p drug selection



Лакомство Milkies Selection Набор для кошек (180 г) Лакомство Milkies Selection Набор для кошек (180 г) Новинка

Лакомство Milkies Selection Набор для кошек (180 г)

796 руб.
Лакомство Milkies Selection Набор для кошек В набор входит: Милкис для очистки зубов - 2шт, Милкис для вывода комочков шерсти из желудка - 2шт, Милкис для поддержания здоровья кожи и шерсти - 1шт, Милкис для поддержания здоровья суставов и связок - 1шт.
Zhou Honghui Drug-Drug Interactions for Therapeutic Biologics Zhou Honghui Drug-Drug Interactions for Therapeutic Biologics Новинка

Zhou Honghui Drug-Drug Interactions for Therapeutic Biologics

10575.57 руб.
Strategize, plan, and execute comprehensive drug-drug interaction assessments for therapeutic biologics Offering both theory and practical guidance, this book fully explores drug-drug interaction assessments for therapeutic biologics during the drug development process. It draws together and analyzes all the latest findings and practices in order to present our current understanding of the topic and point the way to new research. Case studies and examples, coupled with expert advice, enable readers to better understand the complex mechanisms of biologic drug-drug interactions. Drug-Drug Interactions for Therapeutic Biologics features contributions from leading international experts in all areas of therapeutic biologics drug development and drug-drug interactions. The authors' contributions reflect a thorough review and analysis of the literature as well as their own firsthand laboratory experience. Coverage includes such essential topics as: Drug-drug interaction risks in combination with small molecules and other biologics Pharmacokinetic and pharmacodynamic drug-drug interactions In vitro methods for drug-drug interaction assessment and prediction Risk-based strategies for evaluating biologic drug-drug interactions Strategies to minimize drug-drug interaction risk and mitigate toxic interactions Key regulations governing drug-drug interaction assessments for therapeutic biologics. Drug-Drug Interactions for Therapeutic Biologics is recommended for pharmaceutical and biotechnology scientists, clinical pharmacologists, medicinal chemists, and toxicologists. By enabling these readers to understand how therapeutic biologics may interact with other drugs, the book will help them develop safer, more effective therapeutic biologics.
Jie Jack Li Drug Discovery. Practices, Processes, and Perspectives Jie Jack Li Drug Discovery. Practices, Processes, and Perspectives Новинка

Jie Jack Li Drug Discovery. Practices, Processes, and Perspectives

10303.08 руб.
Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as: Target identification and validation Drug metabolism and pharmacokinetics Central nervous system drugs In vitro and in vivo assays Cardiovascular drugs Cancer drugs Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field. Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.
Binghe Wang Evaluation of Drug Candidates for Preclinical Development. Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology Binghe Wang Evaluation of Drug Candidates for Preclinical Development. Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology Новинка

Binghe Wang Evaluation of Drug Candidates for Preclinical Development. Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology

9916.47 руб.
Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the «right» drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development. Encompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical—pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment—this unique resource encourages integrated thinking in drug discovery. The contributors to this volume: Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics Address developability issues that challenge pharma companies, moving beyond isolated experimental results Reveal connections between the key scientific areas that are critical for successful drug discovery and development Inspire forward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace Evaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.
P. G. Wodehouse Something New - From the Manor Wodehouse Collection, a Selection from the Early Works of P. G. Wodehouse P. G. Wodehouse Something New - From the Manor Wodehouse Collection, a Selection from the Early Works of P. G. Wodehouse Новинка

P. G. Wodehouse Something New - From the Manor Wodehouse Collection, a Selection from the Early Works of P. G. Wodehouse

574 руб.
Please visit www.ManorWodehouse.com to see the complete selection of P. G Wodehouse books available in the Manor Wodehouse Collection.
P. G. Wodehouse The Gold Bat . Other Stories - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse P. G. Wodehouse The Gold Bat . Other Stories - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse Новинка

P. G. Wodehouse The Gold Bat . Other Stories - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse

702 руб.
Please visit www.ManorWodehouse.com to see the complete selection of P. G Wodehouse books available in the Manor Wodehouse Collection.
P. G. Wodehouse Tales of St. Austin's - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse P. G. Wodehouse Tales of St. Austin's - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse Новинка

P. G. Wodehouse Tales of St. Austin's - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse

664 руб.
Please visit www.ManorWodehouse.com to see the complete selection of P. G Wodehouse books available in the Manor Wodehouse Collection.
P. G. Wodehouse The Politeness of Princes . Other School Stories - From the Manor Wodehouse Collection, a Selection from the Early Works of P. G. Wodehouse P. G. Wodehouse The Politeness of Princes . Other School Stories - From the Manor Wodehouse Collection, a Selection from the Early Works of P. G. Wodehouse Новинка

P. G. Wodehouse The Politeness of Princes . Other School Stories - From the Manor Wodehouse Collection, a Selection from the Early Works of P. G. Wodehouse

702 руб.
Please visit www.ManorWodehouse.com to see the complete selection of P. G Wodehouse books available in the Manor Wodehouse Collection.
P. G. Wodehouse The Intrusion of Jimmy - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse P. G. Wodehouse The Intrusion of Jimmy - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse Новинка

P. G. Wodehouse The Intrusion of Jimmy - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse

777 руб.
Please visit www.ManorWodehouse.com to see the complete selection of P. G Wodehouse books available in the Manor Wodehouse Collection. Also published as "A Gentleman of Leisure"
P. G. Wodehouse Mile . Psmith - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse P. G. Wodehouse Mile . Psmith - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse Новинка

P. G. Wodehouse Mile . Psmith - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse

814 руб.
Please visit www.ManorWodehouse.com to see the complete selection of P. G Wodehouse books available in the Manor Wodehouse Collection.
P. G. Wodehouse Love Among the Chickens - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse P. G. Wodehouse Love Among the Chickens - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse Новинка

