bioanalytical separations4



Andreas Manz, Nicole Pamme, Dimitri Lossifidis Bioanalytical Chemistry Andreas Manz, Nicole Pamme, Dimitri Lossifidis Bioanalytical Chemistry Новинка

Andreas Manz, Nicole Pamme, Dimitri Lossifidis Bioanalytical Chemistry

5689 руб.
Книга "Bioanalytical Chemistry".
Michael Zhou Regulated Bioanalytical Laboratories. Technical and Regulatory Aspects from Global Perspectives Michael Zhou Regulated Bioanalytical Laboratories. Technical and Regulatory Aspects from Global Perspectives Новинка

Michael Zhou Regulated Bioanalytical Laboratories. Technical and Regulatory Aspects from Global Perspectives

12117.25 руб.
This book provides useful information for bioanalytical / analytical scientists, analysts, quality assurance managers, and all personnel in bioanalytical laboratories through all aspects of bioanalytical technical and regulatory perspectives within bioanalytical operations and processes. Readers learn how to develop and implement strategies for routine, non-routine, and standard bioanalytical methods and on the entire equipment hardware and software qualification process. The book also gives guidelines on qualification of certified standards and in-house reference material as well as on people qualification. Finally, it guides readers through stressless internal and third party laboratory audits and inspections. It takes account to most national and international regulations and quality and accreditation standards, along with corresponding interpretation and inspection guides. The author elaborates on highly comprehensive content, making it easy not only to learn the subject but also to quickly implement the recommendations.
Jie Zhang Handbook of LC-MS Bioanalysis. Best Practices, Experimental Protocols, and Regulations Jie Zhang Handbook of LC-MS Bioanalysis. Best Practices, Experimental Protocols, and Regulations Новинка

Jie Zhang Handbook of LC-MS Bioanalysis. Best Practices, Experimental Protocols, and Regulations

12288.24 руб.
Consolidates the information LC-MS bioanalytical scientists need to analyze small molecules and macromolecules The field of bioanalysis has advanced rapidly, propelled by new approaches for developing bioanalytical methods, new liquid chromatographic (LC) techniques, and new mass spectrometric (MS) instruments. Moreover, there are a host of guidelines and regulations designed to ensure the quality of bioanalytical results. Presenting the best practices, experimental protocols, and the latest understanding of regulations, this book offers a comprehensive review of LC-MS bioanalysis of small molecules and macromolecules. It not only addresses the needs of bioanalytical scientists working on routine projects, but also explores advanced and emerging technologies such as high-resolution mass spectrometry and dried blood spot microsampling. Handbook of LC-MS Bioanalysis features contributions from an international team of leading bioanalytical scientists. Their contributions reflect a review of the latest findings, practices, and regulations as well as their own firsthand analytical laboratory experience. The book thoroughly examines: Fundamentals of LC-MS bioanalysis in drug discovery, drug development, and therapeutic drug monitoring The current understanding of regulations governing LC-MS bioanalysis Best practices and detailed technical instructions for LC-MS bioanalysis method development, validation, and stability assessment of analyte(s) of interest Experimental guidelines and protocols for quantitative LC-MS bioanalysis of challenging molecules, including pro-drugs, acyl glucuronides, N-oxides, reactive compounds, and photosensitive and autooxidative compounds With its focus on current bioanalytical practice, Handbook of LC-MS Bioanalysis enables bioanalytical scientists to develop and validate robust LC-MS assay methods, all in compliance with current regulations and standards.
Susan Mikkelsen R. Bioanalytical Chemistry Susan Mikkelsen R. Bioanalytical Chemistry Новинка

Susan Mikkelsen R. Bioanalytical Chemistry

9603.03 руб.
A timely, accessible survey of the multidisciplinary field of bioanalytical chemistry Provides an all in one approach for both beginners and experts, from a broad range of backgrounds, covering introductions, theory, advanced concepts and diverse applications for each method Each chapter progresses from basic concepts to applications involving real samples Includes three new chapters on Biomimetic Materials, Lab-on-Chip, and Analytical Methods Contains end-of-chapter problems and an appendix with selected answers
Arben Merkoci Biosensing Using Nanomaterials Arben Merkoci Biosensing Using Nanomaterials Новинка

