cicer arietinum and vigna mungo antifungal ca afp gene and assays

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Findlay John W. Ligand-Binding Assays. Development, Validation, and Implementation in the Drug Development Arena Findlay John W. Ligand-Binding Assays. Development, Validation, and Implementation in the Drug Development Arena
:

Findlay John W. Ligand-Binding Assays. Development, Validation, and Implementation in the Drug Development Arena


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10890.75 руб.

A consolidated and comprehensive reference on ligand-binding assays Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in the pharmaceutical industry. Yet, outside of the Crystal City Conference proceedings, little guidance has been available for LBA validation, particularly for assays used to support macromolecule drug development. Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena answers that growing need, serving as a reference text discussing critical aspects of the development, validation, and implementation of ligand-binding assays in the drug development field. Ligand-Binding Assays covers essential topics related to ligand-binding assays, from pharmacokinetic studies, the development of LBAs, assay validation, statistical LBA aspects, and regulatory aspects, to software for LBAs and robotics and other emerging methodologies for LBAs. Highlights include: A general discussion of challenges and proven approaches in the development of ligand-binding assays More detailed examination of characteristics of these assays when applied to support of pharmacokinetic and toxicokinetic studies of compounds at different stages in the discovery or development timeline A concise, but detailed, discussion of validation of ligand-binding assays for macromolecules A practical approach to «fit-for-purpose» validation of assays for biomarkers, those molecules receiving increased attention as potentially demonstrating that the target chosen in discovery is being modulated by the candidate therapeutic, both in nonclinical and clinical studies Written by a team of world-recognized authorities in the field, Ligand-Binding Assays provides key information to a broad range of practitioners, both in the pharmaceutical and allied industries and in related contract research organizations and academic laboratories and, perhaps, even in the field of diagnostics and clinical chemistry.

Michael Corey J. Coupled Bioluminescent Assays. Methods, Evaluations, and Applications Michael Corey J. Coupled Bioluminescent Assays. Methods, Evaluations, and Applications
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Michael Corey J. Coupled Bioluminescent Assays. Methods, Evaluations, and Applications


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12446.57 руб.

This book highlights the applications of coupled bioluminescence assay techniques to real-world problems in drug discovery, environmental and chemical analysis, and biodefense. It separates theoretical aspects from the applied sections in a clear and readable way. Coupled Bioluminescent Assays, explains the uses of CB technologies across drug discovery to analyze toxicity, drug receptors, and enzymes. It covers applications in environmental analysis and biodefense, including cytotoxicity, fertilizer and explosives analysis, and nerve agent and pesticide detection. This is the premier reference on coupled bioluminescent assays for chemists, biochemists, and molecular biologists.

Li Yi Plant Gene Containment Li Yi Plant Gene Containment
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Li Yi Plant Gene Containment


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12831.64 руб.

Gene Containment provides a comprehensive look at genetically modified organisms and the strategies and implementation of key methods to gene containment. The book is divided into 5 parts: An Introduction that discusses the need for biotechnology and GMOs, Section 1 looks at the need for gene containment, Part II discusses varying strategies for gene containment, section III explores the assessment of gene containment approaches, and section IV covers the steps involved in implementing gene containment. Gene Containment will provide a thorough and up to date look at gene containment research and the needs for implementing new strategies in this arena.

Mien-Chie Hung Cancer Gene Therapy by Viral and Non-viral Vectors Mien-Chie Hung Cancer Gene Therapy by Viral and Non-viral Vectors
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Mien-Chie Hung Cancer Gene Therapy by Viral and Non-viral Vectors


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11619.63 руб.

