biological effects of electric and magnetic fields2



Andreas Scherer Batch Effects and Noise in Microarray Experiments. Sources and Solutions Andreas Scherer Batch Effects and Noise in Microarray Experiments. Sources and Solutions Новинка

Andreas Scherer Batch Effects and Noise in Microarray Experiments. Sources and Solutions

9469.06 руб. или Купить в рассрочку!
Batch Effects and Noise in Microarray Experiments: Sources and Solutions looks at the issue of technical noise and batch effects in microarray studies and illustrates how to alleviate such factors whilst interpreting the relevant biological information. Each chapter focuses on sources of noise and batch effects before starting an experiment, with examples of statistical methods for detecting, measuring, and managing batch effects within and across datasets provided online. Throughout the book the importance of standardization and the value of standard operating procedures in the development of genomics biomarkers is emphasized. Key Features: A thorough introduction to Batch Effects and Noise in Microrarray Experiments. A unique compilation of review and research articles on handling of batch effects and technical and biological noise in microarray data. An extensive overview of current standardization initiatives. All datasets and methods used in the chapters, as well as colour images, are available on www.the-batch-effect-book.org, so that the data can be reproduced. An exciting compilation of state-of-the-art review chapters and latest research results, which will benefit all those involved in the planning, execution, and analysis of gene expression studies.
Vinod Krishnan Biological Mechanisms of Tooth Movement Vinod Krishnan Biological Mechanisms of Tooth Movement Новинка

Vinod Krishnan Biological Mechanisms of Tooth Movement

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Biological Mechanisms of Tooth Movement, Second Edition is an authoritative reference to the scientific foundations underpinning clinical orthodontics. Led by an expert editor team and with contributions from an international group of contributors, the book covers key topics including bone biology, the effects of mechanical loading on tissues and cells, genetics, inflammation, tissue remodeling and the effects of diet, drugs, and systemic diseases. Highly-illustrated throughout, this second edition has been fully revised, updated and expanded to new developments in genomics, rapid orthodontics and current controversies in tooth movement research. Trainees, qualified specialists and researchers in orthodontics can rely on this comprehensive text to inform them about the clinical and scientific implications of the biological mechanisms involved in the movement of teeth.
Mourad Elloumi Biological Knowledge Discovery Handbook. Preprocessing, Mining and Postprocessing of Biological Data Mourad Elloumi Biological Knowledge Discovery Handbook. Preprocessing, Mining and Postprocessing of Biological Data Новинка

Mourad Elloumi Biological Knowledge Discovery Handbook. Preprocessing, Mining and Postprocessing of Biological Data

14213.1 руб. или Купить в рассрочку!
The first comprehensive overview of preprocessing, mining, and postprocessing of biological data Molecular biology is undergoing exponential growth in both the volume and complexity of biological data—and knowledge discovery offers the capacity to automate complex search and data analysis tasks. This book presents a vast overview of the most recent developments on techniques and approaches in the field of biological knowledge discovery and data mining (KDD)—providing in-depth fundamental and technical field information on the most important topics encountered. Written by top experts, Biological Knowledge Discovery Handbook: Preprocessing, Mining, and Postprocessing of Biological Data covers the three main phases of knowledge discovery (data preprocessing, data processing—also known as data mining—and data postprocessing) and analyzes both verification systems and discovery systems. BIOLOGICAL DATA PREPROCESSING Part A: Biological Data Management Part B: Biological Data Modeling Part C: Biological Feature Extraction Part D Biological Feature Selection BIOLOGICAL DATA MINING Part E: Regression Analysis of Biological Data Part F Biological Data Clustering Part G: Biological Data Classification Part H: Association Rules Learning from Biological Data Part I: Text Mining and Application to Biological Data Part J: High-Performance Computing for Biological Data Mining Combining sound theory with practical applications in molecular biology, Biological Knowledge Discovery Handbook is ideal for courses in bioinformatics and biological KDD as well as for practitioners and professional researchers in computer science, life science, and mathematics.
Vijay Kumar Advanced Magnetic and Optical Materials Vijay Kumar Advanced Magnetic and Optical Materials Новинка

Vijay Kumar Advanced Magnetic and Optical Materials

17101.87 руб. или Купить в рассрочку!
Advanced Magnetic and OpticalMaterials offers detailed up-to-date chapters on the functional optical and magnetic materials, engineering of quantum structures, high-tech magnets, characterization and new applications. It brings together innovative methodologies and strategies adopted in the research and development of the subject and all the contributors are established specialists in the research area. The 14 chapters are organized in two parts: Part 1: Magnetic Materials Magnetic Heterostructures and superconducting order Magnetic Antiresonance in nanocomposites Magnetic bioactive glass-ceramics for bone healing and hyperthermic treatment of solid tumors Magnetic iron oxide nanoparticles Magnetic nanomaterial-based anticancer therapy Theoretical study of strained carbon-based nanobelts: Structural, energetical, electronic, and magnetic properties Room temperature molecular magnets – Modeling and applications Part 2: Optical Materials Advances and future of white LED phosphors for solid-state lighting Design of luminescent materials with “Turn-on/off” response for anions and cations Recent advancements in luminescent materials and their potential applications Strongly confined quantum dots: Emission limiting, photonic doping, and magneto-optical effects Microstructure characterization of some quantum dots synthesized by mechanical alloying Advances in functional luminescent materials and phosphors Development in organic light emitting materials and their potential applications
Hongzhe Sun Biological Chemistry of Arsenic, Antimony and Bismuth Hongzhe Sun Biological Chemistry of Arsenic, Antimony and Bismuth Новинка

Hongzhe Sun Biological Chemistry of Arsenic, Antimony and Bismuth

15290.21 руб. или Купить в рассрочку!
Arsenic, antimony and bismuth, three related elements of group 15, are all found in trace quantities in nature and have interesting biological properties and uses. While arsenic is most well known as a poison – and indeed the contamination of groundwater by arsenic is becoming a major health problem in Asia – it also has uses for the treatment of blood cancer and has long been used in traditional chinese medicine. Antimony and bismuth compounds are used in the clinic for the treatment of parasitic and bacterial infections. Biological Chemistry of Arsenic, Antimony and Bismuth is an essential overview of the biological chemistry of these three elements, with contributions from an international panel of experts. Topics covered include: chemistry of As, Sb and Bi biological chemistry of arsenic biological chemistry of Sb and Bi arsenic and antimony speciation in environmental and biological samples arsenic in traditional chinese medicine arsenic in aquifers biomethylation of As, Sb and Bi uptake of metalloids by cells bismuth complexes of porphyrins and their potential in medical applications Helicobacter pylori and bismuth metabolism of arsenic trioxide in blood of the acute promyelocytic leukemia patients anticancer properties of As, Sb and Bi radio-Bi in cancer therapy genotoxicity of As, Sb and Bi metallomics as a new technique for As, Sb and Bi metalloproteomics for As, Sb and Bi Biological Chemistry of Arsenic, Antimony and Bismuth conveys the essential aspects of the bioinorganic chemistry of these three elements, making this book a valuable complement to more general bioinorganic chemistry texts and more specialized topical reviews. It will find a place on the bookshelves of practitioners, researchers and students working in bioinorganic chemistry and medicinal chemistry.
Charles Patton The effects of property upon society and government investigated Charles Patton The effects of property upon society and government investigated Новинка

Charles Patton The effects of property upon society and government investigated

Полный вариант заголовка: «The effects of property upon society and government investigated : containing illustration of the influence of property on mental energy, national character, manners, government, and civilazation : to which is added an historical review of the monarchy and republic of Rome, upon the principles derived from the effects of property / by Charles Patton ; historical review by Robert Patton».
Otilia M. Y. Koo Pharmaceutical Excipients. Properties, Functionality, and Applications in Research and Industry Otilia M. Y. Koo Pharmaceutical Excipients. Properties, Functionality, and Applications in Research and Industry Новинка

Otilia M. Y. Koo Pharmaceutical Excipients. Properties, Functionality, and Applications in Research and Industry

13300.89 руб. или Купить в рассрочку!
This book provides an overview of excipients, their functionalities in pharmaceutical dosage forms, regulation, and selection for pharmaceutical products formulation. It includes development, characterization methodology, applications, and up-to-date advances through the perspectives of excipients developers, users, and regulatory experts. Covers the sources, characterization, and harmonization of excipients: essential information for optimal excipients selection in pharmaceutical development Describes the physico-chemical properties and biological effects of excipients Discusses chemical classes, safety and toxicity, and formulation Addresses recent efforts in the standardization and harmonization of excipients
Jerron Smith Adobe After Effects CS5 Digital Classroom Jerron Smith Adobe After Effects CS5 Digital Classroom Новинка

