anti angiogenesis chemotherapy agents



Crump Kenneth Cancer Chemotherapy for the Veterinary Health Team Crump Kenneth Cancer Chemotherapy for the Veterinary Health Team Новинка

Crump Kenneth Cancer Chemotherapy for the Veterinary Health Team

4438.87 руб. или Купить в рассрочку!
Cancer Chemotherapy for the Veterinary Health Team is a clinically relevant and practical manual designed as a guide for the safe and effective administration of cancer chemotherapy. Coverage includes patient assessment, chemotherapy equipment, drug preparation, safety considerations, handling, administration, waste disposal, and management of chemotherapy side effects. An alphabetical listing of common chemotherapy agents offers information on their uses, indications, and toxicities, as well as administration guidelines for methods, routes, and speeds. With background information for effectively communicating with clients, including coverage of veterinary cancer surgery and radiation therapy, the book provides specific strategies that address the challenging emotional issues surrounding the diagnosis and treatment of cancer in pets. With particular insight into the technician's role, Cancer Chemotherapy for the Veterinary Health Team is a must-have reference for any practice offering chemotherapy.
Rosaleen Anderson Antibacterial Agents. Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications Rosaleen Anderson Antibacterial Agents. Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications Новинка

Rosaleen Anderson Antibacterial Agents. Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

13762.9 руб. или Купить в рассрочку!
Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA – quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes – sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis – aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis – β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.
Cao Jiannong Mobile Agents in Networking and Distributed Computing Cao Jiannong Mobile Agents in Networking and Distributed Computing Новинка

Cao Jiannong Mobile Agents in Networking and Distributed Computing

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The book focuses on mobile agents, which are computer programs that can autonomously migrate between network sites. This text introduces the concepts and principles of mobile agents, provides an overview of mobile agent technology, and focuses on applications in networking and distributed computing.
Брелок POP! Keychain Agents of Shield: Ghostrider Брелок POP! Keychain Agents of Shield: Ghostrider Новинка

Брелок POP! Keychain Agents of Shield: Ghostrider

Брелок Agents of Shield: Ghostrider с персонажем комиксов!
Футболка с полной запечаткой для девочек Printio Agents of chaos Футболка с полной запечаткой для девочек Printio Agents of chaos Новинка

Футболка с полной запечаткой для девочек Printio Agents of chaos

Футболка с полной запечаткой для девочек.
Футболка с полной запечаткой (мужская) Printio Agents of chaos Футболка с полной запечаткой (мужская) Printio Agents of chaos Новинка

Футболка с полной запечаткой (мужская) Printio Agents of chaos

Футболка с полной запечаткой (мужская) — пол: МУЖ, материал: СИНТЕТИКА.
Футболка с полной запечаткой (женская) Printio Agents of chaos Футболка с полной запечаткой (женская) Printio Agents of chaos Новинка

Футболка с полной запечаткой (женская) Printio Agents of chaos

Футболка с полной запечаткой (женская) — пол: ЖЕН, материал: СИНТЕТИКА.
Футболка с полной запечаткой для мальчиков Printio Agents of chaos Футболка с полной запечаткой для мальчиков Printio Agents of chaos Новинка

Футболка с полной запечаткой для мальчиков Printio Agents of chaos

Футболка с полной запечаткой для мальчиков.
Parker, Hardman Agents of Atlas №6 Parker, Hardman Agents of Atlas №6 Новинка

Parker, Hardman Agents of Atlas №6

The Agents of Atlas decide the best way to undermine Norman Osborn is not through direct attacks, but rather through one of the members of his Cabal, Namor.
Bruce Kaplan Immunotherapy in Transplantation. Principles and Practice Bruce Kaplan Immunotherapy in Transplantation. Principles and Practice Новинка

Bruce Kaplan Immunotherapy in Transplantation. Principles and Practice

21174.19 руб. или Купить в рассрочку!
This comprehensive reference source will benefit all transplant specialists working with pharmacologic and biologic agents that modulate the immune system. Compiled by a team of world-renowned editors and contributors covering the fields of transplantation, nephrology, pharmacology, and immunology, the book covers all anti-rejection drugs according to a set template and includes the efficacy of each for specific diseases.
Stephen Wiviott D. Antiplatelet Therapy In Ischemic Heart Disease Stephen Wiviott D. Antiplatelet Therapy In Ischemic Heart Disease Новинка

