicotine biosynthesis terpenoid biosynthesis benzylisoquinoline alkaloid biosynthesis monoterpenoid indole alkaloid biosynthesis flavonoid biosynthesis pigment biosynthesis: anthocyanins, betacyanins and carotenoids metabolomics in biotechnology Plant Metabolism and Biotechnology is an essential guide to this important field for researchers and students of biochemistry, plant biology, metabolic engineering, biotechnology, food science, agriculture, and medicine.
Michael Wink Annual Plant Reviews, Biochemistry of Plant Secondary Metabolism Michael Wink Annual Plant Reviews, Biochemistry of Plant Secondary Metabolism Новинка

Michael Wink Annual Plant Reviews, Biochemistry of Plant Secondary Metabolism

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This brand new Annual Plant Reviews volume is the second edition of the highly successful and well-received Annual Plant Reviews, Volume 2. This exciting new volume provides an up-to-date survey of the biochemistry and physiology of plant secondary metabolism. The volume commences with an overview of the biochemistry, physiology and function of secondary metabolism, followed by detailed reviews of the major groups of secondary metabolites: alkaloids and betalains, cyanogenic glucosides, glucosinolates and nonprotein amino acids, phenyl propanoids and related phenolics, terpenoids, cardiac glycosides and saponins. A final chapter discusses the evolution of secondary metabolism. This carefully compiled new edition brings together chapters from some of the world's leading experts in plant secondary metabolism. Completely revised and brought right up to date with much new information, this volume is an essential purchase for advanced students, researchers and professionals in biochemistry, physiology, molecular biology, genetics, plant sciences, agriculture, medicine, pharmacology and pharmacy, working in the academic and industrial sectors, including those working in the pesticide and pharmaceutical industries. Libraries in all universities and research establishments where these subjects are studied and taught will need copies of this excellent volume on their shelves. A companion volume Annual Plant Reviews Volume 39, Functions and Biotechnology of Plant Secondary Metabolites, Second Edition, Edited by M. Wink, is also available.
Raghavan Srinivasan Fatigue of Materials II. Advances and Emergences in Understanding Raghavan Srinivasan Fatigue of Materials II. Advances and Emergences in Understanding Новинка

Raghavan Srinivasan Fatigue of Materials II. Advances and Emergences in Understanding

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The Second International Symposium of Fatigue of Materials: Advances and Emergences in Understanding is a five-session symposium held in conjunction with the Materials Science and Technology Conference 2012 (MS&T 2012) at Pittsburgh, Pennsylvania, during October 7-11, 2012. The abstracts that were submitted for presentation at this symposium cover a diverse range of topics. We have made an attempt to group these papers into sessions that focus on closely-related topics. However, as can be expected, many of the papers could fit into more than one session. In the ensuing discussion, we provide a cohesive, complete and compelling overview of the symposium as well as a summary of the abstracts that were submitted. Session 1(Overview 1) and Session 2 (Overview II) contain papers that (i) Review the current state of knowledge both related and relevant to the subject of fatigue behavior of materials, and (ii) New, innovative, and emerging techniques for experimental evaluation of the fatigue behavior. In concurrence the papers attempt to analyze the data for aspects relevant to design and simultaneously predicting the useful life of components and structures. Session 3 (Aerospace Materials I) and Session 4 (Aerospace Materials II) focus on advanced materials that are used in performance-critical applications in the aerospace and automotive industries, such as the alloys of titanium, nickel, aluminum, and magnesium. Session 5 is a collection of papers relating to other materials of engineering interest, such as iron and steel, polymer, rubber, and even composites. In the summary presented below, the session number and paper number are identified by S and P. Topics related to the influence of both processing and the environment are covered in papers presented in all the sessions of this symposium, and are briefly summarized here as a group with additional discussion included in the individual sessions.
John Clary J. The Toxicology of Methanol John Clary J. The Toxicology of Methanol Новинка

John Clary J. The Toxicology of Methanol

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The Toxicology of Methanol presents a single source of information and an understanding of the toxicity of methanol from animal data, potential environmental effects as well as human effects. The animal data, which goes to making up the majority of the data on the toxicity of methanol and the mechanism of action, is reviewed as it relates to the potential toxicity in humans.
Alexander Samson Locus Amoenus. Gardens and Horticulture in the Renaissance Alexander Samson Locus Amoenus. Gardens and Horticulture in the Renaissance Новинка

Alexander Samson Locus Amoenus. Gardens and Horticulture in the Renaissance

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Locus Amoenus provides a pioneering collection of new perspectives on Renaissance garden history, and the impact of its development. Experts in the field illustrate the extent of our knowledge of how the natural world looked and how humans related to their environment. A ground-breaking collection of new perspectives on garden history Essays demonstrate the extent of our knowledge of how the natural world looked and how humans related to their environment The book's broad coverage includes botany and herbals, literary reflections of changing ideas of landscape and nature, and human's place within it Contributors come from a wide range of experts, including archaeologists, scholars and the librarian and archivist to the Royal Horticultural Society Reflects the growing emergence of this field, which has been assisted both by archaeology and ideas from green studies and environmental criticism Richly illustrated throughout
Pratima Bajpai Environmentally Friendly Production of Pulp and Paper Pratima Bajpai Environmentally Friendly Production of Pulp and Paper Новинка

Pratima Bajpai Environmentally Friendly Production of Pulp and Paper

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Implementing Cleaner Production in the pulp and paper industry The large—and still growing—pulp and paper industry is a capital- and resource-intensive industry that contributes to many environmental problems, including global warming, human toxicity, ecotoxicity, photochemical oxidation, acidification, nutrification, and solid wastes. This important reference for professionals in the pulp and paper industry details how to improve manufacturing processes that not only cut down on the emission of pollutants but also increase productivity and decrease costs. Environmentally Friendly Production of Pulp and Paper guides professionals in the pulp and paper industry to implement the internationally recognized process of Cleaner Production (CP). It provides updated information on CP measures in: Raw material storage and preparation Pulping processes (Kraft, Sulphite, and Mechanical) Bleaching, recovery, and papermaking Emission treatment and recycled fiber processing In addition, the book includes a discussion on recent cleaner technologies and their implementation status and benefits in the pulp and paper industry. Covering every aspect of pulping and papermaking essential to the subject of reducing pollution, this is a must-have for paper and bioprocess engineers, environmental engineers, and corporations in the forest products industry.
Mark Stoneking An Introduction to Molecular Anthropology Mark Stoneking An Introduction to Molecular Anthropology Новинка