P. G. Wodehouse Love Among the Chickens - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse

562 руб.
Please visit www.ManorWodehouse.com to see the complete selection of P. G Wodehouse books available in the Manor Wodehouse Collection.
P. G. Wodehouse The Pothunters - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse P. G. Wodehouse The Pothunters - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse Новинка

P. G. Wodehouse The Pothunters - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse

714 руб.
Please visit www.ManorWodehouse.com to see the complete selection of P. G Wodehouse books available in the Manor Wodehouse Collection.
P. G. Wodehouse Psmith, Journalist - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse P. G. Wodehouse Psmith, Journalist - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse Новинка

P. G. Wodehouse Psmith, Journalist - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse

814 руб.
Please visit www.ManorWodehouse.com to see the complete selection of P. G Wodehouse books available in the Manor Wodehouse Collection.
P. G. Wodehouse The Prince and Betty - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse P. G. Wodehouse The Prince and Betty - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse Новинка

P. G. Wodehouse The Prince and Betty - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse

652 руб.
Please visit www.ManorWodehouse.com to see the complete selection of P. G Wodehouse books available in the Manor Wodehouse Collection.
P. G. Wodehouse Psmith in the City - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse P. G. Wodehouse Psmith in the City - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse Новинка

P. G. Wodehouse Psmith in the City - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse

677 руб.
Please visit www.ManorWodehouse.com to see the complete selection of P. G Wodehouse books available in the Manor Wodehouse Collection.
P. G. Wodehouse The White Feather - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse P. G. Wodehouse The White Feather - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse Новинка

P. G. Wodehouse The White Feather - From the Manor Wodehouse Collection, a selection from the early works of P. G. Wodehouse

702 руб.
Please visit www.ManorWodehouse.com to see the complete selection of P. G Wodehouse books available in the Manor Wodehouse Collection.
Guofeng You Drug Transporters. Molecular Characterization and Role in Drug Disposition Guofeng You Drug Transporters. Molecular Characterization and Role in Drug Disposition Новинка

Guofeng You Drug Transporters. Molecular Characterization and Role in Drug Disposition

14022.12 руб.
This new edition overviews drug transporters and presents the principles of drug transport and associated techniques, featuring new chapters on multidrug and toxin extrusion proteins, placental transport, in silico approaches in drug discovery, and regulatory guidance for drug transport studies in drug development. • Describes drug transporter families, mechanisms, and clinical implications along with experimental methods for studying and characterizing drug transporters • Includes new chapters on multidrug and toxin extrusion proteins, placental transport and in silico approaches in drug discovery • Has a new chapter covering regulatory guidance for the evaluation of drug transport in drug development with global criteria used for drug transporters in clinical trials • Arranges material to go from fundamental mechanisms to clinical outcomes, making the book useful for novice and expert readers
Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad Новинка

Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad

17807.52 руб.
The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development. With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the «good» inhibitions—desirable pharmacological effects—and «bad» inhibitions—drug–drug interactions and toxicity. The book discusses: The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.
Elizabeth Kwong Oral Formulation Roadmap from Early Drug Discovery to Development Elizabeth Kwong Oral Formulation Roadmap from Early Drug Discovery to Development Новинка

Elizabeth Kwong Oral Formulation Roadmap from Early Drug Discovery to Development

11620.18 руб.
Detailing formulation approaches by stage of discovery to early development, this book gives a “playbook” of practical and efficient strategies to formulate drug candidates with the least chance of failing in clinical development. • Comes from contributing authors with experience developing formulations on the frontlines of the pharmaceutical industry • Focuses on pre (or non-) clinical and early stage development, the phases where most compounds are used in drug research • Features case studies to illustrate practical challenges and solutions in formulation selection • Covers regulatory filing, drug metabolism and physical and chemical properties, toxicology formulation, biopharmaceutics classification system (BCS), screening approaches, early stage clinical formulation development, and outsourcing
P. G. Wodehouse Jeeves, Emsworth & Others. A Collection of Articles, Poems & Short Stories- From the Manor Wodehouse Collection, a Selection from the Early Works P. G. Wodehouse Jeeves, Emsworth & Others. A Collection of Articles, Poems & Short Stories- From the Manor Wodehouse Collection, a Selection from the Early Works Новинка

P. G. Wodehouse Jeeves, Emsworth & Others. A Collection of Articles, Poems & Short Stories- From the Manor Wodehouse Collection, a Selection from the Early Works

437 руб.
Please visit www.ManorWodehouse.com to see the complete selection of P. G Wodehouse books available in the Manor Wodehouse Collection.
Arjun Singh Pharmaceutics - Drug Discovery Technology and Tools Arjun Singh Pharmaceutics - Drug Discovery Technology and Tools Новинка

Arjun Singh Pharmaceutics - Drug Discovery Technology and Tools

4983 руб.
Pharmaceutical Technology is versatile research area in the field of Drug Discovery, medicine, biotechnology, and pharmacology. Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques, tools and technologies used in drug discovery and development technology. The major techniques and tools are used in drug discovery, drug design, clinical trial studies and thematic issues describing novel approaches and cutting edge technologies used in all stages of drug discovery. The Book addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process. This Book is essential for all science students, biological scientists and researchers involved in drug discovery who wish to keep abreast of all the modern techniques and technologies used in drug discovery and development. The major topics of discussion related to drug, discovery and therapy will included in the next volume : Pharmaceutical Research & Development, Women's Health Drug Discovery & Therapy, Drug Discovery in Preclinical Research, Cardiovascular Drug Discovery & Therapy, Oncology, Process Chemistry and Drug.
Tabasubano Shekh,Amit Bhople and Sunil Jaiswal Development of Osmotically Controlled Drug Delivery System Tabasubano Shekh,Amit Bhople and Sunil Jaiswal Development of Osmotically Controlled Drug Delivery System Новинка