Stephen Wiviott D. Antiplatelet Therapy In Ischemic Heart Disease

12243.08 руб. или Купить в рассрочку!
This book in the new American Heart Association Clinical Series, explores and explains state-of-the-art use of antiplatelet agents and draws on the expertise of global leaders in antiplatelet therapy. Skillfully organized for fast reference, the book is divided into five parts: Concepts in Platelet Physiology, Function, and Measurement Pharmacology of Oral Antiplatelet Agents Pharmacology of Intravenous Antiplatelet Agents Clinical Use of Antiplatelet Agents in Cardiovascular Disease Special Circumstances. Each chapter in the clinical section contains an overview of guidelines, plus specifics on medical and interventional uses. Clinical cardiologists, platelet biologists, and a wide range of practicing and prospective clinicians in allied fields will find this text an exceptional source of current information.
Andre Richardt CBRN Protection. Managing the Threat of Chemical, Biological, Radioactive and Nuclear Weapons Andre Richardt CBRN Protection. Managing the Threat of Chemical, Biological, Radioactive and Nuclear Weapons Новинка

Andre Richardt CBRN Protection. Managing the Threat of Chemical, Biological, Radioactive and Nuclear Weapons

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Originating in the armed forces of the early 20th century, weapons based on chemical, biological or nuclear agents have become an everpresent threat that has not vanished after the end of the cold war. Since the technology to produce these agents is nowadays available to many countries and organizations, including those with terrorist aims, civil authorities across the world need to prepare against incidents involving these agents and train their personnel accordingly. As an introductory text on NBC CBRN weapons and agents, this book leads the reader from the scientific basics to the current threats and strategies to prepare against them. After an introductory part on the history of NBC CBRN weapons and their international control, the three classes of nuclear/radiological, biological, and chemical weapons are introduced, focusing on agents and delivery vehicles. Current methods for the rapid detection of NBC CBRN agents are introduced, and the principles of physical protection of humans and structures are explained. The final parts addresses more general issues of risk management, preparedness and response management, as the set of tools that authorities and civil services will be needed in a future CBRN scenario as well as the likely future scenarios that authorities and civil services will be faced with in the coming years. This book is a must-have for Health Officers, Public Health Agencies, and Military Authorities.
Parker, Hardman Agents of Atlas №4 Parker, Hardman Agents of Atlas №4 Новинка

Parker, Hardman Agents of Atlas №4

"Most of us don't realize when we're experiencing pivotal history... Today I did. I knew I was witnessing the return of a legend." - S.H.I.E.L.D. Subdirector Derek Khanata, from his report on NAMORA. The Sea Monarch joins the AGENTS OF ATLAS as they take on an evil that looks to be deeper than the ocean itself!
Daniel Lednicer Antineoplastic Drugs. Organic Syntheses Daniel Lednicer Antineoplastic Drugs. Organic Syntheses Новинка

Daniel Lednicer Antineoplastic Drugs. Organic Syntheses

10209.36 руб. или Купить в рассрочку!
The past decade has seen a significant increase of research aimed at discovering new drugs for treating cancer, and the increasing number of new antineoplastic drugs approved by regulatory agencies reflects this. Until now, details on the synthesis of these newer agents have been scattered in various journals and in US and European patents. This timely volume deals with the organic chemistry involved in the synthesis of the agents found within antineoplastic drugs, including descriptions of the synthetic schemes for the preparation of over 200 compounds that have been granted non-proprietary names. Compounds are collected in chapters based on the mechanism of action rather than on their chemical structures. Each individual chapter is preceded by a brief description of that mechanism and includes detailed flow charts of the preparation of those compounds accompanied by discussions of the organic chemistry involved in each step. The first half of this volume is dedicated to the syntheses of established chemotherapy drugs. Kinase inhibitors occupy the following chapters with the largest single chapter dealing with the fifty compounds that inhibit tyrosine kinase. This class stands out since over twenty compounds in this group have been approved for treating patients; a rare track record compared to any other class of therapeutic agents. Antineoplastic Drugs: Organic Syntheses is written to appeal to organic and medicinal chemists in industry and academia. It is beneficial to those composing grant proposals for NCI and related organizations. The book is accessible to advanced undergraduates as well as graduates and researchers as well as those with a thorough grasp of organic chemistry.
Chemotherapy (CANCER): A Complete Guide Chemotherapy (CANCER): A Complete Guide Новинка

