meylers side effects of cardiovascular drugs



Giorgio Minotti Cardiotoxicity of Non-Cardiovascular Drugs Giorgio Minotti Cardiotoxicity of Non-Cardiovascular Drugs Новинка

Giorgio Minotti Cardiotoxicity of Non-Cardiovascular Drugs

13508.39 руб. или Купить в рассрочку!
Some drugs which are not aimed at treating heart disease have nevertheless been found to have profound effects on heart muscle. Cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals.In recent years a number of non-cardiac blockbuster drugs such as terfenadine have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been withdrawn prior to marketing or required labelling changes that significantly restricted their use. In Cardiotoxicity of Non-Cardiovascular Drugs international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Particular emphasis is paid to the preclinical screening of drug cardiotoxicity. Topics include: metabolic targets of cardiotoxicity regulatory aspects translating molecular mechanisms into clinical trials structure-activity relationships in arrhythmias by antihistamines and psychoactive drugs cardiovascular toxicity of antitumor drugs cardiovascular toxicities of non-steroidal anti-inflammatory drugs cardiovascular toxicities of antiretroviral therapies Cardiotoxicity of Non-Cardiovascular Drugs is an essential guide to this important area of drug development. It will find a place on the bookshelves of researchers, regulators and students in medicinal chemistry, drug development, pharmacology, pharmacy and cardiovascular disease.
Y. Li Robert Cardiovascular Diseases. From Molecular Pharmacology to Evidence-Based Therapeutics Y. Li Robert Cardiovascular Diseases. From Molecular Pharmacology to Evidence-Based Therapeutics Новинка

Y. Li Robert Cardiovascular Diseases. From Molecular Pharmacology to Evidence-Based Therapeutics

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Written in an accessible style and consistent format, the book covers both the fundamentals and advances in the pharmacology of cardiovascular drugs, as well as their integrated applications in the management of individual cardiovascular diseases. • Integrates fundamentals and recent advances regarding cardiovascular drugs, blending basic and clinical sciences needed to effectively understand and treat cardiovascular diseases • Facilitates understanding of drug action and mechanism by covering physiology / pathophysiology and pharmacology • Includes guidelines and algorithms for pharmacotherapeutic management of cardiovascular diseases • Uses case presentations and study questions to enhance understanding of the material • Serves as a resource for pharmaceutical and medical students and researchers interested in cardiovascular issues
Ron Waksman Antiplatelet Therapy in Cardiovascular Disease Ron Waksman Antiplatelet Therapy in Cardiovascular Disease Новинка

Ron Waksman Antiplatelet Therapy in Cardiovascular Disease

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Edited by a team of the world’s leading interventional cardiologists and educators, this new book is created with an eye to giving the reader a solid, practical, and clinically focused understanding of this important class of drugs, from basic science to a clear-headed discussion of complex topics such as combination therapies, drug-to-drug interactions, and resistance to antiplatelet agents. This important new book: Begins with a concise but thorough discussion of platelet biology and pathophysiology so that readers understand how antiplatelet agents work and why they produce such a varied range of complications, from minor GI upset to potentially life-threatening conditions such as neutropenia, a critical shortage of white blood cells. Thoroughly covers platelet function testing, including novel techniques. Clarifies current best practice regarding the use of antiplatelet agents in both chronic and acute cardiovascular disease. Reviews all types of antiplatelet agents – from aspirin to recently approved drugs – including indications, clinical outcomes, and side effects. Written by an international “who’s who” of experts in the field, Antiplatelet Therapy in Cardiovascular Disease also includes an entire section covering the use of antiplatelet drugs in PCIs, including percutaneous valve repair, which makes this text particularly essential to interventional cardiologists.
Wilfried M. A. Niessen Interpretation of MS-MS Mass Spectra of Drugs and Pesticides Wilfried M. A. Niessen Interpretation of MS-MS Mass Spectra of Drugs and Pesticides Новинка

Wilfried M. A. Niessen Interpretation of MS-MS Mass Spectra of Drugs and Pesticides

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Provides comprehensive coverage of the interpretation of LC–MS–MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns
Karsten Schrör Acetylsalicylic Acid Karsten Schrör Acetylsalicylic Acid Новинка

Karsten Schrör Acetylsalicylic Acid

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Written by a leading expert on Aspirin-related research, this is the most comprehensive treatise on the pharmacological effects and clinical applications of one of the most successful drugs ever. The text is written with a wide audience in mind, and to be readily understandable for clinicians, pharmacists, biomedical researchers and pharmacologists alike. This second, completely revised edition contains the latest results of clinical and pharmacological research on Acetylsalicylic acid, addressing the multiple pharmacological properties of this famous drug with a balanced view on their translation into clinical practice, including prevention from cardiovascular diseases and colorectal cancer.
Michael Neal J. Medical Pharmacology at a Glance Michael Neal J. Medical Pharmacology at a Glance Новинка

Michael Neal J. Medical Pharmacology at a Glance

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Medical Pharmacology at a Glance is recognised as an excellent starting point for pharmacology study. This international best-seller is the perfect companion for all medical and health students, providing an accessible, visual overview of pharmacology. This 8th edition has been extensively updated, especially in the areas of anaesthetics, drugs used in AIDs, cardiovascular drugs, drugs used in anxiety, depression and schizophrenia, urological drugs, drug metabolism, as well as practical concerns such as drug indications and side effects. Ideal for USMLE and pharmacology exam revision, Medical Pharmacology at a Glance features: • The basic principles of drug action, interaction, absorption and excretion • Chapters based on diseases or syndrome, for efficient clinical learning • An emphasis on drug mechanisms • References to the pathophysiology of disease, to aid understanding of drug choice and action • Case studies with questions and full explanation of answers • A companion website at www.ataglanceseries.com/pharmacology featuring online cases and flashcards
Zaher Radi A. Comparative Pathophysiology and Toxicology of Cyclooxygenases Zaher Radi A. Comparative Pathophysiology and Toxicology of Cyclooxygenases Новинка

Zaher Radi A. Comparative Pathophysiology and Toxicology of Cyclooxygenases

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The first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks Cyclooxygenases (COXs) are enzymes responsible for the formation of an important class of biological mediators called prostanoids. Prostanoids such as prostaglandins mediate inflammatory and anaphylactic reactions. For those suffering from inflammation and pain, the pharmacological inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide relief. Yet the use of NSAIDs can trigger toxicological effects as well, leading to potential health risks. Comparative Pathophysiology and Toxicology of Cyclooxygenases provides a comprehensive overview of how COX inhibitors affect various bodily systems, specifically the toxicity mechanisms triggered when the COX enzyme is inhibited. The book provides an introduction to the discovery of cyclooxygenases, their use as therapeutic agents, as well as an historical perspective. Shedding light on the differences in expression, pathophysiology, and toxicology of COX inhibitors across species, the book offers a systematic examination of the effects and pathophysiology of COX inhibitors and their mechanisms of toxicity, beginning with the GI tract. Subsequent chapters cover: The pathophysiology of COX inhibition on bone, tendon, and ligament healing COX inhibitors and renal system pathophysiology and mechanisms of toxicity The pathophysiologic role of COX inhibition in the ocular system COX inhibition and the respiratory and cardiovascular systems The book also sheds light on the latest research devoted to developing COX inhibitors with no adverse side-effects. The first book to offer a thorough comparative look at the toxicological effects of COX inhibitors throughout the body, this invaluable resource will help advance the research and development of safer and more effective COX drugs.
David Wray Essential Dental Therapeutics David Wray Essential Dental Therapeutics Новинка

