approaches to the inhibition of class ii fbp aldolase



Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad Новинка

Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad

17736.33 руб.
The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development. With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the «good» inhibitions—desirable pharmacological effects—and «bad» inhibitions—drug–drug interactions and toxicity. The book discusses: The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.
Arvnabh Mishra and Dinesh R. Godhani Corrosion and inhibition behavior of some Aluminium Alloys Arvnabh Mishra and Dinesh R. Godhani Corrosion and inhibition behavior of some Aluminium Alloys Новинка

Arvnabh Mishra and Dinesh R. Godhani Corrosion and inhibition behavior of some Aluminium Alloys

5626 руб.
The presented manuscript comprises the behavior of aluminium alloys upon the exposure of organic acid and it also shows the inhibition behavior of various organic and inorganic inhibitors. For the determination of corrosion and inhibition, weight loss and potentiostatic methods are used. Tafel graphs, are also plotted and conductance of the solution is measured for its support. It was observed that inhibition efficiency was decreased on increasing temperature. Langmuir adsorption isotherm was found to obey by all the inhibitors.
Deyab Mohamed New Trends For Corrosion Inhibition of Carbon Steel in Petroleum Field Deyab Mohamed New Trends For Corrosion Inhibition of Carbon Steel in Petroleum Field Новинка

Deyab Mohamed New Trends For Corrosion Inhibition of Carbon Steel in Petroleum Field

6027 руб.
The guidelines given in this book provide important information on the corrosion and corrosion inhibition of carbon steel in petroleum field. Initially, the book provides the information about corrosion definition, rust formation, corrosion costs, corrosion in petroleum field and corrosion forms. The book also presents different and recent types of the corrosion sensors in general and in particular in petroleum field. The book gives comprehensive picture about the standard practices for corrosion control, with highlighting the recent trends. In addition, it summarized the corrosion inhibition mechanism in different media. Recent and novel inhibitors in the field of corrosion inhibition are reviewed and are presented according to the area of application of the inhibitors. A brief overview of recent literature focusing on the corrosion and corrosion inhibition of carbon steel in petroleum is also included
Andrew Hoberek The Twilight of the Middle Class. Post-World War II American Fiction and White-Collar Work Andrew Hoberek The Twilight of the Middle Class. Post-World War II American Fiction and White-Collar Work Новинка

Andrew Hoberek The Twilight of the Middle Class. Post-World War II American Fiction and White-Collar Work

3989 руб.
In The Twilight of the Middle Class, Andrew Hoberek challenges the commonly held notion that post-World War II American fiction eschewed the economic for the psychological or the spiritual. Reading works by Ayn Rand, Ralph Ellison, Saul Bellow, Phillip Roth, Flannery O'Connor, Thomas Pynchon, Don DeLillo, and others, he shows how both the form and content of postwar fiction responded to the transformation of the American middle class from small property owners to white-collar employees. In the process, he produces "compelling new accounts of identity politics and postmodernism that will be of interest to anyone who reads or teaches contemporary fiction. Hoberek argues that despite the financial gains and job security enjoyed by the postwar middle class, the transition to white-collar employment paved the way for its current precarious state in a country marked by increasingly deep class divisions. Postwar fiction provided the middle class with various imaginative substitutes for its former property-owning independence, substitutes that since then have not only allowed but abetted this class's downward mobility. To read this fiction in the light of the middle-class experience is thus not only to restore the severed connections between literary and economic "history in the second half of the twentieth "century, but to explore the roots of the contemporary crisis of the middle class.
Simon Dedic In vitro characterization of oncolytic virus in combination with STAT3 inhibition for improved therapy against pancreatic ductal adenocarcinoma Simon Dedic In vitro characterization of oncolytic virus in combination with STAT3 inhibition for improved therapy against pancreatic ductal adenocarcinoma Новинка

Simon Dedic In vitro characterization of oncolytic virus in combination with STAT3 inhibition for improved therapy against pancreatic ductal adenocarcinoma

3177 руб.
Master's Thesis from the year 2017 in the subject Biology - Diseases, Health, Nutrition, LMU Munich, language: English, abstract: Since there is accumulating evidence that STAT3 is constitutively activated in PDAC and important for the progression and maintenance of this disease, the goal of this thesis was to establish a PDAC model in the lab to further investigate and characterize if the synergistic effect of VSV with STAT3 inhibition would also be effective on this cancer type. Aiming to unravel as many characteristics as in vitro studies allow, this study utilized not just 2D and 3D systems, but also cocultural approaches on both molecular and morphological levels.Pancreatic ductal adenocarcinoma (PDAC) is considered as a very severe diagnosis because of the poor survival rates and the aggressive nature. Further investigations show the high complexity of the mutational cascades in PDAC initiation and progression. The importance of the tumor microenvironment is clarified, but as different studies led to paradoxic results in targeting the stroma, it gives us evidence that it is just poorly understood yet. Given the limitations of current treatments and the failure of various novel approaches, a necessity of further investigating new therapeutic options is unquestionable.
David R. Blumenthal Approaches to Judaism in Medieval Times, Volume II David R. Blumenthal Approaches to Judaism in Medieval Times, Volume II Новинка

David R. Blumenthal Approaches to Judaism in Medieval Times, Volume II

2902 руб.
Книга "Approaches to Judaism in Medieval Times, Volume II".
Dr. B M Prasanna Chloramphenicol and hydralazine as corrosion inhibitors for steel Dr. B M Prasanna Chloramphenicol and hydralazine as corrosion inhibitors for steel Новинка

Dr. B M Prasanna Chloramphenicol and hydralazine as corrosion inhibitors for steel

6102 руб.
Research Paper (postgraduate) from the year 2016 in the subject Chemistry - Materials Chemistry, grade: 10, , language: English, abstract: The corrosion inhibition mechanism of Chlorophenicol and Hydralazine for the mild steel in 1M HCl was studied by chemical, electrochemical and adsorption measurement at 303-333 K temperature regions. The inhibition efficiency of the Chlorophenical and Hydralazine increases with increasing inhibitor but decreases with increase of temperature. The mechanism of the inhibition action attributed due to the adsorption of inhibitor on the surface of the metal, for which this adsorption process obeys Langmuir adsorption isotherm. The electrochemical Tafel analysis shows that the inhibitor acts as a mixed type, and gets adsorbed by either physically or chemically. Surface study was done by scanning electron microscopic method due to the formation of protective film on the metal surface.
Zaher Radi A. Comparative Pathophysiology and Toxicology of Cyclooxygenases Zaher Radi A. Comparative Pathophysiology and Toxicology of Cyclooxygenases Новинка