Jerron Smith Adobe After Effects CS5 Digital Classroom

3233.32 руб. или Купить в рассрочку!
This video and full-color book combo has quite an effect for learning After Effects CS5! Adobe After Effects is a leading motion graphics and visual effects program that allows you to create and deliver compelling motion graphics and visual effects. This full-color book-and-video training package gets you quickly up to speed using the capabilities of the newest release of After Effects and deciphers even the most complex After Effects tasks. Sixteen self-paced lessons explain how to edit and apply effects for stellar visual and special effects. The supplementary video lessons included with the book are each approximately five minutes long and demonstrate the concepts and features covered in the lesson. Escorts you through the basics of editing and applying motion graphics and visual effects with Adobe After Effects CS5 Deciphers even the most advanced After Effects tasks and makes them less intimidating Features full-color book and video tutorials with step-by-step training that complement the topics covered in each lesson of the book Encourages you to absorb each lesson at your own pace Jam-packed with information, this book with videos and lesson files is just like having your own personal instructor guiding you through each unique lesson. Note: DVD and other supplementary materials are not included as part of eBook file. These materials are available for download upon purchase.
Igor Alabugin V. Stereoelectronic Effects. A Bridge Between Structure and Reactivity Igor Alabugin V. Stereoelectronic Effects. A Bridge Between Structure and Reactivity Новинка

Igor Alabugin V. Stereoelectronic Effects. A Bridge Between Structure and Reactivity

6840.46 руб. или Купить в рассрочку!
Stereoelectronic Effects illustrates the utility of stereoelectronic concepts using structure and reactivity of organic molecules An advanced textbook that provides an up-to-date overview of the field, starting from the fundamental principles Presents a large selection of modern examples of stereoelectronic effects in organic reactivity Shows practical applications of stereoelectronic effects in asymmetric catalysis, photochemical processes, bioorganic chemistry and biochemistry, inorganic and organometallic reactivity, supramolecular chemistry and materials science
R. Sabnis W. Handbook of Biological Dyes and Stains. Synthesis and Industrial Applications R. Sabnis W. Handbook of Biological Dyes and Stains. Synthesis and Industrial Applications Новинка

R. Sabnis W. Handbook of Biological Dyes and Stains. Synthesis and Industrial Applications

14125.98 руб. или Купить в рассрочку!
A complete, up-to-date resource of information on more than 200 dyes and stains Handbook of Biological Dyes and Stains is the most comprehensive volume available on the subject, covering all the available dyes and stains known to date in the literature for use in biology and medicine. Top dye expert Dr. Ram Sabnis organizes the compounds alphabetically by the most commonly used chemical name. He presents an easy-to-use reference complete with novel ideas for breakthrough research in medical, biological, chemical, and related fields. This is the first book to give the CAS registry number, chemical structure, Chemical Abstracts index name, all other chemical names, Merck Index number, chemical/dye class, molecular formula, molecular weight, physical form, solubility, melting point, boiling point, pH range, color change at pH, pKa, absorption, and emission maxima of dyes and stains, as well as to provide access to synthesis procedures (lab scale and industrial scale) of dyes and stains. This user-friendly handbook also features references on safety, toxicity, and adverse effects of dyes and stains on humans, animals, and the environment, including: acute/chronic toxicity aquatic toxicity carcinogenicity cytotoxicity ecotoxicity genotoxicity hepatotoxicity marine toxicity mutagenicity nephrotoxicity neurotoxicity oral toxicity phototoxicity phytotoxicity The use of biological dyes and stains has extremely high potential in today's business environment. This makes Handbook of Biological Dyes and Stains a convenient, must-have reference. Its staining, biological, and industrial applications make it a vital resource for industrial and academic researchers; the book also serves as a valuable desktop reference for medical professionals, biologists, chemists, chemical/optical engineers, physicists, materials scientists, intellectual property professionals, students, and professors.
Hugo Kubinyi Drug-Membrane Interactions. Analysis, Drug Distribution, Modeling Hugo Kubinyi Drug-Membrane Interactions. Analysis, Drug Distribution, Modeling Новинка

Hugo Kubinyi Drug-Membrane Interactions. Analysis, Drug Distribution, Modeling

11400.76 руб. или Купить в рассрочку!
Barrier, reservoir, target site – those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.
Rogers Donald W. Molecular Structure. Understanding Steric and Electronic Effects from Molecular Mechanics Rogers Donald W. Molecular Structure. Understanding Steric and Electronic Effects from Molecular Mechanics Новинка

Rogers Donald W. Molecular Structure. Understanding Steric and Electronic Effects from Molecular Mechanics

9469.06 руб. или Купить в рассрочку!
A guide to analyzing the structures and properties of organic molecules Until recently, the study of organic molecules has traveled down two disparate intellectual paths—the experimental, or physical, method and the computational, or theoretical, method. Working somewhat independently of each other, these disciplines have guided research for decades, but they are now being combined efficiently into one unified strategy. Molecular Structure delivers the essential fundamentals on both the experimental and computational methods, then goes further to show how these approaches can join forces to produce more effective analysis of the structure and properties of organic compounds by: Looking at experimental structures: electron, neutron, X-ray diffraction, and microwave spectroscopy as well as computational structures: ab initio, semi-empirical molecular orbital, and molecular mechanics calculations Discussing various electronic effects, particularly stereoelectronic effects, including hyperconjugation, negative hyperconjugation, the Bohlmann and anomeric effects, and how and why these cause changes in structures and properties of molecules Illustrating complex carbohydrate effects such as the gauche effect, the delta-two effect, and the external anomeric torsional effect Covering hydrogen bonding, the CH bond, and how energies, especially heats of formation, can be affected Using molecular mechanics to tie all of these things together in the familiar language of the organic chemist, valence bond pictures Authored by a founding father of computational chemistry, Molecular Structure broadens the scope of the subject by serving as a pioneering guide for workers in the fields of organic, biological, and computational chemistry, as they explore new possibilities to advance their discoveries. This work will also be of interest to many of those in tangential or dependent fields, including medicinal and pharmaceutical chemistry and pharmacology.
Daniel Simberloff Integrating Biological Control into Conservation Practice Daniel Simberloff Integrating Biological Control into Conservation Practice Новинка

Daniel Simberloff Integrating Biological Control into Conservation Practice

Invasive species have a critical and growing effect upon natural areas. They can modify, degrade, or destroy wildland ecosystem structure and function, and reduce native biodiversity. Landscape-level solutions are needed to address these problems. Conservation biologists seek to limit such damage and restore ecosystems using a variety of approaches. One such approach is biological control: the deliberate importation and establishment of specialized natural enemies, which can address invasive species problems and which should be considered as a possible component of restoration. Biological control can be an effective tool against many invasive insects and plants but it has rarely been successfully employed against other groups. Safety is of paramount concern and requires that the natural enemies used be specialized and that targeted pests be drivers of ecological degradation. While modern approaches allow species to be selected with a high level of security, some risks do remain. However, as in all species introductions, these should be viewed in the context of the risk of failing to reduce the impact of the invasive species. This unique book identifies the balance among these factors to show how biological control can be integrated into ecosystem restoration as practiced by conservation biologists. Jointly developed by conservation biologists and biological control scientists, it contains chapters on matching tools to management goals; tools in action; measuring and evaluating ecological outcomes of biological control introductions; managing conflict over biological control; and includes case studies as well as an ethical framework for integrating biological control and conservation practice. Integrating Biological Control into Conservation Practice is suitable for graduate courses in invasive species management and biological control, as well as for research scientists in government and non-profit conservation organizations.
Rokita Steven E. Oxidation of Amino Acids, Peptides, and Proteins. Kinetics and Mechanism Rokita Steven E. Oxidation of Amino Acids, Peptides, and Proteins. Kinetics and Mechanism Новинка

Rokita Steven E. Oxidation of Amino Acids, Peptides, and Proteins. Kinetics and Mechanism

11642.29 руб. или Купить в рассрочку!
Explains the role of reactive intermediates in biological systems as well as in environmental remediation With its clear and systematic approach, this book examined the broad range of reactive intermediate that can be generated in biological environments, detailing the fundamental properties of each reactive intermediate. Readers gain a contemporary understanding of how these intermediates react with different compounds, with an emphasis on amino acids, peptides, and proteins. The author not only sets forth the basic chemistry and nature of reactive intermediates, he also demonstrates how the properties of the intermediates presented in the book compare with each other. Oxidation of Amino Acids, Peptides, and Proteins begins with a discussion of radical and non-radical reactive species as well as an exploration of the significance of reactive species in the atmosphere, disinfection processes, and environmental remediation. Next, the book covers such topics as: Thermodynamics of amino acids and reactive species and the effect of metal-ligand binding in oxidation chemistry Kinetics and mechanisms of reactive halogen, oxygen, nitrogen, carbon, sulfur and phosphate species as well as reactive high-valent Cr, Mn, and Fe species Reactivity of the species with molecules of biological and environmental importance Generation of reactive species in the laboratory for kinetics studies Oxidation of amino acids, peptides, and proteins by permanganate, ferryl, and ferrate species Application of reactive species in purifying water and treating wastewater With this book as their guide, readers will be able to assess the overall effects of reactive intermediates in biological environments. Moreover, they’ll learn how to apply this knowledge for successful water purification and wastewater treatment.
Bittner Michael L. Epistemology of the Cell. A Systems Perspective on Biological Knowledge Bittner Michael L. Epistemology of the Cell. A Systems Perspective on Biological Knowledge Новинка

Bittner Michael L. Epistemology of the Cell. A Systems Perspective on Biological Knowledge