David Wray Essential Dental Therapeutics

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Essential Dental Therapeutics is a practical guide to drugs and their effects on dental care. Covering both medical and dental prescribing, all major categories of prescription drugs, their possible side effects, and potential drug interactions are discussed. The medical section is succinct and easily understandable, providing busy dentists with the information they need about medical conditions and the drugs used to treat them. The dental section offers practical, straightforward information that is relevant to everyday dental prescribing. All clinical contributing authors are medically and dentally trained, and both strands are fully integrated throughout the text. Readers can test their knowledge by using the key topics and learning objectives at the start of each chapter, and by accessing the companion website featuring self-assessment questions. Essential Dental Therapeutics is a practical reference for dental students and practitioners, ensuring they are safe and informed in everyday practice.
Sara Castiglioni Illicit Drugs in the Environment. Occurrence, Analysis, and Fate using Mass Spectrometry Sara Castiglioni Illicit Drugs in the Environment. Occurrence, Analysis, and Fate using Mass Spectrometry Новинка

Sara Castiglioni Illicit Drugs in the Environment. Occurrence, Analysis, and Fate using Mass Spectrometry

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Illicit drugs are an emerging class of environmental contaminants and mass spectrometry is the technique of choice for their analysis. This landmark reference discusses the analytical techniques used to detect illicit drugs in wastewater and surface water, details how to estimate the levels of contaminants in the environment, and explores the behavior, fate, and toxic effects of this new class of contaminants, now a ubiquitous presence in wastewater and surface water. The book details how an estimate of illicit drug consumption in a given population can be developed from an analysis of the residues of illicit drugs in wastewater. An important resource for analytical chemists, environmental researchers, forensic scientists, biologists, and toxicologists.
Abraham Rudolph Congenital Diseases of the Heart. Clinical-Physiological Considerations Abraham Rudolph Congenital Diseases of the Heart. Clinical-Physiological Considerations Новинка

Abraham Rudolph Congenital Diseases of the Heart. Clinical-Physiological Considerations

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This important revision presents the accumulated knowledge of its highly-regarded author, Dr. Abraham Rudolph, who is internationally recognized as one of the world's leading pioneers in the field of Pediatric Cardiology. Fully revised and updated, the book includes sections considering the changes in pathophysiology with growth into adulthood and the effects of various treatment approaches. The author explains the physiology of normal fetal circulation and the effects of congenital cardiac lesions, with particular reference to the interactions between the lesions and fetal cardiovascular development.
David Taylor The Maudsley Prescribing Guidelines in Psychiatry David Taylor The Maudsley Prescribing Guidelines in Psychiatry Новинка

David Taylor The Maudsley Prescribing Guidelines in Psychiatry

6288.25 руб. или Купить в рассрочку!
The fully updated 12th edition of an essential reference for anyone responsible for prescribing drugs for patients with mental health disorders. A well-respected and widely-used source of information on which drugs to prescribe, which side effects to look out for, how best to augment or switch drugs, and more Provides concise reviews of psychiatric disorders and relevant psychopharmacology, along with general guidance based on the data reviewed and current clinical practice Includes specific guidance for schizophrenia, bipolar disorder, depression, anxiety, substance abuse, and special populations such as children, the elderly and pregnant women Each section features a full reference list so the evidence base can be checked quickly and easily This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.
Li Di Blood-Brain Barrier in Drug Discovery. Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs Li Di Blood-Brain Barrier in Drug Discovery. Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs Новинка

Li Di Blood-Brain Barrier in Drug Discovery. Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs

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Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market
Lowe Robert C. Pocket Guide to GastrointestinaI Drugs Lowe Robert C. Pocket Guide to GastrointestinaI Drugs Новинка

Lowe Robert C. Pocket Guide to GastrointestinaI Drugs

5372.66 руб. или Купить в рассрочку!
Learn all you need to know about gastrointestinal drugs and their clinical use with this one-stop, rapid reference pocket guide. Brought to you by many of the world's leading GI drug experts, Pocket Guide to Gastrointestinal Drugs provides comprehensive guidance to the pharmacological properties of drugs used to treat gastrointestinal conditions, including mechanisms of action, appropriate administration, and potential adverse effects associated with their use. Organized by class of drug and ranging from PPIs to immunosupressants, each chapter first examines the specific agents within that class and then their appropriate and judicious use across a range of specific GI disorders. Key features include: Introduction of drug class Basic pharmacology, including mechanism of action, bioavailability, metabolism, interactions, adverse effects, toxicity, and special considerations Dosing information for each GI condition and on- and off-label use Consistent use of both generic and trade names throughout Specific reference to drug use in pediatric patients and during pregnancy Perfect for quick consultation on the wards and in the office, Pocket Guide to Gastrointestinal Drugs is the ideal tool for all those managing patients with GI conditions, including gastroenterologists, GI trainees, emergency physicians, GI specialist nurses, primary care physicians and residents, intensivists and pharmacists.
Hossein Ardehali Manual of Research Techniques in Cardiovascular Medicine Hossein Ardehali Manual of Research Techniques in Cardiovascular Medicine Новинка

Hossein Ardehali Manual of Research Techniques in Cardiovascular Medicine

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While some research methods or techniques are applicable in several areas of medicine, research in cardiovascular diseases requires knowledge of an increasing array of procedures, techniques and measurements that are highly specialized and unique to this area of investigation. Edited by senior clinical investigators who are recognized leaders in cardiovascular medicine worldwide, this book provides readers with a comprehensive, practical “how-to-do-it” review of best-practice techniques for cardiovascular research.
Anzenbacher Pavel Metabolism of Drugs and Other Xenobiotics Anzenbacher Pavel Metabolism of Drugs and Other Xenobiotics Новинка

Anzenbacher Pavel Metabolism of Drugs and Other Xenobiotics

19034.56 руб. или Купить в рассрочку!
A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and «designer» drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.
Mohamed Abou-Donia Mammalian Toxicology Mohamed Abou-Donia Mammalian Toxicology Новинка