Arben Merkoci Biosensing Using Nanomaterials

15443.56 руб.
An interdisciplinary approach to one of the hottest topics in nanotechnology and nanoscience Biosensing Using Nanomaterials introduces novel concepts in the area of bioanalysis based on nanomaterials, opening new opportunities for basic research and new tools for real bioanalytical applications. In fifteen chapters, readers are introduced to the most successful nanomaterials used so far in biosensing, including carbon nanotubes, nanoparticles, and nanochannels. Each chapter provides a theoretical overview of the topic, a discussion of the published data relating to the bioanalytical system, and a selected list of references for further investigation. The result is a book that provides a comprehensive forum of interest to scientists, engineers, researchers, manufacturers, teachers, and students. Biosensing Using Nanomaterials is an important resource for a broad audience involved in the research, teaching, learning, and practice of integrating nanomaterials into biosensing systems for clinical, environmental, and industrial applications.
Bilal Zargar Lcms/MS Method for the Estimation of Montelukast in Human Plasma Bilal Zargar Lcms/MS Method for the Estimation of Montelukast in Human Plasma Новинка

Bilal Zargar Lcms/MS Method for the Estimation of Montelukast in Human Plasma

8739 руб.
Liquid chromatography-tandem mass spectrometry (LCMS/MS) is one of the most advanced techniques in the development of Methods for estimation of drugs in biological fluids. The current work includes basic techniques in Liquid Chromatography, Mass Spectrometry, Sample Preparation in bioanalyses, development of bioanalytical method for the quantitative estimation of Montelukast in human plasma and validating it according to FDA guidelines. The method finds its application in biequivalence studies of Montelukast, a cysteinyl leukotriene receptor antagonist used in the treatment of asthma and other allergic conditions.
Ursula Spichiger-Keller E. Chemical Sensors and Biosensors for Medical and Biological Applications Ursula Spichiger-Keller E. Chemical Sensors and Biosensors for Medical and Biological Applications Новинка

Ursula Spichiger-Keller E. Chemical Sensors and Biosensors for Medical and Biological Applications

16631.52 руб.
This book introduces the principles and concepts of chemical and biochemical sensors for analyzing medical as well as biological samples. For applications like analyzing or monitoring gastric juice or blood plasma, the potential of sensors is exceptionally large. Focussed on these applications, the interpretation of analytical results is explained. Specific advantages are compared to other analytical techniques. Numerous tables with data provide useful information not easily found elsewhere and make a handy source of reference. Ursula E. Spichiger-Keller is head of the Center for Chemical Sensors/Biosensors and Bioanalytical Chemistry at the Swiss Federal Institute of Technology (ETH) in Zurich.
Adrienne Yingling Oxley Semiconductor Nanocrystals Adrienne Yingling Oxley Semiconductor Nanocrystals Новинка

Adrienne Yingling Oxley Semiconductor Nanocrystals

7533 руб.
As biological assays involving fluorophores become more prevalent, due to their high sensitivity, moderate cost and versatility for applications, there is an increasing demand for luminescent reporters with advanced properties for use in bioanalytical applications and biological imaging. The most important properties include the strong resistance to photobleaching and the ability to be discriminated from background fluorescence. We have initiated an innovative strategy to create luminescent reporters possessing the photophysical properties that fulfill these requirements by combining the advantages of semiconductor nanocrystals with those of lanthanide cations. This work is aimed at creating novel antenna for the sensitization of luminescent lanthanide cations emitting in the visible and in the near-infrared. The crystals structure of semiconductor nanocrystals is also used to protect the lanthanides from nonradiative deactivations inducing the increase of the quantum yields.
Mark Vitha F. Hydrophilic Interaction Chromatography. A Guide for Practitioners Mark Vitha F. Hydrophilic Interaction Chromatography. A Guide for Practitioners Новинка