Zaher Radi A. Comparative Pathophysiology and Toxicology of Cyclooxygenases

11879.66 руб.
The first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks Cyclooxygenases (COXs) are enzymes responsible for the formation of an important class of biological mediators called prostanoids. Prostanoids such as prostaglandins mediate inflammatory and anaphylactic reactions. For those suffering from inflammation and pain, the pharmacological inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide relief. Yet the use of NSAIDs can trigger toxicological effects as well, leading to potential health risks. Comparative Pathophysiology and Toxicology of Cyclooxygenases provides a comprehensive overview of how COX inhibitors affect various bodily systems, specifically the toxicity mechanisms triggered when the COX enzyme is inhibited. The book provides an introduction to the discovery of cyclooxygenases, their use as therapeutic agents, as well as an historical perspective. Shedding light on the differences in expression, pathophysiology, and toxicology of COX inhibitors across species, the book offers a systematic examination of the effects and pathophysiology of COX inhibitors and their mechanisms of toxicity, beginning with the GI tract. Subsequent chapters cover: The pathophysiology of COX inhibition on bone, tendon, and ligament healing COX inhibitors and renal system pathophysiology and mechanisms of toxicity The pathophysiologic role of COX inhibition in the ocular system COX inhibition and the respiratory and cardiovascular systems The book also sheds light on the latest research devoted to developing COX inhibitors with no adverse side-effects. The first book to offer a thorough comparative look at the toxicological effects of COX inhibitors throughout the body, this invaluable resource will help advance the research and development of safer and more effective COX drugs.
Botana Luis M. Therapeutic Targets. Modulation, Inhibition, and Activation Botana Luis M. Therapeutic Targets. Modulation, Inhibition, and Activation Новинка

Botana Luis M. Therapeutic Targets. Modulation, Inhibition, and Activation

13063.66 руб.
The Latest Applications For Cellmechanism Research in Drug Discovery Designed to connect research on cell mechanisms with the drug discovery process, Therapeutic Targets: Modulation, Inhibition, and Activation introduces readers to a range of new concepts and novel approaches to drug screening and therapeutic drug targeting to help inform future avenues of drug research. Highly topical, this accessible edited volume features chapters contributed by respected experts from around the globe. The book helps postgraduate students and professional scientists working in academia and industry understand the molecular mechanisms of pharmacology, current pharmacological knowledge, and future perspectives in drug discovery, focusing on important biochemical protein targets and drug targeting strategies for specific diseases. Examining the pharmacology of therapeutically undefined targets and their potential applications, it includes chapters on traditional therapeutic targets, including enzymes (phosphodiesterases and proteases), ion channels, and G protein-coupled receptors, as well as more recently identified avenues of exploration, such as lipids, nuclear receptors, gene promoters, and more. Since different diseases require different targeting techniques, the book also includes dedicated chapters on strategies for investigating Alzheimer's, diabetes, pain, and inflammation treatments. Concluding with a cross-sectional look at new approaches in drug screening, Therapeutic Targets is an invaluable resource for understanding where the next generation of drugs are likely to emerge.
Approaching Yehud. New Approaches to the Study of the Persian Period Approaching Yehud. New Approaches to the Study of the Persian Period Новинка

Approaching Yehud. New Approaches to the Study of the Persian Period

2739 руб.
Книга "Approaching Yehud. New Approaches to the Study of the Persian Period".
Madeline Andersen-Warren, Roger Grainger Practical Approaches to Dramatherapy. The Shield of Perseus Madeline Andersen-Warren, Roger Grainger Practical Approaches to Dramatherapy. The Shield of Perseus Новинка

Madeline Andersen-Warren, Roger Grainger Practical Approaches to Dramatherapy. The Shield of Perseus

4702 руб.
Книга "Practical Approaches to Dramatherapy. The Shield of Perseus".
Frank H. Stephen Firms, Organization and Labour. Approaches to the Economics of Work Organization Frank H. Stephen Firms, Organization and Labour. Approaches to the Economics of Work Organization Новинка

Frank H. Stephen Firms, Organization and Labour. Approaches to the Economics of Work Organization

7877 руб.
Книга "Firms, Organization and Labour. Approaches to the Economics of Work Organization".
Transcending Boundaries. Multi-Disciplinary Approaches to the Study of Gender Transcending Boundaries. Multi-Disciplinary Approaches to the Study of Gender Новинка

Transcending Boundaries. Multi-Disciplinary Approaches to the Study of Gender

4002 руб.
Книга "Transcending Boundaries. Multi-Disciplinary Approaches to the Study of Gender".
Sandra Vergnolle Contrast of the French and German Approaches to e-Democracy Sandra Vergnolle Contrast of the French and German Approaches to e-Democracy Новинка

Sandra Vergnolle Contrast of the French and German Approaches to e-Democracy

8139 руб.
Книга "Contrast of the French and German Approaches to e-Democracy".
Nicolae-Doru Stanescu Classical and Modern Approaches in the Theory of Mechanisms Nicolae-Doru Stanescu Classical and Modern Approaches in the Theory of Mechanisms Новинка

Nicolae-Doru Stanescu Classical and Modern Approaches in the Theory of Mechanisms

9183.93 руб.
Classical and Modern Approaches in the Theory of Mechanisms is a study of mechanisms in the broadest sense, covering the theoretical background of mechanisms, their structures and components, the planar and spatial analysis of mechanisms, motion transmission, and technical approaches to kinematics, mechanical systems, and machine dynamics. In addition to classical approaches, the book presents two new methods: the analytic-assisted method using Turbo Pascal calculation programs, and the graphic-assisted method, outlining the steps required for the development of graphic constructions using AutoCAD; the applications of these methods are illustrated with examples. Aimed at students of mechanical engineering, and engineers designing and developing mechanisms in their own fields, this book provides a useful overview of classical theories, and modern approaches to the practical and creative application of mechanisms, in seeking solutions to increasingly complex problems.
Mary Sterling Jane Algebra II Workbook For Dummies Mary Sterling Jane Algebra II Workbook For Dummies Новинка

Mary Sterling Jane Algebra II Workbook For Dummies

1584.61 руб.
Boost your chances of scoring higher at Algebra II Algebra II introduces students to complex algebra concepts in preparation for trigonometry and calculus. In this new edition of Algebra II Workbook For Dummies, high school and college students will work through the types of Algebra II problems they'll see in class, including systems of equations, matrices, graphs, and conic sections. Plus, the book now comes with free 1-year access to chapter quizzes online! A recent report by ACT shows that over a quarter of ACT-tested 2012 high school graduates did not meet any of the four college readiness benchmarks in mathematics, English, reading, and science. Algebra II Workbook For Dummies presents tricky topics in plain English and short lessons, with examples and practice at every step to help students master the essentials, setting them up for success with each new lesson. Tracks to a typical Algebra II class Can be used as a supplement to classroom learning or for test prep Includes plenty of practice and examples throughout Comes with free access to chapter quizzes online Get ready to take the intimidation out of Algebra II!
New Approaches to Classes and Concepts New Approaches to Classes and Concepts Новинка