9857.14 руб. или Купить в рассрочку!
Honorable mention – Biomedicine and Neuroscience, 2011 Prose Awards An examination of how the cell should be described in order to effectively process biological data «The fruitful pursuit of biological knowledge requires one to take Einstein's admonition [on science without epistemology] as a practical demand for scientific research, to recognize Waddington's characterization of the subject matter of biology, and to embrace Wiener's conception of the form of biological knowledge in response to its subject matter. It is from this vantage point that we consider the epistemology of the cell.» —from the Preface In the era of high biological data throughput, biomedical engineers need a more systematic knowledge of the cell in order to perform more effective data handling. Epistemology of the Cell is the first authored book to break down this knowledge. This text examines the place of biological knowledge within the framework of science as a whole and addresses issues focused on the specific nature of biology, how biology is studied, and how biological knowledge is translated into applications, in particular with regard to medicine. The book opens with a general discussion of the historical development of human understanding of scientific knowledge, the scientific method, and the manner in which scientific knowledge is represented in mathematics. The narrative then gets specific for biology, focusing on knowledge of the cell, the basic unit of life. The salient point is the analogy between a systems-based analysis of factory regulation and the regulation of the cell. Each chapter represents a key topic of current interest, including: Causality and randomness Translational science Stochastic validation: classification Stochastic validation: networks Model-based experimentation in biology Epistemology of the Cell is written for biomedical researchers whose interests include bioinformatics, biological modeling, biostatistics, and biological signal processing.
James Cowan P. The Effects of Sound on People James Cowan P. The Effects of Sound on People Новинка

James Cowan P. The Effects of Sound on People

9500.64 руб. или Купить в рассрочку!
Provides a summary of current research results on the physiological and psychological effects of sound on people Covers how the operation of the hearing mechanism affects our reactions to sounds Includes research results from studies on noise sources of public concern such as transportation, public utility, and recreational sources, with emphasis on low frequency sound and infrasound Covers sounds that affect some but not others, how sounds can be controlled on a practical level, and how and what sounds are regulated Includes coverage of both positive and negative effects of sound
Gregg Stave M. Physical and Biological Hazards of the Workplace Gregg Stave M. Physical and Biological Hazards of the Workplace Новинка

Gregg Stave M. Physical and Biological Hazards of the Workplace

11397.16 руб. или Купить в рассрочку!
Completely updated version this classic reference covers both physical hazards and biological agents Provides updated information on protecting workers from proven and possible health risks from manual material handling, extremes of temperature and pressure, ionizing and non-ionizing (magnetic fields) radiation, shiftwork, and more Details major changes in our understanding of biological hazards including Ebola, Chikungunya, Zika, HIV, Hepatitis C, Lyme disease, MERS-CoV, TB, and much more All infectious diseases have been updated from an occupational health perspective Includes practical guidance on to how to set up medical surveillance for hazards and suggests preventive measures that can be used to reduce occupational diseases
Frank Owens J. Physics of Magnetic Nanostructures Frank Owens J. Physics of Magnetic Nanostructures Новинка

Frank Owens J. Physics of Magnetic Nanostructures

8360.56 руб. или Купить в рассрочку!
A comprehensive coverage of the physical properties and real-world applications of magnetic nanostructures This book discusses how the important properties of materials such as the cohesive energy, and the electronic and vibrational structures are affected when materials have at least one length in the nanometer range. The author uses relatively simple models of the solid state to explain why these changes in the size and dimension in the nanometer regime occur. The text also reviews the physics of magnetism and experimental methods of measuring magnetic properties necessary to understanding how nanosizing affects magnetism. Various kinds of magnetic structures are presented by the author in order to explain how nanosizing influences their magnetic properties. The book also presents potential and actual applications of nanomaterials in the fields of medicine and computer data storage. Physics of Magnetic Nanostructures: Covers the magnetism in carbon and born nitride nanostructures, bulk nanostructured magnetic materials, nanostructured magnetic semiconductors, and the fabrication of magnetic nanostructures Discusses emerging applications of nanomaterials such as targeted delivery of drugs, enhancement of images in MRI, ferrofluids, and magnetic computer data storage Includes end-of-chapter exercises and five appendices Physics of Magnetic Nanostructures is written for senior undergraduate and graduate students in physics and nanotechnology, material scientists, chemists, and physicists.
Cecen Ferhan Activated Carbon for Water and Wastewater Treatment. Integration of Adsorption and Biological Treatment Cecen Ferhan Activated Carbon for Water and Wastewater Treatment. Integration of Adsorption and Biological Treatment Новинка

Cecen Ferhan Activated Carbon for Water and Wastewater Treatment. Integration of Adsorption and Biological Treatment

13194.6 руб. или Купить в рассрочку!
This monograph provides comprehensive coverage of technologies which integrate adsorption and biological processes in water and wastewater treatment. The authors provide both an introduction to the topic as well as a detailed discussion of theoretical and practical considerations. After a review of the basics involved in the chemistry, biology and technology of integrated adsorption and biological removal, they discuss the setup of pilot- and full-scale treatment facilities, covering powdered as well as granular activated carbon. They elucidate the factors that influence the successful operation of integrated systems. Their discussion on integrated systems expands from the effects of environmental to the removal of various pollutants, to regeneration of activated carbon, and to the analysis of such systems in mathematical terms. The authors conclude with a look at future needs for research and develoment. A truly valuable resource for environmental engineers, environmental and water chemists, as well as professionals working in water and wastewater treatment.
Zaher Radi A. Comparative Pathophysiology and Toxicology of Cyclooxygenases Zaher Radi A. Comparative Pathophysiology and Toxicology of Cyclooxygenases Новинка

Zaher Radi A. Comparative Pathophysiology and Toxicology of Cyclooxygenases

11642.29 руб. или Купить в рассрочку!
The first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks Cyclooxygenases (COXs) are enzymes responsible for the formation of an important class of biological mediators called prostanoids. Prostanoids such as prostaglandins mediate inflammatory and anaphylactic reactions. For those suffering from inflammation and pain, the pharmacological inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide relief. Yet the use of NSAIDs can trigger toxicological effects as well, leading to potential health risks. Comparative Pathophysiology and Toxicology of Cyclooxygenases provides a comprehensive overview of how COX inhibitors affect various bodily systems, specifically the toxicity mechanisms triggered when the COX enzyme is inhibited. The book provides an introduction to the discovery of cyclooxygenases, their use as therapeutic agents, as well as an historical perspective. Shedding light on the differences in expression, pathophysiology, and toxicology of COX inhibitors across species, the book offers a systematic examination of the effects and pathophysiology of COX inhibitors and their mechanisms of toxicity, beginning with the GI tract. Subsequent chapters cover: The pathophysiology of COX inhibition on bone, tendon, and ligament healing COX inhibitors and renal system pathophysiology and mechanisms of toxicity The pathophysiologic role of COX inhibition in the ocular system COX inhibition and the respiratory and cardiovascular systems The book also sheds light on the latest research devoted to developing COX inhibitors with no adverse side-effects. The first book to offer a thorough comparative look at the toxicological effects of COX inhibitors throughout the body, this invaluable resource will help advance the research and development of safer and more effective COX drugs.
Shaofan Li Multiscale Simulations and Mechanics of Biological Materials Shaofan Li Multiscale Simulations and Mechanics of Biological Materials Новинка

Shaofan Li Multiscale Simulations and Mechanics of Biological Materials

12920.87 руб. или Купить в рассрочку!
Multiscale Simulations and Mechanics of Biological Materials A compilation of recent developments in multiscale simulation and computational biomaterials written by leading specialists in the field Presenting the latest developments in multiscale mechanics and multiscale simulations, and offering a unique viewpoint on multiscale modelling of biological materials, this book outlines the latest developments in computational biological materials from atomistic and molecular scale simulation on DNA, proteins, and nano-particles, to meoscale soft matter modelling of cells, and to macroscale soft tissue and blood vessel, and bone simulations. Traditionally, computational biomaterials researchers come from biological chemistry and biomedical engineering, so this is probably the first edited book to present work from these talented computational mechanics researchers. The book has been written to honor Professor Wing Liu of Northwestern University, USA, who has made pioneering contributions in multiscale simulation and computational biomaterial in specific simulation of drag delivery at atomistic and molecular scale and computational cardiovascular fluid mechanics via immersed finite element method. Key features: Offers a unique interdisciplinary approach to multiscale biomaterial modelling aimed at both accessible introductory and advanced levels Presents a breadth of computational approaches for modelling biological materials across multiple length scales (molecular to whole-tissue scale), including solid and fluid based approaches A companion website for supplementary materials plus links to contributors’ websites (www.wiley.com/go/li/multiscale)
Jerron Smith Adobe After Effects CS6 Digital Classroom Jerron Smith Adobe After Effects CS6 Digital Classroom Новинка

Jerron Smith Adobe After Effects CS6 Digital Classroom

3233.32 руб. или Купить в рассрочку!
Edit and apply effects for stellar visual and special effects This important resource is like having a personal instructor guiding you through each lesson, while you work at your own pace. It includes 10 self-paced lessons that let you discover essential skills and explore the new features and capabilities of Adobe After Effects. Every lesson is presented in full color with step-by-step instructions. Video tutorials and lesson files on a companion DVD were developed by the same team of professional instructors and After Effects experts who have created many of the official training titles for Adobe Systems. Combines a full-color, step-by-step instructional book along with lesson files and video training from expert instructors Written for After Effects CS6, a leading motion graphics and visual effects program that allows users to create and deliver compelling motion graphics and visual effects Demonstrates how to quickly get up to speed using After Effects to create and animate text, images, and video for the web, TV, and digital displays After Effects CS6 Digital Classroom takes you from the basics through intermediate-level topics, teaching you this complex software in a clear, approachable manner. DVD and other supplementary materials are not included as part of the e-book file, but are available for download after purchase.
Scott Sudhoff D. Power Magnetic Devices. A Multi-Objective Design Approach Scott Sudhoff D. Power Magnetic Devices. A Multi-Objective Design Approach Новинка