Mohamed Abou-Donia Mammalian Toxicology

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Mammalian Toxicology surveys chemical agents and examines how such chemicals impact on human health, emphasizing the importance in minimizing environmental exposure to chemical and physical hazards in our homes, communities and workplaces through such media as contaminated water, soil and air. Starting with the basic principles on a wide range of toxic agents, this textbook describes how they enter the body, their mechanisms of action once inside, and strategies for diagnosis, prevention and treatment. Topics covered include: General principles of toxicology: pharmacological and toxicological principles underpinning the study of toxicology, risk assessments and mechanisms of cell death Disposition: routes of chemical exposures, entry into the body and various tissues, storage, metabolic biotransformation and elimination, with examples from various toxicants. Toxic agents: the occurrences, disposition in the body, health effects, toxic mechanisms, antidotes and treatments of a range of agents including pesticides, metals, solvents, gases, nanomaterials, food components and additives, pharmaceuticals, drugs of abuse, natural toxins, endocrine disruptors, radiation, and warfare weapons. Toxic effects: including neurotoxicity, developmental toxicity, immunotoxicity, teratogenecity, male and female reproductive toxicity, mutagenecity, carcinogenicity, pulmonary toxicity, cardiovascular toxicity, hepatotoxicity, gastrointestinal toxicity and cardiovascular toxicity Toxicology and society: epidemiological studies of chemical-induced diseases in human populations, and a vision for toxicology in the 21st century. Mammalian Toxicology is an essential primer for students of toxicology, biochemistry, biology, medicine and chemistry. It is also appropriate for professional toxicologists in research or regulatory affairs, and anyone who needs to understand the adverse effects of toxic agents on the human body.
Hobbs Richard Cardiovascular Risk Management Hobbs Richard Cardiovascular Risk Management Новинка

Hobbs Richard Cardiovascular Risk Management

Practical ABC style Enables doctors to prioritise treatment using risk-scoring systems and holistic recommendations for reducing cardiovascular risk Includes treatment plans for individuals with diabetes, who are at high risk of developing cardiovascular disease How to reduce cardiovascular risk in other specific patient groups Developed by expert groups in different regions of the world
Sherrel Howard Drugs of Abuse. Pharmacology and Molecular Mechanisms Sherrel Howard Drugs of Abuse. Pharmacology and Molecular Mechanisms Новинка

Sherrel Howard Drugs of Abuse. Pharmacology and Molecular Mechanisms

Drug abuse has been, and continues to be, a global societal issue with diverse sets of impacts. Drugs of Abuse: Pharmacology and Molecular Mechanisms introduces the basic principles of pharmacology and neuroscience of drug abuse. Understanding the chemistry of commonly abused drugs and their impact on brain function will provide students and researchers with a more profound understanding of the molecular basis of drug abuse and addiction. Drugs of Abuse: Pharmacology and Molecular Mechanisms opens with a brief history of drug use and abuse. Subsequent sections look at specific families of drugs, including stimulants, depressants, and hallucinogens among others, and explore how their chemical make-up interacts with brain function. The final chapter provides a brief overview of clinical substance abuse treatment. Providing a concise, accessible introductory overview of the topic, Drugs of Abuse: Pharmacology and Molecular Mechanisms will be a valuable resource for students, researchers, and others interested in how drugs interact with the brain. Introduces readers to the basic principles of neuroscience and pharmacology as related to drug use and abuse. Explores how the chemical make-up of drugs interact with the brain and can lead to addiction Includes coverage of a wide array of commonly abused families of drugs, including stimulants, depressants, hallucinogens, and others. Provides an essential introduction to the chemical and molecular underpinnings of drug use and abuse
Maurie Markman Cancer Nutrition and Recipes For Dummies Maurie Markman Cancer Nutrition and Recipes For Dummies Новинка

Maurie Markman Cancer Nutrition and Recipes For Dummies

Fight cancer from the inside out Cancer treatments such as surgery, chemotherapy, and radiation can be as hard on the body as the disease itself, and detailed nutritional advice is usually not part of the program. Yet eating the right foods can actually help lessen the strength of some of the most powerful symptoms of cancer and the side effects of treatment, allowing the patient to better fight the disease. Now, Cancer Nutrition & Recipes For Dummies is your trusted, informative guide to fighting cancer from the inside out. Designed for cancer patients and their families, Cancer Nutrition & Recipes For Dummies focuses on foods best tolerated during—and that can ease side effects of—cancer treatment. It also offers advice for menu planning, nutritional analysis, diabetic exchanges, and much more. Serves as a guide for cancer nutrition before, during, and after treatment Gives you a wealth of easy, immediate steps to speed up the healing process through diet Offers advice on treatment as well as solutions to common side effects like dehydration, fatigue, and nausea Enables cancer patients to put their strongest foot forward when starting treatment Cancer Nutrition & Recipes For Dummies targets those dealing with cancer and the loved ones who take care of them, aiding both parties in alleviating some of the side effects of the cancer treatment through change in diet.
Marcus Flather Cardiovascular Clinical Trials. Putting the Evidence into Practice Marcus Flather Cardiovascular Clinical Trials. Putting the Evidence into Practice Новинка

Marcus Flather Cardiovascular Clinical Trials. Putting the Evidence into Practice

7505.19 руб. или Купить в рассрочку!
The pace of therapeutic advances in the treatment of cardiovascular diseases is rapid, and new clinically-relevant information appears with such frequency that it can be extremely challenging for clinicians to keep up. Still, knowledge and interpretation of major clinical trials is crucial for the range of clinicians who manage cardiovascular patients, especially since important trial evidence often needs to be implemented soon after it is published. Confidently apply gold standard treatment for 10 of the most critical areas of cardiology Written by an international team of experts, Cardiovascular Clinical Trials: Putting the Evidence into Practice: Provides a succinct overview of recent major clinical trials – the gold standard for all medical treatment – across all the major cardiovascular subspecialties, to ensure you’re up-to-date on the most critical findings Guides cardiology trainees and clinicians on how cardiovascular clinical trials are designed and conducted, including statistical methodology, so you can conduct and/or appraise future trials yourself Addresses methodology as well as clinical effectiveness Offers evidence-based assessments on the most effective treatments and authoritative clinical information on management of the conditions so you can confidently apply what you learn Physicians, surgeons, specialist nurses – any clinician seeking an accessible resource for designing and conducting cardiovascular trials and then translating their results into practice will appreciate this book’s clear guidance and succinct and practical approach.
Jerome Levine Schizophrenia For Dummies Jerome Levine Schizophrenia For Dummies Новинка

Jerome Levine Schizophrenia For Dummies

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Practical tools for leading a happy, productive life Schizophrenia is a chronic, severe, and disabling mental disorder that afflicts one percent of the population, an estimated 2.5 million people in America alone. The firsthand advice in this reassuring guide will empower the families and caregivers of schizophrenia patients to take charge, offering expert advice on identifying the warning signs, choosing the right health professional, understanding currently available drugs and those on the horizon (as well as their side effects), and evaluating traditional and alternative therapies.
Dan Roden M. Cardiovascular Genetics and Genomics Dan Roden M. Cardiovascular Genetics and Genomics Новинка

Dan Roden M. Cardiovascular Genetics and Genomics

12276.52 руб. или Купить в рассрочку!
This comprehensive and concise presentation of genetic factors in cardiovascular disease and their response to therapy consolidates knowledge of this high-interest and emerging topic. Covering broad areas of contemporary genomic medicine and specific cardiovascular diseases, this book is a must for anyone seeking to better understand this rapidly developing field.
The Secret Power of Music: The Transformation of Self and Society Through Musical Energy The Secret Power of Music: The Transformation of Self and Society Through Musical Energy Новинка