Mark Stoneking An Introduction to Molecular Anthropology

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Molecular anthropology uses molecular genetic methods to address questions and issues of anthropological interest. More specifically, molecular anthropology is concerned with genetic evidence concerning human origins, migrations, and population relationships, including related topics such as the role of recent natural selection in human population differentiation, or the impact of particular social systems on patterns of human genetic variation. Organized into three major sections, An Introduction to Molecular Anthropology first covers the basics of genetics – what genes are, what they do, and how they do it – as well as how genes behave in populations and how evolution influences them. The following section provides an overview of the different kinds of genetic variation in humans, and how this variation is analyzed and used to make evolutionary inferences. The third section concludes with a presentation of the current state of genetic evidence for human origins, the spread of humans around the world, the role of selection and adaptation in human evolution, and the impact of culture on human genetic variation. A final, concluding chapter discusses various aspects of molecular anthropology in the genomics era, including personal ancestry testing and personal genomics. An Introduction to Molecular Anthropology is an invaluable resource for students studying human evolution, biological anthropology, or molecular anthropology, as well as a reference for anthropologists and anyone else interested in the genetic history of humans.
Ala Nassar F. Drug Metabolism Handbook. Concepts and Applications Ala Nassar F. Drug Metabolism Handbook. Concepts and Applications Новинка

Ala Nassar F. Drug Metabolism Handbook. Concepts and Applications

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A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism. By providing both a solid conceptual understanding of the drug metabolism system, and a well illustrated, detailed demonstration and explanation of cutting edge tools and techniques, this book serves as a valuable reference tool for bench scientists, medical students, and students of general health sciences.
Alexey Kondrashov S. Crumbling Genome. The Impact of Deleterious Mutations on Humans Alexey Kondrashov S. Crumbling Genome. The Impact of Deleterious Mutations on Humans Новинка

Alexey Kondrashov S. Crumbling Genome. The Impact of Deleterious Mutations on Humans

A thought-provoking exploration of deleterious mutations in the human genome and their effects on human health and wellbeing Despite all of the elaborate mechanisms that a cell employs to handle its DNA with the utmost care, a newborn human carries about 100 new mutations, originated in their parents, about 10 of which are deleterious. A mutation replacing just one of the more than three billion nucleotides in the human genome may lead to synthesis of a dysfunctional protein, and this can be inconsistent with life or cause a tragic disease. Several percent of even young people suffer from diseases that are caused, exclusively or primarily, by pre?]existing and new mutations in their genomes, including both a wide variety of genetically simple Mendelian diseases and diverse complex diseases such as birth anomalies, diabetes, and schizophrenia. Milder, but still substantial, negative effects of mutations are even more pervasive. As of now, we possess no means of reducing the rate at which mutations appear spontaneously. However, the recent flood of genomic data made possible by next-generation methods of DNA sequencing, enabled scientists to explore the impacts of deleterious mutations on humans with previously unattainable precision and begin to develop approaches to managing them. Written by a leading researcher in the field of evolutionary genetics, Crumbling Genome reviews the current state of knowledge about deleterious mutations and their effects on humans for those in the biological sciences and medicine, as well as for readers with only a general scientific literacy and an interest in human genetics. Provides an extensive introduction to the fundamentals of evolutionary genetics with an emphasis on mutation and selection Discusses the effects of pre-existing and new mutations on human genotypes and phenotypes Provides a comprehensive review of the current state of knowledge in the field and considers crucial unsolved problems Explores key ethical, scientific, and social issues likely to become relevant in the near future as the modification of human germline genotypes becomes technically feasible Crumbling Genome is must-reading for students and professionals in human genetics, genomics, bioinformatics, evolutionary biology, and biological anthropology. It is certain to have great appeal among all those with an interest in the links between genetics and evolution and how they are likely to influence the future of human health, medicine, and society.
Short Second Life Bree Tanner Short Second Life Bree Tanner Новинка

Short Second Life Bree Tanner

I turned off my brain. It was time to hunt. I took a deep breath, drawing in the scent of the blood inside the humans below. They weren't the only humans around, but they were the closest. Who you were going to hunt was the kind of decision you had to make before you scented your prey. It was too late now to choose anything.
Mohammad Arashi Statistical Inference for Models with Multivariate t-Distributed Errors Mohammad Arashi Statistical Inference for Models with Multivariate t-Distributed Errors Новинка

Mohammad Arashi Statistical Inference for Models with Multivariate t-Distributed Errors

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This book summarizes the results of various models under normal theory with a brief review of the literature. Statistical Inference for Models with Multivariate t-Distributed Errors: Includes a wide array of applications for the analysis of multivariate observations Emphasizes the development of linear statistical models with applications to engineering, the physical sciences, and mathematics Contains an up-to-date bibliography featuring the latest trends and advances in the field to provide a collective source for research on the topic Addresses linear regression models with non-normal errors with practical real-world examples Uniquely addresses regression models in Student's t-distributed errors and t-models Supplemented with an Instructor's Solutions Manual, which is available via written request by the Publisher
Merrill Singer A Companion to the Anthropology of Environmental Health Merrill Singer A Companion to the Anthropology of Environmental Health Новинка

Merrill Singer A Companion to the Anthropology of Environmental Health

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A Companion to the Anthropology of Environmental Health presents a collection of readings that utilize a medical anthropological approach to explore the interface of humans and the environment in the shaping of health and illness around the world. Features the latest ethnographic research from around the world related to the multiple impacts of the environment on health and of societies on their environments Includes contributions from international medical anthropologists, conservationists, environmental experts, public health professionals, health clinicians, and other social scientists Analyzes the conditions of cultural and social transformation that accompany environmental and ecological impacts in all areas of the world Offers critical perspectives on theoretical and methodological advancements in the anthropology of environmental health, along with future directions in the field
A. Pyle J. Locke A. Pyle J. Locke Новинка