Scott Sudhoff D. Power Magnetic Devices. A Multi-Objective Design Approach

10012.37 руб. или Купить в рассрочку!
Presents a multi-objective design approach to the many power magnetic devices in use today Power Magnetic Devices: A Multi-Objective Design Approach addresses the design of power magnetic devices—including inductors, transformers, electromagnets, and rotating electric machinery—using a structured design approach based on formal single- and multi-objective optimization. The book opens with a discussion of evolutionary-computing-based optimization. Magnetic analysis techniques useful to the design of all the devices considered in the book are then set forth. This material is then used for inductor design so readers can start the design process. Core loss is next considered; this material is used to support transformer design. A chapter on force and torque production feeds into a chapter on electromagnet design. This is followed by chapters on rotating machinery and the design of a permanent magnet AC machine. Finally, enhancements to the design process including thermal analysis and AC conductor losses due to skin and proximity effects are set forth. Power Magnetic Devices: Focuses on the design process as it relates to power magnetic devices such as inductors, transformers, electromagnets, and rotating machinery Offers a structured design approach based on single- and multi-objective optimization Helps experienced designers take advantage of new techniques which can yield superior designs with less engineering time Provides numerous case studies throughout the book to facilitate readers’ comprehension of the analysis and design process Includes Powerpoint-slide-based student and instructor lecture notes and MATLAB-based examples, toolboxes, and design codes Designed to support the educational needs of students, Power Magnetic Devices: A Multi-Objective Design Approach also serves as a valuable reference tool for practicing engineers and designers. MATLAB examples are available via the book support site.
Wang Binghe Carbohydrate Recognition. Biological Problems, Methods, and Applications Wang Binghe Carbohydrate Recognition. Biological Problems, Methods, and Applications Новинка

Wang Binghe Carbohydrate Recognition. Biological Problems, Methods, and Applications

12107.98 руб. или Купить в рассрочку!
This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.
Joaquim Ros Protein Carbonylation. Principles, Analysis, and Biological Implications Joaquim Ros Protein Carbonylation. Principles, Analysis, and Biological Implications Новинка

Joaquim Ros Protein Carbonylation. Principles, Analysis, and Biological Implications

13300.89 руб. или Купить в рассрочку!
Protein carbonylation has attracted the interest of a great number of laboratories since the pioneering studies at the Earl Stadtman’s lab at NIH started in early 1980s. Since then, detecting protein carbonyls in oxidative stress situations became a highly efficient tool to uncover biomarkers of oxidative damage in normal and altered cell physiology. In this book, research groups from several areas of interest have contributed to update the knowledge regarding detection, analyses and identification of carbonylated proteins and the sites where these modifications occur. The scientific community will benefit from these reviews since they deal with specific, detailed technical approaches to study formation and detection of protein carbonyls. Moreover, the biological impact of such modifications in metabolic, physiologic and structural functions and, how these alterations can help understanding the downstream effects on cell function are discussed. Oxidative stress occurs in all living organisms and affects proteins and other macromolecules: Protein carbonylation is a measure of oxidative stress in biological systems Mass spectrometry, fluorescent labelling, antibody based detection, biotinylated protein selection and other methods for detecting protein carbonyls and modification sites in proteins are described Aging, neurodegenerative diseases, obstructive pulmonary diseases, malaria, cigarette smoke, adipose tissue and its relationship with protein carbonylation Direct oxidation, glycoxidation and modifications by lipid peroxidation products as protein carbonylation pathways Emerging methods for characterizing carbonylated protein networks and affected metabolic pathways
Crystalline Electric Field Effects in f-Electron Magnetism Crystalline Electric Field Effects in f-Electron Magnetism Новинка

Crystalline Electric Field Effects in f-Electron Magnetism

The present conference, the fourth successive on this subject, was organized to commemorate the 75th birthday of Professor Wtodzimierz Trzebiatowski, one of the pioneers in the field of f-electron materials structure, particularly in the magnetism of actinides. This volume contains 64 papers presented at the conference held in Wroctaw, Poland, September 22-25, 1981. Twenty-one were invited talks. About 100 participants from 13 countries attended the meeting during four days of lecture presentation (note these two numbers have been constant for the last two conferences). The conference consisted of sessions devoted to the investigation of crystalline electric fields and structural effects by spectroscopic techniques, neutron diffraction, magnetic, thermodynamic and electrical measurements all over broad temperature, magnetic field and pressure ranges. Materials investigated included rare earth intermetallics, hydrides, diluted systems and actinides, and among them some exhibited singlet ground state behavior. The experimental results were supplemented by theory.
Yusuke Hiraku Cancer and Inflammation Mechanisms. Chemical, Biological, and Clinical Aspects Yusuke Hiraku Cancer and Inflammation Mechanisms. Chemical, Biological, and Clinical Aspects Новинка

Yusuke Hiraku Cancer and Inflammation Mechanisms. Chemical, Biological, and Clinical Aspects

9804.95 руб. или Купить в рассрочку!
A new perspective on the link between inflammation and cancer Inflammation is the human body’s normal biological response to threats in the modern world, as well as a defense against the harmful influence of pathogens, the environment, and poor nutrition. But what happens when the inflammatory response is triggered repeatedly and sustained for long periods of time? Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects discusses the mechanisms by which chronic inflammation can lead to cancer, the various causative agents, and possible prevention methods. A compilation of the latest information coming out of the various fields of cancer research, this book provides a detailed look at inflammation-related carcinogenesis from the perspective of researchers at the forefront of the field. It takes an interdisciplinary approach to the topic, and provides comprehensive information about the major factors at work in inflammation, cancer, and the intersection of the two conditions. Topics include: A general overview of inflammation-related cancer The biochemistry of inflammation and its effects on DNA Molecular biology and the role of microRNA in carcinogenesis Specific causative agents including oncogenic viruses, asbestos, and nanomaterial Anti-inflammatories, nutraceuticals, and other preventative measures A deeper understanding of the mechanisms behind inflammation-related carcinogenesis can lead to better patient outcomes by improving diagnostics and prevention, as well as altering the approach to treatment. Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects provides the knowledge base researchers need to push the field forward.
Alexey Kondrashov S. Crumbling Genome. The Impact of Deleterious Mutations on Humans Alexey Kondrashov S. Crumbling Genome. The Impact of Deleterious Mutations on Humans Новинка

Alexey Kondrashov S. Crumbling Genome. The Impact of Deleterious Mutations on Humans

A thought-provoking exploration of deleterious mutations in the human genome and their effects on human health and wellbeing Despite all of the elaborate mechanisms that a cell employs to handle its DNA with the utmost care, a newborn human carries about 100 new mutations, originated in their parents, about 10 of which are deleterious. A mutation replacing just one of the more than three billion nucleotides in the human genome may lead to synthesis of a dysfunctional protein, and this can be inconsistent with life or cause a tragic disease. Several percent of even young people suffer from diseases that are caused, exclusively or primarily, by pre?]existing and new mutations in their genomes, including both a wide variety of genetically simple Mendelian diseases and diverse complex diseases such as birth anomalies, diabetes, and schizophrenia. Milder, but still substantial, negative effects of mutations are even more pervasive. As of now, we possess no means of reducing the rate at which mutations appear spontaneously. However, the recent flood of genomic data made possible by next-generation methods of DNA sequencing, enabled scientists to explore the impacts of deleterious mutations on humans with previously unattainable precision and begin to develop approaches to managing them. Written by a leading researcher in the field of evolutionary genetics, Crumbling Genome reviews the current state of knowledge about deleterious mutations and their effects on humans for those in the biological sciences and medicine, as well as for readers with only a general scientific literacy and an interest in human genetics. Provides an extensive introduction to the fundamentals of evolutionary genetics with an emphasis on mutation and selection Discusses the effects of pre-existing and new mutations on human genotypes and phenotypes Provides a comprehensive review of the current state of knowledge in the field and considers crucial unsolved problems Explores key ethical, scientific, and social issues likely to become relevant in the near future as the modification of human germline genotypes becomes technically feasible Crumbling Genome is must-reading for students and professionals in human genetics, genomics, bioinformatics, evolutionary biology, and biological anthropology. It is certain to have great appeal among all those with an interest in the links between genetics and evolution and how they are likely to influence the future of human health, medicine, and society.
Devaux Philippe Transmembrane Dynamics of Lipids Devaux Philippe Transmembrane Dynamics of Lipids Новинка

