cook potassium channels structure classificati on function amp therapeutic potential



Christian Grimm Endolysosomal Cation Channels of the Transient Receptor Potential Superfamily Christian Grimm Endolysosomal Cation Channels of the Transient Receptor Potential Superfamily Новинка

Christian Grimm Endolysosomal Cation Channels of the Transient Receptor Potential Superfamily

Professorial Dissertation from the year 2014 in the subject Medicine - Pharmacology, grade: Passed, LMU Munich (Pharmacy/Pharmacology), language: English, abstract: Lysosomes are cell organelles involved in the breakdown of proteins, lipids, and other molecules and have been implicated not only in endolysosomal storage disorders (LSDs) such as mucolipidoses or mucopolysaccharidoses but also in metabolic diseases, neurodegenerative disorders such as Alzheimer's and Parkinson's disease, pigmentation disorders, or infectious diseases. Highly critical for the proper function of lysosomes, endosomes, and lysosome-related organelles is the tight regulation of various fusion and fission processes and the regulation of proton and other ionic concentrations within the endolysosomal system. Calcium permeable, non-selective cation channels of the TRP (transient receptor potential) superfamily, namely TRPML channels (mucolipins) and TPCs (two-pore channels) have been found to play important roles in these processes. This thesis provides insights into the function and physiology of TRPML and TPC channels, explains the molecular basis of pathologies associated with diseases caused by loss or mutation of these channels, and discusses potential therapeutic approaches.
Gomtsyan Arthur Vanilloid Receptor TRPV1 in Drug Discovery. Targeting Pain and Other Pathological Disorders Gomtsyan Arthur Vanilloid Receptor TRPV1 in Drug Discovery. Targeting Pain and Other Pathological Disorders Новинка

Gomtsyan Arthur Vanilloid Receptor TRPV1 in Drug Discovery. Targeting Pain and Other Pathological Disorders

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Examines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low back pain, neuropathic pain, and cancer pain, some consider it «the holy grail» of pain management. This dedicated reference summarizes available data related to the potential therapeutic utility for TRPV1 ligands. With contributions from many of the world's leading experts on TRP channels, Vanilloid Receptor TRPV1 in Drug Discovery covers the important TRPV1 target for drugs to treat painful conditions such as inflammation, arthritis, and cancer pain. The book discusses: Recent advances in biology, chemistry, and pharmacology at both the preclinical and clinical stage of the dynamic area of TRPV1 drug discovery research The potential for drugs targeting TRPV1 in painful conditions such as inflammation, arthritis, and cancer The development of analgesic drugs Other applications for TRPV1, including the treatment of respiratory disease and diabetes Featuring data relevant to the therapeutic potential of TRPV1 and the medicinal chemistry involved in designing TRPV1 antagonists, Vanilloid Receptor TRPV1 in Drug Discovery is a key tool for researchers in the pharmaceutical industry and academia involved in pain, ion channels, and analgesic drug development.
Kwok Chow Therapeutic Delivery Solutions Kwok Chow Therapeutic Delivery Solutions Новинка

Kwok Chow Therapeutic Delivery Solutions

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Provides a comprehensive review of all types of medical therapeutic delivery solutions from traditional pharmaceutical therapy development to innovative medical device therapy treatment to the recent advances in cellular and stem cell therapy development • Provides information to potentially allow future development of treatments with greater therapeutic potential and creativity • Includes associated regulatory requirements for the development of these therapies • Provides a comprehensive developmental overview on therapeutic delivery solutions • Provides overview information for both the general reader as well as more detailed references for professionals and specialists in the field
Botana Luis M. Therapeutic Targets. Modulation, Inhibition, and Activation Botana Luis M. Therapeutic Targets. Modulation, Inhibition, and Activation Новинка

Botana Luis M. Therapeutic Targets. Modulation, Inhibition, and Activation

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The Latest Applications For Cellmechanism Research in Drug Discovery Designed to connect research on cell mechanisms with the drug discovery process, Therapeutic Targets: Modulation, Inhibition, and Activation introduces readers to a range of new concepts and novel approaches to drug screening and therapeutic drug targeting to help inform future avenues of drug research. Highly topical, this accessible edited volume features chapters contributed by respected experts from around the globe. The book helps postgraduate students and professional scientists working in academia and industry understand the molecular mechanisms of pharmacology, current pharmacological knowledge, and future perspectives in drug discovery, focusing on important biochemical protein targets and drug targeting strategies for specific diseases. Examining the pharmacology of therapeutically undefined targets and their potential applications, it includes chapters on traditional therapeutic targets, including enzymes (phosphodiesterases and proteases), ion channels, and G protein-coupled receptors, as well as more recently identified avenues of exploration, such as lipids, nuclear receptors, gene promoters, and more. Since different diseases require different targeting techniques, the book also includes dedicated chapters on strategies for investigating Alzheimer's, diabetes, pain, and inflammation treatments. Concluding with a cross-sectional look at new approaches in drug screening, Therapeutic Targets is an invaluable resource for understanding where the next generation of drugs are likely to emerge.
J. Hardwick Marie The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria J. Hardwick Marie The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria Новинка

J. Hardwick Marie The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria

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This book presents advances in the field of neuronal mitochondria – functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases. • Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death • Offers insights on the development of strategies for targeted therapeutic approaches and potential personalized treatments • Includes examples of mitochondrial drugs, development, and mitochondria-targeted approaches for more efficient treatment methods and further developments in the field • Covers the model systems and approaches needed for the development of new drugs for the central nervous system to provide potential modern therapeutics for neurodegenerative disorders
Hugo Kubinyi Aspartic Acid Proteases as Therapeutic Targets Hugo Kubinyi Aspartic Acid Proteases as Therapeutic Targets Новинка

Hugo Kubinyi Aspartic Acid Proteases as Therapeutic Targets

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In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases. A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.
Kontush Anatol High-Density Lipoproteins. Structure, Metabolism, Function and Therapeutics Kontush Anatol High-Density Lipoproteins. Structure, Metabolism, Function and Therapeutics Новинка

Kontush Anatol High-Density Lipoproteins. Structure, Metabolism, Function and Therapeutics

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A complete guide to the role of high-density lipoproteins (HDL) in new and emerging therapies With high-density lipoproteins (HDL) playing an increasing role in cardiovascular disease prevention, there is a growing need for an in-depth look at HDL and its clinical value. This book summarizes the current state of knowledge in the field, providing for the first time a comprehensive, systematic, stylistically coherent, and up-to-date review of the composition, structure, heterogeneity, metabolism, epidemiology, genetics, and function of HDL. Divided into three main parts, High-Density Lipoproteins first examines normal HDL particles, then describes defective HDL, and finally addresses the therapeutic normalization of subnormal levels and defective biological activities of this lipoprotein class. The book highlights the functional properties of HDL, which are relevant to the pathophysiology of atherosclerosis and thrombosis, and discusses the compositional and metabolic heterogeneity of HDL particles. Readers will come away with a clear understanding of the role of HDL in biological processes, the potential value of functional HDL as a therapeutic target, and how current and emerging therapies are poised to influence the treatment of heart disease in the future.
Roland Kontermann Therapeutic Proteins. Strategies to Modulate Their Plasma Half-lives Roland Kontermann Therapeutic Proteins. Strategies to Modulate Their Plasma Half-lives Новинка