A. Pyle J. Locke

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John Locke (1632-1704) has a good claim to the title of the greatest ever English philosopher, and was a founding father of both the empiricist tradition in philosophy and the liberal tradition in politics. This new book provides an accessible introduction to Locke’s thought. Although its primary focus is on the Essay Concerning Human Understanding, it also discusses the Two Treatises on Government, the Essay on Toleration, and the Reasonableness of Christianity, and draws on materials from Locke’s correspondence and notebooks to shed light on the contexts of these major works. Locke’s arguments for his central claims are subjected to close scrutiny, and his replies to his main critics evaluated. A.J. Pyle takes as his guiding theme Locke’s own maxim, that God has given humans enough knowledge for our needs. The philosopher who emerges from these pages is a strikingly modern figure, anti-metaphysical in his attitude both to science and to theology, anti-authoritarian in his politics, and cautiously optimistic about human progress. Locke is indeed one of the founding figures of the Enlightenment, but for Pyle the Lockean Enlightenment is a modest affair of slow and hesitant groping towards the light. As well as serving as an introduction to Locke for students, the book also helps to correct a number of significant errors and misunderstandings that have marred our understanding of Locke and will spark discussion and debate amongst scholars of his work.
Thomas Posch Das Ende der Nacht. Lichtsmog: Gefahren - Perspektiven - Lösungen Thomas Posch Das Ende der Nacht. Lichtsmog: Gefahren - Perspektiven - Lösungen Новинка

Thomas Posch Das Ende der Nacht. Lichtsmog: Gefahren - Perspektiven - Lösungen

Every city dweller is aware that we are seeing fewer stars at night due to the increasing amount of artificial lighting. But that is just the tip of the iceberg, as far as the loss of natural nocturnal darkness is concerned. Humans and animals worldwide are now suffering from the disrupted rhythm of day and night due to extreme lighting at night. In humans this can lead to illness and increased stress. Hitherto only known to experts, this book is the first to comprehensively treat the entire phenomenon of light pollution. Richly illustrated using unusual images taken from the TV documentation «The Dark Side of Light» by Anja Freyhoff and Thomas Uhlmann, this book is for anyone interested in a harmonious coexistence between humans and nature and a healthy work/life rhythm.
Morton James Biochemistry for Sport and Exercise Metabolism Morton James Biochemistry for Sport and Exercise Metabolism Новинка

Morton James Biochemistry for Sport and Exercise Metabolism

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How do our muscles produce energy for exercise and what are the underlying biochemical principles involved? These are questions that students need to be able to answer when studying for a number of sport related degrees. This can prove to be a difficult task for those with a relatively limited scientific background. Biochemistry for Sport and Exercise Metabolism addresses this problem by placing the primary emphasis on sport, and describing the relevant biochemistry within this context. The book opens with some basic information on the subject, including an overview of energy metabolism, some key aspects of skeletal muscle structure and function, and some simple biochemical concepts. It continues by looking at the three macromolecules which provide energy and structure to skeletal muscle – carbohydrates, lipids, and protein. The last section moves beyond biochemistry to examine key aspects of metabolism – the regulation of energy production and storage. Beginning with a chapter on basic principles of regulation of metabolism it continues by exploring how metabolism is influenced during high-intensity, prolonged, and intermittent exercise by intensity, duration, and nutrition. Key Features: A clearly written, well presented introduction to the biochemistry of muscle metabolism. Focuses on sport to describe the relevant biochemistry within this context. In full colour throughout, it includes numerous illustrations, together with learning objectives and key points to reinforce learning. Biochemistry for Sport and Exercise Metabolism will prove invaluable to students across a range of sport-related courses, who need to get to grips with how exercise mode, intensity, duration, training status and nutritional status can all affect the regulation of energy producing pathways and, more important, apply this understanding to develop training and nutrition programmes to maximise athletic performance.
Kate Williams Avoiding Errors in General Practice Kate Williams Avoiding Errors in General Practice Новинка

Kate Williams Avoiding Errors in General Practice

Some of the most important and best lessons in a doctor’s career are learnt from mistakes. However, an awareness of the common causes of medical errors and developing positive behaviours can reduce the risk of mistakes and litigation. Written for Foundation Year doctors, trainees and general practitioners, and unlike any other clinical management title available, Avoiding Errors in General Practice identifies and explains the most common errors likely to occur in an outpatient setting – so that you won’t make them. The first section in this brand new guide discusses the causes of errors in general practice. The second and largest section consists of case scenarios and includes expert and legal comment as well as clinical teaching points and strategies to help you engage in safer practice throughout your career. The final section discusses how to deal with complaints and the subsequent potential medico-legal consequences, helping to reduce your anxiety when dealing with the consequences of an error. Invaluable during the Foundation Years, Specialty Training and for Consultants, Avoiding Errors in General Practice is the perfect guide to help tackle the professional and emotional challenges of life as a GP.
Alexei Verkhratsky Glial Physiology and Pathophysiology Alexei Verkhratsky Glial Physiology and Pathophysiology Новинка

Alexei Verkhratsky Glial Physiology and Pathophysiology

12537.24 руб. или Купить в рассрочку!
Glial Physiology and Pathophysiology provides a comprehensive, advanced text on the biology and pathology of glial cells. Coverae includes: the morphology and interrelationships between glial cells and neurones in different parts of the nervous systems the cellular physiology of the different kinds of glial cells the mechanisms of intra- and inter-cellular signalling in glial networks the mechanisms of glial-neuronal communications the role of glial cells in synaptic plasticity, neuronal survival and development of nervous system the cellular and molecular mechanisms of metabolic neuronal-glial interactions the role of glia in nervous system pathology, including pathology of glial cells and associated diseases – for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson's Neuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it. An up-to-date and fully referenced text on the most numerous cells in the human brain Detailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous system Describes the role og glial cells in neuropathology Focus boxes highlight key points and summarise important facts Companion website with downloadable figures and slides
R. Dods F. Understanding Diabetes. A Biochemical Perspective R. Dods F. Understanding Diabetes. A Biochemical Perspective Новинка