Devaux Philippe Transmembrane Dynamics of Lipids

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The first and only book devoted entirely to MEMBRANE LIPID ASYMMETRY AND ITS BIOLOGICAL IMPLICATIONS Transmembrane Dynamics of Lipids is comprised of contributions from expert authors from leading research groups that present up-to-date quantitative data on the formation, stability, and biological consequences of the asymmetrical organization of lipids in cell membranes. Incorporating an impressive amount of new, previously uncollected data, the book examines transmembrane asymmetry and movement of lipids in biological membranes, and methods for the measurement of transmembrane lipid motion, emphasizing the role of lipid flippases and discusses biological functions associated with lipid asymmetry. In addition, it draws attention to important new discoveries in the field, such as the correlation between malfunction of lipid flippases and human diseases such as thrombosis and cancer. The book also addresses the manifold methods that are used to measure the rate of transmembrane movement of lipids in biological and model systems. The only guide to new discoveries regarding lipids in cell membranes, Transmembrane Dynamics of Lipids is designed to appeal to biophysicists, biochemists, and cellular and molecular biologists working in the growing field of membrane research.
Basel Abu-Jamous Integrative Cluster Analysis in Bioinformatics Basel Abu-Jamous Integrative Cluster Analysis in Bioinformatics Новинка

Basel Abu-Jamous Integrative Cluster Analysis in Bioinformatics

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Clustering techniques are increasingly being put to use in the analysis of high-throughput biological datasets. Novel computational techniques to analyse high throughput data in the form of sequences, gene and protein expressions, pathways, and images are becoming vital for understanding diseases and future drug discovery. This book details the complete pathway of cluster analysis, from the basics of molecular biology to the generation of biological knowledge. The book also presents the latest clustering methods and clustering validation, thereby offering the reader a comprehensive review of clustering analysis in bioinformatics from the fundamentals through to state-of-the-art techniques and applications. Key Features: Offers a contemporary review of clustering methods and applications in the field of bioinformatics, with particular emphasis on gene expression analysis Provides an excellent introduction to molecular biology with computer scientists and information engineering researchers in mind, laying out the basic biological knowledge behind the application of clustering analysis techniques in bioinformatics Explains the structure and properties of many types of high-throughput datasets commonly found in biological studies Discusses how clustering methods and their possible successors would be used to enhance the pace of biological discoveries in the future Includes a companion website hosting a selected collection of codes and links to publicly available datasets
Ronald Pethig R. Dielectrophoresis. Theory, Methodology and Biological Applications Ronald Pethig R. Dielectrophoresis. Theory, Methodology and Biological Applications Новинка

Ronald Pethig R. Dielectrophoresis. Theory, Methodology and Biological Applications

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Comprehensive coverage of the basic theoretical concepts and applications of dielectrophoresis from a world-renowned expert. Features hot application topics including: Diagnostics, Cell-based Drug Discovery, Sensors for Biomedical Applications, Characterisation and Sorting of Stem Cells, Separation of Cancer Cells from Blood and Environmental Monitoring Focuses on those aspects of the theory and practice of dielectrophoresis concerned with characterizing and manipulating cells and other bioparticles such as bacteria, viruses, proteins and nucleic acids. Features the relevant chemical and biological concepts for those working in physics and engineering
Wei Wang Biological Drug Products. Development and Strategies Wei Wang Biological Drug Products. Development and Strategies Новинка

Wei Wang Biological Drug Products. Development and Strategies

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Tested and proven solutions to the challenges of biological drug product development Biological drug products play a central role in combating human diseases; however, developing new successful biological drugs presents many challenges, including labor intensive production processes, tighter regulatory controls, and increased market competition. This book reviews the current state of the science, offering readers a single resource that sets forth the fundamentals as well as tested and proven development strategies for biological drugs. Moreover, the book prepares readers for the challenges that typically arise during drug development, offering straightforward solutions to improve their ability to pass through all the regulatory hurdles and deliver new drug products to the market. Biological Drug Products begins with general considerations for the development of any biological drug product and then explores the strategies and challenges involved in the development of specific types of biologics. Divided into five parts, the book examines: Part 1: General Aspects Part 2: Proteins and Peptides Part 3: Vaccines Part 4: Novel Biologics Part 5: Product Administration/Delivery Each chapter has been prepared by one or more leading experts in biological drug development. Contributions are based on a comprehensive review and analysis of the current literature as well as the authors' first-hand experience developing and testing new drugs. References at the end of each chapter serve as a gateway to original research papers and reviews in the field. By incorporating lessons learned and future directions for research, Biological Drug Products enables pharmaceutical scientists and students to improve their success rate in developing new biologics to treat a broad range of human diseases.
Samiksha Singh UV-B Radiation. From Environmental Stressor to Regulator of Plant Growth Samiksha Singh UV-B Radiation. From Environmental Stressor to Regulator of Plant Growth Новинка

Samiksha Singh UV-B Radiation. From Environmental Stressor to Regulator of Plant Growth

Ultraviolet-B (UV-B) is electromagnetic radiation coming from the sun, with a medium wavelength which is mostly absorbed by the ozone layer. The biological effects of UV-B are greater than simple heating effects, and many practical applications of UV-B radiation derive from its interactions with organic molecules. It is considered particularly harmful to the environment and living things, but what have scientific studies actually shown? UV-B Radiation: From Environmental Stressor to Regulator of Plant Growth presents a comprehensive overview of the origins, current state, and future horizons of scientific research on ultraviolet-B radiation and its perception in plants. Chapters explore all facets of UV-B research, including the basics of how UV-B's shorter wavelength radiation from the sun reaches the Earth's surface, along with its impact on the environment's biotic components and on human biological systems. Chapters also address the dramatic shift in UV-B research in recent years, reflecting emerging technologies, showing how historic research which focused exclusively on the harmful environmental effects of UV-B radiation has now given way to studies on potential benefits to humans. Topics include: UV-B and its climatology UV-B and terrestrial ecosystems Plant responses to UV-B stress UB- B avoidance mechanisms UV-B and production of secondary metabolites Discovery of UVR8 Timely and important, UV-B Radiation: From Environmental Stressor to Regulator of Plant Growth is an invaluable resource for environmentalists, researchers and students who are into the state-of-the-art research being done on exposure to UV-B radiation.
Guanglei Hong Causality in a Social World. Moderation, Mediation and Spill-over Guanglei Hong Causality in a Social World. Moderation, Mediation and Spill-over Новинка

Guanglei Hong Causality in a Social World. Moderation, Mediation and Spill-over

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Causality in a Social World introduces innovative new statistical research and strategies for investigating moderated intervention effects, mediated intervention effects, and spill-over effects using experimental or quasi-experimental data. The book uses potential outcomes to define causal effects, explains and evaluates identification assumptions using application examples, and compares innovative statistical strategies with conventional analysis methods. Whilst highlighting the crucial role of good research design and the evaluation of assumptions required for identifying causal effects in the context of each application, the author demonstrates that improved statistical procedures will greatly enhance the empirical study of causal relationship theory. Applications focus on interventions designed to improve outcomes for participants who are embedded in social settings, including families, classrooms, schools, neighbourhoods, and workplaces.
Felix Polyak Hyaluronic Acid. Production, Properties, Application in Biology and Medicine Felix Polyak Hyaluronic Acid. Production, Properties, Application in Biology and Medicine Новинка

Felix Polyak Hyaluronic Acid. Production, Properties, Application in Biology and Medicine

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Hyaluronic acid is an essential part of connective, epithelial and neural tissues, and contributes to cell proliferation and migration. It is used as a stimulating agent for collagen synthesis and is a common ingredient in skin-care products, a multi-billion dollar industry, as it is believed to be a key factor in fighting the aging process. Hyaluronic Acid: Production, Properties, Application in Biology and Medicine consists of six chapters discussing the various issues of hyaluronic acid research. In Chapter 1, a historical analysis recounts the discovery and milestones of the research leading to the practical applications of hyaluronan. Chapter 2 is dedicated to biological role of the hyaluronic acid in nature, in particular in the human body. The chapter starts from the phylogenesis of hyaluronic acid, then describes hyaluronan functions in human ontogenesis and especially the role which hyaluronan plays in extracellular matrix of the different tissues. Chapter 3 describes the methods to manufacture and purify hyaluronic acid, including the analytical means for assessing quality of the finished product. Chapter 4 discusses the structure and rheological properties of hyaluronic acid considering effects on conformation and biological properties related to molecular weight. In Chapter 5, the physical and chemical methods for modifying the structure of hyaluronan are discussed including cross-linking using bi-functional reagents, solid-phase modification and effects of the combined action of high pressures and shift deformation. The final chapter focuses on the products derived from hyaluronic acid, including therapeutics composed of modified hyaluronan conjugated to vitamins, amino acids and oligo-peptides. The biological roles and medical applications of this polysaccharide have been extensively studied and this book provides a wealth of scientific data demonstrating the critical role of hyaluronic acid and its promise as a multifaceted bio-macromolecule. Approaching hyaluronic acid from multiple angles, this book links relationships between its biological functions, structure and physical–chemical properties. It will be an invaluable resource to researchers, both industrial and academic, involved in all aspects of hyaluronan-based technologies.
Guanglei Hong Causality in a Social World. Moderation, Mediation and Spill-over Guanglei Hong Causality in a Social World. Moderation, Mediation and Spill-over Новинка