Roland Kontermann Therapeutic Proteins. Strategies to Modulate Their Plasma Half-lives

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For this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The result is a comprehensive work covering all approaches and aspects of the topic in one handy volume, making this indispensable reading for companies and research institutions working on the development of biopharmaceuticals.
Kunjumon I Vadakkan Semblance of activity at the shared postsynapses and extracellular matrices. A structure-function hypothesis of memory Kunjumon I Vadakkan Semblance of activity at the shared postsynapses and extracellular matrices. A structure-function hypothesis of memory Новинка

Kunjumon I Vadakkan Semblance of activity at the shared postsynapses and extracellular matrices. A structure-function hypothesis of memory

Semblance Hypothesis is a structure-function hypothesis that explains a possible way of brain function. Based on a definition of memory, the author hypothesize certain structural patterns of the dendritic spines, shows evidence for these structures from the literature and use inductive reasoning for their role in explaining memory and other brain functions.
Patrick Kullmann Managing Distribution Channels in 4 to 5 Star Hotels in Austria Patrick Kullmann Managing Distribution Channels in 4 to 5 Star Hotels in Austria Новинка

Patrick Kullmann Managing Distribution Channels in 4 to 5 Star Hotels in Austria

Diploma Thesis from the year 2003 in the subject Hotel Industry / Catering, grade: 1,5, Ecole hôtelière de Lausanne, 107 entries in the bibliography, language: English, comment: 1,5 (dt. Notensystem) entspricht in der Schweiz der Note 5,5 , abstract: This study summarises relevant literature on traditional and online distribution channels and gives an insight in the management of hotel's room reservation processing as well as potential consequences of intrinsic service failures. Since it was assumed that differences in distribution channel treatment do exist in hotels, investigation was focused on telephone and e-mail reservation channels as the ones with the strongest utilization rates. Therefore, hypothesises were formulated to undertake research on both channels in comparison to room reservation transformation rates, frequency of focal points of service failures and the potential influence of category, size and location as specific hotel characteristics. In order to carry out the investigation, an online questionnaire was established in co-operation with university and industry room reservation professionals. The actual study focused on the Austrian three to five star hotel segments since these categories were expected to provide all relevant investigated communication channels. The aim was to find comparable results to Swiss figures. Therefore, a sample of 800 hotels was contacted. 89 hotels or 11.4 per cent replied in total.The statistical analysis pointed out that t...
Levitan Irena Cholesterol Regulation of Ion Channels and Receptors Levitan Irena Cholesterol Regulation of Ion Channels and Receptors Новинка

Levitan Irena Cholesterol Regulation of Ion Channels and Receptors

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Examines new research on the role of cholesterol in regulating ion channels and receptors and its effect on health Drawing together and analyzing all the latest research findings, this book explores the role of cholesterol in the regulation of ion channels and receptors, including its pathological effects. It is the first book to comprehensively describe the complex mechanisms by which cholesterol regulates two major classes of membrane proteins. Moreover, it sheds new light on how cholesterol affects essential cellular functions such as the contraction of the heart, propagation of nerve impulses, and regulation of blood pressure and kidney function. Written and edited by leading pioneers in the field, Cholesterol Regulation of Ion Channels and Receptors is divided into three parts: Part I, Cholesterol Regulation of Membrane Properties, introduces the heterogeneity of cholesterol distribution in biological membranes and the physical and biological implications of the formation of cholesterol-rich membrane domains. Part II, Cholesterol Regulation of Ion Channels, examines the mechanisms underlying cholesterol sensitivities of ion channels, including the regulation of ion channels by cholesterol as a boundary lipid. Part III, Cholesterol Regulation of Receptors, explores the latest discoveries concerning how cholesterol regulates distinct types of receptors, including G-protein coupled receptors, LDL and scavenger receptors, and innate immune system receptors. Increased levels of cholesterol represent a major health risk. Understanding cholesterol regulation of ion channels and receptors is essential for facilitating the development of new therapeutic strategies to alleviate the impact of pathological cholesterol conditions. With this book as their guide, readers have access to the most current knowledge in the field.
Reichert Janice M. Handbook of Therapeutic Antibodies Reichert Janice M. Handbook of Therapeutic Antibodies Новинка

Reichert Janice M. Handbook of Therapeutic Antibodies

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Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well as their potential. Volumes 3 and 4 feature detailed and specific information about each antibody approved for therapeutic purposes, including clinical data. This unique handbook concludes with a compendium of marketed monoclonal antibodies and an extensive index. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.
Patapios Tranakas Implementation of a Central Electronic mail . Filing Structure Patapios Tranakas Implementation of a Central Electronic mail . Filing Structure Новинка

Patapios Tranakas Implementation of a Central Electronic mail . Filing Structure

The title of this book publication is: "Implementation of a Central Electronic mail & Filing Structure". This is the third edition published on 27.03.2014
Mohammed Khalid A.A. Pumps, Channels and Transporters. Methods of Functional Analysis Mohammed Khalid A.A. Pumps, Channels and Transporters. Methods of Functional Analysis Новинка

Mohammed Khalid A.A. Pumps, Channels and Transporters. Methods of Functional Analysis

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Describes experimental methods for investigating the function of pumps, channels and transporters Covers new emerging analytical methods used to study ion transport membrane proteins such as single-molecule spectroscopy Details a wide range of electrophysiological techniques and spectroscopic methods used to analyze the function of ion channels, ion pumps and transporters Covers state-of-the art analytical methods to study ion pumps, channels, and transporters, and where analytical chemistry can make further contributions
Sharma Nitika, Mukherjee Reena, Kumar Mishra Anil Preventive and Therapeutic Modalities for Control of Bovine Mastitis Sharma Nitika, Mukherjee Reena, Kumar Mishra Anil Preventive and Therapeutic Modalities for Control of Bovine Mastitis Новинка

Sharma Nitika, Mukherjee Reena, Kumar Mishra Anil Preventive and Therapeutic Modalities for Control of Bovine Mastitis

Mastitis, inflammation of mammary gland, is one of the most important diseases causing economic losses to dairy industry worldwide. Antibiotics are the only proven method of treatment against bovine mastitis. Presence of antibiotic residues in milk and food chain are the greatest disadvantage of use of antibiotics for the treatment of mastitis. In addition chemical teat dip residues pose another health hazards. Hence, it becomes necessary to develop new strategies for prophylaxis and treatment of mastitis. The study " Preventive and therapeutic modalities for control of bovine mastitis" was a step in this direction. The effect of 0.2% glutaraldehyde and Aloe vera teat dip on CMT point score and SCC was evaluated in 200 lactating cows for 90 days. Therapeutic efficacy of Amoxycillin, Sulbactam, vitamin E and selenium was judged on the basis of CMT point score and SCC. Antiinflammatory potential of vitamin E and selenium was adjudged by estimation of ceruloplasmin. Antioxidant potential was adjudged by estimation of catalase and glutathione peroxidase (GSH-Px) activity. Antibacterial potential of aqueous extract P. emblica was evaluated against S. aureus.
Kerry Atkinson The Biology and Therapeutic Application of Mesenchymal Cells - Set Kerry Atkinson The Biology and Therapeutic Application of Mesenchymal Cells - Set Новинка