R. Dods F. Understanding Diabetes. A Biochemical Perspective

8300.95 руб. или Купить в рассрочку!
A clear explanation of the cause, diagnosis, and treatment of diabetes Written for a broad range of readers, including students, researchers, policymakers, health care providers, and diabetes patients and caregivers, this book explains the underlying biochemistry and physiology of diabetes mellitus. Each chapter contains a glossary that defines key terms, a summary that highlights essential concepts discussed in each section of the chapter, as well as a set of simple problems to help readers gain a richer and deeper understanding of diabetes, from its history to treatment options. Understanding Diabetes begins with an overview of the disease, its worldwide prevalence and cost, and its connection to the global obesity epidemic. The author then explores the history of diabetes, including the first documented description of the disease dating back to 3400 BCE in Ancient Egypt. The next chapter, A Glucose Metabolism Primer, sets forth the pathways for the metabolism of glucose. Next, the book covers: Regulation of glucose metabolism and glucose metabolism gone wrong Diabetes classification system Diagnosis, including current laboratory tests Complications, such as retinopathy, neuropathy, and cardiovascular disease Hereditary transmission Prevention and treatment, including emerging research Although a cure has still not been found, this book demonstrates that researchers are continuing to make major breakthroughs on all fronts in the fight against diabetes, including a better understanding of its causes and an improved ability to diagnose and treat the disease.
Mark Kirwan J. Handbook of Paper and Paperboard Packaging Technology Mark Kirwan J. Handbook of Paper and Paperboard Packaging Technology Новинка

Mark Kirwan J. Handbook of Paper and Paperboard Packaging Technology

16721.12 руб. или Купить в рассрочку!
The definitive industry reference on the paper and paperboard packaging sector. Now in a fully revised and updated second edition, this book discusses all the main types of packaging based on paper and paperboard. It considers the raw materials, the manufacture of paper and paperboard, and the basic properties and features on which packaging made from these materials depends for its appearance and performance. The manufacture of twelve types of paper- and paperboard-based packaging is described, together with their end-use applications and the packaging machinery involved. The importance of pack design is stressed, as well as how these materials offer packaging designers opportunities for imaginative and innovative design solutions. Environmental factors, including resource sustainability, societal and waste management issues are addressed in a dedicated chapter. The book is directed at readers based in companies which manufacture packaging grades of paper and paperboard, companies involved in the design, printing and production of packaging, and companies which manufacture inks, coatings, adhesives and packaging machinery. It will be essential reading for students of packaging technology and technologists working in food manufacturing who are users of paper and paperboard packaging products. Praise for the First Edition ‘This book is a valuable addition to the library of any forward-looking company by providing in-depth coverage of all aspects of packaging which involve the most ecologically acceptable material, namely paper and paperboard.’—International Journal of Dairy Technology ‘…a welcome contribution to a field where coverage was previously limited to subject-specific books… or to single chapters in textbooks on broader aspects of packaging technology.’—Packaging Technology and Science
Kate Williams Avoiding Errors in Paediatrics Kate Williams Avoiding Errors in Paediatrics Новинка

Kate Williams Avoiding Errors in Paediatrics

4100.96 руб. или Купить в рассрочку!
Some of the most important and best lessons in a doctor’s career are learnt from mistakes. However, an awareness of the common causes of medical errors and developing positive behaviours can reduce the risk of mistakes and litigation. Written for junior paediatric staff and consultants, and unlike any other paediatric clinical management title available, Avoiding Errors in Paediatrics identifies and explains the most common errors likely to occur in a paediatric setting – so that you won’t make them. The first section in this brand new guide discusses the causes of errors in paediatrics. The second and largest section consists of case scenarios and includes expert and legal comment as well as clinical teaching points and strategies to help you engage in safer practice throughout your career. The final section discusses how to deal with complaints and the subsequent potential medico-legal consequences, helping to reduce your anxiety when dealing with the consequences of an error. Invaluable during the Foundation Years, Specialty Training and for Consultants, Avoiding Errors in Paediatrics is the perfect guide to help tackle the professional and emotional challenges of life as a paediatrician.
Lothar Muller White Magic. The Age of Paper Lothar Muller White Magic. The Age of Paper Новинка

Lothar Muller White Magic. The Age of Paper

4524.32 руб. или Купить в рассрочку!
Paper is older than the printing press, and even in its unprinted state it was the great network medium behind the emergence of modern civilization. In the shape of bills, banknotes and accounting books it was indispensible to the economy. As forms and files it was essential to bureaucracy. As letters it became the setting for the invention of the modern soul, and as newsprint it became a stage for politics. In this brilliant new book Lothar Müller describes how paper made its way from China through the Arab world to Europe, where it permeated everyday life in a variety of formats from the thirteenth century onwards, and how the paper technology revolution of the nineteenth century paved the way for the creation of the modern daily press. His key witnesses are the works of Rabelais and Grimmelshausen, Balzac and Herman Melville, James Joyce and Paul Valéry. Müller writes not only about books, however: he also writes about pamphlets, playing cards, papercutting and legal pads. We think we understand the ?Gutenberg era?, but we can understand it better when we explore the world that underpinned it: the paper age. Today, with the proliferation of digital devices, paper may seem to be a residue of the past, but Müller shows that the humble technology of paper is in many ways the most fundamental medium of the modern world.
Hardin James W. Common Errors in Statistics (and How to Avoid Them) Hardin James W. Common Errors in Statistics (and How to Avoid Them) Новинка

Hardin James W. Common Errors in Statistics (and How to Avoid Them)

5196.34 руб. или Купить в рассрочку!
Praise for the Second Edition «All statistics students and teachers will find in this book a friendly and intelligentguide to . . . applied statistics in practice.» —Journal of Applied Statistics «. . . a very engaging and valuable book for all who use statistics in any setting.» —CHOICE «. . . a concise guide to the basics of statistics, replete with examples . . . a valuablereference for more advanced statisticians as well.» —MAA Reviews Now in its Third Edition, the highly readable Common Errors in Statistics (and How to Avoid Them) continues to serve as a thorough and straightforward discussion of basic statistical methods, presentations, approaches, and modeling techniques. Further enriched with new examples and counterexamples from the latest research as well as added coverage of relevant topics, this new edition of the benchmark book addresses popular mistakes often made in data collection and provides an indispensable guide to accurate statistical analysis and reporting. The authors' emphasis on careful practice, combined with a focus on the development of solutions, reveals the true value of statistics when applied correctly in any area of research. The Third Edition has been considerably expanded and revised to include: A new chapter on data quality assessment A new chapter on correlated data An expanded chapter on data analysis covering categorical and ordinal data, continuous measurements, and time-to-event data, including sections on factorial and crossover designs Revamped exercises with a stronger emphasis on solutions An extended chapter on report preparation New sections on factor analysis as well as Poisson and negative binomial regression Providing valuable, up-to-date information in the same user-friendly format as its predecessor, Common Errors in Statistics (and How to Avoid Them), Third Edition is an excellent book for students and professionals in industry, government, medicine, and the social sciences.
Stuart Rice A. Advances in Chemical Physics Stuart Rice A. Advances in Chemical Physics Новинка