Guanglei Hong Causality in a Social World. Moderation, Mediation and Spill-over

6840.46 руб. или Купить в рассрочку!
Causality in a Social World introduces innovative new statistical research and strategies for investigating moderated intervention effects, mediated intervention effects, and spill-over effects using experimental or quasi-experimental data. The book uses potential outcomes to define causal effects, explains and evaluates identification assumptions using application examples, and compares innovative statistical strategies with conventional analysis methods. Whilst highlighting the crucial role of good research design and the evaluation of assumptions required for identifying causal effects in the context of each application, the author demonstrates that improved statistical procedures will greatly enhance the empirical study of causal relationship theory. Applications focus on interventions designed to improve outcomes for participants who are embedded in social settings, including families, classrooms, schools, neighbourhoods, and workplaces.
Brian Henderson Protein Moonlighting in Biology and Medicine Brian Henderson Protein Moonlighting in Biology and Medicine Новинка

Brian Henderson Protein Moonlighting in Biology and Medicine

12917.98 руб. или Купить в рассрочку!
The past 25 years has seen the emergence of a wealth of data suggesting that novel biological functions of known proteins play important roles in biology and medicine. This ability of proteins to exhibit more than one unique biological activity is known as protein moonlighting. Moonlighting proteins can exhibit novel biological functions, thus extending the function of the proteome, and are also implicated in the pathology of a growing number of idiopathic and infectious diseases. This book, written by a cell biologist, protein evolutionary biologist and protein bioinformatician, brings together the latest information on the structure, evolution and biological function of the growing numbers of moonlighting proteins that have been identified, and their roles in human health and disease. This information is revealing the enormous importance protein moonlighting plays in the maintenance of human health and in the induction of disease pathology. Protein Moonlighting in Biology and Medicine will be of interest to a general readership in the biological and biomedical research community.
Tahira Farooqui Neuroprotective Effects of Phytochemicals in Neurological Disorders Tahira Farooqui Neuroprotective Effects of Phytochemicals in Neurological Disorders Новинка

Tahira Farooqui Neuroprotective Effects of Phytochemicals in Neurological Disorders

15198.14 руб. или Купить в рассрочку!
Phytochemicals are naturally occurring bioactive compounds found in edible fruits, plants, vegetables, and herbs. Unlike vitamins and minerals, phytochemicals are not needed for the maintenance of cell viability, but they play a vital role in protecting neural cells from inflammation and oxidative stress associated with normal aging and acute and chronic age-related brain diseases. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the advances in our understanding of the potential neuroprotective benefits that these naturally occurring chemicals contain. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the role that a number of plant-based chemical compounds play in a wide variety of neurological disorders. Chapters explore the impact of phytochemicals on neurotraumatic disorders, such as stroke and spinal cord injury, alongside neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as neuropsychiatric disorders such as depression and schizophrenia. The chapters and sections of this book provide the reader with a big picture view of this field of research. Neuroprotective Effects of Phytochemicals in Neurological Disorders aims to present readers with a comprehensive and cutting edge look at the effects of phytochemicals on the brain and neurological disorders in a manner useful to researchers, neuroscientists, clinical nutritionists, and physicians.
N. Sukumar A Matter of Density. Exploring the Electron Density Concept in the Chemical, Biological, and Materials Sciences N. Sukumar A Matter of Density. Exploring the Electron Density Concept in the Chemical, Biological, and Materials Sciences Новинка

N. Sukumar A Matter of Density. Exploring the Electron Density Concept in the Chemical, Biological, and Materials Sciences

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The origins and significance of electron density in the chemical, biological, and materials sciences Electron density is one of the fundamental concepts underlying modern chemistry and one of the key determinants of molecular structure and stability. It is also the basic variable of density functional theory, which has made possible, in recent years, the application of the mathematical theory of quantum physics to chemical and biological systems. With an equal emphasis on computational and philosophical questions, A Matter of Density: Exploring the Electron Density Concept in the Chemical, Biological, and Materials Sciences addresses the foundations, analysis, and applications of this pivotal chemical concept. The first part of the book presents a coherent and logically connected treatment of the theoretical foundations of the electron density concept. Discussion includes the use of probabilities in statistical physics; the origins of quantum mechanics; the philosophical questions at the heart of quantum theory, like quantum entanglement; and methods for the experimental determination of electron density distributions. The remainder of the book deals with applications of the electron density concept in the chemical, biological, and materials sciences. Contributors offer insights on how a deep understanding of the origins of chemical reactivity can be gleaned from the concepts of density functional theory. Also discussed are the applications of electron density in molecular similarity analysis and electron density-derived molecular descriptors, such as electrostatic potentials and local ionization energies. This section concludes with some applications of modern density functional theory to surfaces and interfaces. An essential reference for students as well as quantum and computational chemists, physical chemists, and physicists, this book offers an unparalleled look at the development of the concept of electron density from its inception to its role in density functional theory, which led to the 1998 Nobel Prize in Chemistry.
Clark Larsen Spencer A Companion to Biological Anthropology Clark Larsen Spencer A Companion to Biological Anthropology Новинка

Clark Larsen Spencer A Companion to Biological Anthropology

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An extensive overview of the rapidly growing field of biological anthropology; chapters are written by leading scholars who have themselves played a major role in shaping the direction and scope of the discipline. Extensive overview of the rapidly growing field of biological anthropology Larsen has created a who’s who of biological anthropology, with contributions from the leading authorities in the field Contributing authors have played a major role in shaping the direction and scope of the topics they write about Offers discussions of current issues, controversies, and future directions within the area Presents coverage of the many recent innovations and discoveries that are transforming the subject
Anne Grauer L. A Companion to Paleopathology Anne Grauer L. A Companion to Paleopathology Новинка

Anne Grauer L. A Companion to Paleopathology

16869.67 руб. или Купить в рассрочку!
A Companion to Paleopathology offers a comprehensive overview of this rapidly growing sub- field of physical anthropology. Presents a broad overview of the field of paleopathology, integrating theoretical and methodological approaches to understand biological and disease processes throughout human history Demonstrates how paleopathology sheds light on the past through the analysis of human and non-human skeletal materials, mummified remains and preserved tissue Integrates scientific advances in multiple fields that contribute to the understanding of ancient and historic diseases, such as epidemiology, histology, radiology, parasitology, dentistry, and molecular biology, as well as archaeological, archival and historical research. Highlights cultural processes that have an impact on the evolution of illness, death and dying in human populations, including subsistence strategies, human environmental adaptations, the effects of malnutrition, differential access to resources, and interpersonal and intercultural violence
Mario Ferreira F. Nonlinear Effects in Optical Fibers Mario Ferreira F. Nonlinear Effects in Optical Fibers Новинка

Mario Ferreira F. Nonlinear Effects in Optical Fibers

8999.49 руб. или Купить в рассрочку!
This book will provide insight into the principles and applications of nonlinear effects in fibers for students, researchers, and developers who have a basic understanding of electromagnetic theory under their belts. It will explore the physics, limitations, applications, and research results surrounding nonlinear effects in fiber optics. In addition to communications, optical fibers are already used in medical procedures, automobiles, and aircraft and are expected to have many other applications. This will expand the range of industry workers who will find a book of this type useful.
Patrick Jjemba K. Pharma-Ecology. The Occurrence and Fate of Pharmaceuticals and Personal Care Products in the Environment Patrick Jjemba K. Pharma-Ecology. The Occurrence and Fate of Pharmaceuticals and Personal Care Products in the Environment Новинка

Patrick Jjemba K. Pharma-Ecology. The Occurrence and Fate of Pharmaceuticals and Personal Care Products in the Environment

12612.48 руб. или Купить в рассрочку!
The revised edition of the guide to environmental impact of pharmaceuticals and personal care products The revised and updated second edition of Pharma-Ecology joins the health and environmental sciences professions' concern over the occurrence and fate of pharmaceutical and personal care products (PPCPs) in the environment and explores how to best minimize their impact. The text highlights the biological effects of various classes of pharmaceutical compounds under clinical settings, their modes of action, and approximate quantities consumed. The second edition contains the most recent knowledge about the ecological impact of PPCPs as more sensitive detection techniques have become available, since the book was first published. The second edition offers the most up-to-date information on pharma ecology and bridges the gap between medicine, public health, and environmental science. This new edition contains helpful learning objectives for each chapter, as well as a brief section at the end of each chapter that presents a set of open ended questions. This vital resource: • Explores the biological effects of pharmaceutical compounds under clinical settings, their modes of action, approximate quantities consumed • Provides researchers and scientists with critical background data on the environmental impacts of PPCPs • Contains the most current information on PPCPs' ecological impacts, based on new detection techniques • Bridges the gap between medicine, public health, and environmental science Written for ecologists, engineers, microbiologists, pharmacists, toxicologists, chemists, physicians, and veterinarians involved in pollution and environmental analysis, the second edition of Pharma-Ecology contains the most current information available on the environmental impact of pharmaceuticals and personal care products.
Anne Grauer L. A Companion to Paleopathology Anne Grauer L. A Companion to Paleopathology Новинка