New Approaches to Classes and Concepts

3489 руб.
Classifying objects --- thus collecting them into classes --- is anoperation both fundamental and common in everyday life as well as inscientific endeavours. Logic, philosophy, mathematics and computerscience analyse this activity by means of such notions as `class',`set', and `type'. Furthermore, according to the so-called ``logical(or naive) conception of classes", these notions are related to thenotion `concept' in that classes are considered `extensions' ofconcepts. This relationship, however, is a delicate one --- as wehave learned from the paradoxes of class theory. The contributions tothis volume shed new light both on concepts and classes and theirdelicate relationship. New and original approaches to these issues(e.g., map theory, epsilon-sets, intensional type theory, AFA settheory) are presented and discussed in the broader context of theirapplication to problems from informatics and linguistics. The focus ison such matters as unrestrictive comprehension, extensionality, therelationship between the notions of concept, class and extension, andon unfounded (circular and infinitely descending) patterns ofelementhood. These and related problems have always played a role inthe development of set theory and have always delivered motivation forthe development of unorthodox views and theories. This is alsodemonstrated in this volume by contributions dealing with the historyof Zermelo's axiomatization of set theory and Ackermann's class theory...
Haresh Chaudhary,B.N. Patel and D.M. Patel Simvastatin Solid Dispersion Prepared By Microwave Fusion Technique Haresh Chaudhary,B.N. Patel and D.M. Patel Simvastatin Solid Dispersion Prepared By Microwave Fusion Technique Новинка

Haresh Chaudhary,B.N. Patel and D.M. Patel Simvastatin Solid Dispersion Prepared By Microwave Fusion Technique

4419 руб.
Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-free solid dispersions and to enhance the solubility and dissolution rate of simvastatin by a solid dispersion.
Jacek Tittenbrun The Middle Class or You only live twice Jacek Tittenbrun The Middle Class or You only live twice Новинка

Jacek Tittenbrun The Middle Class or You only live twice

4539 руб.
Document from the year 2016 in the subject Sociology - Social System, Social Structure, Class, Social Stratification, University of Poznan (Institute of Sociology), language: English, abstract: The book tests the double hypothesis of the death of the middle class. Using U.S. and other developed and developing countries' materials, it seeks to answer whether the popular thesis on its demise is true, and second, it shows it is true in a conceptual sense, viz. , the term in question is a misnomer, referring to a stratum rather than a class. In the course of those investigations other key questions are examined, such as an all-important issue of socio-economic inequality: both in national and world context. The study is underpinned by an original conceptual framework encompassing social class and estate theories and ownership theory. This makes it possible to criticise many other approaches to the problems analysed. For instance, a critique of a well-known book by the French economist Th. Picketty has been undertaken, showing its numerous flaws. In addition, the analysis of the middle class concept demonstrates its defects manifest in its various definitions and usages.
Valeria Frangione Anti-tumor vaccine and immunotherapy based on CD4+ T helper cells Valeria Frangione Anti-tumor vaccine and immunotherapy based on CD4+ T helper cells Новинка

Valeria Frangione Anti-tumor vaccine and immunotherapy based on CD4+ T helper cells

3167 руб.
Vaccination with poorly or not immunogenic tumour cells failed to protect the host from a subsequent challenge in animal models. The mechanisms underlying the failure of these cells to sensitize the therapeutic T cells are not clearly understood, but the inability of the host T cells to recognize the cancer has been implicated. Previous works have shown that an highly aggressive murine mammary adenocarcinoma can be rejected by the host if genetically modified to express MHC class II genes upon transfection of the MHC class II transactivator, CIITA. MHC class II molecules are required for presenting antigenic peptides to the T helper cells and thus activate the cascade of events leading to immune effector functions, such as antibody production and cytolytic T cell activity. The purpose of this work is to investigate whether the above approach could be generalized and thus extended to tumours of different histological origin. Moreover, it was assessed whether anti-tumour lymphocytes generated by this approach could be used as an immunotherapeutic tool for established cancers in different murine models.
Stephen Joseph Theories of Counselling and Psychotherapy. An Introduction to the Different Approaches Stephen Joseph Theories of Counselling and Psychotherapy. An Introduction to the Different Approaches Новинка

Stephen Joseph Theories of Counselling and Psychotherapy. An Introduction to the Different Approaches

6014 руб.
This authoritative overview of the main approaches to counselling and psychotherapy offers a uniquely concise and systematic framework for understanding and comparing different models of working. Bringing together the philosophical and practical elements of a wide range of psychological therapies, Stephen Joseph examines the assumptions and values that underpin different understandings of mental distress and the various approaches to psychological assessment and treatment. He sets his discussion in the context of the contemporary drive towards evidence-based practice. In particular, he:
Jack O'Connell Total Recall. More Reminiscences from the USNA Class of 1952 Jack O'Connell Total Recall. More Reminiscences from the USNA Class of 1952 Новинка

Jack O'Connell Total Recall. More Reminiscences from the USNA Class of 1952

1489 руб.
This book is a follow-up to the first published book of reminiscences by the naval academy class of 1952—As We Recall—published in 2015. It includes tales of life in the service (navy, marine corps, and air force) or afterwards. The stories have been lightly edited to retain the original flavor of the author’s memories. The naval academy class of 1952 is unique in having more general and flag officers graduates than any class since the end of World War II. It also includes four astronauts, another record.
Georg Von Bekesy Sensory Inhibition Georg Von Bekesy Sensory Inhibition Новинка

Georg Von Bekesy Sensory Inhibition

4414 руб.
Psychological experiments carried out over a period of nearly forty years led Georg von Bekesy to realize that inhibition interconnects, at least in one respect, the fields of vision, hearing, skin sensations, taste, and smell. This book indeed almost creates the field of sensory inhibition as a significant one for study, bringing understanding to many observations that formerly seemed uncertain or unrelated and raising many problems still to be solved.Originally published in 1967.The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Karen Lackey Medicinal Chemistry Approaches to Personalized Medicine Karen Lackey Medicinal Chemistry Approaches to Personalized Medicine Новинка

Karen Lackey Medicinal Chemistry Approaches to Personalized Medicine

15057.99 руб.
Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues. Numerous case studies from the first generation of «personalized drugs» are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered. With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come. From the content: * Discovery of Predictive Biomarkers for Anticancer Drugs * Discovery and Development of Vemurafenib * Targeting Basal-Cell Carcinoma * G-Quadruplexes as Therapeutic Targets in Cancer * From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease * Therapeutic Potential of Kinases in Asthma * DNA Damage Repair Pathways and Synthetic Lethality * Medicinal Chemistry in the Context of the Human Genome and many more
Sascha Walter Approaches to the Ex-arte Evaluation of Information Systems Sascha Walter Approaches to the Ex-arte Evaluation of Information Systems Новинка

Sascha Walter Approaches to the Ex-arte Evaluation of Information Systems

9564 руб.
Inhaltsangabe:Summary:This paper critically reviews approaches for the evaluation of investments in information systems prior to their implementation. First, the ground for the review is prepared by examining characteristics of evaluation, information systems and value. A classification of 54 evaluation approaches identified in English and German literature is then presented. Examples of each class are reviewed and their advantages and drawbacks are discussed. Their use in evaluation practice is analysed through the examination of empirical studies and directions for future research are given. A complete overview of state-of-the-art evaluation approaches is given at the end of the paper.Inhaltsverzeichnis:Table of Contents:1.INTRODUCTION12.THEMATIC BACKGROUND32.1Information Systems32.2Evaluation82.3Value133.CRITICAL REVIEW OF EVALUATION APPROACHES173.1Antecedents to the Review173.2Effect-Assessing Approaches203.3Effect-Locating Approaches333.4Discussion of Usability of Approaches414.EVALUATION IN PRACTICE514.1Review of Empirical Studies514.2Interpretation of Empirical Studies554.3Discussion and Future Research575.CONCLUSIONS60APPENDIX61Overview of Evaluation Approaches61Literature Search Strategy64REFERENCES65
Lionel Corbett The Soul in Anguish. Psychotherapeutic Approaches to Suffering Lionel Corbett The Soul in Anguish. Psychotherapeutic Approaches to Suffering Новинка