The Secret Power of Music: The Transformation of Self and Society Through Musical Energy

This study of the hidden side of music and its subtle effects is one of the most detailed books ever written on the subject.
Pedro Merino Chemical Synthesis of Nucleoside Analogues Pedro Merino Chemical Synthesis of Nucleoside Analogues Новинка

Pedro Merino Chemical Synthesis of Nucleoside Analogues

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Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- or heterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field. Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.
Grossman Shamai Cardiovascular Problems in Emergency Medicine. A Discussion-based Review Grossman Shamai Cardiovascular Problems in Emergency Medicine. A Discussion-based Review Новинка

Grossman Shamai Cardiovascular Problems in Emergency Medicine. A Discussion-based Review

8899.42 руб. или Купить в рассрочку!
A unique textbook in cardiovascular emergencies Cardiovascular Problems in Emergency Medicine takes you on rounds with the leading teachers of emergency medicine. Transcripts of in-depth telephone conferences on 27 real-life cardiovascular cases provide a unique and fascinating insight into the way complex cases are diagnosed and managed by some of the most experienced and respected practitioners in the field. Each chapter is then complemented by an authoritative, fully-referenced review of the current literature on the topic. With its unique approach, and the range of cases covered, Cardiovascular Problems in Emergency Medicine is an invaluable source of information for all emergency physicians, both qualified and in training.
Sara Stanner Cardiovascular Disease. Diet, Nutrition and Emerging Risk Factors Sara Stanner Cardiovascular Disease. Diet, Nutrition and Emerging Risk Factors Новинка

Sara Stanner Cardiovascular Disease. Diet, Nutrition and Emerging Risk Factors

7021.86 руб. или Купить в рассрочку!
A comprehensive, accessible summary of the latest research in heart disease risk factors Cardiovascular Disease (CVD) is a major cause of early death and disability across the world. The major markers of risk—including high blood cholesterol, smoking, and obesity—are well known, but studies show that such markers do not account for all cardiovascular risk. Written by a team of renowned experts in the field, this comprehensive and accessible book examines the evidence for emerging and novel risk factors, and their relationship with diet and nutrition. Fully updated throughout, Cardiovascular Disease: Diet, Nutrition and Emerging Risk Factors, 2nd Edition covers everything from the epidemiology of cardiovascular disease, to genetic factors, to inflammation and much more – offering invaluable advice on reducing risk factors and preventing CVD. This new edition: Authoritatively reports on the link between emerging aspects of diet, lifestyle and cardiovascular disease risk Focuses on novel risk factors of CVD, including the human gut microbiome and fetal and childhood origins, and how it can be prevented Features recommendations for interventions and future research Includes references, commonly asked questions that summarise the take-home messages, and an online glossary Cardiovascular Disease: Diet, Nutrition and Emerging Risk Factors, 2nd Edition is an important book for researchers and postgraduate students in nutrition, dietetics, food science, and medicine, as well as for cardiologists and cardiovascular specialists.
Henry Brownstein H. The Handbook of Drugs and Society Henry Brownstein H. The Handbook of Drugs and Society Новинка

Henry Brownstein H. The Handbook of Drugs and Society

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This handbook provides a comprehensive examination of the past and present roles of drugs in society with a focus on theory, research, policy, and practice. Includes 28 original chapters with multi-disciplinary and international perspectives by top social and behavioral scientists Reviews current knowledge in the field, including key research findings, theoretical developments, and methodological debates Identifies ongoing controversies in the field, emergent topics, and areas in need of further inquiry Discusses individual drugs as well as topics like physiological theories of drug use and abuse, public health implications of drugs, patterns of drugs and crime, international drug trade and trafficking, and designer drugs
Betteridge D. John Managing Cardiovascular Complications in Diabetes Betteridge D. John Managing Cardiovascular Complications in Diabetes Новинка

Betteridge D. John Managing Cardiovascular Complications in Diabetes

7982.23 руб. или Купить в рассрочку!
Of all the complications which arise from diabetes, cardiovascular complications are by far the most prevalent and the most deadly. Authored by some of the world's leading names in this area, this outstanding book provides all those managing diabetic patients with clinical, practical and succinct guidance to the diagnosis and management of cardiovascular complications in diabetes. With a joint endocrinology and cardiology focus, and with the very latest in clinical guidelines from the ADA, EASD, AHA, ASC and ESC, selected highlights include: – The role of new biomarkers of cardiovascular disease in diabetes – The latest on diagnosis of cardiovascular problems via vascular imaging – Hypertension and cardiovascular disease in the diabetic patient – Dyslipidaemia and its management in type 2 diabetes – Management of thrombosis, acute coronary syndrome and peripheral arterial disease in diabetes Key points, case studies and self-assessment questions allow for rapid-reference, quick understanding of all topics, thus ensuring that this is perfect reading for endocrinologists, diabetes specialists and cardiologists of all levels managing patients with diabetes and associated cardiovascular problems.
Buchwald Peter Retrometabolic Drug Design and Targeting Buchwald Peter Retrometabolic Drug Design and Targeting Новинка

Buchwald Peter Retrometabolic Drug Design and Targeting

12664.12 руб. или Купить в рассрочку!
Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.
Guo-Qiang Lin Chiral Drugs. Chemistry and Biological Action Guo-Qiang Lin Chiral Drugs. Chemistry and Biological Action Новинка

Guo-Qiang Lin Chiral Drugs. Chemistry and Biological Action

12959.12 руб. или Купить в рассрочку!
An integrated view of chiral drugs—from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies—asymmetric synthesis, biocatalytic process, and chiral resolution—to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective—and safer—drugs.
J. States Christopher Arsenic. Exposure Sources, Health Risks, and Mechanisms of Toxicity J. States Christopher Arsenic. Exposure Sources, Health Risks, and Mechanisms of Toxicity Новинка

J. States Christopher Arsenic. Exposure Sources, Health Risks, and Mechanisms of Toxicity

14783.09 руб. или Купить в рассрочку!
This book illustrates the chemistry, toxicology, and health effects of arsenic using novel modeling techniques, case studies, experimental data, and future perspectives. • Covers exposure sources, health risks, and mechanisms of one of the most toxic minerals in the world • Helps readers understand potential health effects of arsenic, using population studies, mammalian and invertebrate models, and pharmacokinetic and toxicokinetic models • Discusses outcomes, epidemiology, real-life examples, and modes of action for arsenic-induced diseases, like lung cancer, diabetes, cardiovascular and pulmonary diseases, and immunotoxicity • Acts as a reference for toxicologists, environmental chemists, and risk assessors and includes up-to-date, novel modeling techniques for scientists • Includes future perspectives on special topics, like extrapolation from experimental models to human exposures, biomarkers for phenotypic anchoring, and pathology of chronic exposure
János Fischer Successful Drug Discovery, Volume 1 János Fischer Successful Drug Discovery, Volume 1 Новинка