Provides expert, state-of-the-art insight into the current progress of viral and non-viral gene therapy Translational medicine has opened the gateway to the era of personalized or precision medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. This book provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains how these are being used for gene-based cancer therapies. Designed as a volume in the Translational Oncology book series, Cancer Gene Therapy by Viral and Non-viral Vectors deals with the practice of gene-therapy, with reference to vectors for gene expression and gene transfer, as well as viral therapy. It covers the history and current and future applications of gene transfer in cancer, and provides expert insight on the progress of viral and non-viral gene therapy with regard to delivery system, vector design, potential therapeutic genes, and principles and regulations for cancer gene therapy. Presented in three parts, Cancer Gene Therapy by Viral and Non-viral Vectors covers: Delivery Systems • Translational Cancer Research: Gene Therapy by Viral and Non-viral Vectors • Retroviruses for Cancer Therapy • DNA Plasmids for Non-viral Gene Therapy of Cancer • Cancer Therapy with RNAi delivered by Non-viral Membrane/Core Nanoparticles Targeted Expression • Cancer Gene Therapy by Tissue-specific and Cancer-targeting Promptors • MicroRNAs as Drugs and Drug Targets in Cancer Principles of Clinical Trials in Gene Therapy • Regulatory issues for Manufacturers of Viral Vectors and Vector-transduced Cells for Phase I/II Trials • US Regulations Governing Clinical Trials in Gene Therapy • Remaining Obstacles to the Success of Cancer Gene Therapy Focusing on speeding the process in clinical cancer care by bringing therapies as quickly as possible from bench to bedside, Cancer Gene Therapy by Viral and Non-viral Vectors is an absolutely vital book for physicians, clinicians, researchers, and students involved in this area of medicine.

Douglas Bowman An Introduction To High Content Screening. Imaging Technology, Assay Development, and Data Analysis in Biology and Drug Discovery Douglas Bowman An Introduction To High Content Screening. Imaging Technology, Assay Development, and Data Analysis in Biology and Drug Discovery
:

Douglas Bowman An Introduction To High Content Screening. Imaging Technology, Assay Development, and Data Analysis in Biology and Drug Discovery


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9673.78 руб.

Using a collaborative and interdisciplinary author base with experience in the pharmaceutical industry and academia, this book is a practical resource for high content (HC) techniques. • Instructs readers on the fundamentals of high content screening (HCS) techniques • Focuses on practical and widely-used techniques like image processing and multiparametric assays • Breaks down HCS into individual modules for training and connects them at the end • Includes a tutorial chapter that works through sample HCS assays, glossary, and detailed appendices

Dittmar Katharina Evolution after Gene Duplication Dittmar Katharina Evolution after Gene Duplication
:

Dittmar Katharina Evolution after Gene Duplication


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9486.62 руб.

Gene duplication has long been believed to have played a major role in the rise of biological novelty through evolution of new function and gene expression patterns. The first book to examine gene duplication across all levels of biological organization, Evolution after Gene Duplication presents a comprehensive picture of the mechanistic process by which gene duplication may have played a role in generating biodiversity. Key Features: Explores comparative genomics, genome evolution studies and analysis of multi-gene families such as Hox, globins, olfactory receptors and MHC (immune system) A complete post-genome treatment of the topic originally covered by Ohno's 1970 classic, this volume extends coverage to include the fate of associated regulatory pathways Taps the significant increase in multi-gene family data that has resulted from comparative genomics Comprehensive coverage that includes opposing theoretical viewpoints, comparative genomics data, theoretical and empirical evidence and the role of bioinformatics in the study of gene duplication This up-to-date overview of theory and mathematical models along with practical examples is suitable for scientists across various levels of biology as well as instructors and graduate students.

Navjot Kaur Neural Stem Cell Assays Navjot Kaur Neural Stem Cell Assays
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Navjot Kaur Neural Stem Cell Assays


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11619.63 руб.

Neural stem cells offer a valuable model system for delineating the cellular and developmental processes in normal and diseased states of the central nervous system. In particular, neural stem cells have huge potential in regenerative medicine, owing to their expansion capability in culture and the ability to differentiate into multiple sub-neural lineages. Neural Stem Cell Assays provides a detailed and comprehensive review of the basic methods for neural stem cell cultures. Including an overview of progress in the field over the past decade, Neural Stem Cell Assays is a one-stop reference for consistent methods and reliable tools that span the entire assay work flow, from isolation or generation of neural stem cells to characterization, manipulation and final application of neural stem cells in disease paradigms such as Parkinson's disease, multiple sclerosis and amyotrophic lateral sclerosis. An excellent source of information for academic, pharmaceutical and biotechnology researchers who are new to the neural stem cell field, Neural Stem Cell Assays is an invaluable to experienced users who wish to integrate newly developed tools and technologies into their workflow. The book also covers important course material for students at the undergraduate and graduate level who are learning the basics of neural stem cell cultures, and differentiation to sub-neural lineages.

Martin Kussmann Nutrigenomics and Proteomics in Health and Disease. Towards a systems-level understanding of gene-diet interactions Martin Kussmann Nutrigenomics and Proteomics in Health and Disease. Towards a systems-level understanding of gene-diet interactions
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Martin Kussmann Nutrigenomics and Proteomics in Health and Disease. Towards a systems-level understanding of gene-diet interactions


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14997.66 руб.