Lionel Corbett The Soul in Anguish. Psychotherapeutic Approaches to Suffering

3377 руб.
The Soul in Anguish: Psychotherapeutic Approaches to Suffering presents a variety of approaches to psychotherapeutic work with suffering people, from the perspectives of both Jungian and psychoanalytic psychology. An important theme of the book is that suffering may be harmful or helpful to the development of the personality. Our culture tends to assume that suffering is invariably negative or pointless, but this is not necessarily so; suffering may be destructive, but it may lead to positive developments such as enhanced empathy for others, wisdom, or spiritual development. The book offers professionals in any helping profession various frameworks within which to view suffering, so that the individual's suffering does not seem to be random or meaningless. Cognitive-behavioral approaches, the approach of the Diagnostic and Statistical Manual of the American Psychiatric association, and the promise of evidence-based strategies may or may not be applicable to the unique circumstances of the suffering individual. These approaches also ignore the unconscious sources of much suffering, its implications for the ongoing development of the personality, and the nuances of the therapeutic relationship. We cannot objectify or measure suffering; suffering is best viewed from within the individual's perspective, because people with the same diagnosis suffer in unique ways. The Soul in Anguish is a groundbreaking, meticulously researched study from an outstanding Jungian analyst an...
Campbell Rolian Developmental Approaches to Human Evolution Campbell Rolian Developmental Approaches to Human Evolution Новинка

Campbell Rolian Developmental Approaches to Human Evolution

9983.51 руб.
Developmental Approaches to Human Evolution encapsulates the current state of evolutionary developmental anthropology. This emerging scientific field applies tools and approaches from modern developmental biology to understand the role of genetic and developmental processes in driving morphological and cognitive evolution in humans, non-human primates and in the laboratory organisms used to model these changes. Featuring contributions from well-established pioneers and emerging leaders, this volume is designed to build research momentum and catalyze future innovation in this burgeoning field. The book’s broad research scope encompasses soft and hard tissues of the head and body, including the skeleton, special senses and the brain. Developmental Approaches to Human Evolution is an invaluable resource on the mechanisms of primate and vertebrate evolution for scholars across a wide array of intersecting disciplines, including primatology, paleoanthropology, vertebrate morphology, evolutionary developmental biology and health sciences.
Jiby John Mathew, Prem Jose Vazhacharickal, Sajeshkumar N. K. Antimicrobial and phytochemical analysis of lime juice and different types of honey. An overview Jiby John Mathew, Prem Jose Vazhacharickal, Sajeshkumar N. K. Antimicrobial and phytochemical analysis of lime juice and different types of honey. An overview Новинка

Jiby John Mathew, Prem Jose Vazhacharickal, Sajeshkumar N. K. Antimicrobial and phytochemical analysis of lime juice and different types of honey. An overview

3252 руб.
Scientific Study from the year 2016 in the subject Biology - Micro- and Molecular Biology, grade: 1.5, Mar Augusthinose College, language: English, abstract: Citrus, one of the major genes of Rutaceae family and most economically important fruit tree and widely cultivated throughout the country. The Citrus have high nutritional value and medicinal value. Honey and lemon-honey are traditional remedies in the Middle East and China and for many centuries and have been used in the treatment and prevention of the common cold and various upper respiratory tract infections. Three types of honey were collected; 'Cheruthen'-produced by bees belongs to the Trigona irridipennis species; Vanthen'- produced by bees belongs to the Apis indica species; 'Kattutthen'- produced by bees belongs to the Apis dorsata species. The antibacterial activites of honey samples and lime juice were tested aganist Bacillus, Klebsiella, E.coli, Staphylococcus and Micrococcus. The result showed that the samples have differnt antimicrobial activity. Antimicrobial activity of Cheruthen against Klebsiella species showed a zone of inhibition of 10.1 ± 0.73 mm, when 100 µl of Cheruthen is applied. When 200 µl of Cheruthen is applied the zone of inhibition was 30.1 ± 0.23 mm. Antimicrobial activity of Cheruthen against E.coli showed a zone of inhibition of 10.1 ± 0.13 mm, when 100 µl of cheruthen is applied. When 200 µl of cheruthen is applied the zone of inhibition was 30.2 ± 0.23 mm. Also the ...
Tandon Gitanjali Structural . Conformational Characterstics of Tilted Peptides Tandon Gitanjali Structural . Conformational Characterstics of Tilted Peptides Новинка

Tandon Gitanjali Structural . Conformational Characterstics of Tilted Peptides

7139 руб.
Tilted peptides are short helical peptides (11 to 20 aa long), known to destabilize membranes and lipid cores. These characterized by a peculiar distribution of hydrophobic residues: they are amphipathic and their net hydrophobicity increases from one end of the helix to the other, due to an asymmetric distribution of hydrophobic residues along the axis of the α-helix, Such peptides adopt an oblique orientation which can destabilize membranes or lipid cores. Tilted peptides of Prolactin (PRL) and Growth hormone (GH) have attracted immense amount of researches in their structure and their characterstics studies because of their special functional properties: inhibition of angiogenesis, inhibition of endothelial cell proliferation and induce endothelial cell apoptosis.
Varghese John BACE. Lead Target for Orchestrated Therapy of Alzheimer's Disease Varghese John BACE. Lead Target for Orchestrated Therapy of Alzheimer's Disease Новинка

Varghese John BACE. Lead Target for Orchestrated Therapy of Alzheimer's Disease

10137.31 руб.
BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimer's disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research—and inspire new approaches to treatment of AD.
Saharon Shelah Classification Theory for Abstract Elementary Classes Saharon Shelah Classification Theory for Abstract Elementary Classes Новинка

Saharon Shelah Classification Theory for Abstract Elementary Classes

3089 руб.
An abstract elementary class is a class of structures of the same vocabulary (like a class of rings, or a class of fields), with a partial order that generalizes the relation "A is a substructure (or an elementary substructure) of B". The requirements are that the class is closed under isomorphism, and that isomorphic structures have isomorphic (generalized) substructures; we also require that our classes share some of the most basic properties of elementary classes, like closure under unions of increasing chains of substructures.We would like to classify this general family; in the sense of proving dichotomies: either we can understand the structure of all models in our class or there are many to some extent. More specifically we would like to generalize the theory about categoricity and superstability to this context.
Amy Singer Starting with Food. Culinary Approaches to Ottoman History. Edited by Amy Singer Amy Singer Starting with Food. Culinary Approaches to Ottoman History. Edited by Amy Singer Новинка

Amy Singer Starting with Food. Culinary Approaches to Ottoman History. Edited by Amy Singer