Stuart Rice A. Advances in Chemical Physics

15198.14 руб. или Купить в рассрочку!
Advances in Chemical Physics is the only series of volumes available that explores the cutting edge of research in chemical physics. This is the only series of volumes available that presents the cutting edge of research in chemical physics. Includes contributions from experts in this field of research. Contains a representative cross-section of research that questions established thinking on chemical solutions. Structured with an editorial framework that makes the book an excellent supplement to an advanced graduate class in physical chemistry or chemical physics.
Andreja Bakac Physical Inorganic Chemistry. Reactions, Processes, and Applications Andreja Bakac Physical Inorganic Chemistry. Reactions, Processes, and Applications Новинка

Andreja Bakac Physical Inorganic Chemistry. Reactions, Processes, and Applications

14358.83 руб. или Купить в рассрочку!
This go-to text provides information and insight into physical inorganic chemistry essential to our understanding of chemical reactions on the molecular level. One of the only books in the field of inorganic physical chemistry with an emphasis on mechanisms, it features contributors at the forefront of research in their particular fields. This essential text discusses the latest developments in a number of topics currently among the most debated and researched in the world of chemistry, related to the future of solar energy, hydrogen energy, biorenewables, catalysis, environment, atmosphere, and human health.
Steven Churchill E. Thin on the Ground. Neandertal Biology, Archeology and Ecology Steven Churchill E. Thin on the Ground. Neandertal Biology, Archeology and Ecology Новинка

Steven Churchill E. Thin on the Ground. Neandertal Biology, Archeology and Ecology

11777.18 руб. или Купить в рассрочку!
Thin on the Ground: Neandertal Biology, Archeology and Ecology synthesizes the current knowledge about our sister species the Neandertals, combining data from a variety of disciplines to reach a cohesive theory behind Neandertal low population densities and relatively low rate of technological innovation. The book highlights and contrasts the differences between Neandertals and early modern humans and explores the morphological, physiological, and behavioral adaptive solutions which led to the extinction of the Neandertals and the population expansion of modern humans. Written by a world recognized expert in physical anthropology, Thin on the Ground: Neandertal Biology, Archaeology and Ecology will be a must have title for anyone interested in the rise and fall of the Neandertals.
Montague Summers The Werewolf Montague Summers The Werewolf Новинка

Montague Summers The Werewolf

2012 Reprint of 1933 Edition. Exact facsimile of the original edition, not reproduced with Optical Recognition Software. Unsurpassed in its sheer scope and depth, the first definitive work on were-wolfs, employs a theological and philosophical approach, incorporating an extensive range of historical documentation and folklore. Summers examines the supernatural practice of shape-shifting, notes the finer distinctions between werewolfery and lycanthropy, and explores the differences of opinion on exactly how ordinary humans are transformed into creatures. Augustus Montague Summers was an English author and clergyman. He is known primarily for his scholarly work on the English drama of the 17th century, as well as for his idiosyncratic studies on witches, vampires, and werewolves, in all of which he professed to believe. He was responsible for the first English translation, published in 1928, of the notorious 15th-century witch hunter's manual, the Malleus Maleficarum
Jian Wang Chemical Analysis of Antibiotic Residues in Food Jian Wang Chemical Analysis of Antibiotic Residues in Food Новинка

Jian Wang Chemical Analysis of Antibiotic Residues in Food

9652.79 руб. или Купить в рассрочку!
An insightful exploration of the key aspects concerning the chemical analysis of antibiotic residues in food The presence of excess residues from frequent antibiotic use in animals is not only illegal, but can pose serious health risks by contaminating products for human consumption such as meat and milk. Chemical Analysis of Antibiotic Residues in Food is a single-source reference for readers interested in the development of analytical methods for analyzing antibiotic residues in food. It covers themes that include quality assurance and quality control, antibiotic chemical properties, pharmacokinetics, metabolism, distribution, food safety regulations, and chemical analysis. In addition, the material presented includes background information valuable for understanding the choice of marker residue and target animal tissue to use for regulatory analysis. This comprehensive reference: Includes topics on general issues related to screening and confirmatory methods Presents updated information on food safety regulation based on routine screening and confirmatory methods, especially LC-MS Provides general guidance for method development, validation, and estimation of measurement uncertainty Chemical Analysis of Antibiotic Residues in Food is written and organized with a balance between practical use and theory to provide laboratories with a solid and reliable reference on antibiotic residue analysis. Thorough coverage elicits the latest scientific findings to assist the ongoing efforts toward refining analytical methods for producing safe foods of animal origin.
Jens Petter Nielsen Systems Biology Jens Petter Nielsen Systems Biology Новинка

Jens Petter Nielsen Systems Biology

15581.05 руб. или Купить в рассрочку!
Comprehensive coverage of the many different aspects of systems biology, resulting in an excellent overview of the experimental and computational approaches currently in use to study biological systems. Each chapter represents a valuable introduction to one specific branch of systems biology, while also including the current state of the art and pointers to future directions. Following different methods for the integrative analysis of omics data, the book goes on to describe techniques that allow for the direct quantification of carbon fluxes in large metabolic networks, including the use of 13C labelled substrates and genome-scale metabolic models. The latter is explained on the basis of the model organism Escherichia coli as well as the human metabolism. Subsequently, the authors deal with the application of such techniques to human health and cell factory engineering, with a focus on recent progress in building genome-scale models and regulatory networks. They highlight the importance of such information for specific biological processes, including the ageing of cells, the immune system and organogenesis. The book concludes with a summary of recent advances in genome editing, which have allowed for precise genetic modifications, even with the dynamic control of gene expression. This is part of the Advances Biotechnology series, covering all pertinent aspects of the field with each volume prepared by eminent scientists who are experts on the topic in question.
Philip Hughes The Ice Age Philip Hughes The Ice Age Новинка