Tabasubano Shekh,Amit Bhople and Sunil Jaiswal Development of Osmotically Controlled Drug Delivery System

2890 руб.
Etoricoxib is non steroidal anti-inflammatory drug specifically Cyclooxygenase 2 (COX-2) enzyme inhibitor. Etoricoxib have serious side effect like gastric disturbance, gastric ulceration, gastrointestinal (GIT) bleeding. Conventional drug delivery systems do not have much control over the drug release and effective concentration of drug reach at the target site. It may lead to unsteady plasma drug level result into adverse effect due to plasma drug level crossing therapeutic window and undertherparutic response because of plasma drug level below therapeutic window. GIT side effect of Etoricoxib due to unsteady plasma drug level when administered in conventional dosage form. Development of elementary osmotic pump for etoricoxib release the drug in controlled fashion by zero order result in mentainance of constant plasma drug level for long period of time lead to diminished serious GIT side effect of etoricoxib.
Claudio Carini Biomarkers in Drug Development. A Handbook of Practice, Application, and Strategy Claudio Carini Biomarkers in Drug Development. A Handbook of Practice, Application, and Strategy Новинка

Claudio Carini Biomarkers in Drug Development. A Handbook of Practice, Application, and Strategy

15803.73 руб.
Discover how biomarkers can boost the success rate of drug development efforts As pharmaceutical companies struggle to improve the success rate and cost-effectiveness of the drug development process, biomarkers have emerged as a valuable tool. This book synthesizes and reviews the latest efforts to identify, develop, and integrate biomarkers as a key strategy in translational medicine and the drug development process. Filled with case studies, the book demonstrates how biomarkers can improve drug development timelines, lower costs, facilitate better compound selection, reduce late-stage attrition, and open the door to personalized medicine. Biomarkers in Drug Development is divided into eight parts: Part One offers an overview of biomarkers and their role in drug development. Part Two highlights important technologies to help researchers identify new biomarkers. Part Three examines the characterization and validation process for both drugs and diagnostics, and provides practical advice on appropriate statistical methods to ensure that biomarkers fulfill their intended purpose. Parts Four through Six examine the application of biomarkers in discovery, preclinical safety assessment, clinical trials, and translational medicine. Part Seven focuses on lessons learned and the practical aspects of implementing biomarkers in drug development programs. Part Eight explores future trends and issues, including data integration, personalized medicine, and ethical concerns. Each of the thirty-eight chapters was contributed by one or more leading experts, including scientists from biotechnology and pharmaceutical firms, academia, and the U.S. Food and Drug Administration. Their contributions offer pharmaceutical and clinical researchers the most up-to-date understanding of the strategies used for and applications of biomarkers in drug development.
Henry Riordan Critical Pathways to Success in CNS Drug Development Henry Riordan Critical Pathways to Success in CNS Drug Development Новинка

Henry Riordan Critical Pathways to Success in CNS Drug Development

14327.88 руб.
Covering the latest advances in CNS drug development, this book will guide all those involved in pre-clinical to early clinical trials. The authors describe how recent innovations can accelerate the development of novel CNS compounds, improve early detection of efficacy and toxicity signals, and increase the safety of later-stage clinical trials. The current crisis in the drug development industry is critically reviewed, as well as the steps needed to correct the problems, including new government-backed regulations and industry-based innovations designed to accelerate CNS drug development in the future. Animal-based models of major CNS disorders are described in detail, and the ability of the latest in vitro and computer-based models to simulate CNS disease states and predict drug efficacy and side-effects are examined. Particular attention is given to the growing use of biomarkers and how they can be used effectively in early human trials as signals of potential drug efficacy, as well as the increasingly important role of imaging studies to guide dose selection. Cognitive assessments that can be useful indicators of effect in patient populations are also discussed. Written by a team of clinical scientists involved in CNS drug trials for over 20 years, and based on a wealth of drug development and clinical trial experience, Critical Pathways to Success in CNS Drug Developmentis full of practical advice for successfully designing and executing CNS drug trials, avoiding potential pitfalls, and complying with government regulations
Johnson Douglas S. Modern Drug Synthesis Johnson Douglas S. Modern Drug Synthesis Новинка

Johnson Douglas S. Modern Drug Synthesis

10575.57 руб.
Following Contemporary Drug Synthesis and The Art of Drug Synthesis (Wiley, 2004 and 2007), two well-received works, is this new book that demystifies the process of modern drug discovery for practitioners and students. An enhanced introduction covers areas such as background, pharmacology, SAR, PK/PD, efficacy, and safety. Focusing on the advantages of process synthesis versus the discovery synthetic route, Modern Drug Synthesis features authoritative coverage by distinguished editors and authors (some chapter authors are the actual inventor of the drug) of twenty different drug molecules.
Консервы Solid Natura Selection для котят (340 г, Телятина) Консервы Solid Natura Selection для котят (340 г, Телятина) Новинка

Консервы Solid Natura Selection для котят (340 г, Телятина)

71 руб.
Описание Kонсервированное влажное питание Solid Natura Selection. Изготовлено в России. Отличается сбалансированным составом, а также великолепными вкусовыми качествами. Состав Ингредиенты: Телятина, субпродукты мясные, желирующая добавка, рыбий жир, таурин, растительное масло, йодированная соль, вода. Cырой протеин, не менее-10,0 г; сырой жир, не более- 7,0 г; сырая зола, не более- 2,0 г; массовая доля соли-0,3-0,5 г; таурин-0,2 г; влага, не более-82,0%
Buchwald Peter Retrometabolic Drug Design and Targeting Buchwald Peter Retrometabolic Drug Design and Targeting Новинка

Buchwald Peter Retrometabolic Drug Design and Targeting

13120.07 руб.
Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.
Sara A. Hurvitz Antibody-Drug Conjugates. Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer Sara A. Hurvitz Antibody-Drug Conjugates. Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer Новинка