3452 руб.
Food is a marker of identity, culture, and class, and it denotes power, routine, leisure, and celebration. Despite its importance to every aspect of historical research, this topic has not been sufficiently explored in Ottoman history. This volume places the study of food in the mainstream of Ottoman history by analyzing major issues — origins, identity, minorities, Ottomanization, the “golden age,” foreign relations, the nature of modernity — all from the perspective of food. Contributors include Nicolas Trépanier, Iklil O. Selçuk, Rachel Goshgarian, Tülay Artan, and Joanita Vroom.
Michael Ryan Literary Theory. A Practical Introduction Michael Ryan Literary Theory. A Practical Introduction Новинка

Michael Ryan Literary Theory. A Practical Introduction

7347.14 руб.
Literary Theory: A Practical Introduction, Third Edition, presents a comprehensive introduction to the full range of contemporary approaches to the study of literature and culture, from formalism, structuralism, and historicism to ethnic, gender, and science studies. Introduces students to a variety of contemporary approaches to the study of literature and culture Demonstrates how the varying perspectives on texts can lead to different interpretations of the same work Features numerous updates that include new literary texts, new and expanded sections Represents the ideal accompaniment to the upcoming Third Edition of Literary Theory: An Anthology
Christopher Twelves J. A Practical Guide to Designing Phase II Trials in Oncology Christopher Twelves J. A Practical Guide to Designing Phase II Trials in Oncology Новинка

Christopher Twelves J. A Practical Guide to Designing Phase II Trials in Oncology

5992.15 руб.
How to identify optimal phase II trial designs Providing a practical guide containing the information needed to make crucial decisions regarding phase II trial designs, A Practical Guide to Designing Phase II Trials in Oncology sets forth specific points for consideration between the statistician and clinician when designing a phase II trial, including issues such as how the treatment works, choice of outcome measure and randomization, and considering both academic and industry perspectives. A comprehensive and systematic library of available phase II trial designs is included, saving time otherwise spent considering multiple manuscripts, and real-life practical examples of using this approach to design phase II trials in cancer are given. A Practical Guide to Designing Phase II Trials in Oncology: Offers a structured and practical approach to phase II trial design. Considers trial design from both an academic and industry perspective. Includes a structured library of available phase II trial designs. Is relevant to both clinical and statistical researchers at all levels Includes real life examples of applying this approach. For those new to trial design, A Practical Guide to Designing Phase II Trials in Oncology will be a unique and practical learning tool, providing an introduction to the concepts behind informed decision making in phase II trials. For more experienced practitioners, the book will offer an overview of new, less familiar approaches to phase II trial design, providing alternative options to those which they may have previously used.
J. Hardwick Marie The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria J. Hardwick Marie The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria Новинка

J. Hardwick Marie The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria

14981.46 руб.
This book presents advances in the field of neuronal mitochondria – functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases. • Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death • Offers insights on the development of strategies for targeted therapeutic approaches and potential personalized treatments • Includes examples of mitochondrial drugs, development, and mitochondria-targeted approaches for more efficient treatment methods and further developments in the field • Covers the model systems and approaches needed for the development of new drugs for the central nervous system to provide potential modern therapeutics for neurodegenerative disorders
Kerstin Helmes Relationship U-Turn. Approaches to Increase the Value of an Unprofitable Customer Kerstin Helmes Relationship U-Turn. Approaches to Increase the Value of an Unprofitable Customer Новинка

Kerstin Helmes Relationship U-Turn. Approaches to Increase the Value of an Unprofitable Customer

3952 руб.
Customer relationship management concentrates to a great extent on the profitable customers and how to enhance their profitability. Little insight has been given on how to treat the "wrong" customer. This literature research paper shows that customer profitability and overall firm profitability can be improved when dealing with unprofitable customers. The managerial approaches discussed focus on maintaining the customer relationship. For this reason, this paper differs from the general widespread strategy of termination or "firing" an invaluable customer.First, relationship marketing and "Relationship U-turn" are introduced in this paper. Second, customer value and methods of measuring customer value are discussed. The body of this paper concentrates on different approaches that try to turn unprofitable customer relationships into profitable ones. Some of the approaches focus on letting the customer take over more of the value chain activities such as self-service. Other approaches look more at the non-monetary value a customer can provide such as positive word-of-mouth. Examples from business-to-business (B2B) and business-to-consumer (B2C) markets are given for each approach and discussed in detail. The paper concludes with ideas for future research and a discussion. It emphasizes that companies need to realize that every customer is an asset that contributes to the value of a firm. However, customers differ in their needs and a company has to tailor...
Lena Sanders Spatio-temporal Approaches. Geographic Objects and Change Process Lena Sanders Spatio-temporal Approaches. Geographic Objects and Change Process Новинка

Lena Sanders Spatio-temporal Approaches. Geographic Objects and Change Process

6760.39 руб.
Spatio-temporal Approaches presents a well-built set of concepts, methods and approaches, in order to represent and understand the evolution of social and environmental phenomena within the space. It is basedon examples in human geography and archeology (which will enable us to explore questions regarding various temporalities) and tackles social and environmental phenomena. Chapter 1 discusses how to apprehend change: objects, attributes, relations, processes. Chapter 2 introduces multiple points of view about modeling and the authors try to shed a new light on the different, but complementary approaches of geomaticians and thematicians. Chapter 3 is devoted to the construction of spatio-temporal indicators, to various measurements of the change, while highlighting the advantage of an approach crossing several points of view, in order to understand the phenomenon at hand. Chapter 4 presents different categories of simulation model in line with complexity sciences. These models rely notably on the concepts of emergence and self-organization and allow us to highlight the roles of interaction within change. Chapter 5 provides ideas on research concerning the various construction approaches of hybrid objects and model couplings.
Evaluation of Novel Approaches to Software Engineering. 8th International Conference, ENASE 2013, Angers, France, July 4-6, 2013. Revised Selected Papers Evaluation of Novel Approaches to Software Engineering. 8th International Conference, ENASE 2013, Angers, France, July 4-6, 2013. Revised Selected Papers Новинка

Evaluation of Novel Approaches to Software Engineering. 8th International Conference, ENASE 2013, Angers, France, July 4-6, 2013. Revised Selected Papers

9189 руб.
This book constitutes the thoroughly refereed proceedings of the 8th International Conference on Evaluation of Novel Approaches to Software Engineering, ENASE 2013, held in Angers, France, in July 2013. The 18 full papers presented were carefully reviewed and selected from 46 submissions. The papers reflect a growing effort to increase the dissemination of new results among researchers and professionals related to evaluation of novel approaches to software engineering. By comparing novel approaches with established traditional practices and by evaluating them against software quality criteria, the ENASE conferences advance knowledge and research in software engineering, identify most hopeful trends, and propose new directions for consideration by researchers and practitioners involved in large-scale software development and integration.
V. S. Sastri Green Corrosion Inhibitors. Theory and Practice V. S. Sastri Green Corrosion Inhibitors. Theory and Practice Новинка