Philip Hughes The Ice Age

11422.4 руб. или Купить в рассрочку!
This book provides a new look at the climatic history of the last 2.6 million years during the ice age, a time of extreme climatic fluctuations that have not yet ended. This period also coincides with important phases of human development from Neanderthals to modern humans, both of whom existed side by side during the last cold stage of the ice age. The ice age has seen dramatic expansions of glaciers and ice sheets, although this has been interspersed with relatively short warmer intervals like the one we live in today. The book focuses on the changing state of these glaciers and the effects of associated climate changes on a wide variety of environments (including mountains, rivers, deserts, oceans and seas) and also plants and animals. For example, at times the Sahara was green and colonized by humans, and Lake Chad covered 350,000 km2 – larger than the United Kingdom. What happened during the ice age can only be reconstructed from the traces that are left in the ground. The work of the geoscientist is similar to that of a detective who has to reconstruct the sequence of events from circumstantial evidence. The book draws on the specialisms and experience of the authors who are experts on the glacial history of the Earth. Readership: Undergraduate and postgraduate students studying the Quaternary, researchers, and anyone interested in climate change, environmental change and geology. The book provides a rich collection of illustrations and photographs to help the readers at all levels visualise the dramatic consequences of glacier expansions during the Ice Age.
George Tchobanoglous Principles of Water Treatment George Tchobanoglous Principles of Water Treatment Новинка

George Tchobanoglous Principles of Water Treatment

9500.64 руб. или Купить в рассрочку!
Principles of Water Treatment has been developed from the best selling reference work Water Treatment, 3rd edition by the same author team. It maintains the same quality writing, illustrations, and worked examples as the larger book, but in a smaller format which focuses on the treatment processes and not on the design of the facilities.
George Hall M. How To Write a Paper George Hall M. How To Write a Paper Новинка

George Hall M. How To Write a Paper

3488.81 руб. или Купить в рассрочку!
This concise paperback is one of the best known guides to writing a paper for publication in biomedical journals. Its straightforward format – a chapter covering each of part of the structured abstract – makes it relevant and easy to use for any novice paper writer. How to Write a Paper addresses the mechanics of submission, including electronic submission, and how publishers handle papers, writing letters to journals abstracts for scientific meetings, and assessing papers. This new edition also covers how to write a book review and updated chapters on ethics, electronic publication and submission, and the movement for open access.
Matthew McMillan Errors in Veterinary Anesthesia Matthew McMillan Errors in Veterinary Anesthesia Новинка

Matthew McMillan Errors in Veterinary Anesthesia

7600.51 руб. или Купить в рассрочку!
Errors in Veterinary Anesthesia is the first book to offer a candid examination of what can go wrong when anesthetizing veterinary patients and to discuss how we can learn from mistakes. Discusses the origins of errors and how to learn from mistakes Covers common mistakes in veterinary anesthesia Provides strategies for avoiding errors in anesthetizing small and large animal patients Offers tips and tricks to implement in clinical practice Presents actual case studies discussing errors in veterinary anesthesia
Veronika Meyer R. Pitfalls and Errors of HPLC in Pictures Veronika Meyer R. Pitfalls and Errors of HPLC in Pictures Новинка

Veronika Meyer R. Pitfalls and Errors of HPLC in Pictures

6830.14 руб. или Купить в рассрочку!
The third edition of this popular problem-solving guide for this widely-used method includes eleven completely new examples and several updated ones, adding up to 100 contributions about pitfalls and errors in HPLC. Each example is presented on a double page with the text on the left-hand and a fi gure on the right-hand side, true to the motto 'a picture says more than a thousand words'. In addition, the author presents essential fundamentals as well as helpful strategies, such as equipment tests or quality assurance processes. New in this edition * Variability of the standard deviation * Infl uence of the acid type and concentration in the eluent * Water as an unintentional additive in the mobile phase * Inadequate purity of mobile phase water * Incomplete degassing * Inadequate stabilization of the extraction solvent * Tailing of phosphate compounds in the presence of steel * Different detection properties of diastereomers * Detector overload in ELSD * System suitability test * From repeatability to reproducibility A must-have resource for all users – showing how to use HPLC efficiently and obtain reliable results.
Paul Moayyedi GI Epidemiology. Diseases and Clinical Methodology Paul Moayyedi GI Epidemiology. Diseases and Clinical Methodology Новинка

Paul Moayyedi GI Epidemiology. Diseases and Clinical Methodology

12917.98 руб. или Купить в рассрочку!
Identifying how, why and in whom gastrointestinal disease occurs, and what can be done to prevent it, is of key importance for the modern-day gastroenterologist and researcher. Brought to you by the world’s leading gastroenterologists, the second edition of GI Epidemiology: Diseases and Clinical Methodology is the only book that combines detailed analysis of the epidemiology of GI disease with a study of the methodology of clinical research. With a much greater clinical focus on the diagnostic and management approach for each disease than before, all existing chapters are fully updated with the very latest in statistical and clinical data. In addition, the revised edition contains several significant improvements, notably: • Five extra disease epidemiology chapters: Upper GI Bleeding; Hepatitis B and C; Common Tropical GI Diseases; Nutritional Epidemiology and GI Cancers; and Obesity among Adults • More illustrations, including maps of each disease • A more international focus with the inclusion of two experienced European editors • MCQs, summary checklists and key points throughout • Ten extra online-only chapters on methodological issues related to GI epidemiology such as Patient reported GI Epidemiology: Diseases and Clinical Methodology, 2nd Edition is the perfect reference tool for gastroenterologists involved in both patient management and clinical research, and also for epidemiologists involved specifically in GI disease data and more general epidemiological studies. Titles of Related Interest Yamada’s Handbook of Gastroenterology, 3rd Edition Yamada; ISBN 9780470656204 Essentials of Gastroenterology Friedman; ISBN 9780470656259
Advanced Life Support Group (ALSG) Human Factors in the Health Care Setting. A Pocket Guide for Clinical Instructors Advanced Life Support Group (ALSG) Human Factors in the Health Care Setting. A Pocket Guide for Clinical Instructors Новинка