János Fischer Successful Drug Discovery, Volume 1

14404.06 руб. или Купить в рассрочку!
The first volume of the book series «Successful Drug Discovery» is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds: small-molecule-, peptide-, and protein-based drugs. The role of serendipity is analyzed in some very successful drugs where the research targets of the lead molecule and the drug are different. Phenotypic and target-based drug discovery approaches are discussed from the viewpoint of pioneer drugs and analogues. This volume gives an excellent overview of insulin analogues including a discussion of the properties of rapid-acting and long-acting formulations of this important hormone. The major part of the book is devoted to case histories of new drug discoveries described by their key inventors. Eight case histories range across many therapeutic fields. The goal of this book series is to help the participants of the drug research community with a reference book series and to support teaching in medicinal chemistry with case histories and review articles of new drugs.
Mario Mancini Nutritional and Metabolic Bases of Cardiovascular Disease Mario Mancini Nutritional and Metabolic Bases of Cardiovascular Disease Новинка

Mario Mancini Nutritional and Metabolic Bases of Cardiovascular Disease

14551.5 руб. или Купить в рассрочку!
Extraordinary advances in the understanding of the links between nutrition, metabolism, and cardiovascular disease have prompted a systematic reappraisal of knowledge in the field. As a result, it is now imperative that clinicians who care for patients with CVD or its key risk factors have a solid understanding of the often complex interrelationships between cardiovascular health and chronic diseases such as diabetes and obesity. Written by a team of international thought leaders in cardiology, endocrinology, diabetology and nutritional science, this important new book: Examines and updates the role of obesity, hyperlipidemia, diabetes, hypertension, thrombosis, and aging in atherogenesis Describes in detail the scientific and clinical evidence of the etiopathogenesis of ischemic heart disease as well as of peripheral and cerebrovascular disease Focuses on the 6 topics that will be of greatest interest to readers: 1) general nutrition, 2) metabolic syndrome and diabetes, 3) hyperlipidemia and atherosclerosis, 4) hypertension and cerebrovascular disease, 5) hemostasis and thrombosis, 6) aging Throughout the book, in clear and accessible text, contributors illuminate the close relationship between dietary habits, the metabolic processes of nutrients, and their impact on the cardiovascular system, always with an eye on how the physician can use this information to implement better cardiovascular prevention and improve patient care. Nutritional and Metabolic Bases of Cardiovascular Disease is ideal for those who need to update their knowledge of the links between nutrition, metabolism and CVD, from trainees, clinicians and clinical investigators in cardiovascular medicine to endocrinologists, diabetologists, and nutritionists.
Eric Toone J. Advances in Enzymology and Related Areas of Molecular Biology Eric Toone J. Advances in Enzymology and Related Areas of Molecular Biology Новинка

Eric Toone J. Advances in Enzymology and Related Areas of Molecular Biology

11129.07 руб. или Купить в рассрочку!
This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. Advances in Enzymology focuses on enzymes, the primary catalysts of life processes. The explanation of the behavior of enzymes can be found via studies of their chemical mechanisms and can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. The transglutaminases, first described in 1957, are a large, widely-distributed family of enzymes canonically responsible for the amidation/transamidation of protein side chains. The extraordinary diversity of names associated with various enzymatic activities now recognized and aggregated as transglutaminase bears witness to the remarkable diversity of biological roles associated with the activity, including myriad human diseases.
Charles Patton The effects of property upon society and government investigated Charles Patton The effects of property upon society and government investigated Новинка

Charles Patton The effects of property upon society and government investigated

Полный вариант заголовка: «The effects of property upon society and government investigated : containing illustration of the influence of property on mental energy, national character, manners, government, and civilazation : to which is added an historical review of the monarchy and republic of Rome, upon the principles derived from the effects of property / by Charles Patton ; historical review by Robert Patton».
Sean Ainsworth B. Neonatal Formulary. Drug Use in Pregnancy and the First Year of Life Sean Ainsworth B. Neonatal Formulary. Drug Use in Pregnancy and the First Year of Life Новинка

Sean Ainsworth B. Neonatal Formulary. Drug Use in Pregnancy and the First Year of Life

7425.35 руб. или Купить в рассрочку!
Neonatal Formulary is a unique publication that provides comprehensive guidance on the safe use of all the drugs prescribed during pregnancy and commonly given to babies during labour, delivery, and the first year of life. This new edition provides improved and detailed coverage of the many drugs that are given to women during pregnancy and during lactation where the baby's welfare must be borne in mind as well as that of the mother. Thus the whole 'pregnancy through to parenthood' journey is treated as a continuous event with information about drug use and the effects of drugs at all stages of the development from fetus to infant. Containing far more detail than is available in the British National Formulary for Children and with a companion website featuring updates related to specific drugs and dosing, Neonatal Formulary is an essential guide for neonatologists, neonatal nurses, hospital pharmacists, obstetric staff, advanced nurse practitioners and for all health care professionals caring for pregnant women and their infants in the first year of life. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.
Vinod Krishnan Biological Mechanisms of Tooth Movement Vinod Krishnan Biological Mechanisms of Tooth Movement Новинка

Vinod Krishnan Biological Mechanisms of Tooth Movement

16829.31 руб. или Купить в рассрочку!
Biological Mechanisms of Tooth Movement, Second Edition is an authoritative reference to the scientific foundations underpinning clinical orthodontics. Led by an expert editor team and with contributions from an international group of contributors, the book covers key topics including bone biology, the effects of mechanical loading on tissues and cells, genetics, inflammation, tissue remodeling and the effects of diet, drugs, and systemic diseases. Highly-illustrated throughout, this second edition has been fully revised, updated and expanded to new developments in genomics, rapid orthodontics and current controversies in tooth movement research. Trainees, qualified specialists and researchers in orthodontics can rely on this comprehensive text to inform them about the clinical and scientific implications of the biological mechanisms involved in the movement of teeth.
Kazuomi Kario Essential Manual of 24 Hour Blood Pressure Management. From morning to nocturnal hypertension Kazuomi Kario Essential Manual of 24 Hour Blood Pressure Management. From morning to nocturnal hypertension Новинка

Kazuomi Kario Essential Manual of 24 Hour Blood Pressure Management. From morning to nocturnal hypertension

4548.42 руб. или Купить в рассрочку!
It is well known that cardiovascular events occur more frequently in the morning as blood pressure (BP) levels have been shown to increase during the period from night to early morning. In recent years, clinical research using ambulatory blood pressure monitoring (ABPM) or home BP monitoring has clarified that morning BP and BP surge are more closely related to the cardiovascular risk than clinical BP. This practical manual from field leading expert, Dr. Kazuomi Kario, reviews recent evidence on ?morning? and ?nocturnal? hypertension and the IT technologies physicians can use to support patients in home monitoring BP. Guidance on management via antihypertensive drugs is also discussed and with the aim of promoting ?perfect 24 hour BP control?.
David Stott J. Cardiovascular Disease and Health in the Older Patient. Expanded from 'Pathy's Principles and Practice of Geriatric Medicine, Fifth Edition' David Stott J. Cardiovascular Disease and Health in the Older Patient. Expanded from 'Pathy's Principles and Practice of Geriatric Medicine, Fifth Edition' Новинка

David Stott J. Cardiovascular Disease and Health in the Older Patient. Expanded from 'Pathy's Principles and Practice of Geriatric Medicine, Fifth Edition'