Kerry Atkinson The Biology and Therapeutic Application of Mesenchymal Cells - Set

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The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues. • Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications • Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models • Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues • Written and edited by leaders in the field The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine. About the Author Kerry Atkinson, MBBS MD DTM&H FRCP FRACP, is an Adjunct Professor at the University of Queensland Centre for Clinical Research in Brisbane, Australia, an Adjunct Professor in the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia and a Specialist in Internal Medicine at the Salisbury Medical Centre, Brisbane, Queensland, Australia.
Brogden Kim Human Oral Mucosa. Development, Structure and Function Brogden Kim Human Oral Mucosa. Development, Structure and Function Новинка

Brogden Kim Human Oral Mucosa. Development, Structure and Function

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Human Oral Mucosa: Development, Structure and Function is a new text that reflects the considerable increase in knowledge of oral mucosa that has occurred in recent years. Our understanding of the structure of oral mucosa is now established at a molecular rather than a tissue or cellular level. This in turn has revealed a level of function that was previously not suspected, including a sophisticated barrier to the penetration of exogenous materials, and the synthesis of specific antimicrobial compounds, representing components of the innate immune system. There is also a growing realization of commonality in structure and function between regions of oral mucosa and the mucosae of the esophagus and vagina. The aim of the present volume is to provide a more sophisticated text on human oral mucosa than presently exists in textbooks and to bring together information that is otherwise to be found in separate, specialist volumes into a comprehensive text. It relates structure at the molecular, cellular and tissue level to function and to clinical behavior. The volume is directed to advanced students and researchers in oral biology, as well as those in allied areas of investigation, such as dermatology, gynecology, internal medicine and pathology.
Angela Gachassin M.Ed. Autism Therapeutic & Academic Children's Program Angela Gachassin M.Ed. Autism Therapeutic & Academic Children's Program Новинка

Angela Gachassin M.Ed. Autism Therapeutic & Academic Children's Program

Autism Therapeutic & Academic Children's Program was originally created, written, and used for her own son who was diagnosed with highly moderate to severe autism at the tender age of two and remained nonverbal until the age of six. Her autism children's program was the initial building block that began her son's advanced receptive and expressive language skills for effective communication as a nonverbal child and offered simple solutions to his many therapeutic and academic needs. This autism program focuses on developing, building, and strengthening necessary skills to attain proper child development both therapeutically and academically for autistic children. Angela created a "hands-on experience" supplies kit with over fifty different therapeutic and educational items that correlate directly with the 150-plus skills taught throughout the entire autism program for proven successful learning, progression, and mastery! Therapeutic and academic skills development will increase from a wide variety of opportunities for reinforcement to secure learning and advancement emotionally, socially, physically, therapeutically, and academically. The therapeutic content of the autism program focuses on phonics and language-vocabulary building, basic reading skills, beginner handwriting and tracing skills, sensory integration, gross motor skills, fine motor skills, play skills, art skills, music skills, social skills, and self-care development skills. The academic c...
Singh Nirmal, Kaur Japinder, Jaggi Amteshwar S K-Channels in cerebroprotective mechanism of ischemic postconditioning Singh Nirmal, Kaur Japinder, Jaggi Amteshwar S K-Channels in cerebroprotective mechanism of ischemic postconditioning Новинка

Singh Nirmal, Kaur Japinder, Jaggi Amteshwar S K-Channels in cerebroprotective mechanism of ischemic postconditioning

Stroke is the third most common cause of death and has profound negative social and economic effects. The failure, of various clinical trials of exogenously administered drugs as potential stroke therapy has enhanced the ongoing search to identify endogenous mechanisms activated after cerebral ischemia that might be harnessed as neuroprotectants in stroke. Postconditioning (PoCo), is an adaptive technique, whereby brief repetitive cycles of ischemia with intermittent reperfusion immediately following prolonged ischemia elicits tissue protection. Protective role of PoCo has been reported in different organs and animal species. PoCo is recently reported to produce some protective effects in clinical settings and hence it appears to hold great potential at clinical level. However usefulness of PoCo in cerebral ischemia & stroke remains to be explored so there is a need to investigate neuroprotective mechanism of PoCo. Present study investigates the role of K-channels in neuroprotective mechanism of PoCo. Delineating neuroprotective mechanism of PoCo will help in better understanding of its usefulness in ischemic stroke and boost the therapeutic management in a significant manner.
Claudia Rhodes Love Letters. Deep Affection; Fondness. Claudia Rhodes Love Letters. Deep Affection; Fondness. Новинка

Claudia Rhodes Love Letters. Deep Affection; Fondness.

1. “Moments in Time,” a model’s book2. “Style of Dress that Rocks, Fashion Zen Calm”3. “Easy on the Eye” Design & Dec. Made Simple4. “Snoot to Snoot” 3 pug dogs’ tail5. “Where You All From” Cook Book6. “Honor”7. The Sock Monkey & the Teddy Bear8. “Cavier & Dreams to Montrovane”Mary—Oriental Guerino
Liu Mo The Role Of Sting Liu Mo The Role Of Sting Новинка

Liu Mo The Role Of Sting

The book focuses on a novel potential biomarker, STING (Stimulator of Interferon Gene). STING was reported to be mutated in many types of cancers, but its role remains unclear in cancer development. Because of the importance of STING in type I IFNs pathway in innate immunity response, the book is trying to identify the role of STING in cancers especially the affection of its mutation on innate immunity response. The book provide a potential platform for further research to study STING as a potential biomarker for cancer, and a therapeutic target gene against tumorigenesis as well.
Christian Scholz The Role of KATP Channels in Models of Midbrain Dopaminergic Neuron Loss Christian Scholz The Role of KATP Channels in Models of Midbrain Dopaminergic Neuron Loss Новинка

Christian Scholz The Role of KATP Channels in Models of Midbrain Dopaminergic Neuron Loss

The dopaminergic neurons of the ventral midbrain (mesDA neurons) form several distinct sub-populations which are involved in emotional control, reward behaviour and motor control. In patients with Parkinson`s Disease, the dopaminergic neurons of the substantia nigra, pars compacta (SNpc) gradually die. One focus of research has been to find an explanation why the SNpc neurons are more vulnerable to cellular stress than other neuronal populations. KATP channels consist of Sur1 or 2 and Kir6.1 or 6.2 subunits and link the metabolic state of a cell to its membrane potential. Hypothetically, the normal open-closed state of KATP channels might influence cellular survival when the mesDA neurons are under oxidative stress. In this work, I show that blocking KATP channels in vitro by pharmaceutical means has a positive effect on cell survival when mesDA are under oxidative stress. Conversely, forced activation of KATP channels under these conditions leads to an increased rate of cell death. This highlights the importance of KATP channel function and may give a new direction in the development of drugs targeting Parkinson`s disease.
Gabriele Weydert-Bales Anwendungsbereiche von Therapeutic Touch im klinischen Bereich. Ubersicht und Effektivitat der Methode Gabriele Weydert-Bales Anwendungsbereiche von Therapeutic Touch im klinischen Bereich. Ubersicht und Effektivitat der Methode Новинка