V. S. Sastri Green Corrosion Inhibitors. Theory and Practice

9182.98 руб.
A book to cover developments in corrosion inhibitors is long overdue. This has been addressed by Dr Sastri in a book which presents fundamental aspects of corrosion inhibition, historical developments and the industrial applications of inhibitors. The book deals with the electrochemical principles and chemical aspects of corrosion inhibition, such as stability of metal complexes, the Hammett equation, hard and soft acid and base principle, quantum chemical aspects and Hansch' s model and also with the various surface analysis techniques, e.g. XPS, Auger, SIMS and Raman spectroscopy, that are used in industry for corrosion inhibition. The applications of corrosion inhibition are wide ranging. Examples given in this book include: oil and gas wells, petrochemical plants, steel reinforced cement, water cooling systems, and many more. The final chapters discuss economic and environmental considerations which are now of prime importance. The book is written for researchers in academia and industry, practicing corrosion engineers and students of materials science, engineering and applied chemistry.
Huong Ha, R. Lalitha S. Fernando, Sanjeev Kumar Mahajan Disaster Risk Management. Case Studies in South Asian Countries Huong Ha, R. Lalitha S. Fernando, Sanjeev Kumar Mahajan Disaster Risk Management. Case Studies in South Asian Countries Новинка

Huong Ha, R. Lalitha S. Fernando, Sanjeev Kumar Mahajan Disaster Risk Management. Case Studies in South Asian Countries

4764 руб.
This book provides a framework for making administration effective and improving mitigation and rehabilitation measures with a view to ensuring a safer life for citizens.It is an outcome of research studies carried out by eminent scholars and practitioners in South Asian countries in the field of disaster risk management. The authors discuss how different South Asian countries manage disasters and address challenges associated with them. The case studies presented in this book reflect reality versus myth. In the quest to improve the ground-level situation, it is pertinent to understand the interdisciplinary nature of approaches used to tackle the aftermath of disasters. The key features of this book include (i) the adoption of critical and multidisciplinary approaches in discussing disaster-related problems and emerging issues; and (ii) the provision of insights into the approaches to address the challenges and issues of disaster risk management. The different stakeholders, practitioners, policy makers, and researchers will acquire a fuller and richer understanding of the various issues related to disaster risk management.
Ingvar Eidhammer Computational and Statistical Methods for Protein Quantification by Mass Spectrometry Ingvar Eidhammer Computational and Statistical Methods for Protein Quantification by Mass Spectrometry Новинка

Ingvar Eidhammer Computational and Statistical Methods for Protein Quantification by Mass Spectrometry

8216.7 руб.
The definitive introduction to data analysis in quantitative proteomics This book provides all the necessary knowledge about mass spectrometry based proteomics methods and computational and statistical approaches to pursue the planning, design and analysis of quantitative proteomics experiments. The author’s carefully constructed approach allows readers to easily make the transition into the field of quantitative proteomics. Through detailed descriptions of wet-lab methods, computational approaches and statistical tools, this book covers the full scope of a quantitative experiment, allowing readers to acquire new knowledge as well as acting as a useful reference work for more advanced readers. Computational and Statistical Methods for Protein Quantification by Mass Spectrometry: Introduces the use of mass spectrometry in protein quantification and how the bioinformatics challenges in this field can be solved using statistical methods and various software programs. Is illustrated by a large number of figures and examples as well as numerous exercises. Provides both clear and rigorous descriptions of methods and approaches. Is thoroughly indexed and cross-referenced, combining the strengths of a text book with the utility of a reference work. Features detailed discussions of both wet-lab approaches and statistical and computational methods. With clear and thorough descriptions of the various methods and approaches, this book is accessible to biologists, informaticians, and statisticians alike and is aimed at readers across the academic spectrum, from advanced undergraduate students to post doctorates entering the field.
E RAY CANTERBERY BRIEF HISTORY OF ECONOMICS, A. ARTFUL APPROACHES TO THE DISMAL SCIENCE (2ND EDITION) E RAY CANTERBERY BRIEF HISTORY OF ECONOMICS, A. ARTFUL APPROACHES TO THE DISMAL SCIENCE (2ND EDITION) Новинка

E RAY CANTERBERY BRIEF HISTORY OF ECONOMICS, A. ARTFUL APPROACHES TO THE DISMAL SCIENCE (2ND EDITION)

4664 руб.
Книга "BRIEF HISTORY OF ECONOMICS, A. ARTFUL APPROACHES TO THE DISMAL SCIENCE (2ND EDITION)".
Andrew McDonnell A. Managing Aggressive Behaviour in Care Settings. Understanding and Applying Low Arousal Approaches Andrew McDonnell A. Managing Aggressive Behaviour in Care Settings. Understanding and Applying Low Arousal Approaches Новинка

Andrew McDonnell A. Managing Aggressive Behaviour in Care Settings. Understanding and Applying Low Arousal Approaches

10133.35 руб.
A practical guide for health professionals and trainers, offering evidence-based low arousal approaches to defusing and managing aggressive behaviours in a variety of health care settings. Provides both an academic background and practical advice on how to manage and minimize confrontation Illustrates low arousal approaches and offers clear advice on physical restraint and the reduction of these methods Describes the evidence base for recommended approaches Includes a wide range of valuable case examples from a variety of care settings
James P. Madry Multidisciplinary Approaches to the Treatment of Abused and Neglected Children and Their Families. It Takes a Village James P. Madry Multidisciplinary Approaches to the Treatment of Abused and Neglected Children and Their Families. It Takes a Village Новинка

James P. Madry Multidisciplinary Approaches to the Treatment of Abused and Neglected Children and Their Families. It Takes a Village

1852 руб.
Книга "Multidisciplinary Approaches to the Treatment of Abused and Neglected Children and Their Families. It Takes a Village".
CROSSING CLASS. The Invisible Wall CROSSING CLASS. The Invisible Wall Новинка

CROSSING CLASS. The Invisible Wall

2189 руб.
CROSSING CLASS: The Invisible Wall. A Wising Up Anthology. Editors: Charles D. Brockett and Heather Tosteson. CLASS: It's the great unspeakable in a society dedicated to the proposition that all people are created equal, with inalienable rights to life, liberty, and the pursuit of happiness, and that believes in the redistributive power of personal ambition, hard work, self-intention and self-definition. It might be the most powerful and intractable of social divisions, its effects potent even within culture, race, or gender. Whether we buy in consciously or not, we are all subject to the shaping power of class. But what exactly does it mean to be shaped by class? How does this shaping affect what we long for, strive for, believe is possible—not just for us but for those around us and the world at large? What happens to our understanding of class, of our society and of ourselves, when we cross class boundaries upwards ordownwards, willingly or unwillingly, through education, employment, marriage, divorce, friendships and other meaningful relationships, immigration or emigration, illness, economic or political upheaval? How does our experience of class mobility, wanted or unwanted, change our understanding of ourselves, our social relationships, our sense of social agency, our sense of our society? How does it change our understanding of the possibilities and challenges of living out E Pluribus Unum? Thirty contemporary writers help us explore the impact of class and inequ...
Dehmer Matthias Statistical and Machine Learning Approaches for Network Analysis Dehmer Matthias Statistical and Machine Learning Approaches for Network Analysis Новинка

