progress in medicinal chemistry 1919



Jacek Lipkowski Nanopatterned and Nanoparticle-Modified Electrodes Jacek Lipkowski Nanopatterned and Nanoparticle-Modified Electrodes Новинка

Jacek Lipkowski Nanopatterned and Nanoparticle-Modified Electrodes

14060.94 руб. или Купить в рассрочку!
Volume XVII in the «Advances in Electrochemical Science and Engineering» series, this monograph covers progress in this rapidly developing field with a particular emphasis on important applications, including spectroscopy, medicinal chemistry and analytical chemistry. As such it covers nanopatterned and nanoparticle-modified electrodes for analytical detection, surface spectroscopy, electrocatalysis and a fundamental understanding of the relation between the electrode structure and its function. Written by a group of international experts, this is a valuable resource for researchers working in such fields as electrochemistry, materials science, spectroscopy, analytical and medicinal chemistry.
Tim Storr Ligand Design in Medicinal Inorganic Chemistry Tim Storr Ligand Design in Medicinal Inorganic Chemistry Новинка

Tim Storr Ligand Design in Medicinal Inorganic Chemistry

14821.72 руб. или Купить в рассрочку!
Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy. Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated by a disease-specific biological process. Ligand design is discussed in the following areas: Platinum, Ruthenium, and Gold-containing anticancer agents Emissive metal-based optical probes Metal-based antimalarial agents Metal overload disorders Modulation of metal-protein interactions in neurodegenerative diseases Photoactivatable metal complexes and their use in biology and medicine Radiodiagnostic agents and Magnetic Resonance Imaging (MRI) agents Carbohydrate-containing ligands and Schiff-base ligands in Medicinal Inorganic Chemistry Metalloprotein inhibitors Ligand Design in Medicinal Inorganic Chemistry provides graduate students, industrial chemists and academic researchers with a launching pad for new research in medicinal chemistry.
Zhang Wei Green Techniques for Organic Synthesis and Medicinal Chemistry Zhang Wei Green Techniques for Organic Synthesis and Medicinal Chemistry Новинка

Zhang Wei Green Techniques for Organic Synthesis and Medicinal Chemistry

16609.67 руб. или Купить в рассрочку!
An updated overview of the rapidly developing field of green engineering techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.
Werngard Czechtizky Small Molecule Medicinal Chemistry. Strategies and Technologies Werngard Czechtizky Small Molecule Medicinal Chemistry. Strategies and Technologies Новинка

Werngard Czechtizky Small Molecule Medicinal Chemistry. Strategies and Technologies

11400.76 руб. или Купить в рассрочку!
Stressing strategic and technological solutions to medicinal chemistry challenges, this book presents methods and practices for optimizing the chemical aspects of drug discovery. Chapters discuss benefits, challenges, case studies, and industry perspectives for improving drug discovery programs with respect to quality and costs. • Focuses on small molecules and their critical role in medicinal chemistry, reviewing chemical and economic advantages, challenges, and trends in the field from industry perspectives • Discusses novel approaches and key topics, like screening collection enhancement, risk sharing, HTS triage, new lead finding approaches, diversity-oriented synthesis, peptidomimetics, natural products, and high throughput medicinal chemistry approaches • Explains how to reduce design-make-test cycle times by integrating medicinal chemistry, physical chemistry, and ADME profiling techniques • Includes descriptive case studies, examples, and applications to illustrate new technologies and provide step-by-step explanations to enable them in a laboratory setting
Enzo Alessio Bioinorganic Medicinal Chemistry Enzo Alessio Bioinorganic Medicinal Chemistry Новинка

Enzo Alessio Bioinorganic Medicinal Chemistry

16997.75 руб. или Купить в рассрочку!
This book gives a comprehensive overview about medicinal inorganic chemistry. Topics like targeting strategies, mechanism of action, Pt-based antitumor drugs, radiopharmaceuticals are covered in detail and offer the reader an in-depth overview about this important topic.
Li-He Zhang Medicinal Chemistry of Nucleic Acids Li-He Zhang Medicinal Chemistry of Nucleic Acids Новинка

Li-He Zhang Medicinal Chemistry of Nucleic Acids

12992.98 руб. или Купить в рассрочку!
Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acid chemistry and biology Essential information on the use of nucleic acid drugs to treat diseases like cancer A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.
Raimund Mannhold Drug Selectivity. An Evolving Concept in Medicinal Chemistry Raimund Mannhold Drug Selectivity. An Evolving Concept in Medicinal Chemistry Новинка

Raimund Mannhold Drug Selectivity. An Evolving Concept in Medicinal Chemistry

19093.36 руб. или Купить в рассрочку!
The book «Drug Selectivity – An Evolving Concept in Medicinal Chemistry» provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.
V. Nenajdenko Isocyanide Chemistry. Applications in Synthesis and Material Science V. Nenajdenko Isocyanide Chemistry. Applications in Synthesis and Material Science Новинка

V. Nenajdenko Isocyanide Chemistry. Applications in Synthesis and Material Science

2169.35 руб. или Купить в рассрочку!
The efficacy of isocyanide reactions in the synthesis of natural or naturallike products has resulted in a renaissance of isocyanide chemistry. Now isocyanides are widely used in different branches of organic, inorganic, coordination, combinatorial and medicinal chemistry. This invaluable reference is the only book to cover the topic in such depth, presenting all aspects of synthetic isonitrile chemistry. The highly experienced and internationally renowned editor has brought together an equally distinguished team of authors who cover multicomponent reactions, isonitriles in total synthesis, isonitriles in polymer chemistry and much more.
Jacek Lipkowski Bioelectrochemistry. Fundamentals, Applications and Recent Developments Jacek Lipkowski Bioelectrochemistry. Fundamentals, Applications and Recent Developments Новинка

Jacek Lipkowski Bioelectrochemistry. Fundamentals, Applications and Recent Developments

16493.25 руб. или Купить в рассрочку!
Bioelectrochemistry is a fast growing field at the interface between electrochemistry and other sciences such as biochemistry, analytical chemistry and medicinal chemistry. In the recent years, the methods and the understanding of the fundamentals have seen significant progress, which has led to rapid development in the field. Here, the expert editors have carefully selected contributions to best reflect the latest developments in this hot and rapidly growing interdisciplinary topic. The resulting excellent and timely overview of this multifaceted field covers recent methodological advances, as well as a range of new applications for analytical detection, drug screening, tumor therapy, and for energy conversion in biofuel cells. This book is a must-have for all Electrochemists, Biochemists, Analytical Chemists, and Medicinal Chemists.
Hugo Kubinyi Microwaves in Organic and Medicinal Chemistry Hugo Kubinyi Microwaves in Organic and Medicinal Chemistry Новинка

Hugo Kubinyi Microwaves in Organic and Medicinal Chemistry

18621.97 руб. или Купить в рассрочку!
Tailored to the needs of medicinal and natural products chemists, the second edition of this unique handbook brings the contents up to speed, almost doubling the amount of chemical information with an additional volume. As in the predecessor, a short introductory section covers the theoretical background and evaluates currently available instrumentation and equipment. The main part of the book then goes on to systematically survey the complete range of published microwave-assisted synthesis methods from their beginnings in the 1990s to mid-2011, drawing on data from more than 5,000 reports and publications. Throughout, the focus is on those reactions, reagents and reaction conditions that work, and that are the most relevant for medicinal and natural products chemistry. A much expanded section is devoted to combinatorial, highthroughput and flow chemistry methods.
Trabocchi Andrea Peptidomimetics in Organic and Medicinal Chemistry Trabocchi Andrea Peptidomimetics in Organic and Medicinal Chemistry Новинка