Mark Vitha F. Hydrophilic Interaction Chromatography. A Guide for Practitioners

8523.56 руб.
Discover how to use HILIC to analyze and better understand polar compounds An increasingly popular analytical method, hydrophilic interaction chromatography (HILIC) has the ability to retain and separate polar compounds that are often difficult to analyze by reversed-phase high-performance liquid chromatography (HPLC) or other analytical methods. Offering a comprehensive review, this book enables readers to develop a fundamental understanding of how HILIC works and then apply that knowledge to develop and implement a variety of practical applications. Hydrophilic Interaction Chromatography begins with discussions of HILIC retention mechanisms, stationary phases, and general method development. This sets the foundation for the book's extensive coverage of applications. The authors address unique separation challenges for bioanalytical, environmental, pharmaceutical, and biochemical applications. Moreover, there is a thorough discussion of HILIC in two-dimensional chromatography. With contributions from leading analytical scientists who have extensive experience in HILIC as well as HPLC, Hydrophilic Interaction Chromatography serves as a practical guide for researchers, featuring: Detailed examples of HILIC methods and development approaches Thorough explanations of retention mechanisms and the impact of stationary phase and mobile phase properties on separations Step-by-step guidance for developing efficient, sensitive, and robust HILIC methods References to the primary literature at the end of each chapter Hydrophilic Interaction Chromatography is written for scientists who use or develop analytical methods for the separation of polar compounds. In particular, these researchers will discover how HILIC can be used to analyze and better understand the composition of pharmaceutical, bioanalytical, biochemical, chemical, food, and environmental samples.
Tapan Das K. Biophysical Methods for Biotherapeutics. Discovery and Development Applications Tapan Das K. Biophysical Methods for Biotherapeutics. Discovery and Development Applications Новинка

Tapan Das K. Biophysical Methods for Biotherapeutics. Discovery and Development Applications

9910.62 руб.
With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development. • Helps formulation and analytical scientists in pharma and biotech better understand and use biophysical methods • Chapters organized according to the sequential nature of the drug development process • Helps formulation, analytical, and bioanalytical scientists in pharma and biotech better understand and usestrengths and limitations of biophysical methods • Explains how to use biophysical methods, the information obtained, and what needs to be presented in a regulatory filing, assess impact on quality and immunogenicity • With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development.
Surapaneni Sekhar ADME-Enabling Technologies in Drug Design and Development Surapaneni Sekhar ADME-Enabling Technologies in Drug Design and Development Новинка

Surapaneni Sekhar ADME-Enabling Technologies in Drug Design and Development

15205.96 руб.
A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME). ADME-Enabling Technologies in Drug Design and Development focuses on the current state of the art in the field, presenting a comprehensive review of the latest tools for generating ADME data in drug discovery. It examines the broadest possible range of available technologies, giving readers the information they need to choose the right tool for a given application, a key requisite for obtaining favorable results in a timely fashion for regulatory filings. With over thirty contributed chapters by an international team of experts, the book provides: A thorough examination of current tools, covering both electronic/mechanical technologies and biologically based ones Coverage of applications for each technology, including key parameters, optimal conditions for intended results, protocols, and case studies Detailed discussion of emerging tools and techniques, from stem cells and genetically modified animal models to imaging technologies Numerous figures and diagrams throughout the text Scientists and researchers in drug metabolism, pharmacology, medicinal chemistry, pharmaceutics, toxicology, and bioanalytical science will find ADME-Enabling Technologies in Drug Design and Development an invaluable guide to the entire drug development process, from discovery to regulatory issues.
Birendra Pramanik Protein and Peptide Mass Spectrometry in Drug Discovery Birendra Pramanik Protein and Peptide Mass Spectrometry in Drug Discovery Новинка

Birendra Pramanik Protein and Peptide Mass Spectrometry in Drug Discovery

11984.29 руб.
The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry practices, and modern strategies for the characterization of both peptides and proteins in drug discovery. Illustrating the critical role MS technology plays in characterizing target proteins and protein products, the methods used, ion mobility, and the use of microwave radiation to speed proteolysis, the book also covers important emerging applications for neuroproteomics and antigenic peptides. Placing an emphasis on the pharmaceutical industry, the book stresses practice and applications, presenting real-world examples covering the most recent advances in mass spectrometry, and providing an invaluable resource for pharmaceutical scientists in industry and academia, analytical and bioanalytical chemists, and researchers in protein science and proteomics.
Miguel de la Guardia Handbook of Green Analytical Chemistry Miguel de la Guardia Handbook of Green Analytical Chemistry Новинка