Gabriele Weydert-Bales Anwendungsbereiche von Therapeutic Touch im klinischen Bereich. Ubersicht und Effektivitat der Methode

Akademische Arbeit aus dem Jahr 2013 im Fachbereich Pflegewissenschaften, Note: 1,0, Ernst-Abbe-Hochschule Jena, ehem. Fachhochschule Jena (Ernst-Abbe-Fachhochschule Jena), Sprache: Deutsch, Abstract: Die vorliegende Arbeit beschäftigt sich mit den Anwendungsbereichen von Therapeutic Touch in unterschiedlichen klinischen Bereichen und geht hierbei jeweils auf die Effektivität der Methode ein.Aufgrund der Literaturrecherche konnten die folgenden Anwendungsgebiete von Therapeutic Touch im klinischen Bereich identifiziert werden: Palliativmedizin (Aghabati, Mohammadi & Esmaiel 2008; Giasson & Bouchard 1998), im Bereich der Chirurgie (McCormack 2009; Heidt 1981a; Quinn 1984, 1989a; Smith, Reeder, Daniel, Baramee & Hagman 2003; Zare, Shahsavari & Moeini 2010), auf Verbrennungsstationen bzw. in Verbrennungskliniken (Busch et al., 2012; Turner, Clark, Gauthier & Williams 1998), im diagnostischen Bereich (Smith Frank et al., 2007), in der Neonatologie (Whitley & Rich 2008) und im psychiatrischen Bereich (Larden, Palmer & Janssen 2004).Eine detaillierte Darstellung der klinischen Anwendungsbereiche von Therapeutic Touch findet sich zudem in Tabelle 1 im Anhang der Arbeit. In Kapitel 1 wird auf das Studiendesign und die Anwendungsbereiche eingegangen, die Ergebnisse werden gesondert bezogen auf die jeweiligen Anwendungsbereiche zusammenfassend in Kapitel 2 dargestellt.
Gupta Varsha Performance Improvement of Rmpa by Artificial Meta-Material Structure Gupta Varsha Performance Improvement of Rmpa by Artificial Meta-Material Structure Новинка

Gupta Varsha Performance Improvement of Rmpa by Artificial Meta-Material Structure

This book presents a new design of compact microstrip antennas, where metamaterial are placed on structure substrate, have been proposed.The newly designed microstrip provide an optimized patch area resulting into a substantial reduction in size compared to a typical microstrip patch designed at the same frequency of operation.The antenna potential characteristics such as return loss,gain and bandwidth has been calculated for the proposed antenna system and measurement has been done by FS-315 spectrum analyzer and SWR Bridge.
Andreas Goetz W. Electronic Structure Calculations on Graphics Processing Units. From Quantum Chemistry to Condensed Matter Physics Andreas Goetz W. Electronic Structure Calculations on Graphics Processing Units. From Quantum Chemistry to Condensed Matter Physics Новинка

Andreas Goetz W. Electronic Structure Calculations on Graphics Processing Units. From Quantum Chemistry to Condensed Matter Physics

11184.12 руб. или Купить в рассрочку!
Electronic Structure Calculations on Graphics Processing Units: From Quantum Chemistry to Condensed Matter Physics provides an overview of computing on graphics processing units (GPUs), a brief introduction to GPU programming, and the latest examples of code developments and applications for the most widely used electronic structure methods. The book covers all commonly used basis sets including localized Gaussian and Slater type basis functions, plane waves, wavelets and real-space grid-based approaches. The chapters expose details on the calculation of two-electron integrals, exchange-correlation quadrature, Fock matrix formation, solution of the self-consistent field equations, calculation of nuclear gradients to obtain forces, and methods to treat excited states within DFT. Other chapters focus on semiempirical and correlated wave function methods including density fitted second order Møller-Plesset perturbation theory and both iterative and perturbative single- and multireference coupled cluster methods. Electronic Structure Calculations on Graphics Processing Units: From Quantum Chemistry to Condensed Matter Physics presents an accessible overview of the field for graduate students and senior researchers of theoretical and computational chemistry, condensed matter physics and materials science, as well as software developers looking for an entry point into the realm of GPU and hybrid GPU/CPU programming for electronic structure calculations.
Brian Henderson Moonlighting Proteins. Novel Virulence Factors in Bacterial Infections Brian Henderson Moonlighting Proteins. Novel Virulence Factors in Bacterial Infections Новинка

Brian Henderson Moonlighting Proteins. Novel Virulence Factors in Bacterial Infections

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Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections is a complete examination of the ways in which proteins with more than one unique biological action are able to serve as virulence factors in different bacteria. The book explores the pathogenicity of bacterial moonlighting proteins, demonstrating the plasticity of protein evolution as it relates to protein function and to bacterial communication. Highlighting the latest discoveries in the field, it details the approximately 70 known bacterial proteins with a moonlighting function related to a virulence phenomenon. Chapters describe the ways in which each moonlighting protein can function as such for a variety of bacterial pathogens and how individual bacteria can use more than one moonlighting protein as a virulence factor. The cutting-edge research contained here offers important insights into many topics, from bacterial colonization, virulence, and antibiotic resistance, to protein structure and the therapeutic potential of moonlighting proteins. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections will be of interest to researchers and graduate students in microbiology (specifically bacteriology), immunology, cell and molecular biology, biochemistry, pathology, and protein science. About the Editor Brian Henderson, Division of Infection and Immunity, University College London, London, UK
Edward Hammond Clarke The Physiological and Therapeutic Action of the Bromide of Potassium and Bromide of Ammonium . Edward Hammond Clarke The Physiological and Therapeutic Action of the Bromide of Potassium and Bromide of Ammonium . Новинка

Edward Hammond Clarke The Physiological and Therapeutic Action of the Bromide of Potassium and Bromide of Ammonium .

Эта книга — репринт оригинального издания, созданный на основе электронной копии высокого разрешения, которую очистили и обработали вручную, сохранив структуру и орфографию оригинального издания. Редкие, забытые и малоизвестные книги, изданные с петровских времен до наших дней, вновь доступны в виде печатных книг.
Ahmed Mousa The Electric Power System. Generation, Transmission . Distribution Made Simple Ahmed Mousa The Electric Power System. Generation, Transmission . Distribution Made Simple Новинка

Ahmed Mousa The Electric Power System. Generation, Transmission . Distribution Made Simple

This book provides the needed industry practical knowledge related to generation (function, types, steam cylce & critical plant components), transmission (function, design, reliability)& distribution systems (radial, loops, network, reliability), substation (equipment/buses, function & design), transformers (different types, function & ratings), protection, distributed energy resources (solar impact & other DERs), protection (various relays & instrument transformers), reliability, distribution designs, storm response, climate change, blackouts, real & reactive power, load flow (power transfer, normal/emergency system operation) & utility of the future . This book will discuss major electric components from the power plants to the consumer's home.
Edward Hammond Clarke The Physiological and Therapeutic Action of the Bromide of Potassium and . Edward Hammond Clarke The Physiological and Therapeutic Action of the Bromide of Potassium and . Новинка

Edward Hammond Clarke The Physiological and Therapeutic Action of the Bromide of Potassium and .