Chemotherapy (CANCER): A Complete Guide

Chemotherapy (CANCER) Just by listening to the name CANCER everyone gets afraid, and only one thing comes in their mind that is deadly disease leading to death. But gone are those days when people patients suffering from it had no treatment and had no way except death. Now a days due to advancements in technology we have got got hand full of techniques available as a cure to it. That means one way or the other you definitely are going to get rid of this disease. Which is a good news for cancer patients and hence are described in this book.
Набор для опытов и экспериментов Science Agents Большая химическая лаборатория, 45043 Набор для опытов и экспериментов Science Agents Большая химическая лаборатория, 45043 Новинка

Набор для опытов и экспериментов Science Agents Большая химическая лаборатория, 45043

Набор для экспериментов "Большая химическая лаборатория" Science Agents можно рассматривать как занимательную развивающую игру и нестандартный подарок, стимулирующий у детей от 8 лет интерес к науке. Под руководством родителей дети смогут организовать у себя дома целую химическую лабораторию, в которой будет совершено много интересных открытий. Перед началом серии опытов рекомендуем изучить красочную инструкцию, выполненную в виде комикса, который рассказывает о лабораторных приключениях юных химиков. Набор позволяет провести серию научных опытов, состоящую из 43 экспериментов, знакомящих ребенка с особенностями химических веществ и их реакций. Среди доступных исследований есть выращивание цветных полимеров, вулкан в пробирке, опыт с невидимыми чернилами и много других интересных открытий. В комплекте предоставлены все необходимые приборы, инструменты и компоненты для научно-исследовательской деятельности.
Набор для опытов и экспериментов Science Agents Научный детектив, 45045 Набор для опытов и экспериментов Science Agents Научный детектив, 45045 Новинка

Набор для опытов и экспериментов Science Agents Научный детектив, 45045

Набор для экспериментов "Научный детектив" Science Agents состоит из множества приборов, предметов, веществ и компонентов, позволяющих провести 38 химических опытов, в основе которых лежит загадочная детективная история. Красочный буклет-руководство выполнен в виде увлекательного комикса, из которого вы узнаете о поиске похищенных сокровищ. Серия химических экспериментов поможет юному сыщику сопоставить полученные улики и выявить воришку! В наборе вы найдете 6 пробирок с подставками, лупу, мерную ложку, палочку для смешивания, пипетку, 8 стаканов из пластика, мерную емкость, камни, очки для защиты глаз, стикеры, инструкцию и несколько пакетиков с химическими компонентами. Игра станет отличным развивающим и познавательным подарком для детей от 8 лет.
Brubaker, Aja, Lark Secret Avengers №5 Brubaker, Aja, Lark Secret Avengers №5 Новинка

Brubaker, Aja, Lark Secret Avengers №5

Five years ago in Paris, a man resembling Nick Fury is arrested by S.H.I.E.L.D. agents.
Lothar Helm The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging Lothar Helm The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging Новинка

Lothar Helm The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging

17166.5 руб. или Купить в рассрочку!
Magnetic Resonance Imaging (MRI) is one of the most important tools in clinical diagnostics and biomedical research. The number of MRI scanners operating around the world is estimated to be approximately 20,000, and the development of contrast agents, currently used in about a third of the 50 million clinical MRI examinations performed every year, has largely contributed to this significant achievement. This completely revised and extended second edition: Includes new chapters on targeted, responsive, PARACEST and nanoparticle MRI contrast agents. Covers the basic chemistries, MR physics and the most important techniques used by chemists in the characterization of MRI agents from every angle from synthesis to safety considerations. Is written for all of those involved in the development and application of contrast agents in MRI. Presented in colour, it provides readers with true representation and easy interpretation of the images. A word from the Authors: Twelve years after the first edition published, we are convinced that the chemistry of MRI agents has a bright future. By assembling all important information on the design principles and functioning of magnetic resonance imaging probes, this book intends to be a useful tool for both experts and newcomers in the field. We hope that it helps inspire further work in order to create more efficient and specific imaging probes that will allow materializing the dream of seeing even deeper and better inside the living organisms. Reviews of the First Edition: «…attempts, for the first time, to review the whole spectrum of involved chemical disciplines in this technique…»—Journal of the American Chemical Society «…well balanced in its scope and attention to detail…a valuable addition to the library of MR scientists…»—NMR in Biomedicine
Gary Tucker S. Food Preservation and Biodeterioration Gary Tucker S. Food Preservation and Biodeterioration Новинка