Dehmer Matthias Statistical and Machine Learning Approaches for Network Analysis

10058.11 руб.
Explore the multidisciplinary nature of complex networks through machine learning techniques Statistical and Machine Learning Approaches for Network Analysis provides an accessible framework for structurally analyzing graphs by bringing together known and novel approaches on graph classes and graph measures for classification. By providing different approaches based on experimental data, the book uniquely sets itself apart from the current literature by exploring the application of machine learning techniques to various types of complex networks. Comprised of chapters written by internationally renowned researchers in the field of interdisciplinary network theory, the book presents current and classical methods to analyze networks statistically. Methods from machine learning, data mining, and information theory are strongly emphasized throughout. Real data sets are used to showcase the discussed methods and topics, which include: A survey of computational approaches to reconstruct and partition biological networks An introduction to complex networks—measures, statistical properties, and models Modeling for evolving biological networks The structure of an evolving random bipartite graph Density-based enumeration in structured data Hyponym extraction employing a weighted graph kernel Statistical and Machine Learning Approaches for Network Analysis is an excellent supplemental text for graduate-level, cross-disciplinary courses in applied discrete mathematics, bioinformatics, pattern recognition, and computer science. The book is also a valuable reference for researchers and practitioners in the fields of applied discrete mathematics, machine learning, data mining, and biostatistics.
Approaches to Ancient Judaism, Volume VI. Studies in the Ethnography and Literature of Judaism Approaches to Ancient Judaism, Volume VI. Studies in the Ethnography and Literature of Judaism Новинка

Approaches to Ancient Judaism, Volume VI. Studies in the Ethnography and Literature of Judaism

3152 руб.
Книга "Approaches to Ancient Judaism, Volume VI. Studies in the Ethnography and Literature of Judaism".
ALEXANDER PRASOL MODERN JAPAN. ORIGINS OF THE MIND - JAPANESE TRADITIONS AND APPROACHES TO CONTEMPORARY LIFE ALEXANDER PRASOL MODERN JAPAN. ORIGINS OF THE MIND - JAPANESE TRADITIONS AND APPROACHES TO CONTEMPORARY LIFE Новинка

ALEXANDER PRASOL MODERN JAPAN. ORIGINS OF THE MIND - JAPANESE TRADITIONS AND APPROACHES TO CONTEMPORARY LIFE

3164 руб.
Книга "MODERN JAPAN. ORIGINS OF THE MIND - JAPANESE TRADITIONS AND APPROACHES TO CONTEMPORARY LIFE".
Locating the Voice in Film : Critical Approaches and Global Practices Locating the Voice in Film : Critical Approaches and Global Practices Новинка

Locating the Voice in Film : Critical Approaches and Global Practices

8223 руб.
This book locates the voice in cinema in different national and transnational contexts, to explore how the critical approaches to the voice as well as the practices of sound design, technologies and even reception are often grounded in cultural specificity, to present readings which challenge traditional theories of the voice in film.
William A. Shaw The Knights of England. A Complete Record from the Earliest Time to the Present Day of the Knights of all the Orders of Chivalry in England, Scotland, and Ireland, and of Knights Bachelors. Volume II. (Includes Index to Volumes I & II) William A. Shaw The Knights of England. A Complete Record from the Earliest Time to the Present Day of the Knights of all the Orders of Chivalry in England, Scotland, and Ireland, and of Knights Bachelors. Volume II. (Includes Index to Volumes I & II) Новинка

William A. Shaw The Knights of England. A Complete Record from the Earliest Time to the Present Day of the Knights of all the Orders of Chivalry in England, Scotland, and Ireland, and of Knights Bachelors. Volume II. (Includes Index to Volumes I & II)

7264 руб.
Книга "The Knights of England. A Complete Record from the Earliest Time to the Present Day of the Knights of all the Orders of Chivalry in England, Scotland, and Ireland, and of Knights Bachelors. Volume II. (Includes Index to Volumes I & II)".
Luke Mitcheson, Jenny Maslin, Tim Meynen Applied Cognitive and Behavioural Approaches to the Treatment of Addiction. A Practical Treatment Guide Luke Mitcheson, Jenny Maslin, Tim Meynen Applied Cognitive and Behavioural Approaches to the Treatment of Addiction. A Practical Treatment Guide Новинка

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7702 руб.
Книга "Applied Cognitive and Behavioural Approaches to the Treatment of Addiction. A Practical Treatment Guide".
M.D. Maurice J. Rosenthal Defenses Against Loss of Contentment. Humanistic, Research, and Clinical Approaches to the Mood M.D. Maurice J. Rosenthal Defenses Against Loss of Contentment. Humanistic, Research, and Clinical Approaches to the Mood Новинка

M.D. Maurice J. Rosenthal Defenses Against Loss of Contentment. Humanistic, Research, and Clinical Approaches to the Mood

1152 руб.
Книга "Defenses Against Loss of Contentment. Humanistic, Research, and Clinical Approaches to the Mood".
Fatemeh Kazemi,Nosratollah Zarghami, Asadollah Asadi and Hossein Babaei Inhibition of human telomerase reverse transcriptase mRNA expression Fatemeh Kazemi,Nosratollah Zarghami, Asadollah Asadi and Hossein Babaei Inhibition of human telomerase reverse transcriptase mRNA expression Новинка

Fatemeh Kazemi,Nosratollah Zarghami, Asadollah Asadi and Hossein Babaei Inhibition of human telomerase reverse transcriptase mRNA expression

2890 руб.
Telomerase enzyme exists in the most type of cancer cells like breast cancer. Inhibition of telomerase activity could be effective approach for target therapy of cancer. It has been evaluated that curcumin have many application in herbal medicine include treatment of cancer. However, its bioavailability is very poor due to hydrophobicity. Using of some nanoparticles like ß-cyclodextrin (CD) can improve limitation of curcumin in delivery systems.
Andrew McDonnell A. Managing Aggressive Behaviour in Care Settings. Understanding and Applying Low Arousal Approaches Andrew McDonnell A. Managing Aggressive Behaviour in Care Settings. Understanding and Applying Low Arousal Approaches Новинка

Andrew McDonnell A. Managing Aggressive Behaviour in Care Settings. Understanding and Applying Low Arousal Approaches

9829.72 руб.
A practical guide for health professionals and trainers, offering evidence-based low arousal approaches to defusing and managing aggressive behaviours in a variety of health care settings. Provides both an academic background and practical advice on how to manage and minimize confrontation Illustrates low arousal approaches and offers clear advice on physical restraint and the reduction of these methods Describes the evidence base for recommended approaches Includes a wide range of valuable case examples from a variety of care settings
Nima Shakouri,Shabnam Chalabi and Zahra Shakouri Language Teaching Brief-&-Easy Nima Shakouri,Shabnam Chalabi and Zahra Shakouri Language Teaching Brief-&-Easy Новинка

Nima Shakouri,Shabnam Chalabi and Zahra Shakouri Language Teaching Brief-&-Easy

4358 руб.
Language Teaching: Brief-&-Easy is a practical guide to the study of language teaching. Its main aim is to pave the way for better understanding of theories, skills, and methods that you inevitably come across in the field of teaching. The book is designed with the objectives of meeting the needs of the beginning teachers who need some background about methods, approaches, and theories in second language acquisition. Henceforth, teachers are invited to reflect upon their own beliefs and to develop their own approaches to language teaching.
Going First Class? New Approaches to Privileged Travel and Movement Going First Class? New Approaches to Privileged Travel and Movement Новинка