10457.63 руб. или Купить в рассрочку!
As improvements in living conditions and advances in modern medicine lead to increased life expectancy and the number of older adults world-wide continues to grow, so the number of older individuals with cardiac and cerebrovascular disease is rising. Over eighty per cent of all cardiovascular disease-related deaths now occur in patients aged sixty five or older. The high prevalence of co-morbidities, frailty and cognitive decline amongst older patients requires that a holistic approach to the management of cardiovascular disease is required. Written and edited by leading experts in the field, ‘Cardiovascular diseases and health in the older patient’ provides scholarly evidence and data which explain why treating an older patient with cardiovascular disease is often different from treating a young or middle-aged patient with the same disease. The chapters have been updated and expanded from the cardiovascular section of the renowned ‘Pathy’s Principles and Practice of Geriatric Medicine’, edited by Alan J. Sinclair, John E. Morley and Bruno Vellas. The revised chapters contain updated evidence and references to recent clinical practice guidelines in Europe and North America, this book provides complete, authoritative information on this major cause of death, poor health and disability in old age. Covering the epidemiology, pathophysiology and management of cardiovascular disease in the older patient, the book is an excellent reference at all clinical and pre-clinical levels and will appeal particularly to geriatricians, cardiologists, and GPs, as well as cardiac specialist nurses and practice nurses. With a Foreword by Stuart M. Cobbe.
Karsten Schrör Acetylsalicylic Acid Karsten Schrör Acetylsalicylic Acid Новинка

Karsten Schrör Acetylsalicylic Acid

9206.43 руб. или Купить в рассрочку!
Written by a leading expert on Aspirin-related research, this is the first comprehensive treaty of the history, pharmacological effects and clinical applications of one of the most successful drugs ever. The text is written with a wide audience in mind and to be readily understandable for clinicians as well as biomedical researchers and pharmacologists alike. The content is up to date and includes the latest results of clinical and academic research, with a balanced view on the disputed properties of this famous drug.
Victoria Serhiyenko Diabetic cardiovascular neuropathy Victoria Serhiyenko Diabetic cardiovascular neuropathy Новинка

Victoria Serhiyenko Diabetic cardiovascular neuropathy

Cardiac autonomic neuropathy (CAN) is a serious complication of diabetes mellitus, that is strongly associated with increased risk of cardiovascular mortality. Although it is common complication, the significance of CAN has not been fully appreciated and there are no unified treatment algorithms for today. In this review we have analyzed the existing data about the known risk factors, screening and diagnostic algorithm, staging of CAN and possible treatment, including effectiveness of lifestyle modification, intensive glycemic control; treatment of diabetic dyslipidemia; antioxidants; vitamins; correction of vascular endothelial dysfunction; prevention and treatment of thrombosis; treatment of orthostatic hypotension.
Emanuela Corsini Molecular Immunotoxicology Emanuela Corsini Molecular Immunotoxicology Новинка

Emanuela Corsini Molecular Immunotoxicology

14783.09 руб. или Купить в рассрочку!
The human immune system is constantly exposed to chemical contaminants, whether from food, water or air. Some chemicals directly elicit an immune response, while others indirectly activate or deactivate components within the immune system. Thus when tracking or predicting the effect of a chemical on the immune system, many different pathways and modes of action need to be considered. Following an introduction to the various pathways and toxicity mechanisms from a systemic perspective, the main part of this comprehensive reference surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity, using analyses based on molecular effects rather than on animal models. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.
Gerhard Friedrich Müller Protein Kinases as Drug Targets Gerhard Friedrich Müller Protein Kinases as Drug Targets Новинка

Gerhard Friedrich Müller Protein Kinases as Drug Targets

14783.09 руб. или Купить в рассрочку!
This timely guide to kinase inhibitor drug development is the first to cover the entire drug pipeline, from target identification to compound development and clinical application. Edited by the pioneers in the field, on the drug development side this ready reference discusses classical medicinal chemistry approaches as well as current chemical genomics strategies. On the clinical side, both current and future therapeutic application areas for kinase inhibitor drugs are addressed, with a strong focus on oncology drugs. Backed by recent clinical experience with first-generation drugs in the battle against various forms of cancer, this is crucial reading for medicinal, pharmaceutical and biochemists, molecular biologists, and oncologists, as well as those working in the pharmaceutical industry.
Theresa L. Crenshaw, James P. Goldberg Sexual Pharmacology: Drugs that Affect Sexual Function Theresa L. Crenshaw, James P. Goldberg Sexual Pharmacology: Drugs that Affect Sexual Function Новинка

Theresa L. Crenshaw, James P. Goldberg Sexual Pharmacology: Drugs that Affect Sexual Function

Highlighting the complex interaction of biology and emotion in sexual chemistry, this book systematically evaluates drugs that can inhibit desire, cause impotence, block orgasm, or affect sexual functioning in other ways and provides a system for evaluating any and all drugs, even ones not yet on the market, by summarizing sexual mechanisms of action.Издательство - W. W. Norton&company
Igor Alabugin V. Stereoelectronic Effects. A Bridge Between Structure and Reactivity Igor Alabugin V. Stereoelectronic Effects. A Bridge Between Structure and Reactivity Новинка

Igor Alabugin V. Stereoelectronic Effects. A Bridge Between Structure and Reactivity

6822.63 руб. или Купить в рассрочку!
Stereoelectronic Effects illustrates the utility of stereoelectronic concepts using structure and reactivity of organic molecules An advanced textbook that provides an up-to-date overview of the field, starting from the fundamental principles Presents a large selection of modern examples of stereoelectronic effects in organic reactivity Shows practical applications of stereoelectronic effects in asymmetric catalysis, photochemical processes, bioorganic chemistry and biochemistry, inorganic and organometallic reactivity, supramolecular chemistry and materials science
Hugo Müensterberg Psychotherapy Hugo Müensterberg Psychotherapy Новинка

Hugo Müensterberg Psychotherapy

"Psychotherapy is the practice of treating the sick by influencing the mental life. It stands at the side of physicotherapy, which attempts to cure the sick by influencing the body, perhaps with drugs and medicines, or with electricity or baths or diet." - Excerpt from "Psychotherapy", Müensterberg's classic work (with index included).
Michelle Connolly J. The Cardiovascular System at a Glance Michelle Connolly J. The Cardiovascular System at a Glance Новинка

Michelle Connolly J. The Cardiovascular System at a Glance

3331.48 руб. или Купить в рассрочку!
This concise and accessible text provides an integrated overview of the cardiovascular system – considering the basic sciences which underpin the system and applying this knowledge to clinical practice and therapeutics. A general introduction to the cardiovascular system is followed by chapters on key topics such as anatomy and histology, blood and body fluids, biochemistry, excitation-contraction coupling, form and function, integration and regulation, pathology and therapeutics, clinical examination and investigation – all supported by clinical cases for self-assessment. Highly visual colour illustrations complement the text and consolidate learning. The Cardiovascular System at a Glance is the perfect introduction and revision aid to understanding the heart and circulation and now also features: An additional chapter on pulmonary hypertension Even more simplified illustrations to aid easier understanding Reorganized and revised chapters for greater clarity Brand new and updated clinical case studies illustrating clinical relevance and for self-assessment The fourth edition of The Cardiovascular System at a Glance is an ideal resource for medical students, whilst students of other health professions and specialist cardiology nurses will also find it invaluable. Examination candidates who need an authoritative, concise, and clinically relevant guide to the cardiovascular system will find it extremely useful. A companion website featuring cases from this and previous editions, along with additional summary revision aids, is available at www.ataglanceseries.com/cardiovascular.
Jerron Smith Adobe After Effects CS5 Digital Classroom Jerron Smith Adobe After Effects CS5 Digital Classroom Новинка