Now in a revised second edition, Nutrigenomics and Proteomics in Health and Disease brings together the very latest science based upon nutrigenomics and proteomics in food and health. Coverage includes many important nutraceuticals and their impact on gene interaction and health. Authored by an international team of multidisciplinary researchers, this book acquaints food and nutrition professionals with these new fields of nutrition research and conveys the state of the science to date. Thoroughly updated to reflect the most current developments in the field, the second edition includes six new chapters covering gut health and the personal microbiome; gut microbe-derived bioactive metabolites; proteomics and peptidomics in nutrition; gene selection for nutrigenomic studies; gene-nutrient network analysis, and nutrigenomics to nutritional systems biology. An additional five chapters have also been significantly remodelled. The new text includes a rethinking of in vitro and in vivo models with regard to their translatability into human phenotypes, and normative science methods and approaches have been complemented by more comprehensive systems biology-based investigations, deploying a multitude of omic platforms in an integrated fashion. Innovative tools and methods for statistical treatment and biological network analysis are also now included.

The Extended Phenotype The Extended Phenotype
:

The Extended Phenotype


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1500 руб.

In The Selfish Gene, Richard Dawkins crystallized the gene's eye view of evolution developed by W.D. Hamilton and others. The book provoked widespread and heated...

Hitoshi Iba Evolutionary Computation in Gene Regulatory Network Research Hitoshi Iba Evolutionary Computation in Gene Regulatory Network Research
:

Hitoshi Iba Evolutionary Computation in Gene Regulatory Network Research


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10498.36 руб.

Introducing a handbook for gene regulatory network research using evolutionary computation, with applications for computer scientists, computational and system biologists This book is a step-by-step guideline for research in gene regulatory networks (GRN) using evolutionary computation (EC). The book is organized into four parts that deliver materials in a way equally attractive for a reader with training in computation or biology. Each of these sections, authored by well-known researchers and experienced practitioners, provides the relevant materials for the interested readers. The first part of this book contains an introductory background to the field. The second part presents the EC approaches for analysis and reconstruction of GRN from gene expression data. The third part of this book covers the contemporary advancements in the automatic construction of gene regulatory and reaction networks and gives direction and guidelines for future research. Finally, the last part of this book focuses on applications of GRNs with EC in other fields, such as design, engineering and robotics. • Provides a reference for current and future research in gene regulatory networks (GRN) using evolutionary computation (EC) • Covers sub-domains of GRN research using EC, such as expression profile analysis, reverse engineering, GRN evolution, applications • Contains useful contents for courses in gene regulatory networks, systems biology, computational biology, and synthetic biology • Delivers state-of-the-art research in genetic algorithms, genetic programming, and swarm intelligence Evolutionary Computation in Gene Regulatory Network Research is a reference for researchers and professionals in computer science, systems biology, and bioinformatics, as well as upper undergraduate, graduate, and postgraduate students. Hitoshi Iba is a Professor in the Department of Information and Communication Engineering, Graduate School of Information Science and Technology, at the University of Tokyo, Toyko, Japan. He is an Associate Editor of the IEEE Transactions on Evolutionary Computation and the journal of Genetic Programming and Evolvable Machines. Nasimul Noman is a lecturer in the School of Electrical Engineering and Computer Science at the University of Newcastle, NSW, Australia. From 2002 to 2012 he was a faculty member at the University of Dhaka, Bangladesh. Noman is an Editor of the BioMed Research International journal. His research interests include computational biology, synthetic biology, and bioinformatics.

Darius Dziuda M. Data Mining for Genomics and Proteomics. Analysis of Gene and Protein Expression Data Darius Dziuda M. Data Mining for Genomics and Proteomics. Analysis of Gene and Protein Expression Data
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Darius Dziuda M. Data Mining for Genomics and Proteomics. Analysis of Gene and Protein Expression Data


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8553.13 руб.

Data Mining for Genomics and Proteomics uses pragmatic examples and a complete case study to demonstrate step-by-step how biomedical studies can be used to maximize the chance of extracting new and useful biomedical knowledge from data. It is an excellent resource for students and professionals involved with gene or protein expression data in a variety of settings.