Trabocchi Andrea Peptidomimetics in Organic and Medicinal Chemistry

12806.52 руб. или Купить в рассрочку!
A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.
Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Новинка

Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis

17773.9 руб. или Купить в рассрочку!
This is the fourth of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international «who's who» in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides The fourth volume in this series is structured in three main sections. The first section is about protection reactions and amino acid based peptidomimetics. The second, and most extensive, part is devoted to the medicinal chemistry of amino acids. It includes, among others, the chemistry of alpha- and beta amino acids, peptide drugs, and advances in N- and O-glycopeptide synthesis. The final part deals with amino acids in combinatorial synthesis. Methods, such as phage display, library peptide synthesis, and computational design are described. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.
Peter Jacobi A. Introduction to Heterocyclic Chemistry Peter Jacobi A. Introduction to Heterocyclic Chemistry Новинка

Peter Jacobi A. Introduction to Heterocyclic Chemistry

5174.35 руб. или Купить в рассрочку!
A unique approach to a core topic in organic chemistry presented by an experienced teacher to students and professionals Heterocyclic rings are present in the majority of known natural products, contributing to enormous structural diversity. In addition, they often possess significant biological activity. Medicinal chemists have embraced this last property in designing most of the small molecule drugs in use today. This book offers readers a fundamental understanding of the basics of heterocyclic chemistry and their occurrence in natural products such as amino acids, DNA, vitamins, and antibiotics. Based on class lectures that the author has developed over more than 40 years of teaching, it focuses on the chemistry of such heterocyclic substances and how they differ from carbocyclic systems. Introductory Heterocyclic Chemistry offers in-depth chapters covering naturally occurring heterocycles; properties of aromatic heterocycles; π-deficient heterocycles; π-excessive heterocycles; and ring transformations of heterocycles. It then offers an overview of 1,3-dipolar cycloadditions before finishing up with a back-to-basics section on nitriles and amidines. Presents a conversational approach to a fundamental topic in organic chemistry teaching Offers a unique look at this core organic chemistry topic via important naturally occurring and/or biologically active heterocycles Based on the author's many years of class lectures for teaching at the undergraduate and graduate level as well as pharmaceutical-industry courses Clear, concise, and accessible for advanced students of chemistry to gain a fundamental understanding of the basics of heterocyclic chemistry Introductory Heterocyclic Chemistry is an excellent text for undergraduate and graduate students as well as chemists in industrial environments in chemistry, pharmacy, medicinal chemistry, and biology.
Tsaioun Katya ADMET for Medicinal Chemists. A Practical Guide Tsaioun Katya ADMET for Medicinal Chemists. A Practical Guide Новинка

Tsaioun Katya ADMET for Medicinal Chemists. A Practical Guide

11875.14 руб. или Купить в рассрочку!
This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and the tools utilized by ADME scientists in a discovery setting, as applied to medicinal chemistry and structure modification to improve drug-like properties of drug candidates, are examined.
Brian Fulton S. Drug Discovery for the Treatment of Addiction. Medicinal Chemistry Strategies Brian Fulton S. Drug Discovery for the Treatment of Addiction. Medicinal Chemistry Strategies Новинка

Brian Fulton S. Drug Discovery for the Treatment of Addiction. Medicinal Chemistry Strategies

9044.17 руб. или Купить в рассрочку!
With addiction a key target for drug discovery efforts, this book fills an important and timely need for medicinal chemists who need to understand complex neuroscience issues. The author illustrates medicinal chemistry's prominent role in treating addiction and covers specific drugs of abuse including narcotics, stimulants, depressants, nicotine, and marijuana. • Interprets complex neuro- biological and pharmacological information, like the drug-reward system, for medicinal chemists • Emphasizes neurotransmitters and neurochemical mechanisms of addictive drugs • Pulls together information on the many potential drug targets for treating addiction • Stresses unique medicinal chemistry problems when describing pharmacology testing methods and drug development
Jie Jack Li Heterocyclic Chemistry in Drug Discovery Jie Jack Li Heterocyclic Chemistry in Drug Discovery Новинка

Jie Jack Li Heterocyclic Chemistry in Drug Discovery

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Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.
Eric Marsault Practical Medicinal Chemistry with Macrocycles. Design, Synthesis, and Case Studies Eric Marsault Practical Medicinal Chemistry with Macrocycles. Design, Synthesis, and Case Studies Новинка

Eric Marsault Practical Medicinal Chemistry with Macrocycles. Design, Synthesis, and Case Studies

17101.87 руб. или Купить в рассрочку!
Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. • Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations • Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts • Covers design criteria, typical profile of current macrocycles, applications, and limitations
David Milstein Ligand Design in Metal Chemistry. Reactivity and Catalysis David Milstein Ligand Design in Metal Chemistry. Reactivity and Catalysis Новинка

David Milstein Ligand Design in Metal Chemistry. Reactivity and Catalysis

12920.87 руб. или Купить в рассрочку!
The design of ancillary ligands used to modify the structural and reactivity properties of metal complexes has evolved into a rapidly expanding sub-discipline in inorganic and organometallic chemistry. Ancillary ligand design has figured directly in the discovery of new bonding motifs and stoichiometric reactivity, as well as in the development of new catalytic protocols that have had widespread positive impact on chemical synthesis on benchtop and industrial scales. Ligand Design in Metal Chemistry presents a collection of cutting-edge contributions from leaders in the field of ligand design, encompassing a broad spectrum of ancillary ligand classes and reactivity applications. Topics covered include: Key concepts in ligand design Redox non-innocent ligands Ligands for selective alkene metathesis Ligands in cross-coupling Ligand design in polymerization Ligand design in modern lanthanide chemistry Cooperative metal-ligand reactivity P,N Ligands for enantioselective hydrogenation Spiro-cyclic ligands in asymmetric catalysis This book will be a valuable reference for academic researchers and industry practitioners working in the field of ligand design, as well as those who work in the many areas in which the impact of ancillary ligand design has proven significant, for example synthetic organic chemistry, catalysis, medicinal chemistry, polymer science and materials chemistry.
Chao-Jun Li Modern Alkyne Chemistry. Catalytic and Atom-Economic Transformations Chao-Jun Li Modern Alkyne Chemistry. Catalytic and Atom-Economic Transformations Новинка

Chao-Jun Li Modern Alkyne Chemistry. Catalytic and Atom-Economic Transformations

14897.43 руб. или Купить в рассрочку!
A comprehensive and up-to-date overview of alkyne chemistry, taking into account the progress made over the last two decades. The experienced editors are renowned world leaders in the field, while the list of contributors reads like a «Who's Who» of synthetic organic chemistry. The result is a valuable reference not only for organic chemists at universities and in the chemical industry, but also for biologists and material scientists involved in the modern synthesis of organic compounds and materials.
Young Richard Drug Discrimination. Applications to Medicinal Chemistry and Drug Studies Young Richard Drug Discrimination. Applications to Medicinal Chemistry and Drug Studies Новинка

Young Richard Drug Discrimination. Applications to Medicinal Chemistry and Drug Studies