Эта книга — репринт оригинального издания (издательство "J. Campbell", 1872 год), созданный на основе электронной копии высокого разрешения, которую очистили и обработали вручную, сохранив структуру и орфографию оригинального издания. Редкие, забытые и малоизвестные книги, изданные с петровских времен до наших дней, вновь доступны в виде печатных книг.
Karsten Rippe Genome Organization And Function In The Cell Nucleus Karsten Rippe Genome Organization And Function In The Cell Nucleus Новинка

Karsten Rippe Genome Organization And Function In The Cell Nucleus

14324.92 руб. или Купить в рассрочку!
By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair, recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions and non-coding RNAs, chromatin structure, epigenetics and nuclear organization. With its focus on fundamental mechanisms and the associated biomolecules, this will remain essential reading for years to come.
Arthur Hand R. Fundamentals of Oral Histology and Physiology Arthur Hand R. Fundamentals of Oral Histology and Physiology Новинка

Arthur Hand R. Fundamentals of Oral Histology and Physiology

5431.78 руб. или Купить в рассрочку!
Fundamentals of Oral Histology and Physiology is a landmark new text streamlining the essentials of histology and physiology into one clinically accessible textbook. Written for predoctoral dental students, the book brings together structure, function, and clinical correlations for maximum retention and ease of use. Assuming a background in basic biologic sciences, this text focuses on the histology and physiology that students need to know to practice dentistry and to understand and evaluate the current literature, without repeating basic information learned in other courses. Fundamentals of Oral Histology and Physiology concentrates on Oral Structures and Features, including Development, Teeth, Tooth and Jaw Support, Mucosal Structure and Function, and Effectors.
Roy Sabyasachi, Choudhury Dilip Kr. Heavy Flavoured Mesons in Higher Dimension Roy Sabyasachi, Choudhury Dilip Kr. Heavy Flavoured Mesons in Higher Dimension Новинка

Roy Sabyasachi, Choudhury Dilip Kr. Heavy Flavoured Mesons in Higher Dimension

The book culminates theoretical and phenomenological studies on mesons, specifically, heavy-flavoured mesons in the light of non-perturbative phenomenological potential model inspired by Nambu strings. Within the potential model approach, higher dimensional non-relativistic Schrödinger equation is used to get the meson wave function which is then further utilized to study static and dynamic properties of heavy flavoured mesons. The book mainly concentrates on the studies of Isgur-Wise Function and its derivatives like slope and curvature of heavy-light pseudo-scalar mesons. Mass being a fundamental property of a physical system, a part of the book is also devoted to the studies of masses of heavy flavoured mesons in higher dimension.
Kniely Michael Loop and Surface Representations for Finite Density Lattice QED Kniely Michael Loop and Surface Representations for Finite Density Lattice QED Новинка

Kniely Michael Loop and Surface Representations for Finite Density Lattice QED

We investigate a dual formulation of quantum electrodynamics (QED) on the lattice with finite chemical potential. This formulation replaces the conventional degrees of freedom, which are defined on the sites and links of the lattice, by loops and plaquettes on the lattice. These new variables are the dual degrees of freedom. When using the conventional variables, the partition function is an integral over Boltzmann factors, which are complex if the chemical potential is different from zero. Thus, they cannot be employed as a probability weight in a Monte Carlo simulation. But if one uses appropriate dual variables, then the partition function turns into an infinite sum over real quantities, also in the case of a non-trivial chemical potential. We show that all summands are even strictly positive if we restrict ourselves to a certain class of loops. Now, each term of this partition sum can be interpreted as a probability weight for the corresponding dual configuration of loops and plaquettes. This allows us to run a Monte Carlo simulation and to explore various observables for the case of a finite chemical potential.
Olusegun Emmanuel Afolabi Clinical Significance. A Therapeutic Approach to Psychological Assessment in Treatment Planning Olusegun Emmanuel Afolabi Clinical Significance. A Therapeutic Approach to Psychological Assessment in Treatment Planning Новинка

Olusegun Emmanuel Afolabi Clinical Significance. A Therapeutic Approach to Psychological Assessment in Treatment Planning

Research Paper (undergraduate) from the year 2014 in the subject Psychology - Clinic and Health Psychology, Abnormal Psychology, grade: A, Atlantic International University (School of Social and Human Studies), course: Personality Assessment, language: English, abstract: Psychological assessment has long been reported as a key component of clinical psychology. This paper examined and shed light on the complexities surrounding the clinical significance of therapeutic approach to treatment Planning. To achieve this objective, the paper searched and used the PsycINFO and PubMed databases and the reference sections of chapters and journal articles to analysed the underlying themes: 1) a strong basis for the usage of therapeutic approach to psychological assessment in treatment plans, 2) explained the conceptual meaning of clinical significant change in therapeutic assessment, 3) answered some of the questions regarding practicability and the clinical significance of therapeutic approach to treatment plans, particularly during or before treatment, 4) linked therapeutic assessment to change in clients' clinical impression, functioning and therapeutic needs, 5) used initial theory to explain the therapeutic mechanisms of change in clinical practice, 6) analysed the empirically documenting clinically significant change in therapeutic assessment. Finally, the study suggested that though therapeutic assessment is not sufficient for the systematic study of psychotherapy outcome and ...
Mohammad Abdul Salam Effect of Preservation Methods on Giant Freshwater Prawn Mohammad Abdul Salam Effect of Preservation Methods on Giant Freshwater Prawn Новинка

Mohammad Abdul Salam Effect of Preservation Methods on Giant Freshwater Prawn

Master's Thesis from the year 2004 in the subject Biology - Zoology, grade: M SC, Jahangirnagar University (Faculty of Biological Sciences), course: Fisheries (Zoology), language: English, abstract: To inquest a pertinent technology of preservation seasonal (summer, autumn, winter) nutritive values, effects of potassium sorbate, gamma radiation and their combinations preserved at low temperature on sensory, chemical and microbial properties of freshwater prawn (Macrobrachium rosenbergii, de Man-1879) as well as isolation and identification of associated micro-flora with their sensitivity to potassium sorbate and gamma radiation were investigated during February 2003 to April 2004. Nutritive analysis marked seasonal and body-part variations in moisture, protein, lipid, ash, calcium and phosphorus contents i.e., summer, autumn and winter as 80.07%, 80.37%, 76.99%; 19.20%, 18.03%, 21.30%; 1.23%, 1.07%, 2.99%; 1.48%, 2.00%, 1.21%; 0.19%, 0.21%, 0.14% and 0.10%, 0.08% & 0.10% in edible-part while 77.27%, 76.27%, 73.34%; 16.45%, 17.03%, 19.79%; 1.40%, 1.02%, 4.33%; 6.60%, 7.33%, 6.25%; 2.24%, 2.78%, 1.67% and 0.17%, 0.15% & 0.21% in head-on respectively. Quality appraisal of treated (potassium sorbate-2%, gamma radiation-2kGy and their combination) and preserved (00C and 40C) samples were done by organoleptic, chemical and microbial evaluation at an interval of 7 days. The shelf life of freshwater prawn at 40C was 14-21 days which was extended to 21-28 days at 00C. Maxi...
сотейник ILLA Cook on Rock Induction 28 см антипр. кам. покр. алюм. индукц. сотейник ILLA Cook on Rock Induction 28 см антипр. кам. покр. алюм. индукц. Новинка

сотейник ILLA Cook on Rock Induction 28 см антипр. кам. покр. алюм. индукц.