Gary Tucker S. Food Preservation and Biodeterioration

15880.1 руб. или Купить в рассрочку!
Biodeterioration is the breakdown of food by agents of microbiological origin, either directly or indirectly from products of their metabolism. Preservation on the other hand is the process by which food materials are maintained in their original condition or as close to this as possible. This second edition of Food Preservation and Biodeterioration is fully updated and reorganised throughout. It discusses how the agents of food biodeterioration operate and how the commercial methods available to counteract these agents are applied to produce safe and wholesome foods. With this book, readers will discover traditional methods as well as major advances in preservation technology. Both microbiological and chemical pathways are analysed. This topic being important to all producers of food, the readership spans food scientists across industry and academia, particularly those involved with safety and quality.
Набор для опытов и экспериментов Science Agents Наука мыльных пузырей, 45046 Набор для опытов и экспериментов Science Agents Наука мыльных пузырей, 45046 Новинка

Набор для опытов и экспериментов Science Agents Наука мыльных пузырей, 45046

Набор для экспериментов "Наука мыльных пузырей" от Science Agents содержит все что нужно для захватывающих опытов с пузырями и покорения мыльной стихии. Академия мыльных пузырей разработала целый курс обучения, о котором вам расскажет цветное руководство в виде комикса. Познание науки включает 7 этапов: 1) приготовление раствора для мыльных пузырей 2) изготовление палочек специальной формы для надувания пузырей 3) формирование пузыря огромного размера 4) длинные змееподобные пузыри 5) рисование мыльными пузырями 6) пузырь-кубик 7) пузырьковый "волейбол" Пройди каждый из 7 уровней, проведи все 30 научных экспериментов и стань Мастером мыльных пузырей!
Набор для опытов и экспериментов Science Agents Удивительные природные явления, 45047 Набор для опытов и экспериментов Science Agents Удивительные природные явления, 45047 Новинка

Набор для опытов и экспериментов Science Agents Удивительные природные явления, 45047

Набор для экспериментов "Удивительные природные явления" Science Agents станет настоящим открытием для ребенка от 8 лет и позволит ему познать множество интересных фактов из мира природы. Набор сопровождается красочным комиксом, выполняющим роль инструкции, в которой повествуется о приключениях персонажей в мире природных явлений. 9 химических опытов состоят из 48 научных экспериментов, в которых дети под руководством родителей смогут воссоздать в домашних условиях такие чудеса природы как снег, извержение вулкана, торнадо, звездное небо, а также самостоятельно вырастить кристаллы и бриллианты или сделать медузу с осьминогом. В комплекте предусмотрено множество предметов, аксессуаров и химических компонентов для опытов, включая лабораторную посуду и принадлежности, макеты неба и вулкана, очки для защиты глаз, лампу и большое количество веществ и реагентов.
Набор для опытов и экспериментов Science Agents Фабрика веселых проделок, 45044 Набор для опытов и экспериментов Science Agents Фабрика веселых проделок, 45044 Новинка

Набор для опытов и экспериментов Science Agents Фабрика веселых проделок, 45044

Science Agents набор для экспериментов «Фабрика веселых проделок» в игровой и шуточной форме знакомит детей от 8 лет с интересными научными фактами и явлениями. В качестве инструкции выступает цветной комикс про двух приятелей, которые готовят шуточные проделки и розыгрыши для своих друзей с помощью химических опытов. Каждый научный эксперимент из этого набора – замечательная идея и сценарий для веселого шуточного розыгрыша. Проведя серию опытов, описанных в комиксе ребенок сможет сделать громкий конверт, шипящий чай, не льющуюся воду, слизня, искусственную кровь, реалистичную имитацию раны, розыгрыш с пальцем в коробочке, странных цветных существ или макет какашки. В коробке есть все, что понадобится для научно-шуточных экспериментов: химические компоненты, лабораторная посуда и принадлежности, защитные очки и все необходимые аксессуары.
Rachel Airley Cancer Chemotherapy. Basic Science to the Clinic Rachel Airley Cancer Chemotherapy. Basic Science to the Clinic Новинка