Paul Vigna The Truth Machine: The Blockchain and the Future of Everything Paul Vigna The Truth Machine: The Blockchain and the Future of Everything
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Paul Vigna The Truth Machine: The Blockchain and the Future of Everything


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831.7 руб.

From the authors of the fascinating The Age of Cryptocurrency, comes the definitive work on the Internet’s next big thing: the blockchain.Many of the ‘legacy systems’ once designed to make our lives easier and our economy more efficient are no longer up to the task; big banks have grown more entrenched, privacy exists only until the next hack, and credit card fraud has become a fact of life. However, there is a way past all this―a new kind of operating system with the potential to revolutionise our economy: the blockchain.In The Truth Machine, Michael J. Casey and Paul Vigna demystify the blockchain and explain why it can restore personal control over our data, assets, and identities; grant billions of excluded people access to the global economy; and shift the balance of power to revive society’s faith in itself. They reveal the empowerment possible when self-interested middlemen give way to the transparency of the blockchain, while highlighting the job losses, assertion of special interests, and threat to social cohesion that will accompany this shift. With a balanced perspective, Casey and Vigna show why we all must care about the path that blockchain technology takes―moving humanity forward, not backward.

Zhongwei Gu Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery Zhongwei Gu Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery
:

Zhongwei Gu Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery


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13497.9 руб.

Here, front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, encompassing small molecule delivery, delivery of therapeutic proteins and gene delivery. The carriers surveyed include polymeric, proteinaceous and lipid systems on the nanoscale, with a focus on their adaptability for different cargoes and target tissues. Thanks to the broad coverage of carriers as well as cargoes discussed, every researcher in the field will find valuable information here.

Ge Wu Assay Development. Fundamentals and Practices Ge Wu Assay Development. Fundamentals and Practices
:

Ge Wu Assay Development. Fundamentals and Practices


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12597.89 руб.

Essential principles and practice of assay development The first comprehensive, integrated treatment of the subject, Assay Development: Fundamentals and Practices covers the essentials and techniques involved in carrying out an assay project in either a biotechnology/drug discovery setting or a platform setting. Rather than attempting comprehensive coverage of all assay development technologies, the book introduces the most widely used assay development technologies and illustrates the art of assay development through a few commonly encountered biological targets in assay development (e.g., proteases, kinases, ion channels, and G protein-coupled receptors). Just enough biological background for these biological targets is provided so that the reader can follow the logics of assay development. Chapters discuss: The basics of assay development, including foundational concepts and applications Commonly used instrumental methods for both biochemical assays and cell-based assays Assay strategies for protein binding and enzymatic activity Cell-based assays High-throughput screening An in-depth study of the now popular Caliper's off-chip kinase assay provides an instructive, real-world example of the assay development process.

Ge Wu Assay Development. Fundamentals and Practices Ge Wu Assay Development. Fundamentals and Practices
:

Ge Wu Assay Development. Fundamentals and Practices


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13068.9 руб.

Essential principles and practice of assay development The first comprehensive, integrated treatment of the subject, Assay Development: Fundamentals and Practices covers the essentials and techniques involved in carrying out an assay project in either a biotechnology/drug discovery setting or a platform setting. Rather than attempting comprehensive coverage of all assay development technologies, the book introduces the most widely used assay development technologies and illustrates the art of assay development through a few commonly encountered biological targets in assay development (e.g., proteases, kinases, ion channels, and G protein-coupled receptors). Just enough biological background for these biological targets is provided so that the reader can follow the logics of assay development. Chapters discuss: The basics of assay development, including foundational concepts and applications Commonly used instrumental methods for both biochemical assays and cell-based assays Assay strategies for protein binding and enzymatic activity Cell-based assays High-throughput screening An in-depth study of the now popular Caliper's off-chip kinase assay provides an instructive, real-world example of the assay development process.

Nina Fedoroff V. Plant Transposons and Genome Dynamics in Evolution Nina Fedoroff V. Plant Transposons and Genome Dynamics in Evolution
:

Nina Fedoroff V. Plant Transposons and Genome Dynamics in Evolution


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16565.61 руб.