Jerron Smith Adobe After Effects CS5 Digital Classroom

3197.37 руб. или Купить в рассрочку!
This video and full-color book combo has quite an effect for learning After Effects CS5! Adobe After Effects is a leading motion graphics and visual effects program that allows you to create and deliver compelling motion graphics and visual effects. This full-color book-and-video training package gets you quickly up to speed using the capabilities of the newest release of After Effects and deciphers even the most complex After Effects tasks. Sixteen self-paced lessons explain how to edit and apply effects for stellar visual and special effects. The supplementary video lessons included with the book are each approximately five minutes long and demonstrate the concepts and features covered in the lesson. Escorts you through the basics of editing and applying motion graphics and visual effects with Adobe After Effects CS5 Deciphers even the most advanced After Effects tasks and makes them less intimidating Features full-color book and video tutorials with step-by-step training that complement the topics covered in each lesson of the book Encourages you to absorb each lesson at your own pace Jam-packed with information, this book with videos and lesson files is just like having your own personal instructor guiding you through each unique lesson. Note: DVD and other supplementary materials are not included as part of eBook file. These materials are available for download upon purchase.
Ian Colbeck Aerosol Science. Technology and Applications Ian Colbeck Aerosol Science. Technology and Applications Новинка

Ian Colbeck Aerosol Science. Technology and Applications

14934.13 руб. или Купить в рассрочку!
Aerosols influence many areas of our daily life. They are at the core of environmental problems such as global warming, photochemical smog and poor air quality. They can also have diverse effects on human health, where exposure occurs in both outdoor and indoor environments. However, aerosols can have beneficial effects too; the delivery of drugs to the lungs, the delivery of fuels for combustion and the production of nanomaterials all rely on aerosols. Advances in particle measurement technologies have made it possible to take advantage of rapid changes in both particle size and concentration. Likewise, aerosols can now be produced in a controlled fashion. Reviewing many technological applications together with the current scientific status of aerosol modelling and measurements, this book includes: • Satellite aerosol remote sensing • The effects of aerosols on climate change • Air pollution and health • Pharmaceutical aerosols and pulmonary drug delivery • Bioaerosols and hospital infections • Particle emissions from vehicles • The safety of emerging nanomaterials • Radioactive aerosols: tracers of atmospheric processes With the importance of this topic brought to the public’s attention after the eruption of the Icelandic volcano Eyjafjallajökull, this book provides a timely, concise and accessible overview of the many facets of aerosol science.
The Curious World of Drugs and Their Friends: A Very Trippy Miscellany Уцененный товар (№1) The Curious World of Drugs and Their Friends: A Very Trippy Miscellany Уцененный товар (№1) Новинка

The Curious World of Drugs and Their Friends: A Very Trippy Miscellany Уцененный товар (№1)

Following in the tradition of The Ultimate Book of Useless Information, The Curious World of Drugs and Their Friends is a wry potpourri of interesting information about every conceivable kind of drug. Readers can feed their heads with anecdotes, facts, lists, statistics, and illustrations, including:- The test results of animals on LSD - cats lose their fear of dogs, and goats walk in geometric patterns- Drugs found in nature, from magic mushrooms to St. John's wort to beaver secretions- Celebrities who overdosed at age 27 - Jimi Hendrix, Janis Joplin, Jim Morrison, Kurt Cobain, Brian Jones, and Jean Michel-Basquiat- Imaginary drugs in literature and film, from spice the mélange in Dune to Moloko plus in A Clockwork Orange- Nicknames for a joint - from doobie to giggly stick to Mr. Boom Bizzle- The global percentages of adults who have used cannabis -.004 percent in Singapore and 12.6 percent in the United States- The uses of opium in ancient Rome - from treatments for insomnia and epilepsy to colic and deafness- The most glamorous rehab clinics and their celebrity alumni- Mini-biographies of the biggest drug kingpins around the worldWacky but well-researched, unbiased and shameless, The Curious World of Drugs and Their Friends dares to take readers on a long, strange trivia trip.
John Dickenson Molecular Pharmacology. From DNA to Drug Discovery John Dickenson Molecular Pharmacology. From DNA to Drug Discovery Новинка

John Dickenson Molecular Pharmacology. From DNA to Drug Discovery

12504.57 руб. или Купить в рассрочку!
This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current – focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge – highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied – includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible – contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book. A companion website with additional resources is available at www.wiley.com/go/dickenson/dnamolecular
Andreas Scherer Batch Effects and Noise in Microarray Experiments. Sources and Solutions Andreas Scherer Batch Effects and Noise in Microarray Experiments. Sources and Solutions Новинка

Andreas Scherer Batch Effects and Noise in Microarray Experiments. Sources and Solutions

9363.77 руб. или Купить в рассрочку!
Batch Effects and Noise in Microarray Experiments: Sources and Solutions looks at the issue of technical noise and batch effects in microarray studies and illustrates how to alleviate such factors whilst interpreting the relevant biological information. Each chapter focuses on sources of noise and batch effects before starting an experiment, with examples of statistical methods for detecting, measuring, and managing batch effects within and across datasets provided online. Throughout the book the importance of standardization and the value of standard operating procedures in the development of genomics biomarkers is emphasized. Key Features: A thorough introduction to Batch Effects and Noise in Microrarray Experiments. A unique compilation of review and research articles on handling of batch effects and technical and biological noise in microarray data. An extensive overview of current standardization initiatives. All datasets and methods used in the chapters, as well as colour images, are available on www.the-batch-effect-book.org, so that the data can be reproduced. An exciting compilation of state-of-the-art review chapters and latest research results, which will benefit all those involved in the planning, execution, and analysis of gene expression studies.
John Clary J. The Toxicology of Methanol John Clary J. The Toxicology of Methanol Новинка

John Clary J. The Toxicology of Methanol

10515.06 руб. или Купить в рассрочку!
The Toxicology of Methanol presents a single source of information and an understanding of the toxicity of methanol from animal data, potential environmental effects as well as human effects. The animal data, which goes to making up the majority of the data on the toxicity of methanol and the mechanism of action, is reviewed as it relates to the potential toxicity in humans.
James Cowan P. The Effects of Sound on People James Cowan P. The Effects of Sound on People Новинка