13268.33 руб. или Купить в рассрочку!
Drug discrimination: a practical guide to its contributions to the invention of new chemical entities and evaluations of new or known pharmacological agents Drug discrimination can be described as a «drug detection» procedure that uses a pharmacologically active agent as the subjective stimulus. Although the procedure does require some effort to implement, it can be an extremely important tool for understanding drug action. Whereas medicinal chemists should come to learn the types of information that drug discrimination studies can offer, pharmacologists and psychologists might come to realize how medicinal chemists can apply the types of information that the paradigm routinely provides. Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies provides in-depth analyses of the nature and use of drugs as discriminative stimuli and bridges some of the numerous gaps between medicinal chemistry, pharmacology, and psychology. Stressing the practical aspects of drug discrimination, including types of procedures, study design, data, and interpretation, the book details the advantages and limitations of drug discrimination studies versus other pharmacologic evaluations. Practical information from leading researchers in the field addresses specific topics and techniques that are of interest in drug discovery, evaluation, and development. A groundbreaking new guide to the applications of drug discrimination studies for medicinal chemistry and neuroscience, Drug Discrimination is essential for any scientist, researcher, or student whose interests involve the design, development, and/or action of drugs acting at the level of the central nervous system.
Katja Strohfeldt A. Essentials of Inorganic Chemistry. For Students of Pharmacy, Pharmaceutical Sciences and Medicinal Chemistry Katja Strohfeldt A. Essentials of Inorganic Chemistry. For Students of Pharmacy, Pharmaceutical Sciences and Medicinal Chemistry Новинка

Katja Strohfeldt A. Essentials of Inorganic Chemistry. For Students of Pharmacy, Pharmaceutical Sciences and Medicinal Chemistry

5433.07 руб. или Купить в рассрочку!
A comprehensive introduction to inorganic chemistry and, specifically, the science of metal-based drugs, Essentials of Inorganic Chemistry describes the basics of inorganic chemistry, including organometallic chemistry and radiochemistry, from a pharmaceutical perspective. Written for students of pharmacy and pharmacology, pharmaceutical sciences, medicinal chemistry and other health-care related subjects, this accessible text introduces chemical principles with relevant pharmaceutical examples rather than as stand-alone concepts, allowing students to see the relevance of this subject for their future professions. It includes exercises and case studies.
Kenneth Lipkowitz B. Reviews in Computational Chemistry Kenneth Lipkowitz B. Reviews in Computational Chemistry Новинка

Kenneth Lipkowitz B. Reviews in Computational Chemistry

14821.72 руб. или Купить в рассрочку!
The Reviews in Computational Chemistry series brings together leading authorities in the field to teach the newcomer and update the expert on topics centered on molecular modeling, such as computer-assisted molecular design (CAMD), quantum chemistry, molecular mechanics and dynamics, and quantitative structure-activity relationships (QSAR). This volume, like those prior to it, features chapters by experts in various fields of computational chemistry. Topics in Volume 29 include: Noncovalent Interactions in Density-Functional Theory Long-Range Inter-Particle Interactions: Insights from Molecular Quantum Electrodynamics (QED) Theory Efficient Transition-State Modeling using Molecular Mechanics Force Fields for the Everyday Chemist Machine Learning in Materials Science: Recent Progress and Emerging Applications Discovering New Materials via a priori Crystal Structure Prediction Introduction to Maximally Localized Wannier Functions Methods for a Rapid and Automated Description of Proteins: Protein Structure, Protein Similarity, and Protein Folding
Thomas Wirth Microreactors in Organic Chemistry and Catalysis Thomas Wirth Microreactors in Organic Chemistry and Catalysis Новинка

Thomas Wirth Microreactors in Organic Chemistry and Catalysis

17025.43 руб. или Купить в рассрочку!
For the second edition of 'Microreactors in Organic Chemistry and Catalysis' all chapters have been revised and updated to reflect the latest developments in this rapidly developing field. This new edition has 60% more content, and it remains a comprehensive publication covering most aspects of the topic. The use of microreactors in homogeneous, heterogeneous as well as biphasic reactions is covered in the main part of the book, together with catalytic, bioorganic and automation approaches. The initial chapters also provide a solid physical chemistry background on fluidics in microdevices. Finally, a chapter on industrial applications and developments covers recent progress in process chemistry. An excellent reference for beginners and experts alike.
Progress in China's Human Rights Cause in 2003 Progress in China's Human Rights Cause in 2003 Новинка

Progress in China's Human Rights Cause in 2003

Progress in China's Human Rights Cause in 2003
Hongzhe Sun Biological Chemistry of Arsenic, Antimony and Bismuth Hongzhe Sun Biological Chemistry of Arsenic, Antimony and Bismuth Новинка

Hongzhe Sun Biological Chemistry of Arsenic, Antimony and Bismuth

15290.21 руб. или Купить в рассрочку!
Arsenic, antimony and bismuth, three related elements of group 15, are all found in trace quantities in nature and have interesting biological properties and uses. While arsenic is most well known as a poison – and indeed the contamination of groundwater by arsenic is becoming a major health problem in Asia – it also has uses for the treatment of blood cancer and has long been used in traditional chinese medicine. Antimony and bismuth compounds are used in the clinic for the treatment of parasitic and bacterial infections. Biological Chemistry of Arsenic, Antimony and Bismuth is an essential overview of the biological chemistry of these three elements, with contributions from an international panel of experts. Topics covered include: chemistry of As, Sb and Bi biological chemistry of arsenic biological chemistry of Sb and Bi arsenic and antimony speciation in environmental and biological samples arsenic in traditional chinese medicine arsenic in aquifers biomethylation of As, Sb and Bi uptake of metalloids by cells bismuth complexes of porphyrins and their potential in medical applications Helicobacter pylori and bismuth metabolism of arsenic trioxide in blood of the acute promyelocytic leukemia patients anticancer properties of As, Sb and Bi radio-Bi in cancer therapy genotoxicity of As, Sb and Bi metallomics as a new technique for As, Sb and Bi metalloproteomics for As, Sb and Bi Biological Chemistry of Arsenic, Antimony and Bismuth conveys the essential aspects of the bioinorganic chemistry of these three elements, making this book a valuable complement to more general bioinorganic chemistry texts and more specialized topical reviews. It will find a place on the bookshelves of practitioners, researchers and students working in bioinorganic chemistry and medicinal chemistry.
Viktor Iaroshenko Organophosphorus Chemistry. From Molecules to Applications Viktor Iaroshenko Organophosphorus Chemistry. From Molecules to Applications Новинка

Viktor Iaroshenko Organophosphorus Chemistry. From Molecules to Applications

19093.36 руб. или Купить в рассрочку!
Filling the gap for an up-to-date reference that presents the field of organophosphorus chemistry in a comprehensive and clearly structured way, this one-stop source covers the chemistry, properties, and applications from life science and medicine. Divided into two parts, the first presents the chemistry of various phosphorus-containing compounds and their synthesis, including ylides, acids, and heterocycles. The second part then goes on to look at applications in life science and bioorganic chemistry. Last but not least, such important practical aspects as 31P-NMR and protecting strategies for these compounds are presented. For organic, bioinorganic, and medicinal chemists, as well as those working on organometallics, and for materials scientists. The book, a contributed work, features a team of renowned scientists from around the world whose expertise spans the many aspects of modern organophosphorus chemistry.
James Dabrowiak C. Metals in Medicine James Dabrowiak C. Metals in Medicine Новинка