The transposable genetic elements, or transposons, as they are now known, have had a tumultuous history. Discovered in the mid-20th century by Barbara McClintock, they were initially received with puzzlement. When their genomic abundance began to be apparent, they were categorized as «junk DNA» and acquired the label of parasites. Expanding understanding of gene and genome organization has revealed the profound extent of their impact on both. Plant Transposons and Genome Dynamics in Evolution captures and distills the voluminous research literature on plant transposable elements and seeks to assemble the big picture of how transposons shape gene structure and regulation, as well as how they sculpt genomes in evolution. Individual chapters provide concise overviews of the many flavors of plant transposons and of their roles in gene creation, gene regulation, development, genome evolution, and organismal speciation, as well as of their epigenetic regulation. This volume is essential reading for anyone working in plant genetics, epigenetics, or evolutionary biology.

Frans Bruijn J.de Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria, 2 Volume Set Frans Bruijn J.de Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria, 2 Volume Set
:

Frans Bruijn J.de Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria, 2 Volume Set


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41244.28 руб.

Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA’s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable “cross-talk” between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.

Alister E. McGrath Dawkins' God. From The Selfish Gene to The God Delusion Alister E. McGrath Dawkins' God. From The Selfish Gene to The God Delusion
:

Alister E. McGrath Dawkins' God. From The Selfish Gene to The God Delusion


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2171.39 руб.

A fully updated new edition of a critically acclaimed examination of the theories and writings of Richard Dawkins by a world-renowned expert on the relation of science and religion Includes in-depth analysis of Dawkins’ landmark treatise The God Delusion (2006), as well as coverage of his later popular works The Magic of Reality (2011) and The Greatest Show on Earth (2011),and a new chapter on Dawkins as a popularizer of science Tackles Dawkins’ hostile and controversial views on religion, and examine the religious implications of his scientific ideas including a comprehensive investigation of the ‘selfish gene’ Written in an accessible and engaging style that will appeal to anyone interested in better understanding the interplay between science and religion

Patrizia Diana Biosynthesis of Heterocycles. From Isolation to Gene Cluster Patrizia Diana Biosynthesis of Heterocycles. From Isolation to Gene Cluster
:

Patrizia Diana Biosynthesis of Heterocycles. From Isolation to Gene Cluster


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15068.81 руб.

This book describes biosynthetic methods to synthesize heterocyclic compounds, offering a guide for the development of new drugs based on natural products. The authors explain the role of natural products in chemistry and their formation along with important analytical methods and techniques for working with heterocycles. • Covers methods and techniques: isotopic labelling, enzymes and mutants, and pathway identification • Provides a thorough resource of information specifically on heterocyclic natural products and their practical biosynthetic relevance • Explains the role of natural products in chemistry and their formation • Discusses gene cluster identification and the use of biogenetic engineering in pharmaceutical application

Vaidya Vishal S. Biomarkers. In Medicine, Drug Discovery, and Environmental Health Vaidya Vishal S. Biomarkers. In Medicine, Drug Discovery, and Environmental Health
:

Vaidya Vishal S. Biomarkers. In Medicine, Drug Discovery, and Environmental Health


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14157.98 руб.

This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson’s, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.

Туфли Gene Gene GE632AWEMIU8 Туфли Gene Gene GE632AWEMIU8
:

Туфли Gene Gene GE632AWEMIU8


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1920 руб.

Туфли Gene. Цвет: черный. Материал: искусственная кожа.Сезон: Весна-лето 2019. С бесплатной доставкой и примеркой на Lamoda.

Ботинки Gene Gene GE632AWCMWR1 Ботинки Gene Gene GE632AWCMWR1
:

Ботинки Gene Gene GE632AWCMWR1


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3910 руб.

Ботинки Gene. Цвет: синий. Материал: искусственная замша, искусственный мех.Сезон: Осень-зима 2018/2019. С бесплатной доставкой и примеркой на Lamoda.

Ботинки Gene Gene GE632AWCMWP2 Ботинки Gene Gene GE632AWCMWP2
:

Ботинки Gene Gene GE632AWCMWP2


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4670 руб.

Ботинки Gene. Цвет: зеленый. Материал: искусственная замша.Сезон: Осень-зима 2018/2019. С бесплатной доставкой и примеркой на Lamoda.

Дутики Gene Gene GE632AWCMWQ7 Дутики Gene Gene GE632AWCMWQ7
:

Дутики Gene Gene GE632AWCMWQ7


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3840 руб.

Дутики Gene. Цвет: бордовый. Материал: полиэстер.Сезон: Осень-зима 2018/2019. С бесплатной доставкой и примеркой на Lamoda.


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Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA’s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable “cross-talk” between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.
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