James Cowan P. The Effects of Sound on People

9475.88 руб. или Купить в рассрочку!
Provides a summary of current research results on the physiological and psychological effects of sound on people Covers how the operation of the hearing mechanism affects our reactions to sounds Includes research results from studies on noise sources of public concern such as transportation, public utility, and recreational sources, with emphasis on low frequency sound and infrasound Covers sounds that affect some but not others, how sounds can be controlled on a practical level, and how and what sounds are regulated Includes coverage of both positive and negative effects of sound
Gershon Samuel Pharmacotherapy of Child and Adolescent Psychiatric Disorders Gershon Samuel Pharmacotherapy of Child and Adolescent Psychiatric Disorders Новинка

Gershon Samuel Pharmacotherapy of Child and Adolescent Psychiatric Disorders

This book fulfils an urgent need for an updated text on pediatric psychopharmacology. It takes a unique approach in discussing recent findings within the context of current issues, including economic and political ones. The book covers the emerging question of treating children who do not yet meet diagnostic criteria for psychosis, e.g, schizophrenia or bipolar disorder, but who are deemed to be at high risk. This is an active area of debate: such children are being treated in certain centers, while others reject this completely. The book addresses the antidepressant controversy, the placebo response and unique strategies for delineating this, and ways to optimize the differential between active medication and placebo. It reviews the impact of recent American Heart Association guidelines for monitoring children on stimulants and other psychotropics. It adheres closely to DSM-IV diagnostic criteria throughout. The book describes the use of newly approved drugs such as Lexapro for treating adolescent depression and the novel compound Intuniv. It covers the TADS and CAMS studies, which evaluated the use of SSRIs alone and in combination with cognitive behavioral therapy for adolescent depression. Other topics include treatment of bipolar disorders, the increasing popularity of generic equivalents, combination pharmacotherapy and the potential dangers of psychotropic medications. Third edition of the first ever book published on pediatric psychopharmacology from renowned editors. Incorporates current developments with regard to SSRIs, their indications and their safety issues, including possible associated suicidal behavior. Addresses concerns about cardiovascular side effects of the new stimulant medications available, and compares to other FDA-approved medications for ADHD. Features many tables, figures and pictorials, making it highly accessible and reader friendly.
Daniel Lednicer Antineoplastic Drugs. Organic Syntheses Daniel Lednicer Antineoplastic Drugs. Organic Syntheses Новинка

Daniel Lednicer Antineoplastic Drugs. Organic Syntheses

10234.67 руб. или Купить в рассрочку!
The past decade has seen a significant increase of research aimed at discovering new drugs for treating cancer, and the increasing number of new antineoplastic drugs approved by regulatory agencies reflects this. Until now, details on the synthesis of these newer agents have been scattered in various journals and in US and European patents. This timely volume deals with the organic chemistry involved in the synthesis of the agents found within antineoplastic drugs, including descriptions of the synthetic schemes for the preparation of over 200 compounds that have been granted non-proprietary names. Compounds are collected in chapters based on the mechanism of action rather than on their chemical structures. Each individual chapter is preceded by a brief description of that mechanism and includes detailed flow charts of the preparation of those compounds accompanied by discussions of the organic chemistry involved in each step. The first half of this volume is dedicated to the syntheses of established chemotherapy drugs. Kinase inhibitors occupy the following chapters with the largest single chapter dealing with the fifty compounds that inhibit tyrosine kinase. This class stands out since over twenty compounds in this group have been approved for treating patients; a rare track record compared to any other class of therapeutic agents. Antineoplastic Drugs: Organic Syntheses is written to appeal to organic and medicinal chemists in industry and academia. It is beneficial to those composing grant proposals for NCI and related organizations. The book is accessible to advanced undergraduates as well as graduates and researchers as well as those with a thorough grasp of organic chemistry.
William Tennant Thoughts on the effects of the British government on the State of India William Tennant Thoughts on the effects of the British government on the State of India Новинка

William Tennant Thoughts on the effects of the British government on the State of India

Полный вариант заголовка: «Thoughts on the effects of the British government on the State of India : accompanied with hints concerning the means of conveying civil and religious instructions to the natives of that country / by the Rev. William Tennant».
János Fischer Analogue-based Drug Discovery III János Fischer Analogue-based Drug Discovery III Новинка

János Fischer Analogue-based Drug Discovery III

16298.52 руб. или Купить в рассрочку!
Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery can initiate and help new discoveries. Volume III is a continuation of the successful book series with new examples of established and recently introduced drugs. The major part of the book is written by key inventors either as a case study or a study of an analogue class. With its wide range across a variety of therapeutic fields and chemical classes, this is of interest to virtually every researcher in drug discovery and pharmaceutical chemistry, and – together with the previous volumes – constitutes the first systematic approach to drug analogue development.
Moller James H. Pediatric Cardiovascular Medicine Moller James H. Pediatric Cardiovascular Medicine Новинка

Moller James H. Pediatric Cardiovascular Medicine

27780.47 руб. или Купить в рассрочку!
The first edition of this text, edited by two of the world’s most respected pediatric cardiologists, set the standard for a single-volume, clinically focused textbook on this subject. This new edition, revised and updated by contributors representing today’s global thought leaders, offers increased coverage of the most important current topics, such as pediatric electrophysiology, congenital heart disease, cardiovascular genetics/genomics, and the identification and management of risk factors in children, while maintaining the clinical focus. Published with a companion website that features additional images for download, self-assessment questions designed to aid readers who are preparing for examinations, and other features, Pediatric Cardiovascular Medicine, Second Edition, is the perfect reference for residents, fellows, pediatricians, as well as specialists in pediatric cardiology.
Javid Farideh Clinical Physiology and Pharmacology. The Essentials Javid Farideh Clinical Physiology and Pharmacology. The Essentials Новинка

Javid Farideh Clinical Physiology and Pharmacology. The Essentials

15193.11 руб. или Купить в рассрочку!
This book is an accessible collection of case study scenarios ideal for physiology and pharmacology revision for pharmacy, medical, biomedical science, clinical science and healthcare students. Clearly structured and organized by major organ system, the book emphasises ways in which key signs and symptoms of disease inform diagnosis and the choice of treatment, together with the relevant pharmacological mechanisms. Each chapter has a clinical focus and includes clear learning outcomes, key points and model answers with detailed explanations designed to enhance students’ understanding of the physiology and pharmacology underpinning each case study scenario. 50 topics are covered and the cases presented include an extensive range of psychological, neurological, endocrine, cardiovascular, respiratory, renal, gastrointestinal and reproductive disorders, their symptoms, complications and usual treatment along with the actions and uses of some widely- used drugs. An essential revision text designed to help students apply their theoretical knowledge to real-life cases Realistic case studies focusing on commonly occurring conditions and diseases Model answers throughout Learning outcomes provided at the beginning of each chapter Key learning points presented in the cases follow each model answer Helps students to understand the relevance and clinical implications of the topics studied in physiology and pharmacology courses Reinforces major concepts and definitions Includes a glossary with a full list of drugs and disorders to support the text

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This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current – focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge – highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied – includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible – contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book. A companion website with additional resources is available at www.wiley.com/go/dickenson/dnamolecular
Продажа meylers side effects of cardiovascular drugs лучших цены всего мира
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