Rachel Airley Cancer Chemotherapy. Basic Science to the Clinic

14386.29 руб. или Купить в рассрочку!
This textbook is a clear and accessible introduction to the scientific and clinical aspects of the creation, development and administration of drugs or drug regimens used in the treatment of cancer. Unique in its approach, this book enables the student to gain an understanding of the pathological, physiological and molecular processes governing malignancy, whilst also introducing the role of health professionals and scientists in the research and treatment of cancer. The book consolidates all the essential information necessary for a full understanding of cancer chemotherapy, providing an informative, inexpensive and up-to-date coverage of the subject aimed at an undergraduate level readership. Key Features: Incorporates numerous diagrams, tables and illustrations to aid understanding. Examines key pharmacological and pharmaceutical issues such as dosing, toxicity and preparation of anti-cancer drugs. Includes a key chapter of practice essay questions to ease revision. Comprehensive coverage of drugs currently in pre-clinical and clinical development. An indispensable text for undergraduate students studying pharmacy and medicine as well as those doing courses such as molecular biology, biomedical sciences and pharmacology which cover aspects of oncology.
Multinational Distribution: Channel, Tax and Legal Strategies Multinational Distribution: Channel, Tax and Legal Strategies Новинка

Multinational Distribution: Channel, Tax and Legal Strategies

Almost every company in the international trade business has agents and/or distributors abroad, and is concerned with the management of these networks. Multinational Distribution is a clear, concise, step-by-step manual describing how to acquire distributors and agents, negotiate agreements with them, evaluate their effectiveness, and manage the many legal and technical problems arising from these arrangements. In addition, the author provides guidelines for dealing with legal matters such as the Foreign Corrupt Practices Act, and for dealing with political Almost every company in the international trade business has agents and/or distributors abroad, and is concerned with the management of these networks. Multinational Distribution is a clear, concise, step-by-step manual describing how to acquire distributors and agents, negotiate agreements with them, evaluate their effectiveness, and manage the many legal and technical problems arising from these arrangements. In addition, the author provides guidelines for dealing with legal matters such as the Foreign Corrupt Practices Act, and for dealing with political problems between countries. Sample agreements are provided, as well as detailed explanations of different financing and collection arrangements.
Patrick Butaye Detection of Highly Dangerous Pathogens. Microarray Methods for BSL 3 and BSL 4 Agents Patrick Butaye Detection of Highly Dangerous Pathogens. Microarray Methods for BSL 3 and BSL 4 Agents Новинка

Patrick Butaye Detection of Highly Dangerous Pathogens. Microarray Methods for BSL 3 and BSL 4 Agents

7936.47 руб. или Купить в рассрочку!
Written by leading experts in the field as part of an interdisciplinary pan-European research program funded by the EU, the results provided in this booklet provide a unique and comprehensive overview of how microarray technology can be used in safely tracking the most highly dangerous pathogens. A must-have for public health agencies focused on bioterrorism as well as all laboratories working with BSL3 and/or BSL 4 agents.
New Approaches to Macroeconomic Modeling: Evolutionary Stochastic Dynamics, Multiple Equilibria, and Externalities As Field Effects New Approaches to Macroeconomic Modeling: Evolutionary Stochastic Dynamics, Multiple Equilibria, and Externalities As Field Effects Новинка

New Approaches to Macroeconomic Modeling: Evolutionary Stochastic Dynamics, Multiple Equilibria, and Externalities As Field Effects

This book contributes substantively to the current state of art of macroeconomic modeling by providing a method for modeling large collections of possibly heterogeneous agents subject to nonpairwise externality called field effects, that is, feedback of aggregate effects on individual agents or agents using state-dependent strategies. By adopting a level of microeconomic description that keeps track of compositions of fractions of agents by types or strategies, time evolution of the microeconomic states is described by (backward) Chapman-Kolmogorov equations. Macroeconomic dynamics naturally arise from these equations by expansion of the solutions in some power series of the number of participants. Specification of the microeconomic transition rates thus leads to macroeconomic dynamic models. This approach provides a consistent way for dealing with multiple equilibria of macroeconomic dynamics by ergodic decomposition and associated calculations of mean first passage times, and stationary probabilities of equilibria provide further useful information on macroeconomic behavior. This book ends with a set of elaborations, sketches of further topics of research, and a collection of supporting materials in the Appendix.
Mohamed Abou-Donia Mammalian Toxicology Mohamed Abou-Donia Mammalian Toxicology Новинка