Advanced Life Support Group (ALSG) Human Factors in the Health Care Setting. A Pocket Guide for Clinical Instructors

2635.04 руб. или Купить в рассрочку!
Human factors relates to the interaction of humans and technical systems. Human factors engineering analyzes tasks, considering the components in relation to a number of factors focusing particularly on human interactions and the interface between people working within systems. This book will help instructors teach the topic of human factors.
Alan Crozier Teas, Cocoa and Coffee. Plant Secondary Metabolites and Health Alan Crozier Teas, Cocoa and Coffee. Plant Secondary Metabolites and Health Новинка

Alan Crozier Teas, Cocoa and Coffee. Plant Secondary Metabolites and Health

17401.85 руб. или Купить в рассрочку!
In recent years, the role of plant secondary metabolites as protective constituents in the human diet has been a growing area of research. Unlike the traditional vitamins, they are not essential for short-term wellbeing, but there is increasing evidence that modest long-term intakes can have favourable impacts on the incidence of cancers and many chronic diseases, including cardiovascular disease and type II diabetes, which are occurring in Western populations with increasing frequency. This book covers the latest science on the metabolism and potential health benefits of teas, cocoa, coffee and their extracts in the human diet. From an opening chapter tracing the origins of teas, cocoa and coffee as beverage, the book proceeds to explore the phytochemical content of coffee, cocoa and the various types of tea. The bioavailability of secondary metabolites from each of the beverages is then considered in depth, and related directly to their health benefits. Embracing the full range of tea, coffee and cocoa beverages and products, the book offers the most up-to-date and comprehensive treatment of these increasingly important dietary components. As the only book to bring together the latest information on the biochemistry and health benefits of teas, coffee and cocoa, this book is essential reading for food scientists and technologists involved in the production of tea, coffee and cocoa products. Nutritionists will value the book's health focus, while agricultural scientists working on the cultivation of these crops will prize its scope and depth of detail. It is also an important resource for all those who use functional ingredients in other products, whether they are based in industry or research.
Battelino Tadej ATTD 2011 Year Book. Advanced Technologies and Treatments for Diabetes Battelino Tadej ATTD 2011 Year Book. Advanced Technologies and Treatments for Diabetes Новинка

Battelino Tadej ATTD 2011 Year Book. Advanced Technologies and Treatments for Diabetes

7136.72 руб. или Купить в рассрочку!
The traditional agents for controlling the levels of glucose in the blood remain important therapies but they have their downside from the point of view of tolerability and side effects. Moreover, they appear not to be able to counter the natural history deterioration of the disease in terms of the onset of diabetic-related complications. Recent years have seen an influx of new treatment therapies and technologies aimed at achieving better glycaemic control for diabetic patients such as liraglutide (Novo Nordisk) and saxagliptin (BMS/Astra-Zeneca) and insulin pumps, away from the more traditional therapies used (classic insulin therapy, oral hypoglycaemics). This book outlines these new technologies/treatments by collating the best journal articles published in the last year, and providing expert analysis on each one. Advanced Technologies and Treatment for Diabetes 3E brings together and critically analyses the last year’s most important articles published in the world’s leading medical journals on this topic. Chapters are focused on the most current hot topic areas such as: new methods of insulin delivery; internet and IT use in treatment of diabetes; bariatric surgery & diabetes; and immunotherapy for type 1 diabetes. Each chapter includes abstracts of the published articles, scientific conclusions made, as well as annotations and a comments and analysis section from the relevant chapter editor, each of which being a well-known expert in the field. All researchers in the fields of diabetes, endocrinology and metabolism will find this book extremely useful, as will diabetes technology developers, and specialist endocrinologists involved with the care of diabetic patients.
Market Leader: Pre-Intermediate: Business English Practice File (+ CD) Market Leader: Pre-Intermediate: Business English Practice File (+ CD) Новинка

Market Leader: Pre-Intermediate: Business English Practice File (+ CD)

Market Leader 3rd Edition Practice File with Audio CD has been completely revised and updated for use with the Market Leader 3rd Edition. The 3rd Edition Course Book includes: - All new reading texts from the Financial Times; - All new case studies with opinions on DVD-ROM from successful consultants who work in the real world of business; - All new listening texts reflecting the global nature of business, with interviews that can be viewed on the DVD-ROM; - New 'Business Across Cultures' spreads.
Market Leader: Advanced: Business English Practise File (+ CD) Market Leader: Advanced: Business English Practise File (+ CD) Новинка

Market Leader: Advanced: Business English Practise File (+ CD)

Market Leader 3rd Edition Practice File with Audio CD has been completely revised and updated for use with the Market Leader 3rd Edition Course Book. The 3rd Edition Course Book includes: All new reading texts from the Financial Times and other authentic sources. All new case studies with opinions on DVD-ROM from successful consultants who work in the real world of business. All new listening texts reflecting the global nature of business, with interviews that can be viewed on the DVD-ROM. New 'Working Across Cultures' spreads. New Vocabulary Trainer www.marketleader.vocabtrainer.net
Fiasco Fiasco Новинка

Fiasco

"There were two kinds of landscape characteristic of the inner planets of the Sun: the purposeful and the desolate."The planet Quinta is pocked with ugly mounds and covered by a spiderweb-like network draped from spindly poles. It is a kingdom of phantoms and of a beauty afflicted by madness. The Earth spaceship Hermes arrives on Quinta with the best of intentions towards the humans' 'brothers in intelligence'. But something on the planet has gone terribly wrong...
Kenneth Seeskin Maimonides on the Origin of the World Kenneth Seeskin Maimonides on the Origin of the World Новинка

Kenneth Seeskin Maimonides on the Origin of the World

Although Maimonides' discussion of creation is one of his greatest contributions - he himself claims that belief in creation is second in importance only to belief in God - there is still considerable debate on what that contribution was. Kenneth Seeskin takes a close look at the problems Maimonides faced and the sources from which he drew. He argues that Maimonides meant exactly what he said: the world was created by a free act of God so that the existence of everything other than God is contingent. In religious terms, existence is a gift. In order to reach this conclusion, Seeskin examines Maimonides' view of God, miracles, the limits of human knowledge, and the claims of astronomy to be a science. Clearly written and closely argued, Maimonides on the Origin of the World takes up questions of perennial interest.Издательство: CambridgeАвтор: Kenneth Seeskin
Lem S. Fiasco Lem S. Fiasco Новинка