James Dabrowiak C. Metals in Medicine

6460.43 руб. или Купить в рассрочку!
Working from basic chemical principles, Metals in Medicine 2nd Edition describes a wide range of metal-based agents for treating and diagnosing disease. Thoroughly revised and restructured to reflect significant research activity and advances, this new edition contains extensive updates and new pedagogical features while retaining the popular feature boxes and end-of-chapter problems of the first edition. Topics include: Metallo-Drugs and their action Platinum drugs for treating cancer Anticancer agents beyond cisplatin including ruthenium, gold, titanium and gallium Responsive Metal Complexes Treating arthritis and diabetes with metal complexes Metal complexes for killing bacteria, parasites and viruses Metal ion imbalance and its links to diseases including Alzheimer’s, Wilson’s and Menkes disease Metal complexes for detecting disease Nanotechnology in medicine Now in full colour, Metals in Medicine 2nd Edition employs real-life applications and chapter-end summaries alongside feature boxes and problems. It provides a complete and methodical examination of the use of metal complexes in medicine for advanced undergraduate and postgraduate students in medicinal inorganic chemistry, bioinorganic chemistry, biochemistry, pharmacology, biophysics, biology and bioengineering. It is also an invaluable resource for academic researchers and industrial scientists in inorganic chemistry, medicinal chemistry and drug development.
Corey E. J. Name Reactions in Heterocyclic Chemistry II Corey E. J. Name Reactions in Heterocyclic Chemistry II Новинка

Corey E. J. Name Reactions in Heterocyclic Chemistry II

13268.33 руб. или Купить в рассрочку!
The up-to-DATE guide to name reactions in heterocyclic chemistry Name Reactions in Heterocyclic Chemistry II presents a comprehensive treatise on name reactions in heterocyclic chemistry, one of the most exciting—and important—fields within organic chemistry today. The book not only covers fresh ground, but also provides extensive information on new and/or expanded reactions in: Three- and four-membered heterocycles Five-membered heterocycles (pyrroles and pyrrolidines, indoles, furans, thiophenes, and oxazoles) Six-membered heterocycles, including pyridines, quinolines, and isoquinolines Featuring contributions from the leading authorities in heterocyclic chemistry. Each section includes a description of the given reaction, as well as the relevant historical perspective, mechanism, variations and improvements, synthetic utilities, experimental details, and references to the current primary literature. The reactions covered in Name Reactions in Heterocyclic Chemistry have been widely adopted in all areas of organic synthesis, from the medicinal/pharmaceutical field, to agriculture, to fine chemicals, and the book brings the most cutting-edge knowledge to practicing synthetic chemists and students, along with the tools needed to synthesize new and useful molecules.
Philip Fuchs L. Handbook of Reagents for Organic Synthesis. Catalytic Oxidation Reagents Philip Fuchs L. Handbook of Reagents for Organic Synthesis. Catalytic Oxidation Reagents Новинка

Philip Fuchs L. Handbook of Reagents for Organic Synthesis. Catalytic Oxidation Reagents

16113.23 руб. или Купить в рассрочку!
The Handbook is part of the Handbook of Reagents for Organic Chemistry series, aiming at collecting articles on a particular theme that individual researchers in academia or industry can use on a daily basis. The Handbook starts with a section discussing the most important aspects of heteroarene functionalization. The introduction is followed by the alphabetical listing of the most relevant reagents drawn from the EROS database. The Editor, Andre Charette from the University of Montreal, has selected 120 reagent descriptions, many of them updated with heteroarene-specific reactions for this Handbook. Following the standard format for EROS, each article contains an overview of the synthesis and physical properties of the reagents or catalyst, conditions for its storage, and purification methods. Given the importance of heteroarenes in biology and especially in medicinal chemistry, a Handbook that focuses exclusively on heteroarene functionalization has been long overdue. This Handbook will have a broad appeal to many individuals engaged in the area of medicinal chemistry, fine chemical synthesis and industrial-scale chemistry. Key features: Builds on the success of the previously published Handbooks of Reagents for Organic Synthesis Compares the numerous new C-H functionalization reactions that have been developed in the past decade Heteroarene functionalization is widely used in the development of pharmaceuticals and other bioactive compounds Contains listings of secondary reagents for which more information is available in the online edition
Corey E. J. Name Reactions for Carbocyclic Ring Formations Corey E. J. Name Reactions for Carbocyclic Ring Formations Новинка

Corey E. J. Name Reactions for Carbocyclic Ring Formations

14125.98 руб. или Купить в рассрочку!
This book continues the well-established and authoritative series on name reactions in organic chemistry by focusing on name reactions on ring formation. Ring formating reactions have found widespread applicability in traditional organic synthesis, medicinal/pharmaceuticals, agricultural, fine chemicals, and of late, especially in polymer science.
David Crich Modern Synthetic Methods in Carbohydrate Chemistry. From Monosaccharides to Complex Glycoconjugates David Crich Modern Synthetic Methods in Carbohydrate Chemistry. From Monosaccharides to Complex Glycoconjugates Новинка

David Crich Modern Synthetic Methods in Carbohydrate Chemistry. From Monosaccharides to Complex Glycoconjugates

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The fields of glycochemistry and glycoscience are rich and varied and where much can be learned from Nature. As Nature is not always able to produce carbohydrates in quantities useful for not only in research but also as therapeutic agents, new ways need to be found to optimize the yield. This book presents an overview of the latest developments in the field of carbohydrates, ranging from de-novo approaches via cyclodextrin chemistry to the synthesis of such highly complex glycoconjugates as glycosphingolipids and GPI anchors. The main emphasis remains on the synthetic aspects making the book an excellent source of information for those already involved in carbohydrate chemistry, as well as for those organic chemists who are beginners in this field. Equally of interest to synthetic chemists, as well as medicinal chemists and biochemists.
Myung-Hwan Whangbo Orbital Interactions in Chemistry Myung-Hwan Whangbo Orbital Interactions in Chemistry Новинка

Myung-Hwan Whangbo Orbital Interactions in Chemistry

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Explains the underlying structure that unites all disciplines in chemistry Now in its second edition, this book explores organic, organometallic, inorganic, solid state, and materials chemistry, demonstrating how common molecular orbital situations arise throughout the whole chemical spectrum. The authors explore the relationships that enable readers to grasp the theory that underlies and connects traditional fields of study within chemistry, thereby providing a conceptual framework with which to think about chemical structure and reactivity problems. Orbital Interactions in Chemistry begins by developing models and reviewing molecular orbital theory. Next, the book explores orbitals in the organic-main group as well as in solids. Lastly, the book examines orbital interaction patterns that occur in inorganic–organometallic fields as well as cluster chemistry, surface chemistry, and magnetism in solids. This Second Edition has been thoroughly revised and updated with new discoveries and computational tools since the publication of the first edition more than twenty-five years ago. Among the new content, readers will find: Two new chapters dedicated to surface science and magnetic properties Additional examples of quantum calculations, focusing on inorganic and organometallic chemistry Expanded treatment of group theory New results from photoelectron spectroscopy Each section ends with a set of problems, enabling readers to test their grasp of new concepts as they progress through the text. Solutions are available on the book's ftp site. Orbital Interactions in Chemistry is written for both researchers and students in organic, inorganic, solid state, materials, and computational chemistry. All readers will discover the underlying structure that unites all disciplines in chemistry.
Weiss Joachim Handbook of Ion Chromatography, 3 Volume Set Weiss Joachim Handbook of Ion Chromatography, 3 Volume Set Новинка