Mohamed Abou-Donia Mammalian Toxicology

10209.36 руб. или Купить в рассрочку!
Mammalian Toxicology surveys chemical agents and examines how such chemicals impact on human health, emphasizing the importance in minimizing environmental exposure to chemical and physical hazards in our homes, communities and workplaces through such media as contaminated water, soil and air. Starting with the basic principles on a wide range of toxic agents, this textbook describes how they enter the body, their mechanisms of action once inside, and strategies for diagnosis, prevention and treatment. Topics covered include: General principles of toxicology: pharmacological and toxicological principles underpinning the study of toxicology, risk assessments and mechanisms of cell death Disposition: routes of chemical exposures, entry into the body and various tissues, storage, metabolic biotransformation and elimination, with examples from various toxicants. Toxic agents: the occurrences, disposition in the body, health effects, toxic mechanisms, antidotes and treatments of a range of agents including pesticides, metals, solvents, gases, nanomaterials, food components and additives, pharmaceuticals, drugs of abuse, natural toxins, endocrine disruptors, radiation, and warfare weapons. Toxic effects: including neurotoxicity, developmental toxicity, immunotoxicity, teratogenecity, male and female reproductive toxicity, mutagenecity, carcinogenicity, pulmonary toxicity, cardiovascular toxicity, hepatotoxicity, gastrointestinal toxicity and cardiovascular toxicity Toxicology and society: epidemiological studies of chemical-induced diseases in human populations, and a vision for toxicology in the 21st century. Mammalian Toxicology is an essential primer for students of toxicology, biochemistry, biology, medicine and chemistry. It is also appropriate for professional toxicologists in research or regulatory affairs, and anyone who needs to understand the adverse effects of toxic agents on the human body.
Tim Storr Ligand Design in Medicinal Inorganic Chemistry Tim Storr Ligand Design in Medicinal Inorganic Chemistry Новинка

Tim Storr Ligand Design in Medicinal Inorganic Chemistry

14746.53 руб. или Купить в рассрочку!
Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy. Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated by a disease-specific biological process. Ligand design is discussed in the following areas: Platinum, Ruthenium, and Gold-containing anticancer agents Emissive metal-based optical probes Metal-based antimalarial agents Metal overload disorders Modulation of metal-protein interactions in neurodegenerative diseases Photoactivatable metal complexes and their use in biology and medicine Radiodiagnostic agents and Magnetic Resonance Imaging (MRI) agents Carbohydrate-containing ligands and Schiff-base ligands in Medicinal Inorganic Chemistry Metalloprotein inhibitors Ligand Design in Medicinal Inorganic Chemistry provides graduate students, industrial chemists and academic researchers with a launching pad for new research in medicinal chemistry.
Ron Waksman Antiplatelet Therapy in Cardiovascular Disease Ron Waksman Antiplatelet Therapy in Cardiovascular Disease Новинка

Ron Waksman Antiplatelet Therapy in Cardiovascular Disease

Edited by a team of the world’s leading interventional cardiologists and educators, this new book is created with an eye to giving the reader a solid, practical, and clinically focused understanding of this important class of drugs, from basic science to a clear-headed discussion of complex topics such as combination therapies, drug-to-drug interactions, and resistance to antiplatelet agents. This important new book: Begins with a concise but thorough discussion of platelet biology and pathophysiology so that readers understand how antiplatelet agents work and why they produce such a varied range of complications, from minor GI upset to potentially life-threatening conditions such as neutropenia, a critical shortage of white blood cells. Thoroughly covers platelet function testing, including novel techniques. Clarifies current best practice regarding the use of antiplatelet agents in both chronic and acute cardiovascular disease. Reviews all types of antiplatelet agents – from aspirin to recently approved drugs – including indications, clinical outcomes, and side effects. Written by an international “who’s who” of experts in the field, Antiplatelet Therapy in Cardiovascular Disease also includes an entire section covering the use of antiplatelet drugs in PCIs, including percutaneous valve repair, which makes this text particularly essential to interventional cardiologists.
Shayne Gad Cox Development of Therapeutic Agents Handbook Shayne Gad Cox Development of Therapeutic Agents Handbook Новинка