Sara A. Hurvitz Antibody-Drug Conjugates. Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer

11620.18 руб.
Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development
Alessandra Mattei Pharmaceutical Crystals. Science and Engineering Alessandra Mattei Pharmaceutical Crystals. Science and Engineering Новинка

Alessandra Mattei Pharmaceutical Crystals. Science and Engineering

14909.18 руб.
An important resource that puts the focus on understanding and handling of organic crystals in drug development Since a majority of pharmaceutical solid-state materials are organic crystals, their handling and processing are critical aspects of drug development. Pharmaceutical Crystals: Science and Engineering offers an introduction to and thorough coverage of organic crystals, and explores the essential role they play in drug development and manufacturing. Written contributions from leading researchers and practitioners in the field, this vital resource provides the fundamental knowledge and explains the connection between pharmaceutically relevant properties and the structure of a crystal. Comprehensive in scope, the text covers a range of topics including: crystallization, molecular interactions, polymorphism, analytical methods, processing, and chemical stability. The authors clearly show how to find solutions for pharmaceutical form selection and crystallization processes. Designed to be an accessible guide, this book represents a valuable resource for improving the drug development process of small drug molecules. This important text: Includes the most important aspects of solid-state organic chemistry and its role in drug development Offers solutions for pharmaceutical form selection and crystallization processes Contains a balance between the scientific fundamental and pharmaceutical applications Presents coverage of crystallography, molecular interactions, polymorphism, analytical methods, processing, and chemical stability Written for both practicing pharmaceutical scientists, engineers, and senior undergraduate and graduate students studying pharmaceutical solid-state materials, Pharmaceutical Crystals: Science and Engineering is a reference and textbook for understanding, producing, analyzing, and designing organic crystals which is an imperative skill to master for anyone working in the field.
Joanne P Shore Love and Spirituality Joanne P Shore Love and Spirituality Новинка

Joanne P Shore Love and Spirituality

1039 руб.
A selection of love and spiritual poems
P. G. Wodehouse Indiscretions of Archie P. G. Wodehouse Indiscretions of Archie Новинка

P. G. Wodehouse Indiscretions of Archie

764 руб.
Please visit www.ManorWodehouse.com to see the complete selection of P. G Wodehouse books available in the Manor Wodehouse Collection.
Barratt Michael J. Drug Repositioning. Bringing New Life to Shelved Assets and Existing Drugs Barratt Michael J. Drug Repositioning. Bringing New Life to Shelved Assets and Existing Drugs Новинка

Barratt Michael J. Drug Repositioning. Bringing New Life to Shelved Assets and Existing Drugs

10893.64 руб.
The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.
Toshihisa Ishikawa Pharmacogenomics of Human Drug Transporters. Clinical Impacts Toshihisa Ishikawa Pharmacogenomics of Human Drug Transporters. Clinical Impacts Новинка

Toshihisa Ishikawa Pharmacogenomics of Human Drug Transporters. Clinical Impacts

12395.59 руб.
Sets the foundation for safer, more effective drug therapies With this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse drug reactions. Moreover, it sets the foundation for the development of drug therapies that are tailored to an individual patient's genetics. Pharmacogenomics of Human Drug Transporters serves as a comprehensive guide to how transporters regulate the absorption, distribution, and elimination of drugs in the body as well as how an individual's genome affects those processes. The book's eighteen chapters have been authored by a team of leading pioneers in the field. Based on their own laboratory and clinical experience as well as a thorough review of the literature, these authors explore all facets of drug transporter pharmacogenomics, including: Individual drug transporters and transporter families and their clinical significance Principles of altered drug transport in drug–drug interactions, pharmacotherapy, and personalized medicine Emerging new technologies for rapid detection of genetic polymorphisms Clinical aspects of genetic polymorphisms in major drug transporter genes Future research directions of drug transporter pharmacogenomics and the prospect of individualized medicine Pharmacogenomics of Human Drug Transporters opens the door to new drug discovery and development breakthroughs leading to safer and more effective customized drug therapies.The book is recommended for pharmaceutical scientists, biochemists, pharmacologists, clinicians, and genetics and genomics researchers.
Arjun Singh Drug Discovery Technology Arjun Singh Drug Discovery Technology Новинка

Arjun Singh Drug Discovery Technology

4419 руб.
Drug Discovery Technology is versatile research area in the field of medicine, biotechnology, and pharmacology. Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques, tools and technologies used in drug discovery and development technology. The major techniques and tools are used in drug discovery, drug design, clinical trial studies and thematic issues describing novel approaches and cutting edge technologies used in all stages of drug discovery. The Book addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process. This Book is essential for all science students, biological scientists and researchers involved in drug discovery who wish to keep abreast of all the modern techniques and technologies used in drug discovery and development. The major topics of discussion related to drug, discovery and therapy will included in the next volume : Pharmaceutical Research & Development, Translational Medicine, Regenerative Medicine, Enabling Technologies, Structural Biology, Drug Delivery & Targeting, Antiinfectives, Biologics, CNS Drug Discovery & Therapy.
P. G. Wodehouse The Head of Kay.s P. G. Wodehouse The Head of Kay.s Новинка

P. G. Wodehouse The Head of Kay.s

425 руб.
Please visit www.ManorWodehouse.com to see the complete selection of P. G Wodehouse books available in the Manor Wodehouse Collection.
Hugo Kubinyi Data Mining in Drug Discovery Hugo Kubinyi Data Mining in Drug Discovery Новинка