Weiss Joachim Handbook of Ion Chromatography, 3 Volume Set

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This three-volume handbook is the standard reference in the field, unparalleled in its comprehensiveness. It covers every conceivable topic related to the expanding and increasingly important field of ion chromatography. The fourth edition is completely updated and revised to include the latest developments in the instrumentation, now stretching to three volumes to reflect the current state of applications. Ion chromatography is one of the most widely used separation techniques of analytical chemistry with applications in fields such as medicinal chemistry, water chemistry and materials science. Consequently, the number of users of this method is continuously growing, underlining the need for an up-to-date reference. A true pioneer of this method, Joachim Weiss studied chemistry at the Technical University of Berlin (Germany), where he also received his PhD degree in Analytical Chemistry. In 2002, he did his habilitation in Analytical Chemistry at the Leopold-Franzens University in Innsbruck (Austria), where he is also teaching liquid chromatography. Since 1982, Dr. Weiss has worked at Dionex (now being part of Thermo Fisher Scientific), where he currently holds the position of Technical Director for Dionex Products within the Chromatography and Mass Spectrometry Division (CMD) of Thermo Fisher Scientific, located in Dreieich (Germany).
Hani Amouri Chirality in Transition Metal Chemistry. Molecules, Supramolecular Assemblies and Materials Hani Amouri Chirality in Transition Metal Chemistry. Molecules, Supramolecular Assemblies and Materials Новинка

Hani Amouri Chirality in Transition Metal Chemistry. Molecules, Supramolecular Assemblies and Materials

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Chirality in Transition Metal Chemistry is an essential introduction to this increasingly important field for students and researchers in inorganic chemistry. Emphasising applications and real-world examples, the book begins with an overview of chirality, with a discussion of absolute configurations and system descriptors, physical properties of enantiomers, and principles of resolution and preparation of enantiomers. The subsequent chapters deal with the the specifics of chirality as it applies to transition metals. Some reviews of Chirality in Transition Metal Chemistry «…useful to students taking an advanced undergraduate course and particularly to postgraduates and academics undertaking research in the areas of chiral inorganic supramolecular complexes and materials.» Chemistry World, August 2009 “…the book offers an extremely exciting new addition to the study of inorganic chemistry, and should be compulsory reading for students entering their final year of undergraduate studies or starting a Ph.D. in structural inorganic chemistry.” Applied Organometallic Chemistry Volume 23, Issue 5, May 2009 “…In conclusion the book gives a wonderful overview of the topic. It is helpful for anyone entering the field through systematic and detailed introduction of basic information. It was time to publish a new and topical text book covering the important aspect of coordination chemistry. It builds bridges between Inorganic, organic and supramolecular chemistry. I can recommend the book to everybody who is interested in the chemistry of chiral coordination compounds .” Angew. chem. Volume 48, Issue 18, April 2009 About the Series Chirality in Transition Metal Chemistry is the latest addition to the Wiley Inorganic Chemistry Advanced Textbook series. This series reflects the pivotal role of modern inorganic and physical chemistry in a whole range of emerging areas such as materials chemistry, green chemistry and bioinorganic chemistry, as well as providing a solid grounding in established areas such as solid state chemistry, coordination chemistry, main group chemistry and physical inorganic chemistry.
Kenneth Karlin D. Progress in Inorganic Chemistry Kenneth Karlin D. Progress in Inorganic Chemistry Новинка

Kenneth Karlin D. Progress in Inorganic Chemistry

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This series provides inorganic chemists and materials scientists with a forum for critical, authoritative evaluations of advances in every area of the discipline. Volume 59 continues to report recent advances with a significant, up-to-date selection of contributions by internationally-recognized researchers. The chapters of this volume are devoted to the following topics: • Iron Catalysis in Synthetic Chemistry • A New Paradigm for Photodynamic Therapy Drug Design: Multifunctional, Supramolecular DNA Photomodification Agents Featuring Ru(II)/Os(II) Light Absorbers Coupled to Pt(II) or Rh(III) Bioactive Sites • Selective Binding of Zn2+ Complexes to Non-Canonical Thymine or Uracil in DNA or RNA. • Progress Toward the Electrocatalytic Production of Liquid Fuels from Carbon Dioxide • Monomeric Dinitrosyl Iron Complexes: Synthesis and Reactivity • Interactions of Nitrosoalkanes/arenes, Nitrosamines, Nitrosothiols, and Alkyl Nitrites with Metals • Aminopyridine Iron and Manganese Complexes as Molecular Catalysts for Challenging Oxidative Transformations
Nahar Chowdhury Lutfun Steroid Dimers. Chemistry and Applications in Drug Design and Delivery Nahar Chowdhury Lutfun Steroid Dimers. Chemistry and Applications in Drug Design and Delivery Новинка

Nahar Chowdhury Lutfun Steroid Dimers. Chemistry and Applications in Drug Design and Delivery

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Steroid dimers are an important group of compounds produced by various marine organisms, and also synthesized in the laboratories. This group of compounds possesses various pharmacological and biological properties, and can also be used to create “molecular umbrellas” for drug delivery. Steroid Dimers: Chemistry and Applications in Drug Design and Delivery provides an up-to-date overview on the chemistry and applications of steroid dimers of natural and synthetic origins. The book includes easy-to-follow synthetic protocols for various classes of important dimeric steroids, source details, valuable spectroscopic data and depiction of unique structural features of natural steroidal dimers, and the Structure-Activity-Relationships (SARs) of some pharmacologically active dimeric steroids. Topics covered include: introduction to steroid dimers synthesis and chemistry of noncyclic and cyclic steroid dimers naturally occurring steroid dimers – cephalostatins, ritterazines and crellastatins biological and pharmacological functions of steroid dimers and their application in drug design and discovery steroid dimers as “molecular umbrellas” for drug delivery Steroid Dimers: Chemistry and Applications in Drug Design and Delivery is an essential guide to this important class of natural and synthetic compounds for researchers and students of natural products chemistry and biochemistry, synthetic organic and medicinal chemistry, and drug design, discovery and delivery.
Kenneth Karlin D. Progress in Inorganic Chemistry Kenneth Karlin D. Progress in Inorganic Chemistry Новинка

Kenneth Karlin D. Progress in Inorganic Chemistry

11777.18 руб. или Купить в рассрочку!
This series provides inorganic chemists and materials scientists with a forum for critical, authoritative evaluations of advances in every area of the discipline. Volume 58 continues to report recent advances with a significant, up-to-date selection of contributions by internationally-recognized researchers. The chapters of this volume are devoted to the following topics: • Tris(dithiolene) Chemistry: A Golden Jubilee • How to find an HNO needle in a (bio)-chemical Haystack • Photoactive Metal Nitrosyl and Carbonyl Complexes Derived from Designed Auxiliary Ligands: An Emerging Class of Photochemotherapeutics • Metal–Metal Bond-Containing Complexes as Catalysts for C–H Functionalization Iron Catalysis in Synthetic Chemistry • Reactive Transition Metal Nitride Complexes Suitable for inorganic chemists and materials scientists in academia, government, and industries including pharmaceutical, fine chemical, biotech, and agricultural.
Caroli Sergio Analytical Techniques for Clinical Chemistry. Methods and Applications Caroli Sergio Analytical Techniques for Clinical Chemistry. Methods and Applications Новинка

Caroli Sergio Analytical Techniques for Clinical Chemistry. Methods and Applications