Cook on Rock Induction Диаметр: 28 см Покрытие: с каменной крошкой Whitford Материал сковороды: алюминий Индукция: да Материал ручки: бакелит
сковорода ILLA Cook on Rock Induction 20 см антипр. кам. покр. алюм. индукц. сковорода ILLA Cook on Rock Induction 20 см антипр. кам. покр. алюм. индукц. Новинка

сковорода ILLA Cook on Rock Induction 20 см антипр. кам. покр. алюм. индукц.

Cook on Rock Induction Диаметр: 20 см Покрытие: с каменной крошкой Whitford Материал сковороды: алюминий Индукция: да Материал ручки: бакелит
Christof W. Ernst Evaluation of Tax Incentives for Research and Development in Germany Christof W. Ernst Evaluation of Tax Incentives for Research and Development in Germany Новинка

Christof W. Ernst Evaluation of Tax Incentives for Research and Development in Germany

Germany has currently no explicit form of tax incentive for R&D as they exist in many other countries. The objective of this study is to analyse and evaluate aspects that are important when an R&D tax incentive shall be established in Germany. The study is done both from a business and from an economic policy point of view. It broadens the focus to an European perspective, where the results can be of use in other countries. The study derives relevant research questions and outlines a framework for the evaluation of R&D tax incentives. It provides an overview on the different forms of R&D tax incentives in EU member states in 2010. A discussion then outlines potential models that could be used in Germany.A focus is on the analysis of the incentive's impact on the firm's total tax payments and on the R&D cost by means of a simulation model. Sensitivity analyses use different economic settings and model firms. Another focus is on the empirical analysis of effects from R&D tax incentives and corporate income tax burden on patenting behaviour by using firm-specific patent applications at the European Patent Office (EPO). A substantiated political discussion necessarily needs a projection of potential budgetary costs. Thus, the last focus is on the tax burden and on the overall fiscal costs and applies a micro-simulation model based on a financial statements database to quantify the effects induced by the various models of an R&D tax credit.
Ashraf Abueed Pricing Behavior on the Web. Luxury Hotels in Germany Ashraf Abueed Pricing Behavior on the Web. Luxury Hotels in Germany Новинка

Ashraf Abueed Pricing Behavior on the Web. Luxury Hotels in Germany

Master's Thesis from the year 2014 in the subject Tourism, grade: 1,3, Munich University of Applied Sciences, course: Hospitality Management, language: English, abstract: The prominence of the web as a distribution channel for hotel rooms as well as its transparency and ease for price comparison create a need for the hoteliers to think strategically in terms of rate setting and pricing practices on numerous web-based distribution channels. The overarching purpose of this exploratory study is to inves-tigate the current online pricing practices of luxury hotels in Germany and to explore potential challenges that they face in distributing their rooms on the web. The data covering 29 hotels in the top 4 primary cities in Germany was collected from 11 B2C, web-based distribution channels over a 26-day period at 6 separate points in time leading up to predetermined arrival date. These channels, including the hotels' own websites along with 10 indirect channels, represent various types of operation. The data were analyzed by means of descriptive statistics. Personal interviews with the regional director of revenue management and the regional web & e-commerce executive of an international hotel company were conducted to support the findings and to gain supplemental insights into the relevant issues. Key findings of this study were that a complete rate consistency did not exist across the utilized channels, and that a customer who surfs the web for a particular hotel may ...
сковорода ILLA Cook on Rock Induction 24 см антипр. кам. покр. алюм. индукц. сковорода ILLA Cook on Rock Induction 24 см антипр. кам. покр. алюм. индукц. Новинка

сковорода ILLA Cook on Rock Induction 24 см антипр. кам. покр. алюм. индукц.

Cook on Rock Induction Диаметр: 24 см Покрытие: с каменной крошкойWhitfordМатериал сковороды: алюминий Индукция: да Материал ручки: бакелит
Rosalyn Kliot Cook and Color for Comfort Rosalyn Kliot Cook and Color for Comfort Новинка

Rosalyn Kliot Cook and Color for Comfort

This book is designed for all ages who love to cook and color. The recipes are easy, and the coloring pages appeal to various levels of skill. Note pages are added for personal comments or additional recipes. Gluten free recipes are included. Coloring and cooking are enjoyable activities and may have therapeutic benefits. The artist is both a Certified Vocational Counselor and Professional Artist.Make this your custom recipe book, or give as a gift. Enjoy!
Joseph Bertolini Production of Plasma Proteins for Therapeutic Use Joseph Bertolini Production of Plasma Proteins for Therapeutic Use Новинка

Joseph Bertolini Production of Plasma Proteins for Therapeutic Use

12279.93 руб. или Купить в рассрочку!
Sets forth the state of the science and technology in plasma protein production With contributions from an international team of eighty leading experts and pioneers in the field, Production of Plasma Proteins for Therapeutic Use presents a comprehensive overview of the current state of knowledge about the function, use, and production of blood plasma proteins. In addition to details of the operational requirements for the production of plasma derivatives, the book describes the biology, development, research, manufacture, and clinical indications of essentially all plasma proteins with established clinical use or therapeutic potential. Production of Plasma Proteins for Therapeutic Use covers the key aspects of the plasma fractionation industry in five sections: Section 1: Introduction to Plasma Fractionation initially describes the history of transfusion and then covers the emergence of plasma collection and fractionation from its earliest days to the present time, with the commercial and not-for-profit sectors developing into a multi-billion dollar industry. Section 2: Plasma Proteins for Therapeutic Use contains 24 chapters dedicated to specific plasma proteins, including coagulation factors, albumin, immunoglobulin, and a comprehensive range of other plasma-derived proteins with therapeutic indications. Each chapter discusses the physiology, biochemistry, mechanism of action, and manufacture of each plasma protein including viral safety issues and clinical uses. Section 3: Pathogen Safety of Plasma Products examines issues and procedures for enhancing viral safety and reducing the risk of transmissible spongiform encephalopathy transmission. Section 4: The Pharmaceutical Environment Applied to Plasma Fractionation details the requirements and activities associated with plasma collection, quality assurance, compliance with regulatory requirements, provision of medical affairs support, and the manufacture of plasma products. Section 5: The Market for Plasma Products and the Economics of Fractionation reviews the commercial environment and economics of the plasma fractionation industry including future trends, highlighting regions such as Asia, which have the potential to exert a major influence on the plasma fractionation industry in the twenty-first century.
сковорода ILLA Cook on Rock Induction 28 см антипр. кам. покр. алюм. индукц. сковорода ILLA Cook on Rock Induction 28 см антипр. кам. покр. алюм. индукц. Новинка

сковорода ILLA Cook on Rock Induction 28 см антипр. кам. покр. алюм. индукц.

Cook on Rock Induction Диаметр: 28 см Покрытие: с каменной крошкой Whitford Материал сковороды: алюминий Индукция: да Материал ручки: бакелит
сотейник ILLA Cook on Rock Induction 24 см антипр. кам. покр. алюм. индукц. сотейник ILLA Cook on Rock Induction 24 см антипр. кам. покр. алюм. индукц. Новинка

сотейник ILLA Cook on Rock Induction 24 см антипр. кам. покр. алюм. индукц.