Shayne Gad Cox Development of Therapeutic Agents Handbook

21432.1 руб. или Купить в рассрочку!
A comprehensive look at current drug discovery and development methods—and the roadmap for the future Providing both understanding and guidance in characterizing potential drugs and their production and synthesis, Development of Therapeutic Agents Handbook gives professionals a basic tool to facilitate research and development within this challenging process. This comprehensive text brings together, in one resource, a compendium of concepts, approaches, methodologies, and limitations that need to be considered in the formulation of therapeutic agents across a range of therapeutic fields. Both a reference and a call to action for the pharmaceutical industry, Development of Therapeutic Agents Handbook examines recent innovations taking shape in the various medical disciplines involved in drug discovery, and shows why these advances need to be embraced universally among researchers to improve their solution strategies. Additional subject matter includes: Extensive coverage and in-depth look into novel treatments and therapeutics Discussion of hot topics like new drugs and nutraceuticals, the discovery and development of vaccines, cancer therapeutics, and market overviews Coverage of therapeutic drug development for specific disease areas, such as cardiology, oncology, breast cancer, and kidney diseases As research in biology, chemistry, medicine, and technology rapidly progresses, it is becoming increasingly important for medical researchers to maintain an up-to-date knowledge base of emerging trends directing promising new therapies. Development of Therapeutic Agents Handbook serves this purpose, acting as both a one-stop reference rich in valid science, and a tool to carve out new pathways in the pursuit of bringing safer and more effective drugs to the marketplace.
Wu-Kuang Yeh Enzyme Technologies. Pluripotent Players in Discovering Therapeutic Agent Wu-Kuang Yeh Enzyme Technologies. Pluripotent Players in Discovering Therapeutic Agent Новинка

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Sets the stage for advances in drug discovery using the latest enzyme technology Reviewing new and emerging applications of enzyme technology in drug discovery, this book highlights some of the most promising areas of pharmaceutical and biotechnology research. It covers enzyme assay technology, utilization of enzymology for prodrug design, and the application of enzymes as therapeutic agents. Expert reviews highlight how our latest understanding of enzymology is used to develop new practical applications in drug discovery and design. Filled with case studies, Enzyme Technologies: Pluripotent Players in Discovering Therapeutic Agents enables readers to better understand the diverse functions of enzymes and master specific applications in drug discovery research. In addition to small molecule drug discovery, the book explores new developments in enzymes as therapeutic agents for genetic disorders. Section A, Enzymes – Essential Workhorses in Pharmaceutical Research, offers support in selecting the best enzyme targets for drug discovery, designing enzyme inhibitors for therapeutic agents, and evaluating selective enzyme inhibitors. Section B, Enzymes – Indispensable Tools for Improving Druggability, sets forth the principles alongside real-world examples of exploiting specific properties of enzymes to design successful prodrugs. Section C, Enzymes – Powerful Weapons for Correcting Nature's Errors, provides new insights on applying enzymes as therapeutic agents or diagnostic tools to treat genetic disorders. Chapters are contributed by leading experts from around the world. Their contributions are based on a thorough review of the current literature as well as their own research. Reviewing our latest understanding of the nature of enzymes and their role in drug discovery, this book is recommended for researchers in pharmaceuticals and biotechnology as well as for researchers in enzymology, biochemistry, molecular biology, and medicinal chemistry.
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What makes teamwork tick? Cooperation matters, in daily life and in complex applications. After all, many tasks need more than a single agent to be effectively performed. Therefore, teamwork rules! Teams are social groups of agents dedicated to the fulfilment of particular persistent tasks. In modern multiagent environments, heterogeneous teams often consist of autonomous software agents, various types of robots and human beings. Teamwork in Multi-agent Systems: A Formal Approach explains teamwork rules in terms of agents' attitudes and their complex interplay. It provides the first comprehensive logical theory, TeamLog, underpinning teamwork in dynamic environments. The authors justify design choices by showing TeamLog in action. The book guides the reader through a fascinating discussion of issues essential for teamwork to be successful: What is teamwork, and how can a logical view of it help in designing teams of agents? What is the role of agents' awareness in an uncertain, dynamic environment? How does collective intention constitute a team? How are plan-based collective commitments related to team action? How can one tune collective commitment to the team's organizational structure and its communication abilities? What are the methodological underpinnings for teamwork in a dynamic environment? How does a team and its attitudes adjust to changing circumstances? How do collective intentions and collective commitments arise through dialogue? What is the computational complexity of TeamLog? How can one make TeamLog efficient in applications? This book is an invaluable resource for researchers and graduate students in computer science and artificial intelligence as well as for developers of multi-agent systems. Students and researchers in organizational science, in particular those investigating teamwork, will also find this book insightful. Since the authors made an effort to introduce TeamLog as a conceptual model of teamwork, understanding most of the book requires solely a basic logical background.
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Sukhdev Chatu The Hands-on Guide to Clinical Pharmacology Sukhdev Chatu The Hands-on Guide to Clinical Pharmacology Новинка