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Discover how analytical chemistry supports the latest clinical research This book details the role played by analytical chemistry in fostering clinical research. Readers will discover how a broad range of analytical techniques support all phases of clinical research, from early stages to the implementation of practical applications. Moreover, the contributing authors' careful step-by-step guidance enables readers to better understand standardized techniques and steer clear of everyday problems that can arise in the lab. Analytical Techniques for Clinical Chemistry opens with an overview of the legal and regulatory framework governing clinical lab analysis. Next, it details the latest progress in instrumentation and applications in such fields as biomonitoring, diagnostics, food quality, biomarkers, pharmaceuticals, and forensics. Comprised of twenty-five chapters divided into three sections exploring Fundamentals, Selected Applications, and Future Trends, the book covers such critical topics as: Uncertainty in clinical chemistry measurements Metal toxicology in clinical, forensic, and chemical pathology Role of analytical chemistry in the safety of drug therapy Atomic spectrometric techniques for the analysis of clinical samples Biosensors for drug analysis Use of X-ray techniques in medical research Each chapter is written by one or more leading pioneers and experts in analytical chemistry. Contributions are based on a thorough review and analysis of the current literature as well as the authors' own firsthand experiences in the lab. References at the end of each chapter serve as a gateway to the literature, enabling readers to explore individual topics in greater depth. Presenting the latest achievements and challenges in the field, Analytical Techniques for Clinical Chemistry sets the foundation for future advances in laboratory research techniques.
Chris Hren U Can: Chemistry I For Dummies Chris Hren U Can: Chemistry I For Dummies Новинка

Chris Hren U Can: Chemistry I For Dummies

1939.74 руб. или Купить в рассрочку!
Now you can score higher in chemistry Every high school requires a course in chemistry for graduation, and many universities require the course for majors in medicine, engineering, biology, and various other sciences. U Can: Chemistry I For Dummies offers all the how-to content you need to enhance your classroom learning, simplify complicated topics, and deepen your understanding of often-intimidating course material. Plus, you'll find easy-to-follow examples and hundreds of practice problems—as well as access to 1,001 additional Chemistry I practice problems online! As more and more students enroll in chemistry courses,, the need for a trusted and accessible resource to aid in study has never been greater. That's where U Can: Chemistry I For Dummies comes in! If you're struggling in the classroom, this hands-on, friendly guide makes it easy to conquer chemistry. Simplifies basic chemistry principles Clearly explains the concepts of matter and energy, atoms and molecules, and acids and bases Helps you tackle problems you may face in your Chemistry I course Combines 'how-to' with 'try it' to form one perfect resource for chemistry students If you're confused by chemistry and want to increase your chances of scoring your very best at exam time, U Can: Chemistry I For Dummies shows you that you can!
WORK IN PROGRESS Сапоги WORK IN PROGRESS Сапоги Новинка

WORK IN PROGRESS Сапоги

кожа, без аппликаций, одноцветное изделие, узкий носок, конический каблук, внутри кожа, кожаная подошва, содержит нетекстильные части животного происхождения
WORK IN PROGRESS Сапоги WORK IN PROGRESS Сапоги Новинка

WORK IN PROGRESS Сапоги

кожа, без аппликаций, одноцветное изделие, узкий носок, геометрический каблук, внутри кожа, кожаная подошва, содержит нетекстильные части животного происхождения
WORK IN PROGRESS Сандалии WORK IN PROGRESS Сандалии Новинка

WORK IN PROGRESS Сандалии

без аппликаций, одноцветное изделие, пряжка, скругленный носок, шпилька, деревянный каблук, внутри кожа, кожаная подошва, содержит нетекстильные части животного происхождения
Karen Lackey Medicinal Chemistry Approaches to Personalized Medicine Karen Lackey Medicinal Chemistry Approaches to Personalized Medicine Новинка

Karen Lackey Medicinal Chemistry Approaches to Personalized Medicine

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Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues. Numerous case studies from the first generation of «personalized drugs» are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered. With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come. From the content: * Discovery of Predictive Biomarkers for Anticancer Drugs * Discovery and Development of Vemurafenib * Targeting Basal-Cell Carcinoma * G-Quadruplexes as Therapeutic Targets in Cancer * From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease * Therapeutic Potential of Kinases in Asthma * DNA Damage Repair Pathways and Synthetic Lethality * Medicinal Chemistry in the Context of the Human Genome and many more
Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry Новинка

Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry

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This is the third of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international «who's who» in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides This third volume in the series presents an in depth account of recent developments in the (bio-)synthesis of amino acids and peptides. Divided into two parts, the first section deals with amino acids as building blocks, including the generation of alpha-amino acids, beta-lactams, and heterocycles. The second section is devoted to the synthesis of peptides, with the focus on solid phase synthesis. However, solution phase peptide synthesis is covered as well, as are topics such as coupling reagents, chemical ligation, peptide purification and automation. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.
Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry Новинка

Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry

17773.9 руб. или Купить в рассрочку!
This is the third of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international «who's who» in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides This third volume in the series presents an in depth account of recent developments in the (bio-)synthesis of amino acids and peptides. Divided into two parts, the first section deals with amino acids as building blocks, including the generation of alpha-amino acids, beta-lactams, and heterocycles. The second section is devoted to the synthesis of peptides, with the focus on solid phase synthesis. However, solution phase peptide synthesis is covered as well, as are topics such as coupling reagents, chemical ligation, peptide purification and automation. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.
Gerard Jaouen Bioorganometallic Chemistry. Applications in Drug Discovery, Biocatalysis, and Imaging Gerard Jaouen Bioorganometallic Chemistry. Applications in Drug Discovery, Biocatalysis, and Imaging Новинка

Gerard Jaouen Bioorganometallic Chemistry. Applications in Drug Discovery, Biocatalysis, and Imaging

14897.43 руб. или Купить в рассрочку!
An up-to-date reference reflecting the significant advances and important breakthroughs made in this emerging discipline over the last decade. As such, the book provides an overview of the latest developments and future trends in the field, focusing on such applications as the development of potentially active organometallic drugs against incurable diseases, as well as in such areas as catalysis, energy, analytical chemistry, and imaging. The renowned editor, who established the term «bioorganometallics», and his international team of experts have put together a valuable resource for researchers in organometallic, inorganic, medicinal, and biochemistry.
Peer Kirsch Modern Fluoroorganic Chemistry. Synthesis, Reactivity, Applications Peer Kirsch Modern Fluoroorganic Chemistry. Synthesis, Reactivity, Applications Новинка

Peer Kirsch Modern Fluoroorganic Chemistry. Synthesis, Reactivity, Applications

15353.9 руб. или Купить в рассрочку!
The second edition of this classic reference work has been completely revised and updated, as well as being enlarged by 20% to reflect the latest developments in synthetic organic fluorine chemistry, taking into account new applications in materials science and medicinal chemistry. The new developments in transition-metal-catalyzed methods for the introduction of fluorine and fluorinated groups are discussed. In addition, new chapters have been added on such important applications as organic electronics (OLEDs) and fluorinated dyes. Appendices containing synthetic procedures and conversions round off this comprehensive work. This work is a valuable reference for fluorine chemists that also provides nonspecialists with an introduction to the field. From reviews of the first edition: ''… a well-produced book with attractive graphics, photos and schemes. Throughout the book, coloured electrostatic maps of small organofluorine compounds are used toillustrate charge distributions. These are effective as well as attractive. I would point any organic chemist to this book who wants to learn about and do some fluorine chemistry. It provides uncluttered descriptions and a clear orientation to the literature in this important area of the organic chemistry.'' CHEMBIOCHEM – A European Journal of Chemical Biology
Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad Новинка

Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad

17381.94 руб. или Купить в рассрочку!
The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development. With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the «good» inhibitions—desirable pharmacological effects—and «bad» inhibitions—drug–drug interactions and toxicity. The book discusses: The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.
Jay Siegel Forensic Chemistry. Fundamentals and Applications Jay Siegel Forensic Chemistry. Fundamentals and Applications Новинка