Hugo Kubinyi Data Mining in Drug Discovery

15184.14 руб.
Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from compound screening to lead compound selection and personalized medicine. Clearly divided into four sections, the first part discusses the different data sources available, both commercial and non-commercial, while the next section looks at the role and value of data mining in drug discovery. The third part compares the most common applications and strategies for polypharmacology, where data mining can substantially enhance the research effort. The final section of the book is devoted to systems biology approaches for compound testing. Throughout the book, industrial and academic drug discovery strategies are addressed, with contributors coming from both areas, enabling an informed decision on when and which data mining tools to use for one's own drug discovery project.
Kiyohiko Sugano Biopharmaceutics Modeling and Simulations. Theory, Practice, Methods, and Applications Kiyohiko Sugano Biopharmaceutics Modeling and Simulations. Theory, Practice, Methods, and Applications Новинка

Kiyohiko Sugano Biopharmaceutics Modeling and Simulations. Theory, Practice, Methods, and Applications

10893.64 руб.
A comprehensive introduction to using modeling and simulation programs in drug discovery and development Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation design, and toxicological exposure assessment, biopharmaceutical modeling is now seen as the linchpin to a drug's future success. And while there are a number of commercially available software programs for drug modeling, there has not been a single resource guiding pharmaceutical professionals to the actual tools and practices needed to design and test safe drugs. A guide to the basics of modeling and simulation programs, Biopharmaceutics Modeling and Simulations offers pharmaceutical scientists the keys to understanding how they work and are applied in creating drugs with desired medicinal properties. Beginning with a focus on the oral absorption of drugs, the book discusses: The central dogma of oral drug absorption (the interplay of dissolution, solubility, and permeability of a drug), which forms the basis of the biopharmaceutical classification system (BCS) The concept of drug concentration How to simulate key drug absorption processes The physiological and drug property data used for biopharmaceutical modeling Reliable practices for reporting results With over 200 figures and illustrations and a peerless examination of all the key aspects of drug research—including running and interpreting models, validation, and compound and formulation selection—this reference seamlessly brings together the proven practical approaches essential to developing the safe and effective medicines of tomorrow.
Ekins Sean Drug Efficacy, Safety, and Biologics Discovery. Emerging Technologies and Tools Ekins Sean Drug Efficacy, Safety, and Biologics Discovery. Emerging Technologies and Tools Новинка

Ekins Sean Drug Efficacy, Safety, and Biologics Discovery. Emerging Technologies and Tools

11847.82 руб.
Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.
Hugo Kubinyi Drug-Membrane Interactions. Analysis, Drug Distribution, Modeling Hugo Kubinyi Drug-Membrane Interactions. Analysis, Drug Distribution, Modeling Новинка

Hugo Kubinyi Drug-Membrane Interactions. Analysis, Drug Distribution, Modeling

11620.18 руб.
Barrier, reservoir, target site – those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.
Li Chun Drug Delivery Applications of Noninvasive Imaging. Validation from Biodistribution to Sites of Action Li Chun Drug Delivery Applications of Noninvasive Imaging. Validation from Biodistribution to Sites of Action Новинка

Li Chun Drug Delivery Applications of Noninvasive Imaging. Validation from Biodistribution to Sites of Action

13994.75 руб.
Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications. Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers: In vivo imaging techniques and quantitative analysis Imaging drugs and drug carriers at the site of action, including low-molecular weight radiopharmaceuticals, peptides and proteins, siRNA, cells, and nanoparticles Applications of imaging techniques in administration routes other than intravenous injection, such as pulmonary and oral delivery Translational research leading to clinical applications Imaging drug delivery in large animal models Clinical applications of imaging techniques to guide drug development and drug delivery Chapters are based on a thorough review of the current literature as well as the authors' firsthand experience working with imaging techniques for the development of novel drug delivery systems. Presenting state-of-the-technology applications of imaging in preclinical and clinical evaluation of drug delivery systems, Drug Delivery Applications of Noninvasive Imaging offers cost-effective strategies to pharmaceutical researchers and students for developing drug delivery systems that accurately target a broad range of disease conditions.
Консервы Solid Natura Selection для кошек (340 г, Говядина) Консервы Solid Natura Selection для кошек (340 г, Говядина) Новинка

Консервы Solid Natura Selection для кошек (340 г, Говядина)

71 руб.
Описание Kонсервированное влажное питание Solid Natura Selection. Изготовлено в России. Отличается сбалансированным составом, а также великолепными вкусовыми качествами. Состав Ингредиенты: Индейка Мясо индейки, субпродукты мясные, желирующая добавка, рыбий жир, таурин, растительное масло, йодированная соль, вода. Кролик Мясо кролика, мясо кур, субпродукты мясные, желирующая добавка, рыбий жир, таурин, растительное масло, йодированная соль, вода. Говядина говядина, субпродукты мясные, желирующая добавка, рыбий жир, таурин, растительное масло, йодированная соль, вода. Анализ: cырой протеин, не менее-9,0 г; сырой жир, не более- 11,0 г; сырая зола, не более- 2,0 г; массовая доля соли-0,3-0,5 г; таурин-0,2 г; влага, не более-82,0
Rebecca Bader A. Engineering Polymer Systems for Improved Drug Delivery Rebecca Bader A. Engineering Polymer Systems for Improved Drug Delivery Новинка

Rebecca Bader A. Engineering Polymer Systems for Improved Drug Delivery

10303.08 руб.
Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.
Juergen Siepmann Computational Pharmaceutics. Application of Molecular Modeling in Drug Delivery Juergen Siepmann Computational Pharmaceutics. Application of Molecular Modeling in Drug Delivery Новинка

Juergen Siepmann Computational Pharmaceutics. Application of Molecular Modeling in Drug Delivery