Sukhdev Chatu The Hands-on Guide to Clinical Pharmacology

3440.62 руб. или Купить в рассрочку!
Are you about to sit your pharmacology exams? Do you lack confidence in prescribing? Would it help to have a quick reference, pocket-sized reassurance on common drugs and the conditions that they are used in? The Hands-on Guide to Clinical Pharmacology is the perfect companion for students, doctors, nurses, pharmacists and other health care professionals who need help on the ward or are preparing for exams. It includes sections containing both treatment regimens of common conditions and detailed information on the relevant drugs that help you obtain a better understanding of therapeutic management. The benefits include: A-Z of over 100 key drugs in a one-drug-per-page format A systems-based approach Fully indexed text Clear explanations of drug mechanisms – a regular feature of pharmacology exams Management guidelines for common conditions within each system Brand new two-colour design to help with information retrieval A new chapter on chemotherapy agents Take the stress out of clinical pharmacology with The Hands-on Guide!
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"SOLD is a gift to real estate agents everywhere looking to double and triple their business with internet marketing." - Raymond Aaron. New York Times Top Ten Best-Selling Author, Acknowledged Real Estate ExpertAs a real estate agent ...• Did you ever wonder why other real estate agents are at the top of Google and you're not, even though you do more business and are better than they are?• Do you know a real estate agent who is getting so many leads from their website they are having to sell them to other agents?• Have you ever thought there must be a way for a good real estate agent to use the internet to make money?• Have you ever wanted to have an automated system to bring in a steady stream of high quality prospects every month on a reliable basis?These questions and more are answered in SOLD. In this book, you'll discover:• Why cold-call prospecting and door-knocking are not only mind-numbing and demoralizing but also completely ineffective• The appalling lie of traditional old school methods and how the internet will change your business forever• How to avoid the common mistakes that are responsible for 80% of real estate agent failures• How to generate more leads at low cost or even no cost using search engine optimization, Google Pay Per Click, social media and other online strategies• How to quickly set yourself apart from other realtors and dominate your local market• How to generate a steady stream of motivated, qualified clients - any time you need...
Sukhdev Chatu The Hands-on Guide to Clinical Pharmacology Sukhdev Chatu The Hands-on Guide to Clinical Pharmacology Новинка

Sukhdev Chatu The Hands-on Guide to Clinical Pharmacology

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Are you about to sit your pharmacology exams? Do you lack confidence in prescribing? Would it help to have a quick reference, pocket-sized reassurance on common drugs and the conditions that they are used in? The Hands-on Guide to Clinical Pharmacology is the perfect companion for students, doctors, nurses, pharmacists and other health care professionals who need help on the ward or are preparing for exams. It includes sections containing both treatment regimens of common conditions and detailed information on the relevant drugs that help you obtain a better understanding of therapeutic management. The benefits include: A-Z of over 100 key drugs in a one-drug-per-page format A systems-based approach Fully indexed text Clear explanations of drug mechanisms – a regular feature of pharmacology exams Management guidelines for common conditions within each system Brand new two-colour design to help with information retrieval A new chapter on chemotherapy agents Take the stress out of clinical pharmacology with The Hands-on Guide!

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What makes teamwork tick? Cooperation matters, in daily life and in complex applications. After all, many tasks need more than a single agent to be effectively performed. Therefore, teamwork rules! Teams are social groups of agents dedicated to the fulfilment of particular persistent tasks. In modern multiagent environments, heterogeneous teams often consist of autonomous software agents, various types of robots and human beings. Teamwork in Multi-agent Systems: A Formal Approach explains teamwork rules in terms of agents' attitudes and their complex interplay. It provides the first comprehensive logical theory, TeamLog, underpinning teamwork in dynamic environments. The authors justify design choices by showing TeamLog in action. The book guides the reader through a fascinating discussion of issues essential for teamwork to be successful: What is teamwork, and how can a logical view of it help in designing teams of agents? What is the role of agents' awareness in an uncertain, dynamic environment? How does collective intention constitute a team? How are plan-based collective commitments related to team action? How can one tune collective commitment to the team's organizational structure and its communication abilities? What are the methodological underpinnings for teamwork in a dynamic environment? How does a team and its attitudes adjust to changing circumstances? How do collective intentions and collective commitments arise through dialogue? What is the computational complexity of TeamLog? How can one make TeamLog efficient in applications? This book is an invaluable resource for researchers and graduate students in computer science and artificial intelligence as well as for developers of multi-agent systems. Students and researchers in organizational science, in particular those investigating teamwork, will also find this book insightful. Since the authors made an effort to introduce TeamLog as a conceptual model of teamwork, understanding most of the book requires solely a basic logical background.
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