Jay Siegel Forensic Chemistry. Fundamentals and Applications

Forensic Chemistry: Fundamentals and Applications presents a new approach to the study of applications of chemistry to forensic science. It is edited by one of the leading forensic scientists with each chapter written by international experts specializing in their respective fields, and presents the applications of chemistry, especially analytical chemistry, to various topics that make up the forensic scientists toolkit. This comprehensive, textbook includes in-depth coverage of the major topics in forensic chemistry including: illicit drugs, fibers, fire and explosive residues, soils, glass and paints, the chemistry of fingerprint recovery on porous surfaces, the chemistry of firearms analysis, as well as two chapters on the key tools of forensic science, microscopy and chemometrics. Each topic is explored at an advanced college level, with an emphasis, throughout the text, on the use of chemical tools in evidence analysis. Forensic Chemistry: Fundamentals and Applications is essential reading for advanced students of forensic science and analytical chemistry, as well as forensic science practitioners, researchers and faculty, and anyone who wants to learn about the fascinating subject of forensic chemistry in some depth. This book is published as part of the AAFS series ‘Forensic Science in Focus’.
Peter Langer Asymmetric Synthesis of Non-Proteinogenic Amino Acids Peter Langer Asymmetric Synthesis of Non-Proteinogenic Amino Acids Новинка

Peter Langer Asymmetric Synthesis of Non-Proteinogenic Amino Acids

15581.05 руб. или Купить в рассрочку!
Authored by two internationally recognized experts with an excellent track record, this much-needed reference summarizes latest research in the rapidly developing field of stereoselective synthesis of enantiomerically enriched amino acids, particularly of non-proteinogenic origin. It highlights several different catalytic and stoichiometric asymmetric methods for their synthesis and also provides information on origin, biological properties, different synthetic strategies and important applications in medicine and pharmacology. Essential reading for synthetic chemists working in the field of asymmetric synthesis, natural products and peptide synthesis, stereochemistry, medicinal chemistry, biochemistry, pharmacology, and biotechnology.
Lawrence Kobilinsky Forensic Chemistry Handbook Lawrence Kobilinsky Forensic Chemistry Handbook Новинка

Lawrence Kobilinsky Forensic Chemistry Handbook

10633.29 руб. или Купить в рассрочку!
A concise, robust introduction to the various topics covered by the discipline of forensic chemistry The Forensic Chemistry Handbook focuses on topics in each of the major chemistry-related areas of forensic science. With chapter authors that span the forensic chemistry field, this book exposes readers to the state of the art on subjects such as serology (including blood, semen, and saliva), DNA/molecular biology, explosives and ballistics, toxicology, pharmacology, instrumental analysis, arson investigation, and various other types of chemical residue analysis. In addition, the Forensic Chemistry Handbook: Covers forensic chemistry in a clear, concise, and authoritative way Brings together in one volume the key topics in forensics where chemistry plays an important role, such as blood analysis, drug analysis, urine analysis, and DNA analysis Explains how to use analytical instruments to analyze crime scene evidence Contains numerous charts, illustrations, graphs, and tables to give quick access to pertinent information Media focus on high-profile trials like those of Scott Peterson or Kobe Bryant have peaked a growing interest in the fascinating subject of forensic chemistry. For those readers who want to understand the mechanisms of reactions used in laboratories to piece together crime scenes—and to fully grasp the chemistry behind it—this book is a must-have.
Reed Izatt M. Macrocyclic and Supramolecular Chemistry. How Izatt-Christensen Award Winners Shaped the Field Reed Izatt M. Macrocyclic and Supramolecular Chemistry. How Izatt-Christensen Award Winners Shaped the Field Новинка

Reed Izatt M. Macrocyclic and Supramolecular Chemistry. How Izatt-Christensen Award Winners Shaped the Field

14821.72 руб. или Купить в рассрочку!
This book commemorates the 25th anniversary of the International Izatt-Christensen Award in Macrocyclic and Supramolecular Chemistry. The award, one of the most prestigious of small awards in chemistry, recognizes excellence in the developing field of macrocyclic and supramolecular chemistry Macrocyclic and Supramolecular Chemistry: How Izatt-Christensen Award Winners Shaped the Field features chapters written by the award recipients who provide unique perspectives on the spectacular growth in these expanding and vibrant fields of chemistry over the past half century, and on the role of these awardees in shaping this growth. During this time there has been an upsurge of interest in the design, synthesis and characterization of increasingly more complex macrocyclic ligands and in the application of this knowledge to understanding molecular recognition processes in host-guest chemistry in ways that were scarcely envisioned decades earlier. In October 2016, Professor Jean-Pierre Sauvage and Sir J. Fraser Stoddart (author for chapter 22 «Contractile and Extensile Molecular Systems: Towards Molecular Muscles» by Jean -Pierre Sauvage, Vincent Duplan, and Frédéric Niess and 20 «Serendipity» by Paul R. McGonigal and J. Fraser Stoddart respectively) were awarded the Nobel Prize in Chemistry alongside fellow Wiley author Bernard Feringa, for the design and synthesis of molecular machines.
Borisov S., Voronkov M., Lukevits E. Organosilicon Derivatives of Phosphorus and Sulfur Borisov S., Voronkov M., Lukevits E. Organosilicon Derivatives of Phosphorus and Sulfur Новинка

Borisov S., Voronkov M., Lukevits E. Organosilicon Derivatives of Phosphorus and Sulfur

One of the characteristics of the development of chemical science in the middle of the present century is the vigorous pro gress of the "third chemistry," which is often named now the chemistry of heteroorganic compounds. Then in the last decade, among specialists in this field there has been a marked increase in interest in heteroatomic organic derivatives of silicon, i. e. , heteroorganic silicon compounds. However, until recently this new class of chemical substances, which is extremely interesting theoretically and practically, has been without a single specialized monograph which systematizes and generalizes all progress in the heteroorganic chemistry of silicon. The first attempt in this direction was our book "Heteroorganic Compounds of Silicon" [42 (F), 17 (S) *], which appeared at the end of 1966 and was published as an English translation in the USA in 1969. However, as follows from its subtitle "Derivatives of Inorganic Elements," this mono graph could not cover the whole broad field of the chemistry of heteroorganic compounds of silicon. The main reason for this was above all the abundance and variety of original investigations of organosilicon derivatives of inorganic elements, which was un expected even to the authors themselves. As a result of this the planned length of the book compelled us to omit the sections on organosilicon compounds of phosphorus and sulfur, which had al ready been prepared for publication.Издательство - Plenum press
West Anthony R. Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System. From Biology to Drug Discovery West Anthony R. Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System. From Biology to Drug Discovery Новинка

West Anthony R. Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System. From Biology to Drug Discovery

10012.37 руб. или Купить в рассрочку!
This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.
Robert Scott A. Applications of Physical Methods to Inorganic and Bioinorganic Chemistry Robert Scott A. Applications of Physical Methods to Inorganic and Bioinorganic Chemistry Новинка

Robert Scott A. Applications of Physical Methods to Inorganic and Bioinorganic Chemistry