Miguel de la Guardia Handbook of Green Analytical Chemistry

15601.95 руб.
The emerging field of green analytical chemistry is concerned with the development of analytical procedures that minimize consumption of hazardous reagents and solvents, and maximize safety for operators and the environment. In recent years there have been significant developments in methodological and technological tools to prevent and reduce the deleterious effects of analytical activities; key strategies include recycling, replacement, reduction and detoxification of reagents and solvents. The Handbook of Green Analytical Chemistry provides a comprehensive overview of the present state and recent developments in green chemical analysis. A series of detailed chapters, written by international specialists in the field, discuss the fundamental principles of green analytical chemistry and present a catalogue of tools for developing environmentally friendly analytical techniques. Topics covered include: Concepts: Fundamental principles, education, laboratory experiments and publication in green analytical chemistry. The Analytical Process: Green sampling techniques and sample preparation, direct analysis of samples, green methods for capillary electrophoresis, chromatography, atomic spectroscopy, solid phase molecular spectroscopy, derivative molecular spectroscopy and electroanalytical methods. Strategies: Energy saving, automation, miniaturization and photocatalytic treatment of laboratory wastes. Fields of Application: Green bioanalytical chemistry, biodiagnostics, environmental analysis and industrial analysis. This advanced handbook is a practical resource for experienced analytical chemists who are interested in implementing green approaches in their work.
Hugo Kubinyi Reactive Drug Metabolites Hugo Kubinyi Reactive Drug Metabolites Новинка

Hugo Kubinyi Reactive Drug Metabolites

14981.46 руб.
Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.
David Weis D. Hydrogen Exchange Mass Spectrometry of Proteins. Fundamentals, Methods, and Applications David Weis D. Hydrogen Exchange Mass Spectrometry of Proteins. Fundamentals, Methods, and Applications Новинка

David Weis D. Hydrogen Exchange Mass Spectrometry of Proteins. Fundamentals, Methods, and Applications

9603.03 руб.
Hydrogen exchange mass spectrometry is widely recognized for its ability to probe the structure and dynamics of proteins. The application of this technique is becoming widespread due to its versatility for providing structural information about challenging biological macromolecules such as antibodies, flexible proteins and glycoproteins. Although the technique has been around for 25 years, this is the first definitive book devoted entirely to the topic. Hydrogen Exchange Mass Spectrometry of Proteins: Fundamentals, Methods and Applications brings into one comprehensive volume the theory, instrumentation and applications of Hydrogen Exchange Mass Spectrometry (HX-MS) – a technique relevant to bioanalytical chemistry, protein science and pharmaceuticals. The book provides a solid foundation in the basics of the technique and data interpretation to inform readers of current research in the method, and provides illustrative examples of its use in bio- and pharmaceutical chemistry and biophysics In-depth chapters on the fundamental theory of hydrogen exchange, and tutorial chapters on measurement and data analysis provide the essential background for those ready to adopt HX-MS. Expert users may advance their current understanding through chapters on methods including membrane protein analysis, alternative proteases, millisecond hydrogen exchange, top-down mass spectrometry, histidine exchange and method validation. All readers can explore the diversity of HX-MS applications in areas such as ligand binding, membrane proteins, drug discovery, therapeutic protein formulation, biocomparability, and intrinsically disordered proteins.
Peter Walla Jomo Modern Biophysical Chemistry. Detection and Analysis of Biomolecules Peter Walla Jomo Modern Biophysical Chemistry. Detection and Analysis of Biomolecules Новинка

Peter Walla Jomo Modern Biophysical Chemistry. Detection and Analysis of Biomolecules

6145.94 руб.
This updated and up-to-date version of the first edition continues with the really interesting stuff to spice up a standard biophysics and biophysical chemistry course. All relevant methods used in current cutting edge research including such recent developments as super-resolution microscopy and next-generation DNA sequencing techniques, as well as industrial applications, are explained. The text has been developed from a graduate course taught by the author for several years, and by presenting a mix of basic theory and real-life examples, he closes the gap between theory and experiment. The first part, on basic biophysical chemistry, surveys fundamental and spectroscopic techniques as well as biomolecular properties that represent the modern standard and are also the basis for the more sophisticated technologies discussed later in the book. The second part covers the latest bioanalytical techniques such as the mentioned super-resolution and next generation sequencing methods, confocal fluorescence microscopy, light sheet microscopy, two-photon microscopy and ultrafast spectroscopy, single molecule optical, electrical and force measurements, fluorescence correlation spectroscopy, optical tweezers, quantum dots and DNA origami techniques. Both the text and illustrations have been prepared in a clear and accessible style, with extended and updated exercises (and their solutions) accompanying each chapter. Readers with a basic understanding of biochemistry and/or biophysics will quickly gain an overview of cutting edge technology for the biophysical analysis of proteins, nucleic acids and other biomolecules and their interactions. Equally, any student contemplating a career in the chemical, pharmaceutical or bio-industry will greatly benefit from the technological knowledge presented. Questions of differing complexity testing the reader's understanding can be found at the end of each chapter with clearly described solutions available on the Wiley-VCH textbook homepage under: www.wiley-vch.de/textbooks
Naidong Weng Targeted Biomarker Quantitation by LC-MS Naidong Weng Targeted Biomarker Quantitation by LC-MS Новинка