12395.59 руб.
Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems. The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein binding, silica nanoparticles, carbon nanotube-based drug delivery systems, diamond nanoparticles and layered double hydroxides (LDHs) drug delivery systems. Although there are a number of existing books about rational drug design with molecular modeling techniques, these techniques still look mysterious and daunting for pharmaceutical scientists. This book fills the gap between pharmaceutics and molecular modeling, and presents a systematic and overall introduction to computational pharmaceutics. It covers all introductory, advanced and specialist levels. It provides a totally different perspective to pharmaceutical scientists, and will greatly facilitate the development of pharmaceutics. It also helps computational chemists to look for the important questions in the drug delivery field. This book is included in the Advances in Pharmaceutical Technology book series.
Hazem Mohammed Shaheen Biological Evaluation of Some Chemotherapeutic Agents Hazem Mohammed Shaheen Biological Evaluation of Some Chemotherapeutic Agents Новинка

Hazem Mohammed Shaheen Biological Evaluation of Some Chemotherapeutic Agents

5787 руб.
Drug/drug interaction is a situation in which a drug, could affect the activity of another drug, i.e. the effects of the drug are increased or decreased, or produces a new effect that neither of them produces on its own. Thereby often the efficacy or toxicity of a medication is changed. Drug/drug interactions could be attributed into pharmacokinetic or pharmacodynamic interaction. Pharmacokinetic interaction: the drug concentration against time curve in the body is modified. Pharmacokinetic interactions can be based on pharmacokinetic parameters of a drug (absorption, distribution, metabolism and elimination). While, pharmacodynamic interaction: the activity of a drug is modified without changes in the drug concentration versus time profile, usually when two (or more drugs) are competitors (physiological or pharmacological) for binding to the same or different receptor(s). Drugs could act by addition, synergistic or antagonistic manners. It is my study to investigate a method for a biological evaluation of chemotherapeutic agents.
Jens-Uwe Peters Polypharmacology in Drug Discovery Jens-Uwe Peters Polypharmacology in Drug Discovery Новинка

Jens-Uwe Peters Polypharmacology in Drug Discovery

10893.64 руб.
An essential outline of the main facets of polypharmacology in drug discovery research Extending drug discovery opportunities beyond the «one drug, one target» philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and more. Filled with a collection of instructive case studies that reinforce the material and illuminate the subject, this practical guide: Covers the two-sided nature of polypharmacology—its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology Fosters interdisciplinary drug discovery research by embracing computational, synthetic, in vitro and in vivo pharmacological and clinical aspects of polypharmacology A clear road map for helping readers successfully navigate around the problems involved with promiscuous ligands and targets, Polypharmacology in Drug Discovery provides real examples, in-depth explanations and discussions, and detailed reviews and opinions to spark inspiration for new drug discovery projects.
Kun Cheng Advanced Drug Delivery Kun Cheng Advanced Drug Delivery Новинка

Kun Cheng Advanced Drug Delivery

9993.65 руб.
Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases. Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts: Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book. Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.
Sachin Narayanbhai Patel,Kanu R. Patel and Mukesh R. Patel Formulation and Evaluation of ER Tablet of Antipsychotic Drug Sachin Narayanbhai Patel,Kanu R. Patel and Mukesh R. Patel Formulation and Evaluation of ER Tablet of Antipsychotic Drug Новинка

Sachin Narayanbhai Patel,Kanu R. Patel and Mukesh R. Patel Formulation and Evaluation of ER Tablet of Antipsychotic Drug

4983 руб.
The antipsychotic drugs are being used mainly for treatment of schizophrenia. Schizophrenia is a mental disorder characterized by a breakdown of typical emotional responses. Modified drug delivery systems (MDDS) of antipsychotics offer advantages over conventional formulations in provison of convenience, side effects and efficacy. Extended Release tablet of Antipsychotic drug were prepared using varying ratios of drug and polymers were selected for the study. After fixing the ratio of drug and polymer to control the release of drug up to desired time, the release rates were modulated by combination of two different rates controlling material. The effect of polymer concentration and channelizer concentration were studied. Drug release was observed upto 24 hrs.
Young Richard Drug Discrimination. Applications to Medicinal Chemistry and Drug Studies Young Richard Drug Discrimination. Applications to Medicinal Chemistry and Drug Studies Новинка

Young Richard Drug Discrimination. Applications to Medicinal Chemistry and Drug Studies

13593.19 руб.
Drug discrimination: a practical guide to its contributions to the invention of new chemical entities and evaluations of new or known pharmacological agents Drug discrimination can be described as a «drug detection» procedure that uses a pharmacologically active agent as the subjective stimulus. Although the procedure does require some effort to implement, it can be an extremely important tool for understanding drug action. Whereas medicinal chemists should come to learn the types of information that drug discrimination studies can offer, pharmacologists and psychologists might come to realize how medicinal chemists can apply the types of information that the paradigm routinely provides. Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies provides in-depth analyses of the nature and use of drugs as discriminative stimuli and bridges some of the numerous gaps between medicinal chemistry, pharmacology, and psychology. Stressing the practical aspects of drug discrimination, including types of procedures, study design, data, and interpretation, the book details the advantages and limitations of drug discrimination studies versus other pharmacologic evaluations. Practical information from leading researchers in the field addresses specific topics and techniques that are of interest in drug discovery, evaluation, and development. A groundbreaking new guide to the applications of drug discrimination studies for medicinal chemistry and neuroscience, Drug Discrimination is essential for any scientist, researcher, or student whose interests involve the design, development, and/or action of drugs acting at the level of the central nervous system.
Mike Lee S. Oral Bioavailability Assessment. Basics and Strategies for Drug Discovery and Development Mike Lee S. Oral Bioavailability Assessment. Basics and Strategies for Drug Discovery and Development Новинка

Mike Lee S. Oral Bioavailability Assessment. Basics and Strategies for Drug Discovery and Development

13556.87 руб.
Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development • Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) • Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
Josse Thomas R. Global New Drug Development. An Introduction Josse Thomas R. Global New Drug Development. An Introduction Новинка