Anne Grauer L. A Companion to Paleopathology

17226.71 руб. или Купить в рассрочку!
A Companion to Paleopathology offers a comprehensive overview of this rapidly growing sub- field of physical anthropology. Presents a broad overview of the field of paleopathology, integrating theoretical and methodological approaches to understand biological and disease processes throughout human history Demonstrates how paleopathology sheds light on the past through the analysis of human and non-human skeletal materials, mummified remains and preserved tissue Integrates scientific advances in multiple fields that contribute to the understanding of ancient and historic diseases, such as epidemiology, histology, radiology, parasitology, dentistry, and molecular biology, as well as archaeological, archival and historical research. Highlights cultural processes that have an impact on the evolution of illness, death and dying in human populations, including subsistence strategies, human environmental adaptations, the effects of malnutrition, differential access to resources, and interpersonal and intercultural violence
Arieh Warshel Theory and Applications of the Empirical Valence Bond Approach. From Physical Chemistry to Chemical Biology Arieh Warshel Theory and Applications of the Empirical Valence Bond Approach. From Physical Chemistry to Chemical Biology Новинка

Arieh Warshel Theory and Applications of the Empirical Valence Bond Approach. From Physical Chemistry to Chemical Biology

11020.74 руб. или Купить в рассрочку!
A comprehensive overview of current empirical valence bond (EVB) theory and applications, one of the most powerful tools for studying chemical processes in the condensed phase and in enzymes. Discusses the application of EVB models to a broad range of molecular systems of chemical and biological interest, including reaction dynamics, design of artificial catalysts, and the study of complex biological problems Edited by a rising star in the field of computational enzymology Foreword by Nobel laureate Arieh Warshel, who first developed the EVB approach
Patel Dipti ABC of Occupational and Environmental Medicine Patel Dipti ABC of Occupational and Environmental Medicine Новинка

Patel Dipti ABC of Occupational and Environmental Medicine

3799.27 руб. или Купить в рассрочку!
This new edition of Occupational and Environmental Medicine concentrates more on the newer kinds of occupational disease including those (like “RSI” and pesticide poisoning) where exposure and effects are difficult to understand. There is specific emphasis on work, health and wellbeing, with links to public health, health promotion, the value of work, disabled people at work, the aging workforce, vocational rehabilitation, evidence based practice, and further chapters on the health effects of climate change and of occupational health and safety in relation to migration and terrorism.
Linda Reichl E. A Modern Course in Statistical Physics Linda Reichl E. A Modern Course in Statistical Physics Новинка

Linda Reichl E. A Modern Course in Statistical Physics

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A Modern Course in Statistical Physics is a textbook that illustrates the foundations of equilibrium and non-equilibrium statistical physics, and the universal nature of thermodynamic processes, from the point of view of contemporary research problems. The book treats such diverse topics as the microscopic theory of critical phenomena, superfluid dynamics, quantum conductance, light scattering, transport processes, and dissipative structures, all in the framework of the foundations of statistical physics and thermodynamics. It shows the quantum origins of problems in classical statistical physics. One focus of the book is fluctuations that occur due to the discrete nature of matter, a topic of growing importance for nanometer scale physics and biophysics. Another focus concerns classical and quantum phase transitions, in both monatomic and mixed particle systems. This fourth edition extends the range of topics considered to include, for example, entropic forces, electrochemical processes in biological systems and batteries, adsorption processes in biological systems, diamagnetism, the theory of Bose-Einstein condensation, memory effects in Brownian motion, the hydrodynamics of binary mixtures. A set of exercises and problems is to be found at the end of each chapter and, in addition, solutions to a subset of the problems is provided. The appendices cover Exact Differentials, Ergodicity, Number Representation, Scattering Theory, and also a short course on Probability.
Alkaloids: Chemical and Biological Perspectives Alkaloids: Chemical and Biological Perspectives Новинка

Alkaloids: Chemical and Biological Perspectives

This monograph series provides unprecedented interdisciplinary coverage of research relating to the chemistry and biological properties of alkaloids - a class of biologically active compounds of more than 10,000 members. Timely, comprehensive and authoritative, the series features chapters on chemical properties and structure elucidation, synthesis, biosynthesis, taxonomy, spectroscopy, pharmacology, toxicology, and X-ray crystallography of alkaloids. The chapters are written and reviewed by eminent researchers, all of them acknowledged experts in the field. Subject and organism indexes are included for each volume.
Elhadi Yahia M. Fruit and Vegetable Phytochemicals. Chemistry and Human Health, 2 Volumes Elhadi Yahia M. Fruit and Vegetable Phytochemicals. Chemistry and Human Health, 2 Volumes Новинка

Elhadi Yahia M. Fruit and Vegetable Phytochemicals. Chemistry and Human Health, 2 Volumes

26601.78 руб. или Купить в рассрочку!
Now in two volumes and containing more than seventy chapters, the second edition of Fruit and Vegetable Phytochemicals: Chemistry, Nutritional Value and Stability has been greatly revised and expanded. Written by hundreds of experts from across the world, the chapters cover diverse aspects of chemistry and biological functions, the influence of postharvest technologies, analysis methods and important phytochemicals in more than thirty fruits and vegetables. Providing readers with a comprehensive and cutting-edge description of the metabolism and molecular mechanisms associated with the beneficial effects of phytochemicals for human health, this is the perfect resource not only for students and teachers but also researchers, physicians and the public in general.
John Clary J. The Toxicology of Methanol John Clary J. The Toxicology of Methanol Новинка

John Clary J. The Toxicology of Methanol

10633.29 руб. или Купить в рассрочку!
The Toxicology of Methanol presents a single source of information and an understanding of the toxicity of methanol from animal data, potential environmental effects as well as human effects. The animal data, which goes to making up the majority of the data on the toxicity of methanol and the mechanism of action, is reviewed as it relates to the potential toxicity in humans.
Dale Walters Physiological Responses of Plants to Attack Dale Walters Physiological Responses of Plants to Attack Новинка

Dale Walters Physiological Responses of Plants to Attack

6307.56 руб. или Купить в рассрочку!
Despite the research effort put into controlling pathogens, pests and parasitic plants, crop losses are still a regular feature of agriculture worldwide. This makes it important to manage the crop appropriately in order to maximise yield. Understanding the relationship between the occurrence and severity of attack, and the resulting yield loss, is an important step towards improved crop protection. Linked to this, is the need to better understand the mechanisms responsible for reductions in growth and yield in affected crops. Physiological Responses of Plants to Attack is unique because it deals with the effects of different attackers – pathogens, herbivores, and parasitic plants, on host processes involved in growth, reproduction, and yield. Coverage includes effects on photosynthesis, partitioning of carbohydrates, water and nutrient relations, and changes in plant growth hormones. Far from being simply a consequence of attack, the alterations in primary metabolism reflect a more dynamic and complex interaction between plant and attacker, sometimes involving re-programming of plant metabolism by the attacker. Physiological Responses of Plants to Attack is written and designed for use by senior undergraduates and postgraduates studying agricultural sciences, applied entomology, crop protection, plant pathology and plant sciences. Biological and agricultural research scientists in the agrochemical and crop protection industries, and in academia, will find much of use in this book. All libraries in universities and research establishments where biological and agricultural sciences are studied and taught should have copies of this exciting book on their shelves
Laurent Simon Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering Laurent Simon Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering Новинка

Laurent Simon Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering

8611.42 руб. или Купить в рассрочку!
Enables readers to apply process dynamics and control theory to solve bioprocess and drug delivery problems The control of biological and drug delivery systems is critical to the health of millions of people worldwide. As a result, researchers in systems biology and drug delivery rely on process dynamics and control theory to build our knowledge of cell behavior and to develop more effective therapeutics, controlled release devices, and drug administration protocols to manage disease. Written by a leading expert and educator in the field, this text helps readers develop a deep understanding of process dynamics and control theory in order to analyze and solve a broad range of problems in bioprocess and drug delivery systems. For example, readers will learn how stability criteria can be used to gain new insights into the regulation of biological pathways and lung mechanics. They'll also learn how the concept of a time constant is used to capture the dynamics of diffusive processes. Readers will also master such topics as external disturbances, transfer functions, and input/output models with the support of the author's clear explanations, as well as: Detailed examples from the biological sciences and novel drug delivery technologies 160 end-of-chapter problems with step-by-step solutions Demonstrations of how computational software such as MATLAB and Mathematica solve complex drug delivery problems Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering is written primarily for undergraduate chemical and biomedical engineering students; however, it is also recommended for students and researchers in pharmaceutical engineering, process control, and systems biology. All readers will gain a new perspective on process dynamics and control theory that will enable them to develop new and better technologies and therapeutics to treat human disease.
Keith Stine J. Carbohydrate Nanotechnology Keith Stine J. Carbohydrate Nanotechnology Новинка

Keith Stine J. Carbohydrate Nanotechnology

13297.29 руб. или Купить в рассрочку!
Introducing the emerging field carbohydrate nanostructures, this book will be a unique resource for interested researchers to learn a range of methods of applying the field to their own work. Greater access, as well as greater collaboration, to this new interdisciplinary field is intended for both synthetic carbohydrate chemists and researchers in nanoscience related fields. It covers: the main types of nanostructures presently under investigation for modification by carbohydrates, including nanoparticles, nanorods, magnetic particles, dendrimers, nanoporous, and surface confined structures overview and introduction to the field of carbohydrate nanotechnology, and especially its applications to its biological systems Provides a unique resource for researchers to learn about the techniques used to characterize the physical and biological properties of carbohydrate-modified nanostructures
Ramesh Venkatesan Magnetic Resonance Imaging. Physical Principles and Sequence Design Ramesh Venkatesan Magnetic Resonance Imaging. Physical Principles and Sequence Design Новинка