Cook on Rock Induction Диаметр: 24 см Покрытие: с каменной крошкой Whitford Материал сковороды: алюминий Индукция: да Материал ручки: бакелит
Alexander Zuber Export Channel Integration Decisions of Small and Medium-sized Enterprises. A Literature Review Alexander Zuber Export Channel Integration Decisions of Small and Medium-sized Enterprises. A Literature Review Новинка

Alexander Zuber Export Channel Integration Decisions of Small and Medium-sized Enterprises. A Literature Review

Bachelor Thesis from the year 2013 in the subject Business economics - Trade and Distribution, grade: 1,0, Vienna University of Economics and Business (Institute for International Business), language: English, abstract: "The opportunities for channel researchers to contribute to knowledge creation in the marketing discipline and, at the same time, affect business practice are almost endless" (Frazier 1999, p.238). While the theoretical understanding of the internationalization and international marketing strategies of large firms has been in the focus of research since a long time, attention has been given only recently to investigate the same questions for small and medium-sized enterprises (SMEs). Exporters need to question their export channel structure every day in order to remain successful. Should the product be distributed directly or indirectly? Which way is more efficient, effective and/or profitable? Should export channels be changed? (John & Weitz 1988, Huan & Hsu 2003). The decision on channel integration, the extent to which the export channel is performed by the exporting firm without intermediaries, is extremely important, as it affects revenues, investments and costs (Shervani, Frazier & Challagalla 2007). As a research field, export channel structure is vital for two groups. First, there are scholars trying to find evidence for applied theories, and second, managers attempting to reduce risks and improve export performance. Wrong decisions...
Carlton Doc Holliday Finding Cover and Structure for Bass Carlton Doc Holliday Finding Cover and Structure for Bass Новинка

Carlton Doc Holliday Finding Cover and Structure for Bass

A how to manual for finding structure and cover for bass fishing by general lake tendencies of bass and their life cycle. Also has sections on Techniques for bass fishing, environment effects on bass, how to fish cover and structure and how to build your own brush piles.
Etsuro Uemura E. Fundamentals of Canine Neuroanatomy and Neurophysiology Etsuro Uemura E. Fundamentals of Canine Neuroanatomy and Neurophysiology Новинка

Etsuro Uemura E. Fundamentals of Canine Neuroanatomy and Neurophysiology

7441.96 руб. или Купить в рассрочку!
Fundamentals of Canine Neuroanatomy and Neurophysiology introduces the fundamentals of veterinary neuroanatomy and neurophysiology, demonstrating structure and function as it relates to clinical applications with a highly visual approach. Offers a straightforward yet comprehensive introduction to structure and function of the nervous system Demonstrates the relevance of the basic principles to the clinical setting Illustrates concepts using line drawings, photographs, micrographs, and MRIs Includes access to a companion website with review questions and answers and the figures from the book at www.wiley.com/go/uemura/neuroanatomy
Charles Waller A practical treatise on the function and diseases of the unimpregnated womb Charles Waller A practical treatise on the function and diseases of the unimpregnated womb Новинка

Charles Waller A practical treatise on the function and diseases of the unimpregnated womb

Эта книга — репринт оригинального издания (издательство "London : Churchill", 1840 год), созданный на основе электронной копии высокого разрешения, которую очистили и обработали вручную, сохранив структуру и орфографию оригинального издания. Редкие, забытые и малоизвестные книги, изданные с петровских времен до наших дней, вновь доступны в виде печатных книг.A practical treatise on the function and diseases of the unimpregnated womb. Illustrated by plates, &c.. With a chapter on leucorrhoea, fluor albus, or 'weakness'.
Prairna Gupta Sustainable Tall Building Prairna Gupta Sustainable Tall Building Новинка

Prairna Gupta Sustainable Tall Building

'Sustainable Tall Buildings', 'Self Sufficient Ultra-tall Towers', 'Tall & Green Architecture' etc. are expressions used by architects and engineers to conceptualize and/or define building designs. Whatever the building may be called, the structure has to sustain it. The primary argument is in relation to what constitutes a sustainable tall building. Most architects focus on sustainability from the standpoint of the architectural expression and/or the mechanical systems. The design of the structure is often given less significance in the sustainable strategy of the project as structure by its very nature is considered the most sustainable component in a tall building. However, it needs to be realized that certain design strategies can be adopted to enhance the sustainable performance of the structure in a tall building.
Anthony Morgan The basics of business Anthony Morgan The basics of business Новинка

Anthony Morgan The basics of business

This is a small guide to help the new potential business owner find resources that they may not be made aware of. This guide contains small briefs about business structure, marketing, business, ethics, and any last minute questions that the new business owner may have. I touch on my own personal experience as a business owner as well as the beginning stages of a business plan. This guide should be used as a reference, maybe you're not sure where to find something and this guide may have touched on it.
Timothy J Smith How to Profit and Protect Yourself from Artificial Intelligence Timothy J Smith How to Profit and Protect Yourself from Artificial Intelligence Новинка

Timothy J Smith How to Profit and Protect Yourself from Artificial Intelligence

The rapidly growing impact of artificial intelligence permeates our lives through multiple channels from the tech giants such as Amazon, Google, and Facebook to the computers controlling our cars, smartphones, and robots on the factory floor. Analysts project massive disruption in employment from this new technology with many jobs being automated in the next twenty years. The era of artificial intelligence is upon us, and the potential for great profits to society, business, and individuals stems from advances in transportation, healthcare, and manufacturing. The potential for profit stands in contrast to the possible dangers to our jobs, privacy, society and more. Don’t stand on the sidelines. Learn the potentials and limitations of this new technology to best position yourself, your family, and your career for profit and protection in the new era of A.I.
Dietmar Siemann W. Tumor Microenvironment Dietmar Siemann W. Tumor Microenvironment Новинка

Dietmar Siemann W. Tumor Microenvironment

12813.26 руб. или Купить в рассрочку!
The microenvironment in which a tumor originates plays a critical role in its initiation and progression. Tumor Microenvironment reviews the importance of tumor microenvironment in cancer management. Particular emphasis is placed on discussing how the unique characteristics of the tumor microenvironment not only impact disease progression and response to conventional anticancer therapies, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. Tumor Microenvironment also reviews the fundamental basis of target development, preclinical assessment, and the current clinical status of these therapies.
Karim Rubaba The Targeting of Cypd to Identify Novel Cardioprotective Agent Karim Rubaba The Targeting of Cypd to Identify Novel Cardioprotective Agent Новинка

Karim Rubaba The Targeting of Cypd to Identify Novel Cardioprotective Agent

The aim of this book is to provide novel hits for the target CypD that could be used with further optimization in future as the potential therapeutic strategy against cardiovascular disease. The study involved both in silico and in vitro analysis. To do this, fluorescence-based thermal shift assay was employed to screen compounds against CypD that were identified by computer aided docking screen (virtual screening). The assay revealed in vitro interactions (based on the binding affinity) of these novel compounds with the protein target (CypD).
James Cook, James King Charts of A Voyage to the Pacific Ocean by James Cook James Cook, James King Charts of A Voyage to the Pacific Ocean by James Cook Новинка