Naidong Weng Targeted Biomarker Quantitation by LC-MS

14981.46 руб.
The first book to offer a blueprint for overcoming the challenges to successfully quantifying biomarkers in living organisms The demand among scientists and clinicians for targeted quantitation experiments has experienced explosive growth in recent years. While there are a few books dedicated to bioanalysis and biomarkers in general, until now there were none devoted exclusively to addressing critical issues surrounding this area of intense research. Target Biomarker Quantitation by LC-MS provides a detailed blueprint for quantifying biomarkers in biological systems. It uses numerous real-world cases to exemplify key concepts, all of which were carefully selected and presented so as to allow the concepts they embody to be easily expanded to future applications, including new biomarker development. Target Biomarker Quantitation by LC-MS primarily focuses on the assay establishment for biomarker quantitation—a critical issue rarely treated in depth. It offers comprehensive coverage of three core areas of biomarker assay establishment: the relationship between the measured biomarkers and their intended usage; contemporary regulatory requirements for biomarker assays (a thorough understanding of which is essential to producing a successful and defendable submission); and the technical challenges of analyzing biomarkers produced inside a living organism or cell. Covers the theory of and applications for state-of-the-art mass spectrometry and chromatography and their applications in biomarker analysis Features real-life examples illustrating the challenges involved in target biomarker quantitation and the innovative approaches which have been used to overcome those challenges Addresses potential obstacles to obtain effective biomarker level and data interpretation, such as specificity establishment and sample collection Outlines a tiered approach and fit-for-purpose assay protocol for target biomarker quantitation Highlights the current state of the biomarker regulatory environment and protocol standards Target Biomarker Quantitation by LC-MS is a valuable resource for bioanalytical scientists, drug metabolism and pharmacokinetics scientists, clinical scientists, analytical chemists, and others for whom biomarker quantitation is an important tool of the trade. It also functions as an excellent text for graduate courses in pharmaceutical, biochemistry and chemistry.

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The first book to offer a blueprint for overcoming the challenges to successfully quantifying biomarkers in living organisms The demand among scientists and clinicians for targeted quantitation experiments has experienced explosive growth in recent years. While there are a few books dedicated to bioanalysis and biomarkers in general, until now there were none devoted exclusively to addressing critical issues surrounding this area of intense research. Target Biomarker Quantitation by LC-MS provides a detailed blueprint for quantifying biomarkers in biological systems. It uses numerous real-world cases to exemplify key concepts, all of which were carefully selected and presented so as to allow the concepts they embody to be easily expanded to future applications, including new biomarker development. Target Biomarker Quantitation by LC-MS primarily focuses on the assay establishment for biomarker quantitation—a critical issue rarely treated in depth. It offers comprehensive coverage of three core areas of biomarker assay establishment: the relationship between the measured biomarkers and their intended usage; contemporary regulatory requirements for biomarker assays (a thorough understanding of which is essential to producing a successful and defendable submission); and the technical challenges of analyzing biomarkers produced inside a living organism or cell. Covers the theory of and applications for state-of-the-art mass spectrometry and chromatography and their applications in biomarker analysis Features real-life examples illustrating the challenges involved in target biomarker quantitation and the innovative approaches which have been used to overcome those challenges Addresses potential obstacles to obtain effective biomarker level and data interpretation, such as specificity establishment and sample collection Outlines a tiered approach and fit-for-purpose assay protocol for target biomarker quantitation Highlights the current state of the biomarker regulatory environment and protocol standards Target Biomarker Quantitation by LC-MS is a valuable resource for bioanalytical scientists, drug metabolism and pharmacokinetics scientists, clinical scientists, analytical chemists, and others for whom biomarker quantitation is an important tool of the trade. It also functions as an excellent text for graduate courses in pharmaceutical, biochemistry and chemistry.
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