Josse Thomas R. Global New Drug Development. An Introduction

10067.14 руб.
The development of new drugs is very complex, costly and risky. Its success is highly dependent on an intense collaboration and interaction between many departments within the drug development organization, external investigators and service providers, in constant dialogue with regulatory authorities, payers, academic experts, clinicians and patient organizations. Within the different phases of the drug life cycle, drug development is by far the most crucial part for the initial and continued success of a drug on the market. This book offers an introduction to the field of drug development with a clear overview of the different processes that lead to a successful new medicine and of the regulatory pathways that are used to launch a new drug that are both safe and efficacious. “This is the most comprehensive and detailed book on drug development I have ever read and I feel that it is likely to become a staple of drug development courses, such as those taught at Masters Level in my own University…. I think in the light of increasing integration of company and academic approaches to drug development both sides can read this book.. (and, therefore)… this book could not be more timely. “ Professor Mike Coleman, University of Aston., UK ( from his review of the final manuscript)
Kunal Modi,Mukesh Patel and Kanu Patel Design and Development of Time Dependent Montelukast Sodium Tablet Kunal Modi,Mukesh Patel and Kanu Patel Design and Development of Time Dependent Montelukast Sodium Tablet Новинка

Kunal Modi,Mukesh Patel and Kanu Patel Design and Development of Time Dependent Montelukast Sodium Tablet

4419 руб.
To formulate and evaluate time dependent pulsatile drug delivery system of Montelukast sodium to deliver the drug with biological rhythm of asthma after predetermined lag time 5:30 hours. In preliminary study, The core tablet of Montelukast sodium was prepared by using direct compression method containing SSG, Croscarmellose sodium, Crospovidone, MCC and Starcap1500 to obtain fast disintegrating tablet for the selection of super disintegrating agent. PVAP, CAP and Ratio of Eudragit L 100: Eudragit S 100 was used as pH dependent polymer for coating the core tablets. Total 9 batches were formulated as per 32 full factorial design applied to check the effect of polymer ratio (Eudragit L 100: Eudragit S 100) and the effect of % weight gain on dependent variable lag time PRTs. These formulations were evaluated for physical parameters of tablet, drug -excipient compatibility study, lag time of rupture of PRTs and in-vitro drug release study. PDDS of Montelukast Sodium formulated using Croscarmellose sodium as super disintegrant and Eudragit L 100 and Eudragit S 100 as a coating polymers. Formulation M7 can provide site specific delivery with sigmoidal drug release.
D. Young C. Computational Drug Design. A Guide for Computational and Medicinal Chemists D. Young C. Computational Drug Design. A Guide for Computational and Medicinal Chemists Новинка

D. Young C. Computational Drug Design. A Guide for Computational and Medicinal Chemists

10655.09 руб.
Helps you choose the right computational tools and techniques to meet your drug design goals Computational Drug Design covers all of the major computational drug design techniques in use today, focusing on the process that pharmaceutical chemists employ to design a new drug molecule. The discussions of which computational tools to use and when and how to use them are all based on typical pharmaceutical industry drug design processes. Following an introduction, the book is divided into three parts: Part One, The Drug Design Process, sets forth a variety of design processes suitable for a number of different drug development scenarios and drug targets. The author demonstrates how computational techniques are typically used during the design process, helping readers choose the best computational tools to meet their goals. Part Two, Computational Tools and Techniques, offers a series of chapters, each one dedicated to a single computational technique. Readers discover the strengths and weaknesses of each technique. Moreover, the book tabulates comparative accuracy studies, giving readers an unbiased comparison of all the available techniques. Part Three, Related Topics, addresses new, emerging, and complementary technologies, including bioinformatics, simulations at the cellular and organ level, synthesis route prediction, proteomics, and prodrug approaches. The book's accompanying CD-ROM, a special feature, offers graphics of the molecular structures and dynamic reactions discussed in the book as well as demos from computational drug design software companies. Computational Drug Design is ideal for both students and professionals in drug design, helping them choose and take full advantage of the best computational tools available. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.
Walter Korfmacher A. Mass Spectrometry for Drug Discovery and Drug Development Walter Korfmacher A. Mass Spectrometry for Drug Discovery and Drug Development Новинка

Walter Korfmacher A. Mass Spectrometry for Drug Discovery and Drug Development

10225.9 руб.
Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics. Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: HPLC–high-resolution mass spectrometry for quantitative assays Mass spectrometry for siRNA Quantitative analysis of peptides Mass spectrometry analysis of biological drugs Applications that support medicinal chemistry investigations Mass spectrometry imaging and profiling Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field. Mass Spectrometry for Drug Discovery and Drug Development is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.
Rachel Cerdan Comprehensive Analysis of Parasite Biology. From Metabolism to Drug Discovery Rachel Cerdan Comprehensive Analysis of Parasite Biology. From Metabolism to Drug Discovery Новинка

Rachel Cerdan Comprehensive Analysis of Parasite Biology. From Metabolism to Drug Discovery

17817.6 руб.
Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art «omics» technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.
Casper Venter Quality Management in International Forensic Drug Laboratories Casper Venter Quality Management in International Forensic Drug Laboratories Новинка

Casper Venter Quality Management in International Forensic Drug Laboratories

5787 руб.
The aim of this study was first to establish the extent of quality standards and recommendations within the forensic drug environment and secondly, the level to which they were implemented in forensic drug laboratories globally. A questionnaire was developed to measure quality variables according to five categories in forensic drug laboratories, namely equipment, personnel, quality assurance and quality control, customer relationship as well as productivity. A total of seventy international drug laboratories participated in the study which consisted of laboratories from the United States of America, Canada, Australia, New Zealand, Belgium, Finland, Netherlands, Switzerland, Taiwan and Israel. To make statistical inferences on the greater population of forensic drug laboratories, all data was converted to proportions. These proportions were compared to international quality standards such as ISO 17025 and ASCLD/LAB.
Mitchell Cayen N. Early Drug Development. Strategies and Routes to First-in-Human Trials Mitchell Cayen N. Early Drug Development. Strategies and Routes to First-in-Human Trials Новинка