James Cook, James King Charts of A Voyage to the Pacific Ocean by James Cook

Narrative of the famous voyage of Captain James Cook and his collegues Clerke, Gore and King in the years 1776 to 1780 around the world on board of the "Resolution" and "Discovery". This volume contains the charts.
Dietmar Siemann W. Tumor Microenvironment Dietmar Siemann W. Tumor Microenvironment Новинка

Dietmar Siemann W. Tumor Microenvironment

12648.5 руб. или Купить в рассрочку!
The microenvironment in which a tumor originates plays a critical role in its initiation and progression. Tumor Microenvironment reviews the importance of tumor microenvironment in cancer management. Particular emphasis is placed on discussing how the unique characteristics of the tumor microenvironment not only impact disease progression and response to conventional anticancer therapies, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. Tumor Microenvironment also reviews the fundamental basis of target development, preclinical assessment, and the current clinical status of these therapies.
Matthias Patzold Mobile Radio Channels Matthias Patzold Mobile Radio Channels Новинка

Matthias Patzold Mobile Radio Channels

13721.77 руб. или Купить в рассрочку!
Providing a comprehensive overview of the modelling, analysis and simulation of mobile radio channels, this book gives a detailed understanding of fundamental issues and examines state-of-the-art techniques in mobile radio channel modelling. It analyses several mobile fading channels, including terrestrial and satellite flat-fading channels, various types of wideband channels and advanced MIMO channels, providing a fundamental understanding of the issues currently being investigated in the field. Important classes of narrowband, wideband, and space-time wireless channels are explored in detail with descriptions of efficient simulation methods for mobile radio channels being central. Strong emphasis is placed on the detailed origin of the presented channel models and a high degree of mathematical unity is conveyed. Using the described channel models, the reader can evaluate the performance of wireless communication systems under propagation conditions which are typical for multipath channels in various environments. Introduces the fundamentals of stochastic and deterministic channel models Explores the modelling and simulation of both wideband and narrowband mobile radio channels as well as several classes of MIMO channels Describes general concepts including geometrical, reference and simulation models Discusses several methods for the modelling of given Doppler, delay, and angular profiles Elaborates on methods for the design, analysis, and realisation of efficient channel simulators Examines techniques for the development of fast channel simulators Provides links for downloading MATLAB®, programs enabling the simulation and analysis of the mobile fading channels models presented, on the companion website (www.wiley.com/go/paetzold)
John C. Godbold, Jr. Laser Therapy in Veterinary Medicine. Photobiomodulation John C. Godbold, Jr. Laser Therapy in Veterinary Medicine. Photobiomodulation Новинка

John C. Godbold, Jr. Laser Therapy in Veterinary Medicine. Photobiomodulation

11162.23 руб. или Купить в рассрочку!
Laser Therapy in Veterinary Medicine: Photobiomodulation is a complete guide to using therapeutic lasers to treat veterinary patients, focusing on practical information. Offers a comprehensive resource for incorporating therapeutic lasers in veterinary practice Focuses on practical information tailored for the veterinary clinic Written by 37 leading experts in veterinary laser therapy Provides a thorough foundation on this standard-of-care modality Emphasizes clinical applications with a real-world approach
Cook County Education Board Course of study of the Cook County Normal School, Cook County, Illinois Cook County Education Board Course of study of the Cook County Normal School, Cook County, Illinois Новинка

Cook County Education Board Course of study of the Cook County Normal School, Cook County, Illinois

Course of study of the Cook County Normal School, Cook County, Illinois is an unchanged, high-quality reprint of the original edition of 1895.Hansebooks is editor of the literature on different topic areas such as research and science, travel and expeditions, cooking and nutrition, medicine, and other genres. As a publisher we focus on the preservation of historical literature. Many works of historical writers and scientists are available today as antiques only. Hansebooks newly publishes these books and contributes to the preservation of literature which has become rare and historical knowledge for the future.
Aamir Ahmad Nutraceuticals and Natural Product Derivatives. Disease Prevention & Drug Discovery Aamir Ahmad Nutraceuticals and Natural Product Derivatives. Disease Prevention & Drug Discovery Новинка

Aamir Ahmad Nutraceuticals and Natural Product Derivatives. Disease Prevention & Drug Discovery

18090.24 руб. или Купить в рассрочку!
Introduces readers to the growing applications of nutraceuticals and other natural product derivatives This comprehensive book presents a prophylactic and therapeutic approach to chronic disease prevention strategy by highlighting the translational potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies. It also shares the experiences of highly reputed experts working in the area of phytomedicine and nutraceutical agents in chemoprevention, to promote the significance of natural products and dietary factors as an elite priority for containing chronic diseases in the human population. Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery starts by examining natural food sources for the control of glycemia and the prevention of diabetic complications. It then looks at the anti-aging effects of sulfur-containing amino acids and nutraceuticals, and the potential of garcinia fruits to combat metabolic syndrome. Other topics covered include honey- and propolis-mediated regulation of protein networks in cancer cells; recent trends in drug discovery against Alzheimer’s disease; the therapeutic potential of metalloherbal nanoceuticals; and much more. Offers an alternative, natural approach to the prevention of chronic diseases Emphasizes the potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies Features contributions from world-renowned experts in the field of phytomedicine and nutraceutical agents in chemoprevention Includes prevention strategies in normal/risk populations through routine inclusion of specific dietary regimens and as therapeutic strategy for better management through adjuvant interventions with conventional treatment protocols Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery will appeal to graduate students and professionals in cell and molecular biology, translational research, pharmacology/drug discovery, medicinal chemistry, and clinical nutrition.

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Sets forth the state of the science and technology in plasma protein production With contributions from an international team of eighty leading experts and pioneers in the field, Production of Plasma Proteins for Therapeutic Use presents a comprehensive overview of the current state of knowledge about the function, use, and production of blood plasma proteins. In addition to details of the operational requirements for the production of plasma derivatives, the book describes the biology, development, research, manufacture, and clinical indications of essentially all plasma proteins with established clinical use or therapeutic potential. Production of Plasma Proteins for Therapeutic Use covers the key aspects of the plasma fractionation industry in five sections: Section 1: Introduction to Plasma Fractionation initially describes the history of transfusion and then covers the emergence of plasma collection and fractionation from its earliest days to the present time, with the commercial and not-for-profit sectors developing into a multi-billion dollar industry. Section 2: Plasma Proteins for Therapeutic Use contains 24 chapters dedicated to specific plasma proteins, including coagulation factors, albumin, immunoglobulin, and a comprehensive range of other plasma-derived proteins with therapeutic indications. Each chapter discusses the physiology, biochemistry, mechanism of action, and manufacture of each plasma protein including viral safety issues and clinical uses. Section 3: Pathogen Safety of Plasma Products examines issues and procedures for enhancing viral safety and reducing the risk of transmissible spongiform encephalopathy transmission. Section 4: The Pharmaceutical Environment Applied to Plasma Fractionation details the requirements and activities associated with plasma collection, quality assurance, compliance with regulatory requirements, provision of medical affairs support, and the manufacture of plasma products. Section 5: The Market for Plasma Products and the Economics of Fractionation reviews the commercial environment and economics of the plasma fractionation industry including future trends, highlighting regions such as Asia, which have the potential to exert a major influence on the plasma fractionation industry in the twenty-first century.
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