Lem S. Fiasco

There were two kinds of landscape characteristic of the inner planets of the Sun: the purposeful and the desolate. The planet Quinta is pocked with ugly mounds and covered by a spiderweb - like network draped from spindly poles. It is a kingdom of phantoms and of a beauty afflicted by madness. The Earth spaceship Hermes arrives on Quinta with the best of intentions towards the humans brothers in intelligence. But something on the planet has gone terribly wrong...
Herbert Holik Handbook of Paper and Board Herbert Holik Handbook of Paper and Board Новинка

Herbert Holik Handbook of Paper and Board

27133.96 руб. или Купить в рассрочку!
Papermaking is a fascinating art and technology. The second edition of this successful 2 volume handbook provides a comprehensive view on the technical, economic, ecologic and social background of paper and board. It has been updated, revised and largely extended in depth and width including the further use of paper and board in converting and printing. A wide knowledge basis is a prerequisite in evaluating and optimizing the whole process chain to ensure efficient paper and board production. The same is true in their application and end use. The book covers a wide range of topics: * Raw materials required for paper and board manufacturing such as fibers, chemical additives and fillers * Processes and machinery applied to prepare the stock and to produce the various paper and board grades including automation and trouble shooting * Paper converting and printing processes, book preservation * The different paper and board grades as well as testing and analysing fiber suspensions, paper and board products, and converted or printed matters * Environmental and energy factors as well as safety aspects. The handbook will provide professionals in the field, e. g. papermakers as well as converters and printers, laymen, students, politicians and other interested people with the most up-to-date and comprehensive information on the state-of- the-art techniques and aspects involved in paper making, converting and printing.
Janet Norton On the Other Side. The Fall Janet Norton On the Other Side. The Fall Новинка

Janet Norton On the Other Side. The Fall

The ancients believed that every person has an Idea of himself somewhere in another better world, and that he is only a mere Shadow of that idea, surrounded by the shadows of others. In the novel that world of ideas is the world of the Ena, winged eternal creations of Light. But now the Enas world is far from perfection just like the world of humans. The Last War has begun, and heroes have to face a choice between the Light and the Darkness. Read the first chapter to start your journey with us!
А. Е. Mikusheva Survey on statistical inferences in weakly-identified instrumental variable models А. Е. Mikusheva Survey on statistical inferences in weakly-identified instrumental variable models Новинка

А. Е. Mikusheva Survey on statistical inferences in weakly-identified instrumental variable models

This paper provides a brief review of the current state of knowledge on the topic of weakly-identified instrumental variable regression. We describe the essence of the problem of weak identification, possible methods for detecting it in applied work as well as methods robust to weak identification. Special attention is devoted to the question of hypothesis testing in the presence of weak identification.
Michael Luntley Wittgenstein. Opening Investigations Michael Luntley Wittgenstein. Opening Investigations Новинка

Michael Luntley Wittgenstein. Opening Investigations

7757.65 руб. или Купить в рассрочку!
In this provocatively compelling new book, Michael Luntley offers a revolutionary reading of the opening section of Wittgenstein’s Philosophical Investigations Critically engages with the most recent exegetical literature on Wittgenstein and other state-of-the-art philosophical work Encourages the re-incorporation of Wittgenstein studies into the mainstream philosophical conversation Has profound consequences for how we go on to read the rest of Wittgenstein’s major work Makes a significant contribution not only to the literature on Wittgenstein, but also to studies in philosophy of language
Michael Luntley Wittgenstein. Opening Investigations Michael Luntley Wittgenstein. Opening Investigations Новинка

Michael Luntley Wittgenstein. Opening Investigations

In this provocatively compelling new book, Michael Luntley offers a revolutionary reading of the opening section of Wittgenstein’s Philosophical Investigations Critically engages with the most recent exegetical literature on Wittgenstein and other state-of-the-art philosophical work Encourages the re-incorporation of Wittgenstein studies into the mainstream philosophical conversation Has profound consequences for how we go on to read the rest of Wittgenstein’s major work Makes a significant contribution not only to the literature on Wittgenstein, but also to studies in philosophy of language

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A thought-provoking exploration of deleterious mutations in the human genome and their effects on human health and wellbeing Despite all of the elaborate mechanisms that a cell employs to handle its DNA with the utmost care, a newborn human carries about 100 new mutations, originated in their parents, about 10 of which are deleterious. A mutation replacing just one of the more than three billion nucleotides in the human genome may lead to synthesis of a dysfunctional protein, and this can be inconsistent with life or cause a tragic disease. Several percent of even young people suffer from diseases that are caused, exclusively or primarily, by pre?]existing and new mutations in their genomes, including both a wide variety of genetically simple Mendelian diseases and diverse complex diseases such as birth anomalies, diabetes, and schizophrenia. Milder, but still substantial, negative effects of mutations are even more pervasive. As of now, we possess no means of reducing the rate at which mutations appear spontaneously. However, the recent flood of genomic data made possible by next-generation methods of DNA sequencing, enabled scientists to explore the impacts of deleterious mutations on humans with previously unattainable precision and begin to develop approaches to managing them. Written by a leading researcher in the field of evolutionary genetics, Crumbling Genome reviews the current state of knowledge about deleterious mutations and their effects on humans for those in the biological sciences and medicine, as well as for readers with only a general scientific literacy and an interest in human genetics. Provides an extensive introduction to the fundamentals of evolutionary genetics with an emphasis on mutation and selection Discusses the effects of pre-existing and new mutations on human genotypes and phenotypes Provides a comprehensive review of the current state of knowledge in the field and considers crucial unsolved problems Explores key ethical, scientific, and social issues likely to become relevant in the near future as the modification of human germline genotypes becomes technically feasible Crumbling Genome is must-reading for students and professionals in human genetics, genomics, bioinformatics, evolutionary biology, and biological anthropology. It is certain to have great appeal among all those with an interest in the links between genetics and evolution and how they are likely to influence the future of human health, medicine, and society.
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