Mitchell Cayen N. Early Drug Development. Strategies and Routes to First-in-Human Trials

14471.84 руб.
The focus of early drug development has been the submission of an Investigational New Drug application to regulatory agencies. Early Drug Development: Strategies and Routes to First-in-Human Trials guides drug development organizations in preparing and submitting an Investigational New Drug (IND) application. By explaining the nuts and bolts of preclinical development activities and their interplay in effectively identifying successful clinical candidates, the book helps pharmaceutical scientists determine what types of discovery and preclinical research studies are needed in order to support a submission to regulatory agencies.
Priya Patel,Tejal Soni and Vaishali Thakkar Nanoparticle For Pulmonary Drug Delivery System Priya Patel,Tejal Soni and Vaishali Thakkar Nanoparticle For Pulmonary Drug Delivery System Новинка

Priya Patel,Tejal Soni and Vaishali Thakkar Nanoparticle For Pulmonary Drug Delivery System

3212 руб.
A new value paradigm is taking shape in the drug delivery market. Nanotechnology delivery techniques will shape the future of drug delivery. ”Nanotechnology-enabled drug delivery systems (DDS) over the next five years are forecast to dramatically reshape the way existing drugs are delivered”. The growing range of nanotechnology enabled drug delivery methods is poised to change the way new compounds are formulated, and to extend the life cycle of existing compounds. Nanoparticles hold promise as therapeutic agents for a number of diseases. In this book give a brief introduction regarding pulmonary drug delivery system. Determining the physicochemical characteristics of inhaled nanoparticles on their ability to cross the lungs alveolar epithelial surface is an important step in understanding the biological effects associated with exposure to these particles.
Dionysios Douroumis Drug Delivery Strategies for Poorly Water-Soluble Drugs Dionysios Douroumis Drug Delivery Strategies for Poorly Water-Soluble Drugs Новинка

Dionysios Douroumis Drug Delivery Strategies for Poorly Water-Soluble Drugs

15261.31 руб.
Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, polymeric drug encapsulation delivery systems, self–microemulsifying drug delivery systems, nanocrystals, hydrosol colloidal dispersions, microemulsions, solid dispersions, cosolvent use, dendrimers, polymer- drug conjugates, polymeric micelles, and mesoporous silica nanoparticles. For each approach the book discusses the main instrumentation, operation principles and theoretical background, with a focus on critical formulation features and clinical studies. Finally, the book includes some recent and novel applications, scale-up considerations and regulatory issues. Drug Delivery Strategies for Poorly Water-Soluble Drugs is an essential multidisciplinary guide to this important area of drug formulation for researchers in industry and academia working in drug delivery, polymers and biomaterials.
Huang Xianhai Case Studies in Modern Drug Discovery and Development Huang Xianhai Case Studies in Modern Drug Discovery and Development Новинка

Huang Xianhai Case Studies in Modern Drug Discovery and Development

11927.34 руб.
Learn why some drug discovery and development efforts succeed . . . and others fail Written by international experts in drug discovery and development, this book sets forth carefully researched and analyzed case studies of both successful and failed drug discovery and development efforts, enabling medicinal chemists and pharmaceutical scientists to learn from actual examples. Each case study focuses on a particular drug and therapeutic target, guiding readers through the drug discovery and development process, including drug design rationale, structure-activity relationships, pharmacology, drug metabolism, biology, and clinical studies. Case Studies in Modern Drug Discovery and Development begins with an introductory chapter that puts into perspective the underlying issues facing the pharmaceutical industry and provides insight into future research opportunities. Next, there are fourteen detailed case studies, examining: All phases of drug discovery and development from initial idea to commercialization Some of today's most important and life-saving medications Drugs designed for different therapeutic areas such as cardiovascular disease, infection, inflammation, cancer, metabolic syndrome, and allergies Examples of prodrugs and inhaled drugs Reasons why certain drugs failed to advance to market despite major research investments Each chapter ends with a list of references leading to the primary literature. There are also plenty of tables and illustrations to help readers fully understand key concepts, processes, and technologies. Improving the success rate of the drug discovery and development process is paramount to the pharmaceutical industry. With this book as their guide, readers can learn from both successful and unsuccessful efforts in order to apply tested and proven science and technologies that increase the probability of success for new drug discovery and development projects.
Suryakanta Swain,Subas Chandra Dinda and Muddana Eswara Bhanoji Rao Liposome as a Drug Delivery Vehicle Suryakanta Swain,Subas Chandra Dinda and Muddana Eswara Bhanoji Rao Liposome as a Drug Delivery Vehicle Новинка

Suryakanta Swain,Subas Chandra Dinda and Muddana Eswara Bhanoji Rao Liposome as a Drug Delivery Vehicle

4749 руб.
Liposomes are found to be having passively targeted drug carrier to tumor cells because of its enhanced permeability and retention effect. Liposomes remain at the front of the drug delivery systems owing to its non-toxic, bio-degradable and non-immunogenic nature. It has been explored as carrier for delivery of drug molecules such as protein and peptides, genes, vaccines, genosomes, lipopolyplex, fusogenic liposomes and virsomes, etc. Stealth liposomes utilized for targeting hydrophilic anticancer drugs such as doxorubicin, mitoxantrone, etc. Still there is quest in developing drug delivery and drug targeting system utilizing liposomal formulations in the thrust area of cancer chemotherapy, antiviral, and such other biotechnological products.

кешбака
Страницы:


The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.
Продажа p drug selection лучших цены всего мира
Посредством этого сайта магазина - каталога товаров мы очень легко осуществляем продажу p drug selection у одного из интернет-магазинов проверенных фирм. Определитесь с вашими предпочтениями один интернет-магазин, с лучшей ценой продукта. Прочитав рекомендации по продаже p drug selection легко охарактеризовать производителя как превосходную и доступную фирму.