Going First Class? New Approaches to Privileged Travel and Movement

3827 руб.
"The publication of this book... is timely... Interesting and accessibly written, Going First Class? offers not only ethnographically rich reflections on the subject of privileged travel, but... it provides valuable critical insights on the nature of places and the methodological issues surrounding their study." · JRAI"... this collection of chapters deserves to be widely read and discussed - together, they demonstrate the imperative for ethnographic research in conversation, but not necessarily in cahoots, with reigning critical theories of modernity and the contemporary world." · Social AnthropologyPeople travel as never before. However, anthropological research has tended to focus primarily on either labor migration or on tourism. In contrast, this collection of essays explores a diversity of circumstances and impetuses towards contemporary mobility. It ranges from expatriates to peripatetic professionals to middle class migrants in search of extended educational and career opportunities to people seeking self development through travel, either by moving after retirement or visiting educational retreats. These situations, however, converge in the significant resources, variously of finances, time, credentials or skills, which these voyagers are able to call on in embarking on their respective journeys. Accordingly, this volume seeks to tease out the scope and implications of the relatively privileged circumstances under which these voyages are being underta...
Harbers Matthias Tag-based Next Generation Sequencing Harbers Matthias Tag-based Next Generation Sequencing Новинка

Harbers Matthias Tag-based Next Generation Sequencing

16310.77 руб.
Tag-based approaches were originally designed to increase the throughput of capillary sequencing, where concatemers of short sequences were first used in expression profiling. New Next Generation Sequencing methods largely extended the use of tag-based approaches as the tag lengths perfectly match with the short read length of highly parallel sequencing reactions. Tag-based approaches will maintain their important role in life and biomedical science, because longer read lengths are often not required to obtain meaningful data for many applications. Whereas genome re-sequencing and de novo sequencing will benefit from ever more powerful sequencing methods, analytical applications can be performed by tag-based approaches, where the focus shifts from 'sequencing power' to better means of data analysis and visualization for common users. Today Next Generation Sequence data require powerful bioinformatics expertise that has to be converted into easy-to-use data analysis tools. The book's intention is to give an overview on recently developed tag-based approaches along with means of their data analysis together with introductions to Next-Generation Sequencing Methods, protocols and user guides to be an entry for scientists to tag-based approaches for Next Generation Sequencing.
John Moore T. Chemistry II For Dummies John Moore T. Chemistry II For Dummies Новинка

John Moore T. Chemistry II For Dummies

1320.4 руб.
The tools you need to ace your Chemisty II course College success for virtually all science, computing, engineering, and premedical majors depends in part on passing chemistry. The skills learned in chemistry courses are applicable to a number of fields, and chemistry courses are essential to students who are studying to become nurses, doctors, pharmacists, clinical technicians, engineers, and many more among the fastest-growing professions. But if you're like a lot of students who are confused by chemistry, it can seem like a daunting task to tackle the subject. That's where Chemistry II For Dummies can help! Here, you'll get plain-English, easy-to-understand explanations of everything you'll encounter in your Chemistry II class. Whether chemistry is your chosen area of study, a degree requirement, or an elective, you'll get the skills and confidence to score high and enhance your understanding of this often-intimidating subject. So what are you waiting for? Presents straightforward information on complex concepts Tracks to a typical Chemistry II course Serves as an excellent supplement to classroom learning Helps you understand difficult subject matter with confidence and ease Packed with approachable information and plenty of practice opportunities, Chemistry II For Dummies is just what you need to make the grade.
H. Schuhart Design and Implementation of a Database Programming Language for XML-Based Applications H. Schuhart Design and Implementation of a Database Programming Language for XML-Based Applications Новинка

H. Schuhart Design and Implementation of a Database Programming Language for XML-Based Applications

9077 руб.
This publication focuses on two main aspects; the seamless integration of XML and persistency concepts into the object-oriented programming language Java. XML is the de facto standard data exchange format between arbitrary applications. There have been many efforts to integrate XML into programming languages reaching from the simple document object model (DOM) to whole XML class generators. These approaches are available in most popular programming languages. The integration of persistency into programming languages has been done by database programming languages as well as by certain new popular frameworks like Hibernate or approaches like EJB. Nevertheless, these approaches suffer from certain limitations concerning in particular transparency and object-orientation. While existing database programming languages integrate the relational model, Hibernate and EJB 3.x does not support polymorphism in general. EJB 2.x does not even support inheritance. In addition, although they try to, the approaches except by some database programming languages are not transparent. In this work, transparency means that arbitrary types may become persistent. Moreover, algorithms remain unchanged whether they are executed on transient or persistent objects. Finally, users can work with persistency on a very high level. Since there are so many currently developed frameworks trying to solve the integration problem of XML and persistency into object-oriented programming languages, the need for a ho...
Barthwal Varun, Kishore Jaydeep, Joshi Bhagawati Prasad Estimation of Software Metrics using Function Point Analysis Barthwal Varun, Kishore Jaydeep, Joshi Bhagawati Prasad Estimation of Software Metrics using Function Point Analysis Новинка

Barthwal Varun, Kishore Jaydeep, Joshi Bhagawati Prasad Estimation of Software Metrics using Function Point Analysis

8927 руб.
Unified modelling language (UML) can be used to implement an object oriented software system, how to map this UML to function point analysis various approaches are suggested by software practitioners, we have used UML diagrams to map UML to function point analysis. Various rules were proposed earlier, these rules can be applied on UML to estimate function points. We have used UML class diagram for data function analysis and UML sequence diagram for transaction function analysis than we have applied transformation rules and guidelines to estimates function point. We have developed a tool based estimation technique for object oriented software metrics which extracts required information from UML diagrams and its logical view report to estimate size of software then using COCOMO II rest of the software metrics are calculated e.g. effort, development time, productivity and cost.

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The first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks Cyclooxygenases (COXs) are enzymes responsible for the formation of an important class of biological mediators called prostanoids. Prostanoids such as prostaglandins mediate inflammatory and anaphylactic reactions. For those suffering from inflammation and pain, the pharmacological inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide relief. Yet the use of NSAIDs can trigger toxicological effects as well, leading to potential health risks. Comparative Pathophysiology and Toxicology of Cyclooxygenases provides a comprehensive overview of how COX inhibitors affect various bodily systems, specifically the toxicity mechanisms triggered when the COX enzyme is inhibited. The book provides an introduction to the discovery of cyclooxygenases, their use as therapeutic agents, as well as an historical perspective. Shedding light on the differences in expression, pathophysiology, and toxicology of COX inhibitors across species, the book offers a systematic examination of the effects and pathophysiology of COX inhibitors and their mechanisms of toxicity, beginning with the GI tract. Subsequent chapters cover: The pathophysiology of COX inhibition on bone, tendon, and ligament healing COX inhibitors and renal system pathophysiology and mechanisms of toxicity The pathophysiologic role of COX inhibition in the ocular system COX inhibition and the respiratory and cardiovascular systems The book also sheds light on the latest research devoted to developing COX inhibitors with no adverse side-effects. The first book to offer a thorough comparative look at the toxicological effects of COX inhibitors throughout the body, this invaluable resource will help advance the research and development of safer and more effective COX drugs.
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