Ramesh Venkatesan Magnetic Resonance Imaging. Physical Principles and Sequence Design

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New edition explores contemporary MRI principles and practices Thoroughly revised, updated and expanded, the second edition of Magnetic Resonance Imaging: Physical Principles and Sequence Design remains the preeminent text in its field. Using consistent nomenclature and mathematical notations throughout all the chapters, this new edition carefully explains the physical principles of magnetic resonance imaging design and implementation. In addition, detailed figures and MR images enable readers to better grasp core concepts, methods, and applications. Magnetic Resonance Imaging, Second Edition begins with an introduction to fundamental principles, with coverage of magnetization, relaxation, quantum mechanics, signal detection and acquisition, Fourier imaging, image reconstruction, contrast, signal, and noise. The second part of the text explores MRI methods and applications, including fast imaging, water-fat separation, steady state gradient echo imaging, echo planar imaging, diffusion-weighted imaging, and induced magnetism. Lastly, the text discusses important hardware issues and parallel imaging. Readers familiar with the first edition will find much new material, including: New chapter dedicated to parallel imaging New sections examining off-resonance excitation principles, contrast optimization in fast steady-state incoherent imaging, and efficient lower-dimension analogues for discrete Fourier transforms in echo planar imaging applications Enhanced sections pertaining to Fourier transforms, filter effects on image resolution, and Bloch equation solutions when both rf pulse and slice select gradient fields are present Valuable improvements throughout with respect to equations, formulas, and text New and updated problems to test further the readers' grasp of core concepts Three appendices at the end of the text offer review material for basic electromagnetism and statistics as well as a list of acquisition parameters for the images in the book. Acclaimed by both students and instructors, the second edition of Magnetic Resonance Imaging offers the most comprehensive and approachable introduction to the physics and the applications of magnetic resonance imaging.
Stig Pedersen-Bjergaard Bioanalysis of Pharmaceuticals. Sample Preparation, Separation Techniques and Mass Spectrometry Stig Pedersen-Bjergaard Bioanalysis of Pharmaceuticals. Sample Preparation, Separation Techniques and Mass Spectrometry Новинка

Stig Pedersen-Bjergaard Bioanalysis of Pharmaceuticals. Sample Preparation, Separation Techniques and Mass Spectrometry

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Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry is the first student textbook on the separation science and mass spectrometry of pharmaceuticals present in biological fluids with an educational presentation of the principles, concepts and applications. It discusses the chemical structures and properties of low- and high-molecular drug substances; the different types of biological samples and fluids that are used; how to prepare the samples by extraction, and how to perform the appropriate analytical measurements by chromatographic and mass spectrometric methods. Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry: Is an introductory student textbook discussing the different principles and concepts clearly and comprehensively, with many relevant and educational examples Focuses on substances that are administered as human drugs, including low-molecular drug substances, peptides, and proteins Presents both the basic principles that are regularly taught in universities, along with the practical use of bioanalysis as carried out by researchers in the pharmaceutical industry and in hospital laboratories Is aimed at undergraduate students, scientists, technicians and researchers in industry working in the areas of pharmaceutical analyses, biopharmaceutical analyses, biological and life sciences The book includes multiple examples to illustrate the theory and application, with many practical aspects including calculations, thus helping the student to learn how to convert the data recorded by instruments into the real concentration of the drug substances within the biological sample.
Claude Fermon Nanomagnetism. Applications and Perspectives Claude Fermon Nanomagnetism. Applications and Perspectives Новинка

Claude Fermon Nanomagnetism. Applications and Perspectives

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This first book to focus on the applications of nanomagnetism presents those already realized while also suggesting bold ideas for further breakthroughs. The first part is devoted to the concept of spin electronics and its use for data storage and magnetic sensing, while the second part concentrates on magnetic nanoparticles and their use in industrial environment, biological and medical applications. The third, more prospective part goes on to describe emerging applications related to spin current creation and manipulation, dynamics, spin waves and binary logic based on nano-scale magnetism. With its unique choice of topics and authors, this will appeal to academic as well as corporate researchers in a wide range of disciplines from physics via materials science to engineering, chemistry and life science.
Julie Laity J Deserts and Desert Environments Julie Laity J Deserts and Desert Environments Новинка

Julie Laity J Deserts and Desert Environments

6830.14 руб. или Купить в рассрочку!
Taking a global perspective, this book provides a concise overview of drylands, including their physical, biological, temporal, and human components. Examines the physical systems occurring in desert environments, including climate, hydrology, past and present lakes, weathering, hillslopes, geomorphic surfaces, water as a geomorphic agent, and aeolian processes Offers an accessible introduction to the physical, biological, temporal, and human components of drylands Investigates the nature, environmental requirements, and essential geomorphic roles of plants and animals in this stressful biological environment Highlights the impact of human population growth on climate, desertification, water resources, and dust storm activity Includes an examination of surface/atmosphere interactions and the impact of ENSO events.
Andrey Rubin B. Fundamentals of Biophysics Andrey Rubin B. Fundamentals of Biophysics Новинка

Andrey Rubin B. Fundamentals of Biophysics

15596.79 руб. или Купить в рассрочку!
Biophysics is a science that comprises theoretical plotting and models based on contemporary physicochemical conceptions. They mirror physical specificity of the molecular organization and elementary processes in living organisms, which in their turn form the molecular basis of biological phenomena. Presentation of a complete course in biophysics requires vast biological material as well as additional involvement of state-of-the-art concepts in physics, chemistry and mathematics. This is essential for the students to “perceive” the specific nature and peculiarity of molecular biological processes and see how this specificity is displayed in biological systems. This is the essence of the up-to-date biophysical approach to the analysis of biological processes. Fundamentals of Biophysics offers a complete, thorough coverage of the material in a straightforward and no-nonsense format, offering a new and unique approach to the material that presents the appropriate topics without extraneous and unneeded filler material.
James Larminie Electric Vehicle Technology Explained James Larminie Electric Vehicle Technology Explained Новинка

James Larminie Electric Vehicle Technology Explained

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Fully updated throughout, Electric Vehicle Technology, Second Edition, is a complete guide to the principles, design and applications of electric vehicle technology. Including all the latest advances, it presents clear and comprehensive coverage of the major aspects of electric vehicle development and offers an engineering-based evaluation of electric motor scooters, cars, buses and trains. This new edition includes: important new chapters on types of electric vehicles, including pickup and linear motors, overall efficiencies and energy consumption, and power generation, particularly for zero carbon emissions expanded chapters updating the latest types of EV, types of batteries, battery technology and other rechargeable devices, fuel cells, hydrogen supply, controllers, EV modeling, ancillary system design, and EV and the environment brand new practical examples and case studies illustrating how electric vehicles can be used to substantially reduce carbon emissions and cut down reliance on fossil fuels futuristic concept models, electric and high-speed trains and developments in magnetic levitation and linear motors an examination of EV efficiencies, energy consumption and sustainable power generation. MATLAB® examples can be found on the companion website www.wiley.com/go/electricvehicle2e Explaining the underpinning science and technology, this book is essential for practicing electrical, automotive, power, control and instrumentation engineers working in EV research and development. It is also a valuable reference for academics and students in automotive, mechanical, power and electrical engineering.
Gunter Mayer The Chemical Biology of Nucleic Acids Gunter Mayer The Chemical Biology of Nucleic Acids Новинка

Gunter Mayer The Chemical Biology of Nucleic Acids

14902.13 руб. или Купить в рассрочку!
With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.

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A thought-provoking exploration of deleterious mutations in the human genome and their effects on human health and wellbeing Despite all of the elaborate mechanisms that a cell employs to handle its DNA with the utmost care, a newborn human carries about 100 new mutations, originated in their parents, about 10 of which are deleterious. A mutation replacing just one of the more than three billion nucleotides in the human genome may lead to synthesis of a dysfunctional protein, and this can be inconsistent with life or cause a tragic disease. Several percent of even young people suffer from diseases that are caused, exclusively or primarily, by pre?]existing and new mutations in their genomes, including both a wide variety of genetically simple Mendelian diseases and diverse complex diseases such as birth anomalies, diabetes, and schizophrenia. Milder, but still substantial, negative effects of mutations are even more pervasive. As of now, we possess no means of reducing the rate at which mutations appear spontaneously. However, the recent flood of genomic data made possible by next-generation methods of DNA sequencing, enabled scientists to explore the impacts of deleterious mutations on humans with previously unattainable precision and begin to develop approaches to managing them. Written by a leading researcher in the field of evolutionary genetics, Crumbling Genome reviews the current state of knowledge about deleterious mutations and their effects on humans for those in the biological sciences and medicine, as well as for readers with only a general scientific literacy and an interest in human genetics. Provides an extensive introduction to the fundamentals of evolutionary genetics with an emphasis on mutation and selection Discusses the effects of pre-existing and new mutations on human genotypes and phenotypes Provides a comprehensive review of the current state of knowledge in the field and considers crucial unsolved problems Explores key ethical, scientific, and social issues likely to become relevant in the near future as the modification of human germline genotypes becomes technically feasible Crumbling Genome is must-reading for students and professionals in human genetics, genomics, bioinformatics, evolutionary biology, and biological anthropology. It is certain to have great appeal among all those with an interest in the links between genetics and evolution and how they are likely to influence the future of human health, medicine, and society.
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