20597.81 руб. или Купить в рассрочку!
Modern spectroscopic and instrumental techniques are essential to the practice of inorganic and bioinorganic chemistry. This first volume in the new Wiley Encyclopedia of Inorganic Chemistry Methods and Applications Series provides a consistent and comprehensive description of the practical applicability of a large number of techniques to modern problems in inorganic and bioinorganic chemistry. The outcome is a text that provides invaluable guidance and advice for inorganic and bioinorganic chemists to select appropriate techniques, whilst acting as a source to the understanding of these methods. This volume is also available as part of Encyclopedia of Inorganic Chemistry, 5 Volume Set. This set combines all volumes published as EIC Books from 2007 to 2010, representing areas of key developments in the field of inorganic chemistry published in the Encyclopedia of Inorganic Chemistry. Find out more.
Armando J. L. Pombeiro Advances in Organometallic Chemistry and Catalysis. The Silver / Gold Jubilee International Conference on Organometallic Chemistry Celebratory Book Armando J. L. Pombeiro Advances in Organometallic Chemistry and Catalysis. The Silver / Gold Jubilee International Conference on Organometallic Chemistry Celebratory Book Новинка

Armando J. L. Pombeiro Advances in Organometallic Chemistry and Catalysis. The Silver / Gold Jubilee International Conference on Organometallic Chemistry Celebratory Book

14589.52 руб. или Купить в рассрочку!
A contemporary compilation of recent achievements in organometallic chemistry The prestigious International Conference on Organometallic Chemistry (ICOMC) was launched in 1963, providing a forum for researchers from around the world to share their findings and explore new paths to advance our knowledge and application of organometallic chemistry. The 25th ICOMC, held in Lisbon in 2012, gathered more than 1,200 participants from 54 countries. This volume celebrates the 25th Silver Edition and the 50th Gold Year of the ICOMC. Featuring contributions from invited 25th ICOMC speakers, Advances in Organometallic Chemistry and Catalysis highlights recent achievements and new and emerging areas of research in the field. Its seven sections cover: Activation and Functionalization of Carbon Single Bonds and Small Molecules Organometallic Synthesis and Catalysis Organometallic Polymerization Catalysis Organometallic Polymers and Materials Organometallic Chemistry and Sustainable Energy Bioorganometallic Chemistry Organometallic Electrochemistry Chapters discuss fundamental underlying concepts, offer illustrative examples and cases, and explore future avenues for continued research. Readers will discover basic principles and properties of organometallic compounds, reaction mechanisms, and detailed descriptions of current applications. Collectively, these chapters underscore the versatility, richness, and potential of modern organometallic chemistry, including its interrelationships with other scientific disciplines. All the contributions are extensively referenced, providing a gateway to the most important original research papers and reviews in organometallic chemistry. Presenting a contemporary understanding of organometallic chemistry and its many applications, Advances in Organometallic Chemistry and Catalysis is recommended for all researchers in the field, from students to advanced investigators.
Hugo Kubinyi Prodrugs and Targeted Delivery. Towards Better ADME Properties Hugo Kubinyi Prodrugs and Targeted Delivery. Towards Better ADME Properties Новинка

Hugo Kubinyi Prodrugs and Targeted Delivery. Towards Better ADME Properties

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This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.
Gerhard Friedrich Müller Protein Kinases as Drug Targets Gerhard Friedrich Müller Protein Kinases as Drug Targets Новинка

Gerhard Friedrich Müller Protein Kinases as Drug Targets

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This timely guide to kinase inhibitor drug development is the first to cover the entire drug pipeline, from target identification to compound development and clinical application. Edited by the pioneers in the field, on the drug development side this ready reference discusses classical medicinal chemistry approaches as well as current chemical genomics strategies. On the clinical side, both current and future therapeutic application areas for kinase inhibitor drugs are addressed, with a strong focus on oncology drugs. Backed by recent clinical experience with first-generation drugs in the battle against various forms of cancer, this is crucial reading for medicinal, pharmaceutical and biochemists, molecular biologists, and oncologists, as well as those working in the pharmaceutical industry.
Harmata Michael Silver in Organic Chemistry Harmata Michael Silver in Organic Chemistry Новинка

Harmata Michael Silver in Organic Chemistry

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The first authoritative book on using silver cations in organic chemistry—for catalysis and more! With more sophisticated catalytic methodologies fueling a resurgence in the study of cation-based chemistry, gold and platinum have stepped to the fore as the unique agents used to create new chemical reactions. Although these metals have become a primary focus of researchers in the field, another coinage metal that is often overlooked—but is as powerful as the others—is silver, a far less costly alternative to gold and platinum in aiding the development of new reactions. Making a strong case for the use of silver as a catalyst and structural element in organometal constructs, this authoritative book is the first to explore the benefits of using silver in organic chemistry by taking a close look at silver’s unique reactivity and structural characteristics for the development of new methods and materials. Silver in Organic Chemistry is: The first book to address catalysis using silver, whose use in organic chemistry is on the verge of exploding A resource for researchers wishing to do chemistry with silver cations, an area that stands in the shadow of gold chemistry, but still glistens, demonstrating that all that glitters is not gold—sometimes it’s silver! A guide for “first attempts” in working with silver cations Edited by a very well-respected, highly visible authority in this field Silver in Organic Chemistry promotes further scientific discussion by offering important new ways to examine the future possibilities of an emerging field. By elevating the importance of silver chemistry, this thought-provoking guide illustrates how this versatile metal can become an increasingly significant player in opening the door to new catalytic organic reactions and new organometal materials.
Richard Langley H. Organic Chemistry II For Dummies Richard Langley H. Organic Chemistry II For Dummies Новинка

Richard Langley H. Organic Chemistry II For Dummies

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A plain-English guide to one of the toughest courses around So, you survived the first semester of Organic Chemistry (maybe even by the skin of your teeth) and now it's time to get back to the classroom and lab! Organic Chemistry II For Dummies is an easy-to-understand reference to this often challenging subject. Thanks to this book, you'll get friendly and comprehensible guidance on everything you can expect to encounter in your Organic Chemistry II course. An extension of the successful Organic Chemistry I For Dummies Covers topics in a straightforward and effective manner Explains concepts and terms in a fast and easy-to-understand way Whether you're confused by composites, baffled by biomolecules, or anything in between, Organic Chemistry II For Dummies gives you the help you need – in plain English!

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Chirality in Transition Metal Chemistry is an essential introduction to this increasingly important field for students and researchers in inorganic chemistry. Emphasising applications and real-world examples, the book begins with an overview of chirality, with a discussion of absolute configurations and system descriptors, physical properties of enantiomers, and principles of resolution and preparation of enantiomers. The subsequent chapters deal with the the specifics of chirality as it applies to transition metals. Some reviews of Chirality in Transition Metal Chemistry «…useful to students taking an advanced undergraduate course and particularly to postgraduates and academics undertaking research in the areas of chiral inorganic supramolecular complexes and materials.» Chemistry World, August 2009 “…the book offers an extremely exciting new addition to the study of inorganic chemistry, and should be compulsory reading for students entering their final year of undergraduate studies or starting a Ph.D. in structural inorganic chemistry.” Applied Organometallic Chemistry Volume 23, Issue 5, May 2009 “…In conclusion the book gives a wonderful overview of the topic. It is helpful for anyone entering the field through systematic and detailed introduction of basic information. It was time to publish a new and topical text book covering the important aspect of coordination chemistry. It builds bridges between Inorganic, organic and supramolecular chemistry. I can recommend the book to everybody who is interested in the chemistry of chiral coordination compounds .” Angew. chem. Volume 48, Issue 18, April 2009 About the Series Chirality in Transition Metal Chemistry is the latest addition to the Wiley Inorganic Chemistry Advanced Textbook series. This series reflects the pivotal role of modern inorganic and physical chemistry in a whole range of emerging areas such as materials chemistry, green chemistry and bioinorganic chemistry, as well as providing a solid grounding in established areas such as solid state chemistry, coordination chemistry, main group chemistry and physical inorganic chemistry.
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